valproic acid has been researched along with Fetal Resorption in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Fetal Resorption: The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 7.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| "Valproic acid, a drug commonly used to treat seizures and other psychiatric disorders, causes neural tube defects (NTDs) in exposed fetuses at a rate 20 times higher than in the general population." | 3.73 | Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. ( Holladay, SD; Hrubec, TC; Salafia, CM; Yan, M; Ye, K, 2006) |
| " Before 1000 when the ratios of folate metabolites were stable, the rate of valproic acid-induced neural tube defects was reduced from 49% of living fetuses to 12% by coapplication of folinic acid via subcutaneously implanted minipumps." | 3.68 | Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent. ( Nau, H; Wegner, C, 1991) |
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 3.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| " Using whole rat embryo cultures, the simultaneous addition of methionine and sodium valproate to the medium provided no protection from neural tube defects, nor did the addition of methionine to a medium of serum obtained from rats previously dosed with sodium valproate." | 1.28 | Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations. ( Klein, NW; Nosel, PG, 1992) |
| " Two VA-filled Alzet osmotic minipumps were implanted subcutaneously on gestation day 5 for continuous exposure of a total daily dosage of 850 mg/kg on gestation days 5-12." | 1.27 | Effects of sodium valproate and oxygen on the CD-1 mouse fetus. ( Hayes, TG; Kernan, B; Oca, M; Paulson, RB; Sachs, LA; Sucheston, ME; Weiss, HS; Weiss, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hrubec, TC | 1 |
| Yan, M | 1 |
| Ye, K | 1 |
| Salafia, CM | 1 |
| Holladay, SD | 1 |
| Sonoda, T | 1 |
| Ohdo, S | 1 |
| Ohba, K | 1 |
| Okishima, T | 1 |
| Hayakawa, K | 1 |
| Nosel, PG | 1 |
| Klein, NW | 1 |
| Wegner, C | 1 |
| Nau, H | 2 |
| Collins, MD | 1 |
| Fradkin, R | 1 |
| Scott, WJ | 1 |
| Paulson, RB | 1 |
| Sucheston, ME | 1 |
| Hayes, TG | 1 |
| Weiss, HS | 1 |
| Sachs, LA | 1 |
| Oca, M | 1 |
| Kernan, B | 1 |
| Weiss, S | 1 |
| Finnell, RH | 1 |
| Bennett, GD | 1 |
| Karras, SB | 1 |
| Mohl, VK | 1 |
8 other studies available for valproic acid and Fetal Resorption
| Article | Year |
|---|---|
Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Animals; Anticonvulsants; Dose-Response Relatio | 2006 |
Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Heart Defec | 1993 |
Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations.
Topics: Animals; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Resor | 1992 |
Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent.
Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Decidu | 1991 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Effects of sodium valproate and oxygen on the CD-1 mouse fetus.
Topics: Animals; Female; Fetal Resorption; Fetus; Hematoma; Hypoxia; Mice; Mice, Inbred Strains; Oxygen; Pre | 1988 |
Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite.
Topics: Animals; Disease Susceptibility; Fatty Acids, Monounsaturated; Female; Fetal Resorption; Male; Mice; | 1988 |
Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse.
Topics: Animals; Female; Fetal Resorption; Injections, Subcutaneous; Mice; Neural Tube Defects; Pregnancy; T | 1985 |