Page last updated: 2024-10-26

valproic acid and Ependymoma

valproic acid has been researched along with Ependymoma in 1 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)

Research Excerpts

ExcerptRelevanceReference
"HL-60 cells and whole blood samples from healthy volunteers were incubated with valproic acid (0-8 mM) for 0-24 hours, with additional blood samples collected from ependymoma patients receiving valproic acid on the SIOP Ependymoma II clinical trial."5.30A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells. ( Hutton, C; Jamieson, D; Uitrakul, S; Veal, GJ, 2019)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uitrakul, S1
Hutton, C1
Veal, GJ1
Jamieson, D1

Trials

1 trial available for valproic acid and Ependymoma

ArticleYear
A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells.
    European journal of clinical investigation, 2019, Volume: 49, Issue:7

    Topics: Acetylation; Analysis of Variance; Antineoplastic Agents; Child; Dose-Response Relationship, Drug; E

2019