valproic acid has been researched along with Exanthem in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy." | 3.75 | Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009) |
| "Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period." | 2.69 | An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998) |
| " The dosage schedule was: 5 mg every day or every second day for 14 days, increased by 5 mg every 14th day to 25 mg a day." | 1.33 | Lamotrigine-induced rash--worth a rechallenge. ( Dam, M; P-Codrea Tigaran, S; Sidenius, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanoria, A | 1 |
| Arora, R | 1 |
| Dokania, P | 1 |
| Toker, O | 1 |
| Tal, Y | 1 |
| Horev, L | 1 |
| Shmoeli, D | 1 |
| Gilboa, T | 1 |
| Ferguson, LP | 1 |
| Dargan, PI | 1 |
| Hood, JL | 1 |
| Tibby, SM | 1 |
| Wang, XQ | 1 |
| Lang, SY | 1 |
| Shi, XB | 1 |
| Tian, HJ | 1 |
| Wang, RF | 1 |
| Yang, F | 1 |
| Marsden, D | 1 |
| Libretto, SE | 1 |
| P-Codrea Tigaran, S | 1 |
| Sidenius, P | 1 |
| Dam, M | 1 |
| Rahman, M | 1 |
| Haider, N | 1 |
| Pellock, JM | 1 |
| Gilliam, F | 1 |
| Vazquez, B | 1 |
| Sackellares, JC | 1 |
| Chang, GY | 1 |
| Messenheimer, J | 1 |
| Nyberg, J | 1 |
| Risner, ME | 1 |
| Rudd, GD | 1 |
| Wong, IC | 1 |
| Mawer, GE | 1 |
| Sander, JW | 1 |
| Anderson, GD | 1 |
2 reviews available for valproic acid and Exanthem
| Article | Year |
|---|---|
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; | 1997 |
Children versus adults: pharmacokinetic and adverse-effect differences.
Topics: Adolescent; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 2002 |
1 trial available for valproic acid and Exanthem
| Article | Year |
|---|---|
An active-control trial of lamotrigine monotherapy for partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E | 1998 |
8 other studies available for valproic acid and Exanthem
| Article | Year |
|---|---|
Bilateral acute angle closure as presenting feature of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS).
Topics: Acute Disease; Adult; Anterior Eye Segment; Anticonvulsants; Carbamazepine; Drug Hypersensitivity Sy | 2019 |
Valproic acid hypersensitivity and desensitization.
Topics: Anticonvulsants; Child; Epilepsy, Absence; Exanthema; Humans; Male; Valproic Acid | 2015 |
Life-threatening organ failure after lamotrigine therapy.
Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma | 2009 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Chi | 2010 |
Hypersensitivity to topiramate sprinkle capsules does not preclude the use of topiramate tablets.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepines; Capsules; Carbamazepine; Clobaza | 2004 |
Lamotrigine-induced rash--worth a rechallenge.
Topics: Anticonvulsants; Epilepsy, Generalized; Exanthema; Humans; Lamotrigine; Retrospective Studies; Risk | 2005 |
Anticonvulsant hypersensitivity syndrome from addition of lamotrigine to divalproex.
Topics: Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Fema | 2005 |
Factors influencing the incidence of lamotrigine-related skin rash.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Therapy, Combinati | 1999 |