valproic acid has been researched along with Fetal Growth Restriction in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Maternal treatment with valproic acid (VPA) during pregnancy induces NTD in susceptible fetuses." | 7.73 | Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. ( Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| " Maternal treatment with valproic acid (VPA) during pregnancy induces NTD in susceptible fetuses." | 3.73 | Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. ( Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| " Two NaVP-filled Alzet osmotic minipumps were implanted subcutaneously on day 5 of gestation for continuous delivery of a total daily dosage of 850 mg/kg for 7 days." | 1.28 | Effects of sodium valproate and oxygen on the craniofacial skeletal pattern in the CD-1 mouse embryo. ( Hayes, TG; Paulson, RB; Sucheston, ME; Weiss, HS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Veiby, G | 1 |
| Daltveit, AK | 1 |
| Engelsen, BA | 1 |
| Gilhus, NE | 1 |
| Fujimura, K | 1 |
| Mitsuhashi, T | 1 |
| Shibata, S | 1 |
| Shimozato, S | 1 |
| Takahashi, T | 1 |
| Nagai, K | 1 |
| Natori, T | 1 |
| Nishino, T | 1 |
| Kodaira, F | 1 |
| Ozkinay, F | 1 |
| Cogulu, O | 1 |
| Gunduz, C | 1 |
| Yilmaz, D | 1 |
| Kultursay, N | 1 |
| Padmanabhan, R | 1 |
| Shafiullah, M | 1 |
| Benedict, S | 1 |
| Nagelkerke, N | 1 |
| Koch, S | 1 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 1 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Andrew, M | 1 |
| Barr, RD | 1 |
| Holmes, LB | 1 |
| Harvey, EA | 1 |
| Coull, BA | 1 |
| Huntington, KB | 1 |
| Khoshbin, S | 1 |
| Hayes, AM | 1 |
| Ryan, LM | 1 |
| Paulson, RB | 1 |
| Sucheston, ME | 1 |
| Hayes, TG | 1 |
| Weiss, HS | 1 |
| Bertollini, R | 1 |
| Källen, B | 1 |
| Mastroiacovo, P | 1 |
| Robert, E | 1 |
1 review available for valproic acid and Fetal Growth Restriction
| Article | Year |
|---|---|
Increased platelet destruction in infancy and childhood.
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Animals; Autoimmune Diseases; Blood Platelets; Child; Ch | 1982 |
1 trial available for valproic acid and Fetal Growth Restriction
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
8 other studies available for valproic acid and Fetal Growth Restriction
| Article | Year |
|---|---|
Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Cohort Studies; Epilepsy; Female; | 2014 |
In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation.
Topics: Acetylation; Animals; Anticonvulsants; Apoptosis; Brain; Cell Cycle; Cell Differentiation; Cell Prol | 2016 |
Epigenetic disregulation induces cell growth retardation in primary cultured glial cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Epigenesis, Genetic; Female; Fetal Gr | 2008 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2006 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Effects of sodium valproate and oxygen on the craniofacial skeletal pattern in the CD-1 mouse embryo.
Topics: Animals; Facial Bones; Female; Fetal Growth Retardation; Maternal-Fetal Exchange; Mice; Osteogenesis | 1989 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |