valproic acid has been researched along with Esophageal Squamous Cell Carcinoma in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Esophageal Squamous Cell Carcinoma: A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a well-known drug used to treat seizure disorders and epilepsy, and has been shown to inhibit HDACs." | 1.42 | Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells. ( Fushida, S; Harada, S; Hayashi, H; Kinoshita, J; Makino, I; Makita, N; Miyashita, T; Nakagawara, H; Nakanuma, S; Ninomiya, I; Ohta, T; Okamoto, K; Oyama, K; Sakai, S; Tajima, H; Takamura, H; Tsukada, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Makita, N | 1 |
| Ninomiya, I | 1 |
| Tsukada, T | 1 |
| Okamoto, K | 1 |
| Harada, S | 1 |
| Nakanuma, S | 1 |
| Sakai, S | 1 |
| Makino, I | 1 |
| Kinoshita, J | 1 |
| Hayashi, H | 1 |
| Oyama, K | 1 |
| Nakagawara, H | 1 |
| Miyashita, T | 1 |
| Tajima, H | 1 |
| Takamura, H | 1 |
| Fushida, S | 1 |
| Ohta, T | 1 |
1 other study available for valproic acid and Esophageal Squamous Cell Carcinoma
| Article | Year |
|---|---|
Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; Esophageal Neop | 2015 |