valproic acid and Epilepsies, Myoclonic studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Epilepsies, Myoclonic: A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.

Research Excerpts

Excerpt	Relevance	Reference
" Following its clinical development, in September 2019 the European Medicines Agency approved its indication for the adjunctive therapy of epileptic seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS), combined with clobazam (CLB), in patients of 2 years of age and older."	9.12	Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. ( García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V, 2021)
"In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome."	7.96	Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020)
" At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG."	7.91	A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."	7.81	Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
" Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake."	7.78	Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012)
" The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans."	7.72	Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004)
"Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)."	6.82	A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022)
"Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies."	5.62	Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021)
"Add-on cannabidiol (CBD) significantly reduced seizures associated with Dravet syndrome (DS) in a randomized, double-blind, placebo-controlled trial: GWPCARE1 Part B (NCT02091375)."	5.30	Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial. ( Devinsky, O; Laux, L; Miller, I; Nabbout, R; Roberts, C; Wright, S; Zolnowska, M, 2019)
"Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)."	5.29	Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993)
" Following its clinical development, in September 2019 the European Medicines Agency approved its indication for the adjunctive therapy of epileptic seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS), combined with clobazam (CLB), in patients of 2 years of age and older."	5.12	Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. ( García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V, 2021)
"Highly purified cannabidiol (CBD) has demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut syndrome or Dravet syndrome in randomized, double-blind, add-on, controlled phase 3 trials."	5.05	Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs. ( Critchley, D; Gidal, B; Morrison, G; Patsalos, PN; Szaflarski, JP; VanLandingham, K, 2020)
"Valproic acid, a new anticonvulsant, is most effective in absence seizures (simple and complex), but it has produced improvement in tonicclonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy."	5.04	Valproic acid (Depakene). A new anticonvulsant agent. ( Lewis, JR, 1978)
"In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome."	3.96	Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020)
" At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG."	3.91	A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."	3.81	Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"Stiripentol is an effective and well-tolerated therapy that markedly reduced frequency of prolonged seizures in Dravet syndrome."	3.79	Stiripentol in Dravet syndrome: results of a retrospective U.S. study. ( Chancharme, L; Chugani, H; de Menezes, MS; Devinsky, O; Franz, DN; Hamiwka, L; Hernandez, A; Laux, L; Le Guern, ME; Mikati, MA; Morse, RP; Saneto, RP; Sullivan, J; Valencia, I; Wirrell, EC, 2013)
" Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake."	3.78	Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012)
"5 years old male with myoclonic epilepsy on Valproic acid (VPA) monotherapy, developed an acute pancreatitis."	3.77	VPA-induced recurrent pancreatitis in a cystic fibrosis carrier. ( Alexopoulou, E; Attilakos, A; Dinopoulos, A; Fretzayas, A; Karapanou, O; Tzetis, M, 2011)
"Valproate (VPA) interferes with mitochondrial metabolism causing hyperammonemia, thereby shifting the balance reaction of glutamine (Gln)/glutamate (Glu) toward Gln."	3.75	Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. ( Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S, 2009)
"A child with Sturge-Weber syndrome and a left occipital leptomeningeal angioma developed focal seizures at 6 years of age that responded initially to oxcarbazepine."	3.74	Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome. ( Comi, AM; Ewen, JB; Kossoff, EH, 2007)
"Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ)."	3.73	Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. ( Baldy-Moulinier, M; Berramdane, M; Coubes, P; Crespel, A; Gelisse, P; Genton, P; Monicard, C, 2005)
" The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans."	3.72	Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004)
" Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred."	3.68	[Suspected convulsive side-effect of mefloquine (Lariam)]. ( Besser, R; Krämer, G, 1991)
" Seizures were uninfluenced by treatment with carbamazepine."	3.68	Myoclonic epilepsy--pitfalls in diagnosis and management. ( Brodie, MJ; Larkin, JG; McGinn, G; McKee, PJ, 1991)
"To investigate whether treatment with valproic acid in pregnancy decreases adrenocorticotropic hormone and cortisol secretion, we measured their concentrations in maternal and umbilical cord blood from a patient receiving valproic acid."	3.67	Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy. ( Hatjis, CG; Pippitt, C; Rose, JC; Swain, M, 1985)
"Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)."	2.82	A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022)
" Twenty-two patients experienced stiripentol-related adverse events, with two having severe ones."	2.80	Long-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan. ( Inoue, Y; Ohtsuka, Y, 2015)
"Levetiracetam was stopped and he remained seizure-free for 10 months."	2.72	Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature. ( Basel-Salmon, L; Fellner, A; Goldberg-Stern, H; Gonzaga-Jauregui, C; Lev-El Halabi, N; Lidzbarsky, G; Orenstein, N; Shuldiner, AR; Stern, T, 2021)
" They could be so severe in patients over 12 years of age that the stiripentol dosage could not be increased to 50 mg kg-1 j-1."	2.70	[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)]. ( Chiron, C; Dellatolas, G; Dulac, O; Pons, G; Rey, E; Thanh, TN; Vincent, J, 2002)
"There was no significant difference in seizure frequency between the two doses."	2.69	Valproate as monotherapy for juvenile myoclonic epilepsy: dose-effect study. ( Lundkvist, B; Sundqvist, A; Tomson, T, 1998)
"Afebrile convulsions occurred before the onset of myoclonic seizures or during the clinical course in six patients, but the accurate type of these seizures remains to be clarified."	2.69	Benign myoclonic epilepsy in infants: video-EEG features and long-term follow-up. ( Aso, K; Itomi, K; Kuboda, T; Lin, Y; Negoro, T; Okumura, A; Takada, H; Watanabe, K, 1998)
" We conclude that the pharmacokinetic requirements for therapeutic drug monitoring of VPA are established."	2.68	Pharmacokinetics of valproic acid in patients with juvenile myoclonic epilepsy on monotherapy. ( Lundkvist, B; Sundqvist, A; Tomson, T, 1997)
"Over time, with careful delineation of Dravet syndrome, we have gained experience in treatments most likely to lead to improvement in seizures, as well as those that should be avoided."	2.61	Dravet syndrome: Treatment options and management of prolonged seizures. ( Caraballo, RH; Cross, JH; Guerrini, R; Lagae, L; Nabbout, R; Vigevano, F, 2019)
"Severe myoclonic epilepsy of infants usually worsens with lamotrigine, but occasionally, children improve."	2.40	Myoclonus and epilepsy in childhood: a review of treatment with valproate, ethosuximide, lamotrigine and zonisamide. ( Wallace, SJ, 1998)
"Progressive myoclonus epilepsy of the Unverricht-Lundborg type is the most common cause of progressive myoclonus epilepsy worldwide."	2.40	Clinical features and genetics of progressive myoclonus epilepsy of the Univerricht-Lundborg type. ( Koskiniemi, M; Lehesjoki, AE, 1998)
"Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is characterized by onset at age 6-15 years, stimulus-sensitive myoclonus, tonic-clonic seizures, and typical EEG findings, with marked sensitivity to photic stimulation."	2.40	Progressive myoclonus epilepsy of Unverricht-Lundborg type. ( Koskiniemi, M; Lehesjoki, AE, 1999)
"Juvenile myoclonic epilepsy (JME) is a primary generalized epilepsy that affects approximately 7% of adolescent and adult epilepsy patients."	2.38	Juvenile myoclonic epilepsy: characteristics of a primary generalized epilepsy. ( Dreifuss, FE, 1989)
"Juvenile myoclonic epilepsy is a well defined clinical entity that responds well to valproate and is usually associated with a good outlook."	2.37	Juvenile myoclonic epilepsy. ( Clement, MJ; Wallace, SJ, 1988)
"Neocortical focal seizures are characterized by motor jerks in one limb (Jacksonian type), head turning (adversive attack), or localized sensory manifestations, and limbic or psychomotor attacks by brief impairment of consciousness and often by motor automatisms."	2.37	[Therapy of brain-related minor seizures]. ( Hess, CW, 1988)
"Valproic acid is a new antiepileptic drug."	2.36	Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979)
"Familial adult myoclonus epilepsy (FAME) is a genetic condition characterized by the occurrence of cortical tremor, myoclonus, and epilepsy."	1.91	Current treatment options for familial adult myoclonus epilepsy. ( Bilo, L; Carreno, M; Coppola, A; Cuccurullo, C; Dubbioso, R; Hirsch, E; Licchetta, L, 2023)
"Epilepsy with myoclonic atonic seizures (EMAtS) was previously thought to occur in normally developing children."	1.91	A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation. ( Fujita, A; Goji, A; Matsumoto, N; Mizuguchi, T; Mori, T; Sakamoto, M; Tayama, T; Toda, Y; Urushihara, M, 2023)
"Four (80%) had a referral diagnosis of focal epilepsy based on historical focal features with exacerbation of seizures on oxcarbazepine."	1.62	Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes! ( Er, S; Menon, RN; Radhakrishnan, A; Rudrabhatla, PK, 2021)
"Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies."	1.62	Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021)
" The aim was to use long-term TDM to investigate pharmacokinetic variability of ASMs in these patients."	1.56	Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome. ( Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E, 2020)
"Ataxia was observed in 7/34 cases."	1.48	Defining the phenotypic spectrum of SLC6A1 mutations. ( Abi-Warde, MT; Afenjar, A; Bird, LM; Carvill, GL; Chae, JH; Chelly, J; Choi, M; Christensen, J; Courage, C; Czapansky-Beilman, D; de Saint Martin, A; Devinsky, O; Doummar, D; Dubbs, H; Gardella, E; Gleeson, JG; Helbig, I; Helbig, KL; Hopkins, S; Johannesen, KM; Keren, B; Lehesjoki, AE; Lesca, G; Linnankivi, T; Mecarelli, O; Mefford, HC; Merritt, JL; Mignot, C; Millichap, JJ; Myers, CT; Møller, RS; Nava, C; Nespeca, M; Pal, DK; Pendziwiat, M; Pisani, L; Piton, A; Reichert, SC; Rodan, LH; Rubboli, G; Schaefer, E; Schelhaas, HJ; Shaw, JE; Specchio, N; Striano, P; Tan, WH; Tang, S; Trivisano, M; Verhoeven, JS; Weber, YG; Yoo, Y, 2018)
"Dravet syndrome is a catastrophic form of pediatric treatment-resistant epilepsy with few effective treatment options."	1.48	Economic Evaluation of Stiripentol for Dravet Syndrome: A Cost-Utility Analysis. ( Clifford, T; Coyle, D; Elliott, J; McCoy, B; Wells, GA, 2018)
"Twenty-eight patients with Dravet syndrome (age range, 1-35 years) undergoing combination therapy with VPA and STP were included in this study."	1.46	Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy. ( Fukuda, M; Imai, K; Inoue, Y; Jogamoto, T; Ohtsuka, Y; Suzuki, Y; Takahashi, Y; Yamamoto, Y, 2017)
"Response to AED and change in seizure frequency/pattern on follow-up were noted."	1.43	Epilepsy with myoclonic absences: Electroclinical characteristics in a distinctive pediatric epilepsy phenotype. ( Jagtap, S; Karkare, K; Menon, RN; Radhakrishnan, A; Soni, H; Zanzmera, P, 2016)
"Thirty-five children with epilepsy were included in a prospective population pharmacokinetic study (using NONMEM(®) software)."	1.42	Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid. ( Chhun, S; Chiron, C; Dulac, O; Jullien, V; Pons, G; Rey, E; Tod, M, 2015)
"In addition, the effect on seizure count was compared with that of various AED regimen and the vagus nerve stimulation (VNS)."	1.42	Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen. ( Benninger, F; Dressler, A; Feucht, M; Grassl, R; Gröppel, G; Mühlebner, A; Reiter-Fink, E; Reithofer, E; Trimmel-Schwahofer, P, 2015)
"We present data from 274 patients with Dravet syndrome from 15 European countries."	1.42	The European patient with Dravet syndrome: results from a parent-reported survey on antiepileptic drug use in the European population with Dravet syndrome. ( Aras, LM; Isla, J; Mingorance-Le Meur, A, 2015)
"Benign myoclonic epilepsy in infancy (BMEI) is a well-defined electro-clinical syndrome, classically associated with a good prognosis."	1.40	[Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome]. ( Carreras-Sáez, I; Domínguez-Carral, J; Fournier-Del Castillo, MC; García-Peñas, JJ; Jiménez-Echevarría, S; Pérez-Jiménez, MÁ, 2014)
"The seizures were easily controlled with valproate and clobazam."	1.40	Neck myoclonia with absence seizures in an Indian girl. ( Aneja, S; Jain, P; Sharma, S, 2014)
"The mean and median ages at seizure onset were 16 and 18 months, respectively (range 3-40 months)."	1.39	Myoclonic epilepsy in infancy: an electroclinical study and long-term follow-up of 38 patients. ( Caraballo, RH; Flesler, S; Fortini, S; Lopez Avaria, MF; Pasteris, MC; Vilte, C, 2013)
"We present a patient affected by Dravet syndrome."	1.39	Dravet phenotype in a subject with a der(4)t(4;8)(p16.3;p23.3) without the involvement of the LETM1 gene. ( Bayindir, B; Brustia, F; Ciccone, R; Dehghani, MR; Della Mina, E; Limongelli, I; Piazza, E; Veggiotti, P; Zuffardi, O, 2013)
"Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures."	1.39	Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. ( Baraban, SC; Dinday, MT; Hortopan, GA, 2013)
"Lamotrigine was stopped and progressively the drops of the legs disappeared within 6 months but valproate was continued."	1.38	Worsening of negative myoclonus by lamotrigine in a case of idiopathic focal epilepsy of children with long-term follow-up. ( Crespel, A; Gélisse, P; Genton, P; Serafini, A; Velizarova, R, 2012)
"We report a child with idiopathic generalized epilepsy who developed myoclonic seizures and had an abnormal electroencephalogram (EEG) when oral suspension of OXC was introduced."	1.38	Myoclonus precipitated by oral suspension of oxcarbazepine in idiopathic generalized epilepsy. ( Deng, S; Huang, L; Luo, R; Mao, M, 2012)
"Our case supports the notion of adult myoclonic epilepsy with possible occurrence of praxis-activation of seizures, as has been noted with the other idiopathic generalised epilepsies."	1.38	Late-onset, praxis-induced myoclonic epilepsy. ( Carrazana, EJ; Glenn, M; Lopez, MR; Wallace, DM, 2012)
"Seizures were controlled in 1 case, suspiciously controlled in 1 case, decreased in frequency in 4 cases and were still frequent in 1 case."	1.38	[Clinical and electroencephalographic characteristics of Jeavons syndrome]. ( Liu, XY; Qin, J; Yang, ZX; Zhang, YH, 2012)
"There is no effective therapy for early myoclonic encephalopathy."	1.38	[The clinical and electroencephalographic characteristics of early myoclonic encephalopathy]. ( Huang, R; Li, B; Liu, CT; Yin, F, 2012)
"Prednisolone was tapered to 20 mg/day for 5 months."	1.36	Rheumatoid leptomeningitis: radiological alteration of cerebral hypoperfusion and subarachnoid lesions. ( Ikeda, K; Ishikawa, Y; Ito, H; Iwasaki, Y; Kawabe, K; Miura, K; Takazawa, T; Yoshii, Y, 2010)
"The aggravation of habitual seizures and interictal discharges indicate ENM."	1.35	A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009)
"Myoclonic epilepsy is a common epileptic syndrome with high genetic contribution."	1.34	Adult-onset autosomal dominant myoclonic epilepsy: report of a family with an overlooked epileptic syndrome. ( Chen, YH; Chuang, MF; Harnod, T; Hsin, YL; Lin, CY; Shyu, WC, 2007)
"(1) Severe myoclonic epilepsy of infancy (Dravet's syndrome) is associated with multiple seizures and progressive onset of mental retardation."	1.33	Stiripentol: new preparation. Severe myoclonic epilepsy of infancy: promising. ( , 2005)
"BMEI may be followed by juvenile myoclonic epilepsy."	1.33	Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients. ( Auvin, S; Badinand, N; De Bellecize, J; Isnard, H; Lamblin, MD; Motte, J; Pandit, F; Vallée, L; Villeneuve, N, 2006)
"Reflex myoclonic epilepsy of infancy is an idiopathic epileptic disorder characterized by myoclonic attacks, with onset in the first 2 years of life precipitated exclusively by unexpected tactile or auditory stimuli."	1.32	Reflex myoclonic epilepsy in infancy: a benign age-dependent idiopathic startle epilepsy. ( Kontopoulos, E; Vargiami, E; Zafeiriou, D, 2003)
"This case of non-progressive reflex myoclonic epilepsy of infancy triggered only by head tapping (and not by acoustic stimuli) is an extremely rare phenomenon."	1.32	An unusual case of benign reflex myoclonic epilepsy of infancy. ( King, MD; Kurian, MA, 2003)
"The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)."	1.32	Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004)
"A patient suffering from juvenile myoclonic epilepsy experienced myoclonic jerks, fairly regularly, while playing chess."	1.32	Chess-playing epilepsy: a case report with video-EEG and back averaging. ( Debrand, E; Gueguen, B; Guillou, S; Mann, MW; Soufflet, C, 2004)
"Treatment with valproic acid and clonazepam completely controlled the seizures in all three patients."	1.30	[Reading-induced epilepsy: three new cases]. ( Abad, F; Iñiguez, C; Jericó, I; Mauri, JA; Morales, F; Mostacero, E, 1997)
"Benign myoclonic epilepsy of childhood is a rare syndrome which appears at between 4 months and 3 years of age."	1.30	[Benign myoclonic epilepsy in childhood. A case report]. ( Ribacoba-Montero, R; Salas-Puig, J, 1997)
"A total of 21 patients with juvenile myoclonic epilepsy (JME) and 21 with temporal lobe epilepsy (TLE) were included; 18 patients were treated with carbamazepine (CBZ), 16 with valproate (VPA) and seven with phenytoin (PHT)."	1.30	Heart rate variability in patients with epilepsy. ( Ericson, M; Ihrman, C; Lindblad, LE; Tomson, T, 1998)
"Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)."	1.30	Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997)
"We report four patients with juvenile myoclonic epilepsy who had generalized spike or polyspike and wave discharges on EEG in addition to clinical and EEG evidence of focality."	1.30	Electroencephalogram and clinical focalities in juvenile myoclonic epilepsy. ( Riviello, JJ; Sanger, T; Schmid, R; So, GM; Thiele, EA, 1998)
" Poor compliance may contribute to the occurrence of status epilepticus, resulting in the need for substantial increases in anticonvulsant dosing to suppress seizures."	1.30	Status epilepticus during pregnancy. A case report. ( Licht, EA; Sankar, R, 1999)
"The two patients with mental retardation have been treated with polytherapy."	1.30	Epilepsy with myoclonic absences with early onset: a follow-up study. ( Chiarelli, F; Domizio, S; Greco, R; Morgese, G; Sabatino, G; Verrotti, A, 1999)
"Juvenile myoclonic epilepsy is a relatively common, though under diagnosed, form of epilepsy that commences in adolescence."	1.29	Juvenile myoclonic epilepsy. ( Buchanan, N, 1995)
"Benign myoclonic epilepsy of infancy (BMEI) is an idiopathic disorder characterized by spontaneous myoclonic attacks with onset in the first 2 years of life."	1.29	Reflex myoclonic epilepsy in infancy: a new age-dependent idiopathic epileptic syndrome related to startle reaction. ( Cusmai, R; Fusco, L; Ricci, S; Vigevano, F, 1995)
"Juvenile myoclonic epilepsy is a common, under-recognised form of epilepsy which is best treated with sodium valproate."	1.29	Juvenile myoclonic epilepsy: diagnosis, management and outcome. ( Buchanan, N; Sharpe, C, 1995)
"We report a 3 year-old girl with a myoclonic epilepsy."	1.29	Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency. ( Chabrol, B; Chretien, D; Mancini, J; Munnich, A; Pinsard, N; Rustin, P, 1994)
"The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder."	1.29	Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994)
"Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)."	1.29	Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993)
"Juvenile myoclonic epilepsy is a genetically transferred generalized epilepsy that affects approximately 7% of adolescents and adults with epilepsy."	1.29	Juvenile myoclonic epilepsy. ( Kibria, EM, 1993)
"Lamotrigine is a useful alternative in the management of JME."	1.29	The use of lamotrigine in juvenile myoclonic epilepsy. ( Buchanan, N, 1996)
"Discontinuation of VPA resulted in recurrence of myoclonic jerks and then GTCS, but were completely controlled by reinstitution of VPA."	1.29	[Juvenile myoclonic epilepsy--an underdiagnosed epileptic syndrome]. ( Ravid, S; Shahar, E, 1996)
"Eleven patients with Juvenile Myoclonic Epilepsy were treated using small doses of a sustained-release form of valproic acid (500 mg/day)."	1.29	[Treatment of juvenile myoclonic epilepsy with low-dose sodium valproate]. ( Autret, A; De Toffol, B, 1996)
"Myoclonic dystonia is a rare disorder that occurs in an hereditary and a sporadic form."	1.28	Myoclonic dystonia. ( Friedman, JH; Pueschel, SM; Shetty, T, 1992)
"We describe the case of a 26 years old woman in chronic therapy with phenobarbital, carbamazepine, valproic acid (VPA) and clonazepam who showed a hyperammonemic encephalopathy after an increase in dosage of VPA."	1.28	State of stupor from valproic acid during chronic treatment: case report. ( Buffa, C; Gentile, S; Ravetti, C; Sacerdote, I, 1991)
"Data from 50 patients with juvenile myoclonic epilepsy (JME) were analyzed retrospectively to assess the response to drug therapy--long-term seizure control, relapse rates, and confounding factors in seizure recurrence."	1.28	Juvenile myoclonic epilepsy: long-term response to therapy. ( Dean, JC; Penry, JK; Riela, AR, 1989)
"Progressive myoclonus epilepsy without Lafora's bodies (PME) is a rare inherited disease found predominantly in Finland, where the incidence is one case per 20,000 to 30,000 children."	1.27	Concentrations of gamma-aminobutyric acid and adenosine in the CSF in progressive myoclonus epilepsy without Lafora's bodies. ( Fredholm, BB; Hare, TA; Murros, K; Ohisalo, JJ, 1983)
"Twelve patients with benign juvenile myoclonic epilepsy (BJME) representing 4% of our population of epileptics (n = 275) are presented."	1.27	Some clinical and EEG aspects of benign juvenile myoclonic epilepsy. ( Asconapé, J; Penry, JK, 1984)
"A sporadic case of myoclonus epilepsy of adult onset with a benign course is presented."	1.27	A sporadic case of benign myoclonus epilepsy of adult onset: its clinical aspects and electroencephalographic, polygraphic study. ( Ishigooka, J; Murasaki, M; Takahashi, A; Wakatabe, H; Yoshida, Y, 1986)
"A diagnosis of benign juvenile myoclonic epilepsy was made, and the seizures were controlled with valproic acid."	1.27	Benign juvenile myoclonic epilepsy. ( Dean, C; Hauswald, M, 1987)
" Accordingly, camptocormia is a dose-dependent side effect of valproate."	1.27	Camptocormia, a new side effect of sodium valproate. ( Iivanainen, M; Kiuru, S, 1987)
" Children can begin to receive valproate treatment in a dosage of 20 to 30 mg/kg per day in two or three divided doses."	1.27	Valproate monotherapy in children. ( Murphy, JV, 1988)
"Only 21% of those with myoclonic astatic epilepsy have become free from seizures."	1.26	Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982)
" The following results were found while DPA was administered in a relatively high dosage with a mean of 48 mg/kg body weight/day and ranging from 7 to 125 mg/kg/day."	1.26	Treatment of childhood epilepsy with dipropylacetic acid (DPA). ( Blaschke, E; Fehr, R; Lagenstein, I; Rothe, M; Sternowsky, HJ, 1978)
"Valproic acid is a new antiepileptic drug recently introduced in the United States for the treatment of absence seizures."	1.26	Clinical efficacy of valproic acid in relation to plasma levels. ( Bruni, J; Crawford, LE; Thomas, M; Villarreal, HJ; Wilder, BJ; Willmore, LJ, 1978)
" Dosage varied from 23 to 54mg/kg and twice-daily administration was usual."	1.26	Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim"). ( Clark, JE; Jeavons, PM; Maheshwari, MC, 1977)

Research

Studies (186)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Change From Baseline in Median Monthly Convulsive Seizure Frequency

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (23.66)	18.7374
1990's	51 (27.42)	18.2507
2000's	33 (17.74)	29.6817
2010's	41 (22.04)	24.3611
2020's	17 (9.14)	2.80

Authors	Studies
García-Peñas, JJ	2
Gil Nagel-Rein, A	1
Sánchez-Carpintero, R	1
Villanueva-Haba, V	1
Yang, Y	1
Zeng, Q	1
Cheng, M	1
Niu, X	1
Xiangwei, W	1
Gong, P	1
Li, W	1
Ma, J	1
Zhang, X	1
Yang, X	1
Yang, Z	2
Sun, D	1
Zhou, S	1
Liao, J	1
Jiang, Y	2
Zhang, Y	3
Mir, A	1
Alghamdi, A	1
Alotaibi, W	1
Samreen, D	1
Alotaibi, M	1
Albaradie, R	1
Bashir, S	1
Zhou, X	1
Coppola, A	1
Dubbioso, R	1
Cuccurullo, C	1
Licchetta, L	1
Carreno, M	1
Hirsch, E	1
Bilo, L	1
Mori, T	1
Sakamoto, M	1
Tayama, T	1
Goji, A	1
Toda, Y	1
Fujita, A	1
Mizuguchi, T	1
Urushihara, M	1
Matsumoto, N	1
Cross, JH	1
Caraballo, RH	2
Nabbout, R	3
Vigevano, F	5
Guerrini, R	1
Lagae, L	2
Specchio, N	3
Pietrafusa, N	1
Ferretti, A	1
Trivisano, M	3
Johannessen Landmark, C	1
Heger, K	1
Lund, C	1
Burns, ML	1
Bjørnvold, M	1
Sætre, E	1
Johannessen, SI	1
McNamara, NA	1
Dang, LT	1
Sturza, J	1
Ziobro, JM	1
Fedak Romanowski, EM	1
Smith, GC	1
Joshi, SM	1
Leber, SM	1
Carlson, M	1
Robertson, P	1
Shellhaas, RA	1
Patsalos, PN	1
Szaflarski, JP	1
Gidal, B	1
VanLandingham, K	1
Critchley, D	1
Morrison, G	1
Nickels, K	1
Kossoff, EH	2
Eschbach, K	1
Joshi, C	1
Stern, T	1
Orenstein, N	1
Fellner, A	1
Lev-El Halabi, N	1
Shuldiner, AR	1
Gonzaga-Jauregui, C	1
Lidzbarsky, G	1
Basel-Salmon, L	1
Goldberg-Stern, H	1
Rudrabhatla, PK	1
Er, S	1
Radhakrishnan, A	2
Menon, RN	2
Finsterer, J	1
Tarka, S	1
Devinsky, O	4
King, L	1
Schwartz, D	1
Conway, E	1
Price, D	1
Morimoto, M	1
Shimakawa, S	2
Hashimoto, T	1
Kitaoka, T	1
Kyotani, S	1
Johannesen, KM	1
Gardella, E	1
Linnankivi, T	1
Courage, C	1
de Saint Martin, A	1
Lehesjoki, AE	3
Mignot, C	1
Afenjar, A	1
Lesca, G	1
Abi-Warde, MT	1
Chelly, J	1
Piton, A	1
Merritt, JL	1
Rodan, LH	1
Tan, WH	1
Bird, LM	1
Nespeca, M	1
Gleeson, JG	1
Yoo, Y	1
Choi, M	1
Chae, JH	1
Czapansky-Beilman, D	1
Reichert, SC	1
Pendziwiat, M	1
Verhoeven, JS	1
Schelhaas, HJ	1
Christensen, J	1
Weber, YG	1
Nava, C	1
Keren, B	1
Doummar, D	1
Schaefer, E	1
Hopkins, S	1
Dubbs, H	1
Shaw, JE	1
Pisani, L	1
Myers, CT	1
Tang, S	2
Pal, DK	1
Millichap, JJ	1
Carvill, GL	1
Helbig, KL	1
Mecarelli, O	1
Striano, P	1
Helbig, I	1
Rubboli, G	1
Mefford, HC	1
Møller, RS	1
Elliott, J	1
McCoy, B	1
Clifford, T	1
Wells, GA	1
Coyle, D	1
Miller, I	1
Laux, L	2
Zolnowska, M	1
Wright, S	1
Roberts, C	1
Kosaka, T	1
Ohta, G	1
Kometani, H	1
Kawatani, M	1
Ohshima, Y	1
Schubert-Bast, S	1
Wolff, M	1
Wiemer-Kruel, A	1
von Spiczak, S	1
Trollmann, R	1
Reif, PS	1
Pritchard, C	1
Polster, T	1
Neubauer, BA	1
Mayer, T	1
Macdonald, D	1
Kurlemann, G	1
Kluger, G	1
Klein, KM	1
Kieslich, M	1
Kay, L	1
Kalski, M	1
Irwin, J	1
Herting, A	1
Carroll, J	1
Bettendorf, U	1
Bast, T	1
Rosenow, F	1
Strzelczyk, A	1
Yamamoto, Y	2
Takahashi, Y	2
Ikeda, H	1
Imai, K	2
Kagawa, Y	1
Inoue, Y	4
Wirrell, EC	1
Franz, DN	1
Sullivan, J	1
Saneto, RP	1
Morse, RP	1
Chugani, H	1
Hernandez, A	1
Hamiwka, L	1
Mikati, MA	1
Valencia, I	2
Le Guern, ME	1
Chancharme, L	1
de Menezes, MS	1
Flesler, S	1
Pasteris, MC	1
Lopez Avaria, MF	1
Fortini, S	1
Vilte, C	1
Bayindir, B	1
Piazza, E	1
Della Mina, E	1
Limongelli, I	1
Brustia, F	1
Ciccone, R	1
Veggiotti, P	1
Zuffardi, O	1
Dehghani, MR	1
Baraban, SC	1
Dinday, MT	1
Hortopan, GA	1
Domínguez-Carral, J	1
Pérez-Jiménez, MÁ	1
Fournier-Del Castillo, MC	1
Carreras-Sáez, I	1
Jiménez-Echevarría, S	1
Jain, P	1
Sharma, S	1
Aneja, S	1
Ohtsuka, Y	3
Jullien, V	1
Chhun, S	1
Rey, E	4
Dulac, O	6
Tod, M	1
Chiron, C	4
Pons, G	3
Dressler, A	1
Trimmel-Schwahofer, P	1
Reithofer, E	1
Mühlebner, A	1
Gröppel, G	1
Reiter-Fink, E	1
Benninger, F	1
Grassl, R	1
Feucht, M	1
Gélisse, P	3
Crespel, A	3
Aller-Alvarez, JS	1
Menéndez-González, M	1
Ribacoba-Montero, R	2
Salvado, M	1
Vega, V	1
Suárez-Moro, R	1
Sueiras, M	1
Toledo, M	1
Salas-Puig, J	2
Álvarez-Sabin, J	1
Aras, LM	1
Isla, J	1
Mingorance-Le Meur, A	1
Inoue, S	1
Yazawa, S	1
Murahara, T	1
Yamauchi, R	1
Shimohama, S	1
Kecskés, A	1
Copmans, D	1
Langlois, M	1
Crawford, AD	1
Ceulemans, B	1
de Witte, PA	1
Esguerra, CV	1
Popławska, M	1
Wróblewska, D	1
Borowicz, KK	3
Grande-Martín, A	1
Pardal-Fernández, JM	1
Carrascosa-Romero, MC	1
De Cabo, C	1
De Liso, P	1
Chemaly, N	1
Laschet, J	1
Barnerias, C	1
Hully, M	1
Leunen, D	1
Desguerre, I	1
Zanzmera, P	1
Karkare, K	1
Soni, H	1
Jagtap, S	1
Jogamoto, T	1
Fukuda, M	1
Suzuki, Y	1
Liu, X	1
Qin, J	2
Bao, X	1
Chang, X	1
Wang, S	1
Wu, Y	1
Xiong, H	1
Garcia, M	1
Huppertz, HJ	1
Ziyeh, S	1
Buechert, M	1
Schumacher, M	1
Mader, I	1
Kotini, A	1
Mavraki, E	1
Anninos, P	1
Piperidou, H	1
Prassopoulos, P	1
Yu, MJ	1
Shi, YW	1
Gao, MM	1
Deng, WY	1
Liu, XR	1
Chen, L	1
Long, YS	1
Yi, YH	1
Liao, WP	1
Arhan, E	1
Serdaroglu, A	1
Kurt, AN	1
Aslanyavrusu, M	1
Ikeda, K	1
Takazawa, T	1
Ito, H	1
Ishikawa, Y	1
Miura, K	1
Yoshii, Y	1
Kawabe, K	1
Iwasaki, Y	1
Genton, P	2
Velizarova, R	1
Serafini, A	1
Dhillon, N	1
Högler, W	1
Dinopoulos, A	1
Karapanou, O	1
Alexopoulou, E	1
Tzetis, M	1
Attilakos, A	1
Fretzayas, A	1
Deng, S	1
Luo, R	1
Mao, M	1
Huang, L	1
Calabrò, RS	1
Italiano, D	1
Militi, D	1
Bramanti, P	1
Glenn, M	1
Carrazana, EJ	1
Lopez, MR	1
Wallace, DM	1
Yang, ZX	1
Liu, XY	1
Zhang, YH	1
Piskorska, B	1
Stępniak, B	1
Czuczwar, SJ	2
Liu, CT	1
Yin, F	1
Huang, R	1
Li, B	1
Watanabe, K	2
Oguni, H	1
Sano, A	1
Adachi, M	1
Tsuneishi, S	1
Nakamura, H	1
Thanh, TN	1
Dellatolas, G	1
Vincent, J	2
Shahar, E	2
Barak, S	1
Wheless, JW	1
Zafeiriou, D	1
Vargiami, E	1
Kontopoulos, E	1
Kurian, MA	1
King, MD	1
Perunova, NIu	1
Teich, M	1
Longin, E	1
Dempfle, CE	1
König, S	1
Luszczki, JJ	1
Patel, R	1
Jha, S	1
Dravet, C	2
Bureau, M	2
Kothare, SV	1
Khurana, DS	1
Hardison, H	1
Melvin, JJ	1
Legido, A	1
Burneo, JG	1
Miller, S	1
Bebin, EM	1
Prasad, A	1
Mann, MW	1
Gueguen, B	1
Guillou, S	1
Debrand, E	1
Soufflet, C	1
Begum, M	1
Aujard, Y	1
Ponsot, G	1
Livet, MO	1
Berramdane, M	1
Coubes, P	1
Monicard, C	1
Baldy-Moulinier, M	1
Auvin, S	1
Pandit, F	1
De Bellecize, J	1
Badinand, N	1
Isnard, H	1
Motte, J	1
Villeneuve, N	1
Lamblin, MD	2
Vallée, L	2
Aldenkamp, A	1
Arzimanoglou, A	1
Covanis, A	2
Kakinuma, H	1
Fujiki, T	1
Nakamura, T	1
Takahashi, H	1
Hsin, YL	1
Chuang, MF	1
Shyu, WC	1
Lin, CY	1
Chen, YH	1
Harnod, T	1
Capovilla, G	1
Beccaria, F	1
Gambardella, A	2
Montagnini, A	1
Avantaggiato, P	1
Seri, S	1
Ewen, JB	1
Comi, AM	1
Piantino, JA	1
Torres, A	1
Savina, TA	1
Balashova, OA	1
Shchipakina, TG	1
Murphy, MJ	1
Lyon, IW	1
Taylor, JW	1
Mitts, G	1
Eeg-Olofsson, O	1
Lindskog, U	1
Ohisalo, JJ	1
Murros, K	1
Fredholm, BB	1
Hare, TA	1
Wilder, BJ	4
Ramsay, RE	1
Murphy, JV	2
Karas, BJ	1
Marquardt, K	1
Hammond, EJ	1
Asconapé, J	1
Penry, JK	2
Delgado-Escueta, AV	1
Enrile-Bacsal, F	1
Arthuis, M	2
Bruni, J	3
Bauman, AW	1
Willmore, LJ	2
Koch-Weser, J	1
Browne, TR	1
Coulter, DL	1
Allen, RJ	1
Leary, PM	1
Morris, S	1
Rodin, EA	1
DeSousa, G	1
Haidukewych, D	1
Lodhi, R	1
Berchou, RC	1
Iivanainen, M	2
Himberg, JJ	1
Gupta, AK	1
Jeavons, PM	2
Buchanan, N	4
Ricci, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Fenfluramine in CKDL5 Deficiency Disorder (CDD)[NCT03861871]	Phase 2	7 participants (Actual)	Interventional	2019-10-29	Completed
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Completed
Evaluating the Impact of Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Co-Occurring PTSD and Substance Use Disorders[NCT05536908]		50 participants (Anticipated)	Interventional	2023-06-22	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Change between baseline and Week 14 in the median number of monthly convulsive seizures. (NCT03861871)
Timeframe: Baseline, Week 14

Change in Caregiver Global Impression of Change (CGIC) Score

Intervention	Number of monthly seizures (Median)
Fenfluramine Hydrochloride	88.429

The CGIC is a 1-item, parent/caregiver-completed assessment used determine how much their child/care-recipient has improved with treatment. The instrument asks parents/caregivers to rate their child's/care-recipient's improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14

Change in Investigator Global Impression of Change (IGIC) Score

Intervention	score on a scale (Mean)
Fenfluramine Hydrochloride	-2.429

The IGIC is a 1-item, investigator-completed assessment used determine how much a patient has improved with treatment. The instrument asks the investigator to rate patients' improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14

Change in Pediatric Quality Of Life (PEDS-QL) Epilepsy Module Raw Score

Intervention	score on a scale (Mean)
Fenfluramine Hydrochloride	1.571

The PedsQL Epilepsy Module is a 29-item measure with five scales: Impact, Cognitive, Sleep, Executive Function, and Mood/Behavior. The Impact scale (nine items) assesses how epilepsy interferes with daily activities, interacting with peers, independence, and increased disease burden due to treatment. The Cognitive Scale (six items) assesses memory, ability to learn new materials, school-related difficulties, and reading difficulties. The Sleep Scale (three items) assesses fatigue and sleep difficulties. The Executive Function Scale (six items) assesses organization, task initiation, impulsivity, and inattention. The Mood/Behavior Scale (five items) assesses feelings of anger, sadness, worries, and frustration tolerance. Scores range from 0-100 for each subscale, with higher scores representing better quality of life. The raw score is the sum of each subscale score and ranges from 0-500. (NCT03861871)
Timeframe: Baseline, Week 14

Change in Quality of Life in Childhood Epilepsy (QOLCE) Score

Intervention	score on a scale (Mean)
Fenfluramine Hydrochloride	-103.571

Parent/caregiver-completed assessment assessing how epilepsy affects day-to-day functioning of their child/care-recipient in various life areas. Each item is ranked on a 5-point Likert scale from 1 (response correlated with the lowest possible quality of life) to 5 (response correlated with the highest possible quality of life). Item scores are then transformed to a 0-100 scale as follows: 1 = 0, 2 = 25, 3 = 50, 4=75, and 5=100. The total score is the average of all item scores and ranges from 0-100. Higher scores indicate greater quality of life; an increase in scores indicates quality of life increased during the observational period. (NCT03861871)
Timeframe: Baseline, Week 14

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

Intervention	score on a scale (Mean)
Fenfluramine Hydrochloride	-0.429

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

Intervention	Abscence seizures (Number)
Week 8 Baseline	165
Week 12 Verapamil 4mg/kg/Day	101

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

Intervention	General tonic-clonic seizures (Number)
Week 8 Baseline	39
Week 12 Verapamil 4mg/kg/Day	14

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Article	Year
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. Revista de neurologia, 2021, 09-10, Volume: 73, Issue:S01 Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedu	2021
A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus Epileptic disorders : international epilepsy journal with videotape, 2022, 08-01, Volume: 24, Issue:4 Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Generalized; Humans; Immunoglobulin E; Levetiracet	2022
Dravet syndrome: Treatment options and management of prolonged seizures. Epilepsia, 2019, Volume: 60 Suppl 3 Topics: Anticonvulsants; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures; Valproic Acid	2019
Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs. Epilepsia, 2020, Volume: 61, Issue:9 Topics: Anticonvulsants; Cannabidiol; Clinical Trials as Topic; Clobazam; Cytochrome P-450 CYP2C19; Cytochro	2020
Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature. American journal of medical genetics. Part A, 2021, Volume: 185, Issue:3 Topics: 14-3-3 Proteins; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Diagnosis, Differential	2021
Seizure management and prescription patterns of anticonvulsants in Dravet syndrome: A multicenter cohort study from Germany and review of literature. Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A Topics: Anticonvulsants; Clobazam; Cohort Studies; Drug Prescriptions; Drug Therapy, Combination; Epilepsies	2019
[Benign myoclonic epilepsy in infancy]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsies, Myoclonic; Humans; In	2002
[Epilepsy with myoclonic absences]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Child; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalography;	2002
[Benign adult familial myoclonic epilepsy(BAFME)]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Adult; Chromosomes, Human, Pair 8; Clonazepam; Diagnosis, Differential; Epilepsies, Myoclonic; Human	2002
[Eyelid myoclonia with absences (EMA)]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsie	2002
Acute management of seizures in the syndromes of idiopathic generalized epilepsies. Epilepsia, 2003, Volume: 44 Suppl 2 Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche	2003
Benign myoclonic epilepsy in infancy. Advances in neurology, 2005, Volume: 95 Topics: Age of Onset; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Fema	2005
Role of valproate across the ages. Treatment of epilepsy in children. Acta neurologica Scandinavica. Supplementum, 2006, Volume: 184 Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epi	2006
Drug therapy: Valproic acid. The New England journal of medicine, 1980, Mar-20, Volume: 302, Issue:12 Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil	1980
Mechanism of action of antiepileptic and antimyoclonic drugs. Advances in neurology, 1995, Volume: 67 Topics: Animals; Anticonvulsants; Barbiturates; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Humans; Rece	1995
Myoclonus and epilepsy in childhood: a review of treatment with valproate, ethosuximide, lamotrigine and zonisamide. Epilepsy research, 1998, Volume: 29, Issue:2 Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Ethosuximide; Humans; Infant; Isoxa	1998
Clinical features and genetics of progressive myoclonus epilepsy of the Univerricht-Lundborg type. Annals of medicine, 1998, Volume: 30, Issue:5 Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Child; Child, Preschool; Disease Progression;	1998
[Unverricht-Lundborg disease]. Ryoikibetsu shokogun shirizu, 1999, Issue:27 Pt 2 Topics: Anticonvulsants; Diagnosis, Differential; Epilepsies, Myoclonic; Genes, Recessive; Humans; Valproic	1999
Progressive myoclonus epilepsy of Unverricht-Lundborg type. Epilepsia, 1999, Volume: 40 Suppl 3 Topics: Adolescent; Age of Onset; Child; Chromosome Mapping; Cystatin B; Cystatins; Cysteine Proteinase Inhi	1999
Valproic acid. Review of a new antiepileptic drug. Archives of neurology, 1979, Volume: 36, Issue:7 Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha	1979
The neuropharmacology of juvenile myoclonic epilepsy. Clinical neuropharmacology, 1990, Volume: 13, Issue:6 Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsies, Myoclonic; Female; Humans; Male; Valproic Aci	1990
Juvenile myoclonic epilepsy: characteristics of a primary generalized epilepsy. Epilepsia, 1989, Volume: 30 Suppl 4 Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclonic; Humans; Valproic Acid	1989
Valproate: an updated review. Acta neurologica Scandinavica, 1985, Volume: 72, Issue:2 Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi	1985
Myoclonus. Neurologic clinics, 1985, Volume: 3, Issue:1 Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen	1985
Use of ethosuximide and valproate in the treatment of epilepsy. Neurologic clinics, 1986, Volume: 4, Issue:3 Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P	1986
Juvenile myoclonic epilepsy. Archives of disease in childhood, 1988, Volume: 63, Issue:9 Topics: Adolescent; Adolescent Behavior; Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclon	1988
Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders. The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Humans; Valproic Acid	1988
[Therapy of brain-related minor seizures]. Schweizerische medizinische Wochenschrift, 1988, Dec-17, Volume: 118, Issue:50 Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial;	1988

Article	Year
Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial. Epilepsia, 2019, Volume: 60, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Double-Blind Method; Drug	2019
Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence. Epilepsy research, 2014, Volume: 108, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Asian People; Benzodiazepines; Child; Child, Preschool; Clobazam	2014
Long-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan. Epilepsy research, 2015, Volume: 113 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes;	2015
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions. Annals of agricultural and environmental medicine : AAEM, 2012, Volume: 19, Issue:3 Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants;	2012
[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:11 Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dioxolanes; Epile	2002
Comparison of valproic acid and phenytoin in newly diagnosed tonic-clonic seizures. Neurology, 1983, Volume: 33, Issue:11 Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsies, Myoclonic; Female; Humans; Male; Middle Aged	1983
Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges. Neurology, 1980, Volume: 30, Issue:1 Topics: Clinical Trials as Topic; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence	1980
Drug therapy: Valproic acid. The New England journal of medicine, 1980, Mar-20, Volume: 302, Issue:12 Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil	1980
Valproate and clonazepam in the treatment of severe progressive myoclonus epilepsy. Archives of neurology, 1982, Volume: 39, Issue:4 Topics: Adolescent; Adult; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Drug Therapy, Combinatio	1982
Pharmacokinetics of valproic acid in patients with juvenile myoclonic epilepsy on monotherapy. Therapeutic drug monitoring, 1997, Volume: 19, Issue:2 Topics: Adolescent; Adult; Drug Monitoring; Epilepsies, Myoclonic; Female; Humans; Male; Middle Aged; Valpro	1997
Valproate lowered the amplitude of visual and somatosensory evoked potentials in two cases of untreated juvenile myoclonic epilepsy. Psychiatry and clinical neurosciences, 1997, Volume: 51, Issue:6 Topics: Adolescent; Anticonvulsants; Child; Epilepsies, Myoclonic; Evoked Potentials, Somatosensory; Evoked	1997
Valproate as monotherapy for juvenile myoclonic epilepsy: dose-effect study. Therapeutic drug monitoring, 1998, Volume: 20, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Disease-Free Survival; Dose-Response Relations	1998
Benign myoclonic epilepsy in infants: video-EEG features and long-term follow-up. Neuropediatrics, 1998, Volume: 29, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; F	1998
Valproate monotherapy in juvenile myoclonic epilepsy: dose-related effects on electroencephalographic and other neurophysiologic tests. Therapeutic drug monitoring, 1999, Volume: 21, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Contrast Sensitivity; Dose-Response Relationship, Drug; Double-B	1999
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet (London, England), 2000, Nov-11, Volume: 356, Issue:9242 Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dioxolanes; Doubl	2000
Valproic acid (Depakene). A new anticonvulsant agent. JAMA, 1978, Nov-10, Volume: 240, Issue:20 Topics: Animals; Child; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsies, Myoclonic;	1978
[Treatment of pyknoleptic petit mal epilepsy and juvenile myoclonic epilepsy with dipropyl acetate (Deprakine). A pilot study of therapy-resistant patients during control of plasma concentration]. Ugeskrift for laeger, 1977, May-02, Volume: 139, Issue:18 Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Epilepsies, My	1977

Article	Year
GABRB3-related epilepsy: novel variants, clinical features and therapeutic implications. Journal of neurology, 2022, Volume: 269, Issue:5 Topics: Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Fever; Humans; Infant; Levetiracetam; Recep	2022
Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy. Medicine, 2022, Sep-23, Volume: 101, Issue:38 Topics: Electroencephalography; Epilepsies, Myoclonic; Humans; Retrospective Studies; Seizures; Valproic Aci	2022
Current treatment options for familial adult myoclonus epilepsy. Epilepsia, 2023, Volume: 64 Suppl 1 Topics: Adult; Anticonvulsants; Epilepsies, Myoclonic; Epilepsy; Humans; Myoclonus; Tremor; Valproic Acid	2023
A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation. Brain & development, 2023, Volume: 45, Issue:7 Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; GAB	2023
Successful use of fenfluramine in nonconvulsive status epilepticus of Dravet syndrome. Epilepsia, 2020, Volume: 61, Issue:4 Topics: Anticonvulsants; Child; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Fenfluramine; Hu	2020
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome. Therapeutic drug monitoring, 2020, Volume: 42, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes;	2020
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. Epilepsia, 2020, Volume: 61, Issue:8 Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Resistant Epilepsy; Drug The	2020
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. Epilepsia, 2021, Volume: 62, Issue:1 Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Developmental Disabilities; Diet, Ketogeni	2021
Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes! Epileptic disorders : international epilepsy journal with videotape, 2021, Apr-01, Volume: 23, Issue:2 Topics: Adolescent; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Abs	2021
Valproic acid for myoclonic epilepsy in POLG1 carriers can be fatal. Folia neuropathologica, 2021, Volume: 59, Issue:1 Topics: Acute Disease; Anticonvulsants; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma;	2021
A response to Letter to the Editor titled: Valproic acid for myoclonic epilepsy in POLG1 carriers can be fatal. Folia neuropathologica, 2021, Volume: 59, Issue:1 Topics: Epilepsies, Myoclonic; Humans; Valproic Acid	2021
Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. Epilepsia, 2021, Volume: 62, Issue:7 Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy, Tonic-	2021
Marked efficacy of combined three-drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome. Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:4 Topics: Anticonvulsants; Child, Preschool; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Epi	2018
Defining the phenotypic spectrum of SLC6A1 mutations. Epilepsia, 2018, Volume: 59, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Child; Child, Preschool; Cohort Studies; Electroencephal	2018
Economic Evaluation of Stiripentol for Dravet Syndrome: A Cost-Utility Analysis. PharmacoEconomics, 2018, Volume: 36, Issue:10 Topics: Anticonvulsants; Canada; Child; Clobazam; Cost-Benefit Analysis; Dioxolanes; Drug Therapy, Combinati	2018
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. Brain & development, 2019, Volume: 41, Issue:8 Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital;	2019
Impact of CYP2C19 Phenotypes on Clinical Efficacy of Stiripentol in Japanese Patients With Dravet Syndrome. Therapeutic drug monitoring, 2020, Volume: 42, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Asian People; Child; Child, Preschool; Clobazam; Cytochrome P-45	2020
Stiripentol in Dravet syndrome: results of a retrospective U.S. study. Epilepsia, 2013, Volume: 54, Issue:9 Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Therapy, Combi	2013
Myoclonic epilepsy in infancy: an electroclinical study and long-term follow-up of 38 patients. Epilepsia, 2013, Volume: 54, Issue:9 Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; Follow-Up	2013
Dravet phenotype in a subject with a der(4)t(4;8)(p16.3;p23.3) without the involvement of the LETM1 gene. European journal of medical genetics, 2013, Volume: 56, Issue:10 Topics: Anticonvulsants; Calcium-Binding Proteins; Child; Chromosomes, Human, Pair 4; Epilepsies, Myoclonic;	2013
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications, 2013, Volume: 4 Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinic	2013
[Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome]. Revista de neurologia, 2014, Feb-01, Volume: 58, Issue:3 Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child Behavior Disorders; Cognition	2014
Neck myoclonia with absence seizures in an Indian girl. Journal of child neurology, 2014, Volume: 29, Issue:11 Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Electroencephalography; Epilepsies, Myoclo	2014
Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid. Clinical pharmacokinetics, 2015, Volume: 54, Issue:5 Topics: Anticonvulsants; Benzodiazepines; Body Weight; Child; Child, Preschool; Clobazam; Dioxolanes; Drug I	2015
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:2 Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni	2015
Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen. Epilepsy research, 2015, Volume: 109 Topics: Adolescent; Anticonvulsants; Benzodiazepines; Bromides; Child; Child, Preschool; Clobazam; Diet, Ket	2015
Mixed myoclonic-absence status epilepticus in juvenile myoclonic epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2015, Volume: 17, Issue:1 Topics: Anticonvulsants; Bipolar Disorder; Catatonia; Clonazepam; Electroencephalography; Epilepsies, Myoclo	2015
Myoclonic epilepsy in Down syndrome and Alzheimer disease. Neurologia (Barcelona, Spain), 2017, Volume: 32, Issue:2 Topics: Adult; Aged; Alzheimer Disease; Anticonvulsants; Down Syndrome; Electroencephalography; Epilepsies,	2017
The European patient with Dravet syndrome: results from a parent-reported survey on antiepileptic drug use in the European population with Dravet syndrome. Epilepsy & behavior : E&B, 2015, Volume: 44 Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Epileps	2015
[Dramatic seizure reduction with levetiracetam in adult Dravet syndrome: a case report]. Rinsho shinkeigaku = Clinical neurology, 2015, Volume: 55, Issue:3 Topics: Adult; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Levetiracetam; Male; Piracetam; Sta	2015
Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine. PloS one, 2015, Volume: 10, Issue:5 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Myoclonic; Fenfluramine; Gene Knockdow	2015
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures. Pharmacological reports : PR, 2015, Volume: 67, Issue:6 Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani	2015
Tonic Seizure Status Epilepticus Triggered by Valproate in a Child with Doose Syndrome. Neuropediatrics, 2016, Volume: 47, Issue:3 Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclonic; Humans; Male; Seizures; Statu	2016
Patients with dravet syndrome in the era of stiripentol: A French cohort cross-sectional study. Epilepsy research, 2016, Volume: 125 Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cross-	2016
Epilepsy with myoclonic absences: Electroclinical characteristics in a distinctive pediatric epilepsy phenotype. Epilepsy & behavior : E&B, 2016, Volume: 64, Issue:Pt A Topics: Anticonvulsants; Brain; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Electroe	2016
Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy. Epilepsy research, 2017, Volume: 130 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P	2017
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. Brain & development, 2009, Volume: 31, Issue:4 Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam;	2009
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. Epilepsia, 2009, Volume: 50, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies,	2009
Magnetoencephalographic findings in two cases of juvenile myoclonus epilepsy. Brain topography, 2010, Volume: 23, Issue:1 Topics: Adult; Anticonvulsants; Brain; Brain Mapping; Electroencephalography; Epilepsies, Myoclonic; Female;	2010
Milder phenotype with SCN1A truncation mutation other than SMEI. Seizure, 2010, Volume: 19, Issue:7 Topics: Adolescent; Anticonvulsants; Base Sequence; Child, Preschool; Chromatography, High Pressure Liquid;	2010
Drug treatment failures and effectivity in children with newly diagnosed epilepsy. Seizure, 2010, Volume: 19, Issue:9 Topics: Adolescent; Age of Onset; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Pre	2010
Rheumatoid leptomeningitis: radiological alteration of cerebral hypoperfusion and subarachnoid lesions. Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:17 Topics: Affective Symptoms; Anticonvulsants; Arthritis, Rheumatoid; Cerebrovascular Circulation; Diffusion M	2010
Worsening of negative myoclonus by lamotrigine in a case of idiopathic focal epilepsy of children with long-term follow-up. Brain & development, 2012, Volume: 34, Issue:3 Topics: Anticonvulsants; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsies, My	2012
Fractures and Fanconi syndrome due to prolonged sodium valproate use. Neuropediatrics, 2011, Volume: 42, Issue:3 Topics: Child; Disabled Children; Epilepsies, Myoclonic; Fanconi Syndrome; Female; Femoral Fractures; Humans	2011
VPA-induced recurrent pancreatitis in a cystic fibrosis carrier. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2011, Volume: 15, Issue:5 Topics: Anticonvulsants; Child, Preschool; Cystic Fibrosis; Epilepsies, Myoclonic; Genetic Carrier Screening	2011
Myoclonus precipitated by oral suspension of oxcarbazepine in idiopathic generalized epilepsy. International journal of clinical pharmacology and therapeutics, 2012, Volume: 50, Issue:4 Topics: Administration, Oral; Anticonvulsants; Carbamazepine; Drug Substitution; Electroencephalography; Epi	2012
Levetiracetam-associated loss of libido and anhedonia. Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:2 Topics: Adult; Anhedonia; Anticonvulsants; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, C	2012
Late-onset, praxis-induced myoclonic epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:2 Topics: Age of Onset; Anticonvulsants; Brain; Craniocerebral Trauma; Electroencephalography; Epilepsies, Myo	2012
[Clinical and electroencephalographic characteristics of Jeavons syndrome]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:6 Topics: Adolescent; Age of Onset; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Electrom	2012
[The clinical and electroencephalographic characteristics of early myoclonic encephalopathy]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:12 Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Infant; Infant, Newb	2012
Favorable outcome of epileptic blindness in children. Journal of child neurology, 2003, Volume: 18, Issue:1 Topics: Acute Disease; Adolescent; Anticonvulsants; Blindness, Cortical; Carbamazepine; Child; Electroenceph	2003
Reflex myoclonic epilepsy in infancy: a benign age-dependent idiopathic startle epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2003, Volume: 5, Issue:2 Topics: Acoustic Stimulation; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsies, Myoclon	2003
An unusual case of benign reflex myoclonic epilepsy of infancy. Neuropediatrics, 2003, Volume: 34, Issue:3 Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Reflex; Humans; Infant; Ma	2003
[The use of depakene and depakene-chrono in idiopathic generalized epilepsy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2003, Volume: 103, Issue:9 Topics: Adolescent; Adult; Anticonvulsants; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy, G	2003
Factor XIII deficiency associated with valproate treatment. Epilepsia, 2004, Volume: 45, Issue:2 Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Epistaxis;	2004
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. Epilepsia, 2004, Volume: 45, Issue:10 Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D	2004
Intravenous valproate in post-anoxic myoclonic status epilepticus: a report of ten patients. Neurology India, 2004, Volume: 52, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; H	2004
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug	2004
Video-EEG study in an adult and a child with eyelid myoclonia with absences. Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4 Topics: Adult; Anticonvulsants; Child; Dominance, Cerebral; Drug Therapy, Combination; Electroencephalograph	2004
Chess-playing epilepsy: a case report with video-EEG and back averaging. Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4 Topics: Adult; Anticonvulsants; Attention; Electroencephalography; Electromyography; Epilepsies, Myoclonic;	2004
Clozapine-induced stuttering, facial tics and myoclonic seizures: a case report. The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:3 Topics: Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilep	2005
Stiripentol: new preparation. Severe myoclonic epilepsy of infancy: promising. Prescrire international, 2005, Volume: 14, Issue:76 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clinical Trials as Top	2005
[Rickets. A rare complication of anti-epileptic treatments. Report of two cases in children]. Annales de pediatrie, 1976, Dec-02, Volume: 23, Issue:12 Topics: Anticonvulsants; Black People; Calcifediol; Child; Contraindications; Drug Monitoring; Electroenceph	1976
Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology, 2005, Sep-13, Volume: 65, Issue:5 Topics: Adult; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Epilepsie	2005
Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients. Epilepsia, 2006, Volume: 47, Issue:2 Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Comorbid	2006
Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy due to neonatal asphyxia. Pediatrics international : official journal of the Japan Pediatric Society, 2006, Volume: 48, Issue:6 Topics: Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Child, Preschool; Echovirus Infections; Enceph	2006
Adult-onset autosomal dominant myoclonic epilepsy: report of a family with an overlooked epileptic syndrome. Seizure, 2007, Volume: 16, Issue:2 Topics: Adult; Age of Onset; Aged; Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; G	2007
Photosensitive benign myoclonic epilepsy in infancy. Epilepsia, 2007, Volume: 48, Issue:1 Topics: Age of Onset; Anticonvulsants; Child; Child, Preschool; Comorbidity; Electroencephalography; Epileps	2007
Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome. Pediatric neurology, 2007, Volume: 36, Issue:2 Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Pa	2007
Myoclonic seizures in a patient with Charcot-Marie-tooth disease. Pediatric neurology, 2007, Volume: 36, Issue:2 Topics: Anticonvulsants; Carbamazepine; Charcot-Marie-Tooth Disease; Child; Developmental Disabilities; Drug	2007
Effect of chronic consumption of sodium valproate and melatonin on seizure activity in Krushinskii-Molodkina rats. Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:5 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Drug Combinations; Epilepsies, Myoclonic; Epilepsy,	2006
Valproic acid associated pancreatitis in an adult. Lancet (London, England), 1981, Jan-03, Volume: 1, Issue:8210 Topics: Age Factors; Aged; Epilepsies, Myoclonic; Humans; Male; Pancreatitis; Valproic Acid	1981
Acute intoxication with valproate. Lancet (London, England), 1982, Jun-05, Volume: 1, Issue:8284 Topics: Acute Disease; Adolescent; Adult; Child, Preschool; Epilepsies, Myoclonic; Female; Humans; Infant; M	1982
Concentrations of gamma-aminobutyric acid and adenosine in the CSF in progressive myoclonus epilepsy without Lafora's bodies. Archives of neurology, 1983, Volume: 40, Issue:10 Topics: Adenosine; Adolescent; Adult; Clonazepam; Epilepsies, Myoclonic; Female; gamma-Aminobutyric Acid; Hu	1983
Some clinical and EEG aspects of benign juvenile myoclonic epilepsy. Epilepsia, 1984, Volume: 25, Issue:1 Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Combinations; Electroencephalography; Epile	1984
Juvenile myoclonic epilepsy of Janz. Neurology, 1984, Volume: 34, Issue:3 Topics: Adolescent; Adult; Age Factors; Aged; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Absen	1984
Open trials with valproate in epilepsy. Epilepsia, 1984, Volume: 25 Suppl 1 Topics: Drug Therapy; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Temporal Lobe; Humans; Valproic Acid	1984
Pancreatitis associated with valproic acid therapy for epilepsy. Annals of neurology, 1980, Volume: 7, Issue:1 Topics: Child; Epilepsies, Myoclonic; Humans; Male; Pancreatitis; Valproic Acid	1980
Clinical experience with sodium valproate in children. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, May-24, Volume: 57, Issue:21 Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Abs	1980
Dissociation between free and bound phenytoin levels in presence of valproate sodium. Archives of neurology, 1981, Volume: 38, Issue:4 Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Phenytoi	1981
[The benign myoclonic epilepsy of infancy (author's transl)]. Revue d'electroencephalographie et de neurophysiologie clinique, 1981, Volume: 11, Issue:3-4 Topics: Age Factors; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic	1981
Sodium valproate: monotherapy and polytherapy. Epilepsia, 1982, Volume: 23, Issue:6 Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part	1982
Juvenile myoclonic epilepsy. Journal of paediatrics and child health, 1995, Volume: 31, Issue:4 Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; Child; Circadian Rhythm; Clonazepam; Cricetinae;	1995
Reflex myoclonic epilepsy in infancy: a new age-dependent idiopathic epileptic syndrome related to startle reaction. Epilepsia, 1995, Volume: 36, Issue:4 Topics: Acoustic Stimulation; Age Factors; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; In	1995
Effects of antiepileptic drugs on EEG background activity in children with epilepsy: initial phase of therapy. Clinical EEG (electroencephalography), 1995, Volume: 26, Issue:2 Topics: Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Delta Rhythm; Electroencephalography; Epilepsie	1995
Juvenile myoclonic epilepsy: diagnosis, management and outcome. The Medical journal of Australia, 1995, Feb-06, Volume: 162, Issue:3 Topics: Adolescent; Adult; Alcohol Drinking; Anticonvulsants; Carbamazepine; Epilepsies, Myoclonic; Female;	1995
Therapeutic interaction of lamotrigine and sodium valproate in intractable myoclonic epilepsy. Seizure, 1994, Volume: 3, Issue:2 Topics: Adolescent; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combina	1994
Juvenile myoclonic epilepsy. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1994, Volume: 53, Issue:6 Topics: Adolescent; Child; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Male; Valproic Aci	1994
Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency. European journal of pediatrics, 1994, Volume: 153, Issue:2 Topics: Amino Acids; Child, Preschool; Chromatography, Gas; Cytochrome-c Oxidase Deficiency; Epilepsies, Myo	1994
Novel rat cardiac arrest model of posthypoxic myoclonus. Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:2 Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani	1994
[Spasm after awakening; harmless?]. Nederlands tijdschrift voor geneeskunde, 1993, Dec-18, Volume: 137, Issue:51 Topics: Adult; Diagnosis, Differential; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Humans; Male;	1993
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:3 Topics: Aged; Electroencephalography; Electromyography; Epilepsies, Myoclonic; Epilepsy, Generalized; Evoked	1993
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin]. Anales espanoles de pediatria, 1993, Volume: 38, Issue:3 Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic;	1993
Juvenile myoclonic epilepsy. The Journal of the American Osteopathic Association, 1993, Volume: 93, Issue:1 Topics: Adult; Carbamazepine; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Valproic Acid	1993
Post anoxic action myoclonus. Journal of the Royal Society of Medicine, 1993, Volume: 86, Issue:5 Topics: Clonazepam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Hypoxia; Male; Middle Aged; Pi	1993
Pharmacology of cortical epileptic afterdischarges in rats. Epilepsia, 1996, Volume: 37, Issue:4 Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal	1996
The use of lamotrigine in juvenile myoclonic epilepsy. Seizure, 1996, Volume: 5, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Lamotrigine; Triazines; V	1996
[Juvenile myoclonic epilepsy--an underdiagnosed epileptic syndrome]. Harefuah, 1996, Nov-01, Volume: 131, Issue:9 Topics: Adolescent; Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Male; Re	1996
[Treatment of juvenile myoclonic epilepsy with low-dose sodium valproate]. Revue neurologique, 1996, Volume: 152, Issue:11 Topics: Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Female; Human	1996
[Reading-induced epilepsy: three new cases]. Revista de neurologia, 1997, Volume: 25, Issue:137 Topics: Adult; Anticonvulsants; Clonazepam; Electroencephalography; Epilepsies, Myoclonic; Humans; Male; Man	1997
[Benign reflex myoclonic epilepsy in infants]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1997, Volume: 4, Issue:8 Topics: Age Factors; Anticonvulsants; Child, Preschool; Electroencephalography; Electromyography; Epilepsies	1997
[Benign myoclonic epilepsy in childhood. A case report]. Revista de neurologia, 1997, Volume: 25, Issue:144 Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Sleep, REM; V	1997
Misdiagnosis and treatment in juvenile myoclonic epilepsy. Seizure, 1998, Volume: 7, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalography; Epilepsi	1998
Heart rate variability in patients with epilepsy. Epilepsy research, 1998, Volume: 30, Issue:1 Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Myoclonic; Epilepsy, Temporal Lobe; Female; Heart	1998
Negative myoclonic status due to antiepileptic drug tapering: report of three cases. Epilepsia, 1997, Volume: 38, Issue:7 Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral	1997
[Case of myoclonic epilepsy in infant complicated with idiopathic eruptions]. No to hattatsu = Brain and development, 1998, Volume: 30, Issue:3 Topics: Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Exanthema Subitum; Female; Herpesvirus 6,	1998
Valproic acid-induced Stevens-Johnson syndrome. Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:5 Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Male; Stevens-John	1998
Electroencephalogram and clinical focalities in juvenile myoclonic epilepsy. Journal of child neurology, 1998, Volume: 13, Issue:11 Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Electroenc	1998
Status epilepticus during pregnancy. A case report. The Journal of reproductive medicine, 1999, Volume: 44, Issue:4 Topics: Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Obstetric Labor Complications; Pregnancy; Pr	1999
[Clinical-epidemiological study of patients with juvenile myoclonic epilepsy in Santa Catarina State, Brazil]. Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:2B Topics: Adolescent; Adult; Anticonvulsants; Brazil; Child; Cross-Sectional Studies; Epilepsies, Myoclonic; F	1999
Epilepsy with myoclonic absences with early onset: a follow-up study. Journal of child neurology, 1999, Volume: 14, Issue:11 Topics: Anticonvulsants; Child, Preschool; Developmental Disabilities; Drug Therapy, Combination; Epilepsies	1999
Intravenous valproic acid for myoclonic status epilepticus. Neurology, 2000, Mar-14, Volume: 54, Issue:5 Topics: Adolescent; Adult; Epilepsies, Myoclonic; Female; Humans; Status Epilepticus; Valproic Acid	2000
[A case of report of idiopathic epilepsy with combined attacks of typical absence and sylvian seizure]. No to hattatsu = Brain and development, 2000, Volume: 32, Issue:2 Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Pa	2000
Reversible cortical atrophy and cognitive decline induced by valproic acid. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 1998, Volume: 2, Issue:4 Topics: Adolescent; Anticonvulsants; Atrophy; Cerebral Cortex; Cognition Disorders; Electroencephalography;	1998
Focal reflex epilepsy with myoclonus; electrophysiological investigation and therapeutic implications. Electroencephalography and clinical neurophysiology, 1977, Volume: 42, Issue:1 Topics: Animals; Arm; Baclofen; Cats; Electric Stimulation; Electroencephalography; Electromyography; Epilep	1977
Treatment of childhood epilepsy with dipropylacetic acid (DPA). Archiv fur Psychiatrie und Nervenkrankheiten, 1978, Oct-09, Volume: 226, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy;	1978
Urinary excretion of indican in progressive myoclonus epilepsy without Lafora bodies. The effect of sodium valproate. Journal of the neurological sciences, 1978, Volume: 39, Issue:2-3 Topics: Adult; Anticonvulsants; Clonazepam; Epilepsies, Myoclonic; Humans; Indican; Phenobarbital; Valproic	1978
Clinical efficacy of valproic acid in relation to plasma levels. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1978, Volume: 5, Issue:4 Topics: Adolescent; Adult; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Female; Humans; Male; Valproi	1978
Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim"). Developmental medicine and child neurology, 1977, Volume: 19, Issue:1 Topics: Adolescent; Automatism; Child; Drug Evaluation; Electroencephalography; Epilepsies, Myoclonic; Epile	1977
Sodium valproate for the treatment of childhood epilepsies. The Medical journal of Australia, 1977, Jan-22, Volume: 1, Issue:4 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsies, Myoclonic; Epil	1977
The anticonvulsant action of sodium valproate (Epilim) in 100 patients with various forms of epilepsy. The Medical journal of Australia, 1977, Jun-18, Volume: 1, Issue:25 Topics: Adolescent; Adult; Child; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lob	1977
The therapy of benign myoclonic epilepsy in infants. Epilepsy research. Supplement, 1992, Volume: 6 Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencep	1992
Diagnosis by axilla skin biopsy in an early case of Lafora's disease. Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:11 Topics: Adolescent; Axilla; Biopsy; Epilepsies, Myoclonic; Female; Humans; Male; Skin; Valproic Acid	1992
Myoclonic dystonia. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1992, Volume: 8, Issue:2 Topics: Adult; Biopsy; Cerebellum; Diseases in Twins; Drug Therapy, Combination; Dystonia; Epilepsies, Myocl	1992
Juvenile myoclonic epilepsy. The Medical journal of Australia, 1992, Jun-01, Volume: 156, Issue:11 Topics: Adolescent; Adult; Epilepsies, Myoclonic; Female; Humans; Valproic Acid	1992
Abolition of photoparoxysmal response in progressive myoclonus epilepsy. European neurology, 1991, Volume: 31, Issue:6 Topics: Adolescent; Clonazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephal	1991
A case of idiopathic palatal myoclonus: treatment with sodium valproate. European neurology, 1991, Volume: 31, Issue:6 Topics: Adult; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Humans; Male; Palatal Muscles; Valpr	1991
[Suspected convulsive side-effect of mefloquine (Lariam)]. Der Nervenarzt, 1991, Volume: 62, Issue:12 Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clo	1991
Gingival hyperplasia due to sodium valproate. Journal of neurology, neurosurgery, and psychiatry, 1991, Volume: 54, Issue:3 Topics: Child; Epilepsies, Myoclonic; Female; Gingival Hyperplasia; Humans; Valproic Acid	1991
Myoclonic epilepsy--pitfalls in diagnosis and management. Scottish medical journal, 1991, Volume: 36, Issue:1 Topics: Adolescent; Adult; Carbamazepine; Diagnosis, Differential; Epilepsies, Myoclonic; Female; Humans; Ma	1991
State of stupor from valproic acid during chronic treatment: case report. Italian journal of neurological sciences, 1991, Volume: 12, Issue:2 Topics: Adult; Brain Diseases; Carbamazepine; Clonazepam; Electroencephalography; Epilepsies, Myoclonic; Fem	1991
[Advantages of a single daily dose of sodium valproate in the child]. Archives francaises de pediatrie, 1989, Volume: 46, Issue:4 Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy;	1989
Juvenile myoclonic epilepsy: long-term response to therapy. Epilepsia, 1989, Volume: 30 Suppl 4 Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Myoclonic; Female;	1989
Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy. American journal of obstetrics and gynecology, 1985, Jun-01, Volume: 152, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Epilepsies, Myoclonic; Female; Fetal Blood; Fetus; Humans; Hydro	1985
[Progressive myoclonus epilepsy and pregnancy]. Duodecim; laaketieteellinen aikakauskirja, 1986, Volume: 102, Issue:2 Topics: Adult; Benzodiazepinones; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies,	1986
Writing epilepsy. Clinical EEG (electroencephalography), 1986, Volume: 17, Issue:1 Topics: Adult; Electroencephalography; Epilepsies, Myoclonic; Female; Handwriting; Humans; Valproic Acid; Wr	1986
Sodium valproate monotherapy in childhood epilepsy. Brain & development, 1986, Volume: 8, Issue:1 Topics: Adolescent; Adult; Body Weight; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclon	1986
[Possible uses of Convulsofin liquid in the treatment of pediatric epilepsies]. Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:3 Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsies, Partia	1986
A sporadic case of benign myoclonus epilepsy of adult onset: its clinical aspects and electroencephalographic, polygraphic study. The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:2 Topics: Adult; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Female;	1986
Benign juvenile myoclonic epilepsy. The American journal of emergency medicine, 1987, Volume: 5, Issue:6 Topics: Adolescent; Adult; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Male; Seizures; Va	1987
Camptocormia, a new side effect of sodium valproate. Epilepsy research, 1987, Volume: 1, Issue:4 Topics: Adult; Epilepsies, Myoclonic; Female; Humans; Movement Disorders; Posture; Valproic Acid	1987
Valproate monotherapy in children. The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absenc	1988

valproic acid and Epilepsies, Myoclonic