valproic acid has been researched along with Epilepsy, Tonic-Clonic in 158 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 8.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 7.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 7.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 7.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 7.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 5.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 5.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 5.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 4.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 3.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| "This report highlights clinical and histological description, aetiology and management of gingival overgrowth in a partially edentulous (non-denture wearer) 60-year-old female patient with epilepsy on phenytoin and phenobarbital drugs from past 7 years." | 3.78 | Gingival overgrowth in partially edentulous ridges in an elderly female patient with epilepsy: a case report. ( Dhingra, K; Prakash, S, 2012) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 3.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 3.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| "Valproate (VPA) interferes with mitochondrial metabolism causing hyperammonemia, thereby shifting the balance reaction of glutamine (Gln)/glutamate (Glu) toward Gln." | 3.75 | Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. ( Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S, 2009) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Pancreatitis is a serious adverse effect of valproic acid (VPA)." | 3.70 | On the toxicity of valproic-acid. ( Alonso, R; Cuiña, L; Moreiras Plaza, M; Rodríguez Goyanes, G, 1999) |
| "We observed a young patient with slight mental retardation, suffering from drug-resistant tonic-clonic seizures, who presented a status epilepticus (SE), in two separate periods when valproic acid (VPA) was added to the phenobarbital (PB) already being used in the patient's therapy." | 3.70 | Valproate-induced epileptic tonic status. ( Balducci, A; Capocchi, G; Cecconi, M; Pelli, MA; Picchiarelli, A; Silvestrelli, G; Zampolini, M, 1998) |
| " Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred." | 3.68 | [Suspected convulsive side-effect of mefloquine (Lariam)]. ( Besser, R; Krämer, G, 1991) |
| "A female neonate, whose mother had been treated throughout pregnancy with valproic acid and phenytoin, showed evident signs of liver damage, confirmed by laboratory investigations and biopsy." | 3.67 | Congenital liver damage after treatment of mother with valproic acid and phenytoin? ( Felding, I; Rane, A, 1984) |
| "The EEGs of 16 newly diagnosed children with primary generalized epilepsy were examined before and during up to 3 years of antiepileptic therapy with valproic acid." | 3.67 | Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid. ( Benninger, C; Matthis, P; Scheffner, D, 1985) |
| "Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described." | 3.67 | Fetal valproate syndrome: is there a recognisable phenotype? ( Burn, J; Donnai, D; Tucker, SM; Winter, RM, 1987) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 3.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Oxcarbazepine (OXC) has been licensed as monotherapy and add-on treatment in epilepsy patients with partial seizures with or without secondarily generalized seizures (PS) and generalized tonic-clonic seizures without partial onset (GTCS)." | 2.68 | A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy. ( Brodie, MJ; Christe, W; Krämer, G; Moore, A; Pohlmann, H; Steinhoff, BJ; Vigonius, U, 1997) |
| "The proportion of children with recurrence did not differ among the 3 groups." | 2.68 | Comparison of phenobarbitone, phenytoin with sodium valproate: randomized, double-blind study. ( Banu, K; Ratnam, RS; Thilothammal, N, 1996) |
| "Carbamazepine was also superior according to a composite score that combined scores for the control of seizures and for adverse effects (P less than 0." | 2.67 | A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. ( Collins, JF; Cramer, JA; Mattson, RH, 1992) |
| " The bioavailability was not affected by the change in dosage regimen." | 2.67 | [A single daily dose with valproic acid. A pharmacodynamic and clinical study]. ( Mamoli, B; Pelzl, G, 1992) |
| "Occurrence of generalized tonic-clonic seizures (GTCS) is one of the most important risk factors of seizure-related complications and comorbidities in patients with epilepsy." | 2.50 | Pharmacotherapy for tonic-clonic seizures. ( Rheims, S; Ryvlin, P, 2014) |
| "Status epilepticus is an emergency situation that can often lead to death or neurocognitive deficits despite adequate therapy is conducted." | 2.41 | [Status epilepticus and its treatment]. ( Futó, J; Katalin, T, 2002) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures is an extremely rare condition." | 1.91 | Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report. ( Jiang, Y; Zhou, X, 2023) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 1.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 1.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "Age at onset of tonic-clonic seizures was 25." | 1.51 | Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). ( Abraira, L; Iniesta, M; Puig, J; Salas-Puig, X, 2019) |
| "The boy is currently seizure-free under valproic acid, after twelve months of follow-up." | 1.42 | A child with ictal vocalizations and generalized epilepsy. ( Heritier Barras, AC; Korff, CM; Kurian, M, 2015) |
| "Seven out of 9 patients had generalized tonic clonic seizures (GTCS) during the course of disease, of whom 5 experienced only one episode." | 1.38 | [Clinical and electroencephalographic characteristics of Jeavons syndrome]. ( Liu, XY; Qin, J; Yang, ZX; Zhang, YH, 2012) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 1.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "About 40% of children with childhood absence epilepsy develop generalized tonic-clonic seizures." | 1.36 | Polyspike and waves do not predict generalized tonic-clonic seizures in childhood absence epilepsy. ( Cauley, R; Durner, M; Kugler, SL; Mandelbaum, DE; Pal, DK; Vierck, E, 2010) |
| "Absence status was aggravated with carbamazepine and generalised tonic-clonic seizures were not controlled with ethosuximide." | 1.36 | Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status. ( Genton, P; Velizarova, R, 2010) |
| "Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide." | 1.35 | Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009) |
| "Visual auras are reported to be uncommon or rare in patients with idiopathic generalized epilepsy." | 1.35 | [Visual auras in idiopathic generalized epilepsy]. ( Coubes, P; Crespel, A; Gelisse, P, 2008) |
| "Transient hyperammonemia was noted." | 1.35 | Postictal transient hyperammonemia. ( Liu, KT; Su, CS, 2008) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy." | 1.33 | [Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine]. ( Guillon, B; Maiga, Y; Nogues, B, 2006) |
| "The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)." | 1.32 | Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004) |
| " We consider this episode of SIADH to be the result of a combination of factors including a weakness of the central nervous system and the long-term administration of VPA." | 1.31 | Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone. ( Horiguchi, J; Ishino, H; Itoga, M; Kishi, T; Miyaoka, T; Seno, H, 2001) |
| " The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system." | 1.30 | Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| "The treatment with valproic acid (VPA) and clonazepam (CZP), has been very effective." | 1.30 | [Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients]. ( Bauzano-Poley, E; Delgado-Marqués, MP; Mora-Ramírez, MD; Rodríguez-Barrionuevo, AC; Tosina-García, E, 1998) |
| "Generalized seizures could be evoked in 78% (59/76) of the surviving rats by a 60 s exposure to a loud sound (bell, 110 dB) beginning 24 h after the ischemic episode." | 1.29 | Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats. ( Iyer, V; Keelen, P; Miller, J; Payne, RS; Reid, KH; Schurr, A; Tseng, M; Young, C, 1996) |
| "Juvenile myoclonic epilepsy is a relatively common, though under diagnosed, form of epilepsy that commences in adolescence." | 1.29 | Juvenile myoclonic epilepsy. ( Buchanan, N, 1995) |
| "A series of 5 generalized tonic-clonic seizures within 30 min was induced by repeated transauricular electrical stimulation in mice." | 1.28 | Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin. ( Hönack, D; Löscher, W, 1992) |
| "Valproic acid blood levels were on average 183% of those in maternal blood (n = 15)." | 1.28 | [The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "We report on 2 cases of oligoasthenoteratozoospermia due to therapy with valproic acid, which had been given on account of mal grand epilepsy in both cases." | 1.27 | [Oligoasthenoteratozoospermia in valproic acid therapy]. ( Falker, G; Krause, W, 1988) |
| "28 children with Petit mal epilepsy were treated with valproic acid either as drug of primary choice or because of resistance to other antiepileptic drugs." | 1.26 | [Valproic acid -- clinical efficiency and serum concentration in the treatment of petit mal epilepsy in childhood (author's transl)]. ( Fritsch, G; Gleispach, H; Haidvogl, M; Ladurner, G, 1981) |
| " A twice daily dosage regime was satisfactory." | 1.26 | Sodium valproate (Epilim) in epilepsy: a trial. ( Briant, RH; Foote, SE; Wallis, WE, 1978) |
| "79 patients with primary generalized epilepsies have been treated with DPA in a medium dosage of 51 mg/kg bodyweight/day, range 14 to 125 mg/kg/day, for a medium time of 22 months, range 2 to 49 months." | 1.26 | [The treatment of primary generalized epilepsies with dipropyl acetate (DPA)]. ( Blaschke-Zimmermann, E; Fehr, R; Iffland, E; Lagenstein, I; Sternowsky, HJ, 1977) |
| " In rather short time reliable information concerning indication, compatibility and dosage can be received." | 1.26 | [Austrian complex-study on dipropylacetate. Pediatric experiences]. ( Groh, Ch; Rosenmayr, FW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (25.32) | 18.7374 |
| 1990's | 53 (33.54) | 18.2507 |
| 2000's | 34 (21.52) | 29.6817 |
| 2010's | 27 (17.09) | 24.3611 |
| 2020's | 4 (2.53) | 2.80 |
| Authors | Studies |
|---|---|
| Yaryari, AM | 1 |
| Mazdeh, M | 1 |
| Mohammadi, M | 1 |
| Haghi, AR | 1 |
| Ghiasian, M | 1 |
| Mehrpooya, M | 1 |
| Jiang, Y | 1 |
| Zhou, X | 1 |
| Devinsky, O | 1 |
| King, L | 1 |
| Schwartz, D | 1 |
| Conway, E | 1 |
| Price, D | 1 |
| Abdelmesih, SK | 1 |
| Elkhateeb, N | 1 |
| Zakaria, M | 1 |
| Girgis, MY | 1 |
| Coppola, G | 3 |
| Piccorossi, A | 1 |
| Operto, FF | 1 |
| Verrotti, A | 4 |
| Salas-Puig, X | 1 |
| Iniesta, M | 1 |
| Abraira, L | 1 |
| Puig, J | 1 |
| Nolan, SJ | 3 |
| Tudur Smith, C | 3 |
| Pulman, J | 2 |
| Marson, AG | 3 |
| Belze, O | 1 |
| Remérand, F | 1 |
| Pujol, A | 1 |
| Fusciardi, J | 1 |
| Grosso, S | 1 |
| D'Egidio, C | 1 |
| Parisi, P | 2 |
| Spalice, A | 1 |
| Pavone, P | 1 |
| Capovilla, G | 1 |
| Agostinelli, S | 1 |
| Ennaim, N | 1 |
| Bourrous, M | 1 |
| Rada, N | 1 |
| Draiss, G | 1 |
| Bouskraoui, M | 1 |
| Li, Q | 2 |
| Chen, XY | 1 |
| He, L | 2 |
| Zhou, D | 2 |
| Rheims, S | 1 |
| Ryvlin, P | 1 |
| Gómez, CD | 1 |
| Buijs, RM | 1 |
| Sitges, M | 1 |
| Kurian, M | 1 |
| Heritier Barras, AC | 1 |
| Korff, CM | 1 |
| Weston, J | 1 |
| Moyal, D | 1 |
| Sanyal, S | 1 |
| Khanna, A | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Garcia, M | 1 |
| Huppertz, HJ | 1 |
| Ziyeh, S | 1 |
| Buechert, M | 1 |
| Schumacher, M | 1 |
| Mader, I | 1 |
| Chen, X | 1 |
| Fiori, F | 1 |
| Franzoni, E | 1 |
| Chiarelli, F | 1 |
| Crespel, A | 2 |
| Velizarova, R | 2 |
| Genton, P | 2 |
| Coubes, P | 2 |
| Gélisse, P | 2 |
| Kubová, H | 1 |
| Mares, P | 1 |
| Vining, EP | 1 |
| Vierck, E | 1 |
| Cauley, R | 1 |
| Kugler, SL | 1 |
| Mandelbaum, DE | 1 |
| Pal, DK | 1 |
| Durner, M | 1 |
| Arcieri, S | 1 |
| D'Aniello, A | 1 |
| Messana, T | 1 |
| Signoriello, G | 1 |
| Pascotto, A | 1 |
| Zachary, D | 1 |
| Shekar, A | 1 |
| Letourneau, C | 1 |
| Neill, M | 1 |
| Arhan, E | 1 |
| Serdaroglu, A | 2 |
| Kurt, AN | 1 |
| Aslanyavrusu, M | 1 |
| Weissbach, A | 1 |
| Tirosh, I | 1 |
| Scheuerman, O | 1 |
| Hoffer, V | 1 |
| Garty, BZ | 1 |
| Cao, Z | 1 |
| Yu, R | 1 |
| Dun, K | 1 |
| Burke, J | 1 |
| Caplin, N | 1 |
| Greenaway, T | 1 |
| Spriet, I | 1 |
| Willems, L | 1 |
| García-Ramos, R | 1 |
| Moreno Ramos, T | 1 |
| Villarejo Galende, A | 1 |
| Porta Etessam, J | 1 |
| Dhingra, K | 1 |
| Prakash, S | 1 |
| Yang, ZX | 1 |
| Liu, XY | 1 |
| Qin, J | 1 |
| Zhang, YH | 1 |
| Mawhinney, E | 1 |
| Craig, J | 1 |
| Morrow, J | 1 |
| Russell, A | 1 |
| Smithson, WH | 1 |
| Parsons, L | 1 |
| Morrison, PJ | 1 |
| Liggan, B | 1 |
| Irwin, B | 1 |
| Delanty, N | 1 |
| Hunt, SJ | 1 |
| Swallow, RA | 1 |
| Hillier, CE | 1 |
| Smith, PE | 1 |
| Tanaka, M | 1 |
| Inoue, Y | 1 |
| Hashimoto, Y | 1 |
| Araki, H | 1 |
| Futagami, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 1 |
| Wheless, JW | 1 |
| Birnbaum, AK | 1 |
| Kriel, RL | 1 |
| Norberg, SK | 1 |
| Wical, BS | 1 |
| Le, DN | 1 |
| Leppik, IE | 1 |
| Cloyd, JC | 1 |
| Toomes, M | 1 |
| Maleck, WH | 1 |
| Koetter, KP | 1 |
| Petroianu, GA | 1 |
| Oh, J | 1 |
| Park, KD | 1 |
| Cho, HJ | 1 |
| Choi, KG | 1 |
| Jung, SM | 1 |
| Kothare, SV | 1 |
| Valencia, I | 1 |
| Khurana, DS | 1 |
| Hardison, H | 1 |
| Melvin, JJ | 1 |
| Legido, A | 1 |
| Foster, R | 1 |
| Olajide, D | 1 |
| Famularo, G | 1 |
| De Simone, C | 1 |
| Minisola, G | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Zenkov, LR | 2 |
| Surve, TY | 1 |
| Mittal, G | 1 |
| Khadse, SS | 1 |
| Khanna, SA | 1 |
| Aldenkamp, A | 1 |
| Vigevano, F | 1 |
| Arzimanoglou, A | 1 |
| Covanis, A | 1 |
| Maiga, Y | 1 |
| Nogues, B | 1 |
| Guillon, B | 1 |
| Marklund, N | 1 |
| Enblad, P | 1 |
| Ronne-Engström, E | 1 |
| Borowicz, KK | 1 |
| Malek, R | 1 |
| Luszczki, JJ | 1 |
| Ratnaraj, N | 1 |
| Patsalos, PN | 2 |
| Czuczwar, SJ | 3 |
| Tóth, V | 1 |
| Rásonyi, G | 1 |
| Fogarasi, A | 1 |
| Kovács, N | 1 |
| Auer, T | 1 |
| Janszky, J | 1 |
| Greiner, C | 1 |
| Wittmann, M | 1 |
| Haen, E | 1 |
| Fernández, EA | 1 |
| González, CG | 1 |
| Pardillo, JC | 1 |
| García, VM | 1 |
| Cansu, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fenfluramine in CKDL5 Deficiency Disorder (CDD)[NCT03861871] | Phase 2 | 7 participants (Actual) | Interventional | 2019-10-29 | Completed | ||
| Efficacy of New Lenses in Abolishing Photoparoxysmal Responses in Paediatric Patients With Photosensitive Epilepsy (PSE)[NCT04076410] | 76 participants (Anticipated) | Interventional | 2021-02-20 | Recruiting | |||
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change between baseline and Week 14 in the median number of monthly convulsive seizures. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | Number of monthly seizures (Median) |
|---|---|
| Fenfluramine Hydrochloride | 88.429 |
The CGIC is a 1-item, parent/caregiver-completed assessment used determine how much their child/care-recipient has improved with treatment. The instrument asks parents/caregivers to rate their child's/care-recipient's improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -2.429 |
The IGIC is a 1-item, investigator-completed assessment used determine how much a patient has improved with treatment. The instrument asks the investigator to rate patients' improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | 1.571 |
The PedsQL Epilepsy Module is a 29-item measure with five scales: Impact, Cognitive, Sleep, Executive Function, and Mood/Behavior. The Impact scale (nine items) assesses how epilepsy interferes with daily activities, interacting with peers, independence, and increased disease burden due to treatment. The Cognitive Scale (six items) assesses memory, ability to learn new materials, school-related difficulties, and reading difficulties. The Sleep Scale (three items) assesses fatigue and sleep difficulties. The Executive Function Scale (six items) assesses organization, task initiation, impulsivity, and inattention. The Mood/Behavior Scale (five items) assesses feelings of anger, sadness, worries, and frustration tolerance. Scores range from 0-100 for each subscale, with higher scores representing better quality of life. The raw score is the sum of each subscale score and ranges from 0-500. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -103.571 |
Parent/caregiver-completed assessment assessing how epilepsy affects day-to-day functioning of their child/care-recipient in various life areas. Each item is ranked on a 5-point Likert scale from 1 (response correlated with the lowest possible quality of life) to 5 (response correlated with the highest possible quality of life). Item scores are then transformed to a 0-100 scale as follows: 1 = 0, 2 = 25, 3 = 50, 4=75, and 5=100. The total score is the average of all item scores and ranges from 0-100. Higher scores indicate greater quality of life; an increase in scores indicates quality of life increased during the observational period. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -0.429 |
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
17 reviews available for valproic acid and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Anticonvulsant drugs for generalized tonic-clonic epilepsy.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Fructose; Humans | 2017 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; I | 2013 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2013 |
WITHDRAWN: Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2014 |
Pharmacotherapy for tonic-clonic seizures.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fructose; Humans; Lacosa | 2014 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2016 |
Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2009 |
[Epilepsy with GTCs on awakening].
Topics: Adolescent; Adult; Child; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Pr | 2002 |
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
Role of valproate across the ages. Treatment of epilepsy in children.
Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epi | 2006 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
A comment on the efficacy of valproate in the treatment of partial seizures.
Topics: Carbamazepine; Clinical Trials as Topic; Drugs, Investigational; Epilepsies, Partial; Epilepsy, Toni | 1994 |
Valproate in the treatment of partial epilepsies.
Topics: Adolescent; Adult; Carbamazepine; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsies, | 1994 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combinati | 1993 |
[Status epilepticus and its treatment].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsia Partialis Continua; Epilepsies, Par | 2002 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.
Topics: Adolescent; Adult; Age Factors; Animals; Cerebral Cortex; Child; Child, Preschool; Drug Evaluation; | 1975 |
9 trials available for valproic acid and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Idiopathic generalized tonic-clonic epilepsy and photosensitivity: a long-term follow-up study.
Topics: Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Drug Therapy, Combination; Electroencep | 2009 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; | 1995 |
Hepatic functions in epileptics on sodium valproate monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Humans; Liver; Liver Function Te | 1995 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 1996 |
Comparison of phenobarbitone, phenytoin with sodium valproate: randomized, double-blind study.
Topics: Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Humans; Phenobarbital; Phenytoin; Recurrenc | 1996 |
A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Double-Bl | 1997 |
A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.
Topics: Adolescent; Adult; Aged; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Epilepsy, To | 1992 |
[A single daily dose with valproic acid. A pharmacodynamic and clinical study].
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Com | 1992 |
133 other studies available for valproic acid and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Evaluation of serum levels of asprosin and other metabolic profiles in patients with idiopathic tonic-clonic generalized epilepsy on treatment with valproic acid.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Body Weights and Measures; Cross-Sectional S | 2022 |
Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report.
Topics: Adult; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fem | 2023 |
Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy, Tonic- | 2021 |
Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures.
Topics: Anticonvulsants; Child; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Infant; Levetiracetam | 2021 |
Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study).
Topics: Accidental Injuries; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cross-Sectional St | 2019 |
Hyperammonaemic encephalopathy and a flat electroencephalogram caused by valproic acid.
Topics: Adult; Anesthesia, General; Anticonvulsants; Brain Diseases; Craniocerebral Trauma; Electroencephalo | 2013 |
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Reflex; Epilepsy, Tonic-Clonic | 2014 |
[Lennox-Gastaut syndrome: Experience of Marrakech University Hospital].
Topics: Accidental Falls; Anticonvulsants; Asphyxia Neonatorum; Atrophy; Cerebral Cortex; Child; Child, Pres | 2013 |
The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Behavior, Animal; Blotting, Western; Carbamazepine; Convu | 2014 |
A child with ictal vocalizations and generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Electroencephalography; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; | 2015 |
Valproate induced cerebellar atrophy presenting as movement disorder.
Topics: Adult; Anticonvulsants; Atrophy; Cerebellum; Electroencephalography; Epilepsy, Tonic-Clonic; Female; | 2017 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, | 2009 |
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera | 2009 |
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; E | 2010 |
Ethosuximide in childhood absence epilepsy--older and better.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuxi | 2010 |
Polyspike and waves do not predict generalized tonic-clonic seizures in childhood absence epilepsy.
Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Clinical Protocols; Electroencephalogra | 2010 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Gen | 2010 |
Probing past a seizure.
Topics: Anticonvulsants; Cryptococcus neoformans; Epilepsy, Tonic-Clonic; HIV Infections; Humans; Male; Meni | 2010 |
Drug treatment failures and effectivity in children with newly diagnosed epilepsy.
Topics: Adolescent; Age of Onset; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Pre | 2010 |
Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Anticonvulsants; Carbamazepine; Child; Confusion; Dose-R | 2010 |
Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Diagnosis, Differential; Dose-Response Relationship, D | 2010 |
22q11.2 deletion presenting with severe hypocalcaemia, seizure and basal ganglia calcification in an adult man.
Topics: Adult; Age of Onset; Anticonvulsants; Basal Ganglia; Brain; Calcinosis; Chromosome Deletion; Chromos | 2011 |
No interaction between valproate and meropenem in a cirrhotic patient.
Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Enterobacteriaceae Infections; Epilepsy, | 2011 |
Phenytoin-induced acute orofacial dyskinesia.
Topics: Aged, 80 and over; Anticonvulsants; Epilepsy, Tonic-Clonic; Hematoma, Subdural; Humans; Male; Moveme | 2013 |
Gingival overgrowth in partially edentulous ridges in an elderly female patient with epilepsy: a case report.
Topics: Anticonvulsants; Denture, Complete; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Gingiva; Ging | 2012 |
[Clinical and electroencephalographic characteristics of Jeavons syndrome].
Topics: Adolescent; Age of Onset; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Electrom | 2012 |
Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Generalize | 2013 |
Sudden unexplained death in epilepsy (SUDEP) following previous seizure-related pulmonary oedema: case report and review of possible preventative treatment.
Topics: Adolescent; Anticonvulsants; Death, Sudden; Epilepsy, Tonic-Clonic; Fatal Outcome; Humans; Male; Pul | 2002 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Ki | 2003 |
Rapid infusion of sodium valproate in acutely ill children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru | 2003 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
Spasmodic dysphonia induced by valproic acid.
Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Male; Valproic Acid; Voice Disorders | 2004 |
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug | 2004 |
A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Epilepsy, Tonic-Clonic; Female; Humans; Sch | 2005 |
Stevens-Johnson syndrome associated with single high dose of lamotrigine in a patient taking valproate.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Male; Steven | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 2005 |
Epilepsy with myoclonic absences.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; F | 2006 |
[Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine].
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Male; M | 2006 |
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.
Topics: Adult; Anticonvulsants; Brain Edema; Critical Care; Epilepsy, Tonic-Clonic; Humans; Intracranial Hyp | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Juvenile myoclonic epilepsy starting in the eighth decade.
Topics: Aged; Anticonvulsants; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Magnetic Reso | 2007 |
Lamotrigine serum concentrations under valproate comedication: "contraindication" or "safe combination"? A case report.
Topics: Adult; Anticonvulsants; Antimanic Agents; Chromatography, High Pressure Liquid; Contraindications; D | 2007 |
Nitromethane encephalopathy MRI.
Topics: Adolescent; Anticonvulsants; Brain; Cerebellar Diseases; Cerebellum; Epilepsy, Tonic-Clonic; Humans; | 2008 |
Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Carbamazepine; Corpus Luteum; Disease Models, Animal; Dose-Resp | 2008 |
Postictal transient hyperammonemia.
Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Hyperammonemia; Liver Function Tests; Male; | 2008 |
[Visual auras in idiopathic generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Behavior; Electroencephalography; Epilepsy; Epilepsy, Generalized; Epil | 2008 |
Fatal hepatotoxicity in child on phenobarbitone and sodium valproate.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy, Tonic-Clonic; Humans; Male; Phenobarbital; | 1980 |
Sodium valproate and neural tube defects.
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meningocele | 1982 |
[Therapy of generalized epilepsies with long-term EEG guided single dose administration of sodium valproate].
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Electroencephalography; Epilepsies, Partial; | 1983 |
Abnormal metabolism of valproic acid in fatal hepatic failure.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy, Tonic-Clonic; Humans; Liver Diseases; Male; | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
[Stupor associated with the treatment of epilepsy with valproate].
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Epilepsy, Tonic-Clonic; Female; Human | 1984 |
Congenital liver damage after treatment of mother with valproic acid and phenytoin?
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Liver; Liver Diseases; Maternal-Fetal Exchang | 1984 |
One drug for childhood grand mal: medical audit for three-year remissions.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Epilepsy, Tonic-Clo | 1984 |
Clinical experience with sodium valproate in children.
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Abs | 1980 |
[Problems of therapeutic service in primidone therapy].
Topics: Adolescent; Drug Administration Schedule; Drug Interactions; Epilepsy, Tonic-Clonic; Female; Half-Li | 1980 |
[Valproic acid -- clinical efficiency and serum concentration in the treatment of petit mal epilepsy in childhood (author's transl)].
Topics: Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Epilepsy, Tempor | 1981 |
[Effect of valproate monotherapy on spike-wave activity in generalized epilepsies (author's transl)].
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalogra | 1981 |
[The benign myoclonic epilepsy of infancy (author's transl)].
Topics: Age Factors; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic | 1981 |
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb | 1982 |
Juvenile myoclonic epilepsy.
Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; Child; Circadian Rhythm; Clonazepam; Cricetinae; | 1995 |
Isolated increase in serum alkaline phosphatase with sodium valproate therapy.
Topics: Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Epilepsy, Tonic-Clonic; Female; Humans | 1995 |
Effect of sodium valproate on serum amylase in epileptics.
Topics: Adolescent; Adult; Amylases; Epilepsy, Tonic-Clonic; Female; Humans; Male; Time Factors; Valproic Ac | 1993 |
Lamotrigine versus carbamazepine in epilepsy.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1995 |
Valproate encephalopathy and hypocarnitinaemia in diabetic patients.
Topics: Adolescent; Adult; Brain Diseases; Carnitine; Diabetes Mellitus, Type 1; Electroencephalography; Epi | 1994 |
Valproic acid-induced rapid changes of met-enkephalin levels in rat brain. Probable association with abstinence behavior and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid | 1994 |
Unilateral musical hallucinations and all that jazz.
Topics: Aged; Auditory Perceptual Disorders; Cerebrovascular Disorders; Dominance, Cerebral; Drug Therapy, C | 1994 |
Valproate as a cause of hyperammonemia in heterozygotes with ornithine-transcarbamylase deficiency.
Topics: Ammonia; Child; Epilepsy, Tonic-Clonic; Female; Heterozygote; Humans; Ornithine Carbamoyltransferase | 1995 |
A reversible parkinsonian syndrome and hepatotoxcity following addition of carbamazepine to sodium valproate.
Topics: Aged; Carbamazepine; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Interactions; Drug Th | 1994 |
Disabling tremor after lamotrigine with sodium valproate.
Topics: Anticonvulsants; Drug Interactions; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1993 |
Central analgesic effect of valproate in patients with epilepsy.
Topics: Adolescent; Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Electric Stimulati | 1993 |
[Spasm after awakening; harmless?].
Topics: Adult; Diagnosis, Differential; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Humans; Male; | 1993 |
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin].
Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; | 1993 |
Sodium valproate: quantitative EEG and serum levels in volunteers and epileptics.
Topics: Adult; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Male; Valproic Acid | 1993 |
[Parkinsonism induced by sodium valproate].
Topics: Aged; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Humans; Parkinson Disease; Valproic Acid | 1995 |
Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Biomechanical Phenomena; Blood Glu | 1996 |
Effect of valproate on bone mineral density.
Topics: Adolescent; Anticonvulsants; Bone Density; Epilepsy, Tonic-Clonic; Humans; Male; Osteoporosis; Spina | 1996 |
Epileptic fits under intravenous midazolam sedation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Anticonvulsants; Conscious Sedation; Epilepsy, | 1996 |
Influence of a potential anti-asthmatic drug, CR 2039, upon the anticonvulsive activity of conventional antiepileptics against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Asthma; Avoidance Learning; Benzamides; Bronchodilator Agents; Carbamazepi | 1996 |
Nonconvulsive status epilepticus with generalized 'fast activity'.
Topics: Alpha Rhythm; Anticonvulsants; Cerebral Cortex; Diagnosis, Differential; Drug Therapy, Combination; | 1997 |
Medium chain acyl-CoA dehydrogenase deficiency and fatal valproate toxicity.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Anticonvulsants; Cells, Cultured; Child; Epilepsy, | 1997 |
Quantitative pharmaco-EEG of sustained release valproate in epileptics.
Topics: Adult; Anticonvulsants; Delayed-Action Preparations; Electroencephalography; Epilepsy, Tonic-Clonic; | 1997 |
[Reversible dementia due to valproic acid therapy].
Topics: Aged; Anticonvulsants; Dementia; Epilepsy, Tonic-Clonic; Female; Frontal Lobe; Humans; Valproic Acid | 1997 |
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate; | 1997 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Dizziness; Electroencephalography; Emergency Service, Hospital; Epilepsy, Tonic-Clo | 1997 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
[Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Pa | 1998 |
Valproate-induced epileptic tonic status.
Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, T | 1998 |
Idiopathic generalised epilepsy in adults manifested by phantom absences, generalised tonic-clonic seizures, and frequent absence status.
Topics: Adult; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Evo | 1998 |
Primary reading epilepsy.
Topics: Adult; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Illusions; Language; Male; Multilingu | 1998 |
Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, To | 1998 |
On the toxicity of valproic-acid.
Topics: Acute Disease; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Kidney Failure, Chronic; Male | 1999 |
[Freedom from seizures in epilepsy].
Topics: Anticonvulsants; Epilepsy, Tonic-Clonic; Follow-Up Studies; Humans; Recurrence; Risk Factors; Valpro | 1999 |
[Increased fracture risk in a 67-year-old patient with hypocalcemia of unknown etiology].
Topics: Aged; Anticonvulsants; Biopsy; Bone and Bones; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Fe | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 1999 |
[Epilepsy in an adult with chromosome 22q11 micro-deletion].
Topics: Adult; Anticonvulsants; Atrophy; Brain; Chromosome Deletion; Chromosomes, Human, Pair 22; DiGeorge S | 1999 |
Edema associated with valproate therapy.
Topics: Adolescent; Anticonvulsants; Edema; Epilepsy, Tonic-Clonic; Female; Humans; Valproic Acid | 1999 |
Absence seizures with evolution into generalized tonic-clonic activity: clinical and EEG features.
Topics: Adolescent; Adult; Age of Onset; Comorbidity; Electroencephalography; Epilepsy, Absence; Epilepsy, T | 2000 |
Temporary pure red-cell aplasia during valproate monotherapy: clinical observations and spectral electroencephalographic aspects.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Tonic-Clonic; Follow-Up Studies | 2000 |
Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Hyponatremia; Inappropriate ADH Syndrome; M | 2001 |
Changes in the antioxidant system in epileptic children receiving antiepileptic drugs: two-year prospective studies.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Glutathione; Glu | 2001 |
[Clinical importance of EEG changes during the treatment of epilepsy with valproate (depakene chrono)].
Topics: Adolescent; Adult; Anticonvulsants; Child; Diagnosis, Computer-Assisted; Drug Resistance; Electroenc | 2002 |
Sodium valproate (Epilim) in epilepsy: a trial.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Cloni | 1978 |
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc | 1977 |
[Atypical petit mal status. Case contribution on diagnostic difficulties].
Topics: Adult; Cerebral Ventricle Neoplasms; Diagnostic Errors; Electroencephalography; Epilepsy, Absence; E | 1977 |
[The treatment of primary generalized epilepsies with dipropyl acetate (DPA)].
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-C | 1977 |
[Disorders of hemostasis caused by dipropylacetate].
Topics: Blood Platelet Disorders; Child; Disseminated Intravascular Coagulation; Epilepsy, Tonic-Clonic; Fem | 1977 |
Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study.
Topics: Adult; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 1978 |
The treatment of childhood epilepsy with sodium valproate.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, | 1975 |
[Austrian complex-study on dipropylacetate. Pediatric experiences].
Topics: Austria; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans | 1976 |
Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Female; H | 1975 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
[The effect of dipropyl acetic acid (Convules) in epileptic adults with a high frequency of seizures].
Topics: Adult; Aged; Barbiturates; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-C | 1976 |
Unresponsiveness to human recombinant erythropoietin in an epileptic dialysis patient secondary to valproic acid toxicity.
Topics: Adult; Electrocardiography; Epilepsy, Tonic-Clonic; Erythropoietin; Female; Humans; Kidney Failure, | 1992 |
Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroshock; Epilepsy, Tonic-Clonic; Inje | 1992 |
Unresponsiveness to etretinate during anticonvulsant therapy.
Topics: Adolescent; Carbamazepine; Drug Interactions; Epilepsy, Tonic-Clonic; Etretinate; Female; Humans; Pi | 1992 |
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin | 1991 |
[Suspected convulsive side-effect of mefloquine (Lariam)].
Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clo | 1991 |
[Vitamin K deficiency with erythromycin. Observation of a boy treated with valproate].
Topics: Blood Coagulation Tests; Child; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Erythromycin; Fev | 1990 |
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Ep | 1989 |
[Decrease of plasma prolactin in valproate therapy--expression of an increase in the activity of the central GABAergic system].
Topics: Adolescent; Brain; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; gamma | 1987 |
[Possible uses of Convulsofin liquid in the treatment of pediatric epilepsies].
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsies, Partia | 1986 |
[Neutropenia during treatment with valproate].
Topics: Agranulocytosis; Child; Epilepsy, Tonic-Clonic; Female; Humans; Neutropenia; Valproic Acid | 1987 |
Pseudoatrophy of the brain with valproic acid monotherapy.
Topics: Adolescent; Atrophy; Brain; Cerebral Ventricles; Cognition Disorders; Electroencephalography; Epilep | 1987 |
Fetal valproate syndrome: is there a recognisable phenotype?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy, Tonic-Clonic; Female; Humans; Infant | 1987 |
[Oligoasthenoteratozoospermia in valproic acid therapy].
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Humans; Infertility, Male; Male; Ol | 1988 |
Ictus emeticus induced by photic stimulation.
Topics: Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Humans; Middle Aged | 1988 |
Episodic twilight state with severe autonomic symptoms in an epileptic patient.
Topics: Amygdala; Autonomic Nervous System; Carbamazepine; Child; Cognition Disorders; Consciousness Disorde | 1988 |
Treatment for teenagers with epilepsy.
Topics: Adolescent; Carbamazepine; Epilepsy, Tonic-Clonic; Female; Humans; Valproic Acid | 1985 |
Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, | 1985 |
Longterm follow-up of childhood epilepsy with absences. II. Absence-epilepsy with initial grand mal.
Topics: Adolescent; Adult; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Follow-Up Studie | 1985 |