valproic acid has been researched along with Endotoxemia in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, R | 1 |
| Yu, D | 1 |
| Yoon, J | 1 |
| Park, J | 1 |
| Sugiura, S | 1 |
| Ishihara, Y | 1 |
| Komatsu, T | 1 |
| Hagiwara, M | 1 |
| Tanigawa, N | 1 |
| Kato, Y | 1 |
| Mizutani, H | 1 |
| Kawahara, K | 1 |
| Maruyama, I | 1 |
| Noguchi, T | 1 |
| Matsushita, K | 1 |
2 other studies available for valproic acid and Endotoxemia
| Article | Year |
|---|---|
Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo).
Topics: Animals; Anti-Inflammatory Agents; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Endotoxemia | 2015 |
Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Endotoxemia; Flavonoids; HMGB1 Protein; Inflam | 2011 |