Page last updated: 2024-10-26

valproic acid and Fever

valproic acid has been researched along with Fever in 27 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."7.81Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"To determine the incidence, characteristics, and predictors of clozapine-induced fever in a sample of patients in a local psychiatric unit."7.74The incidence and characteristics of clozapine- induced fever in a local psychiatric unit in Hong Kong. ( Chan, WF; Chung, KF; Lai-wah Dunn, E; Pui-yin Chung, J; Shiu-yin Chong, C; Wai-nang Tang, O, 2008)
"Valproic acid is a carboxylic acid used for the treatment of both seizure and mood disorders."5.32Valproic acid-induced eosinophilic pleural effusion. ( Federman, DG; Kravetz, JD, 2003)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."3.81Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy."3.75Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009)
"To determine the incidence, characteristics, and predictors of clozapine-induced fever in a sample of patients in a local psychiatric unit."3.74The incidence and characteristics of clozapine- induced fever in a local psychiatric unit in Hong Kong. ( Chan, WF; Chung, KF; Lai-wah Dunn, E; Pui-yin Chung, J; Shiu-yin Chong, C; Wai-nang Tang, O, 2008)
"Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered."2.72Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature. ( Aghavali, S; Babadi, M; Daraie, P; Emamikhah, M; Jalili, M; Mehrabani, M; Mohaghegh, F; Pouranian, M; Rohani, M; Zaribafian, M, 2021)
"The risk of recurrences was significantly lower in children receiving continuous phenobarbital therapy than placebo (odds ratio 0."2.40A meta-analytic review of the preventive treatment of recurrences of febrile seizures. ( Rantala, H; Tarkka, R; Uhari, M, 1997)
"DRESS syndrome is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, lymph node enlargement, and liver or renal dysfunctions."1.38DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. ( Albayrak, A; Albayrak, F; Cerrah, S; Dursun, H; Uyanik, A; Yildirim, R, 2012)
"Valproic acid is a carboxylic acid used for the treatment of both seizure and mood disorders."1.32Valproic acid-induced eosinophilic pleural effusion. ( Federman, DG; Kravetz, JD, 2003)
"This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs."1.32[Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004)
"There was a greater risk of recurrence among girls."1.28[Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989)
"Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion."1.26Sodium valproate in the prophylaxis of simple febrile convulsions. ( Evans-Jones, LG; Groom, PJ; Kindley, AD; Williams, AJ, 1979)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19906 (22.22)18.7374
1990's2 (7.41)18.2507
2000's8 (29.63)29.6817
2010's8 (29.63)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Yang, Y1
Zeng, Q1
Cheng, M1
Niu, X1
Xiangwei, W1
Gong, P1
Li, W1
Ma, J1
Zhang, X1
Yang, X1
Yang, Z1
Sun, D1
Zhou, S1
Liao, J1
Jiang, Y1
Zhang, Y1
Stuver, R1
Khanna, P1
Wischhusen, JW1
Cobb, C1
Bockorny, B1
Emamikhah, M1
Babadi, M1
Mehrabani, M1
Jalili, M1
Pouranian, M1
Daraie, P1
Mohaghegh, F1
Aghavali, S1
Zaribafian, M1
Rohani, M1
Gupta, J1
Sinha, R1
Jauhari, P1
Malik, R1
Chakrabarty, B1
Gulati, S1
Hesemann, J1
Lauer, E1
Ziska, S1
Noonan, K1
Nemeth, B1
Scott-Schwoerer, J1
McCarty, C1
Rasmussen, K1
Goldberg, JM1
Sund, S1
Eickhoff, J1
Raggio, CL1
Giampietro, PF1
Miller, MW1
Church, CC1
Trivisano, M1
Specchio, N1
Vigevano, F1
Bamford, A1
Crowe, BH1
Hacohen, Y1
Lin, JP1
Clarke, A1
Tudor-Williams, G1
Sancho-Shimizu, V1
Vincent, A1
Lim, M1
Pullaperuma, SP1
Johannsen, J1
Nickel, M1
Schulz, A1
Denecke, J1
Pui-yin Chung, J1
Shiu-yin Chong, C1
Chung, KF1
Lai-wah Dunn, E1
Wai-nang Tang, O1
Chan, WF1
Ferguson, LP1
Dargan, PI1
Hood, JL1
Tibby, SM1
Albayrak, F1
Cerrah, S1
Albayrak, A1
Dursun, H1
Yildirim, R1
Uyanik, A1
Bowen, DJ1
Lucas, NL1
Braude, S1
Audic-Gerard, F1
Szepetowski, P1
Genton, P1
Kravetz, JD1
Federman, DG1
Papp, Z1
Török, L1
Bourgeois, JA1
Koike, AK1
Simmons, JE1
Telles, S1
Eggleston, C1
Nesseler, N1
Polard, E1
Arvieux, C1
Coquerel, N1
Michelet, C1
Tattevin, P1
Nowack, WJ1
Johnson, RN1
Hanna, GR1
Procopis, PG1
Seghieri, G1
De Giorgio, LA1
Innocenti, F1
Pettiná, G1
Zolfanelli, F1
Apicella, P1
Rantala, H1
Tarkka, R1
Uhari, M1
Tonnelier, JM1
Mocquard, Y1
Broch, C1
Vandhuick, O1
Goas, P1
Goas, JY1
Williams, AJ1
Evans-Jones, LG1
Kindley, AD1
Groom, PJ1
Sánchez Romero, A1
Onsurbe Ramírez, I1
Herranz Fernández, JL1
Armijo Simón, JA1
Arteaga Manjón-Cabeza, R1
Thiessen, JJ1
Albright, PS1
Bruni, J1
Suria, D1

Reviews

3 reviews available for valproic acid and Fever

ArticleYear
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
    Journal of neurovirology, 2021, Volume: 27, Issue:1

    Topics: Adult; Anticonvulsants; Ataxia; Azithromycin; Clonazepam; Cough; COVID-19; COVID-19 Drug Treatment;

2021
Arrhenius thermodynamics and birth defects: chemical teratogen synergy. Untested, testable, and projected relevance.
    Birth defects research. Part C, Embryo today : reviews, 2013, Volume: 99, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Drug Synergism; Female; Fever; Human

2013
A meta-analytic review of the preventive treatment of recurrences of febrile seizures.
    The Journal of pediatrics, 1997, Volume: 131, Issue:6

    Topics: Anticonvulsants; Chi-Square Distribution; Child; Diazepam; Drug Administration Schedule; Fever; Huma

1997

Other Studies

24 other studies available for valproic acid and Fever

ArticleYear
GABRB3-related epilepsy: novel variants, clinical features and therapeutic implications.
    Journal of neurology, 2022, Volume: 269, Issue:5

    Topics: Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Fever; Humans; Infant; Levetiracetam; Recep

2022
Isolated severe thrombocytopenia in the setting of extreme hyperthermia.
    Annals of hematology, 2020, Volume: 99, Issue:10

    Topics: Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Blood Platelets

2020
Acute Severe Pancreatitis: A Dreadful Complication of Sodium Valproate.
    Indian journal of pediatrics, 2019, Volume: 86, Issue:7

    Topics: Abdominal Pain; Acute Disease; Child; Fever; Humans; Male; Pancreatitis; Tachypnea; Valproic Acid

2019
Analysis of maternal risk factors associated with congenital vertebral malformations.
    Spine, 2013, Mar-01, Volume: 38, Issue:5

    Topics: Abnormalities, Multiple; Adolescent; Adult; Alcohol Drinking; Child; Clomiphene; Diabetes Mellitus,

2013
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:2

    Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni

2015
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
    Journal of the Pediatric Infectious Diseases Society, 2015, Volume: 4, Issue:2

    Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonid

2015
Considering Valproate as a Risk Factor for Rapid Exacerbation of Complex Movement Disorder in Progressed Stages of Late-Infantile CLN2 Disease.
    Neuropediatrics, 2016, Volume: 47, Issue:3

    Topics: Anticonvulsants; Child; Child, Preschool; Consciousness Disorders; Creatine Kinase; Deprescriptions;

2016
The incidence and characteristics of clozapine- induced fever in a local psychiatric unit in Hong Kong.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2008, Volume: 53, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder;

2008
Life-threatening organ failure after lamotrigine therapy.
    Pediatric neurology, 2009, Volume: 40, Issue:5

    Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma

2009
DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result.
    Rheumatology international, 2012, Volume: 32, Issue:7

    Topics: Anti-Bacterial Agents; Antibodies, Antineutrophil Cytoplasmic; Anticonvulsants; Brucellosis; Drug Er

2012
Persistent febrile illness with multisystem organ failure associated with clozapine.
    Internal medicine journal, 2012, Volume: 42, Issue:1

    Topics: Abdominal Pain; Adult; Antipsychotic Agents; Clozapine; Combined Modality Therapy; Diagnostic Errors

2012
[GEFS + syndrome: phenotypic variations from the newborn to the adult in a large French pedigree].
    Revue neurologique, 2003, Volume: 159, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Gener

2003
Valproic acid-induced eosinophilic pleural effusion.
    Southern medical journal, 2003, Volume: 96, Issue:8

    Topics: Adult; Anti-Bacterial Agents; Antimanic Agents; Ceftazidime; Chest Pain; Cough; Drainage; Drug Thera

2003
[Anticonvulsant hypersensitivity syndrome].
    Orvosi hetilap, 2004, Aug-08, Volume: 145, Issue:32

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug

2004
Adjunctive valproic acid for delirium and/or agitation on a consultation-liaison service: a report of six cases.
    The Journal of neuropsychiatry and clinical neurosciences, 2005,Spring, Volume: 17, Issue:2

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Delirium; Fever; Humans; Injections, Intra

2005
Aseptic meningitis associated with lamotrigine: report of two cases.
    European journal of neurology, 2007, Volume: 14, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anticonvulsants; Blood; Blood Chemical Analysis; Cerebros

2007
Effect of hyperthermia on a thalamocortical system in the kitten and the cat: a preliminary study.
    Neurological research, 1983, Volume: 5, Issue:3

    Topics: Animals; Cats; Cerebral Cortex; Fever; Phenytoin; Seizures, Febrile; Thalamus; Valproic Acid

1983
Febrile convulsions.
    Australian family physician, 1983, Volume: 12, Issue:9

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Rec

1983
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
    Giornale di clinica medica, 1982, Volume: 63, Issue:9

    Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb

1982
[Febrile pleuropericarditis during valproic acid treatment].
    Presse medicale (Paris, France : 1983), 2001, Jan-20, Volume: 30, Issue:2

    Topics: Anticonvulsants; Epilepsy; Female; Fever; Humans; Middle Aged; Pericarditis; Pleural Effusion; Valpr

2001
Sodium valproate in the prophylaxis of simple febrile convulsions.
    Clinical pediatrics, 1979, Volume: 18, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Evaluation; Fever; Gastrointes

1979
[Interaction of valproic acid and erythromycin].
    Anales espanoles de pediatria, 1990, Volume: 32, Issue:1

    Topics: Child, Preschool; Drug Interactions; Erythromycin; Female; Fever; Humans; Seizures; Valproic Acid

1990
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
    Anales espanoles de pediatria, 1989, Volume: 31, Issue:2

    Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi

1989
Valproic acid disposition in rabbits during chronic treatment with Escherichia coli endotoxin.
    Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:4

    Topics: Animals; Blood Proteins; Endotoxins; Escherichia coli; Fatty Acids, Nonesterified; Fever; Kinetics;

1985