valproic acid has been researched along with Endometrioma in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Endometrioma: An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to evaluate the effect of valproic acid (VPA) and progesterone (P4) in a rat model of endometriosis on serum tumor necrosis factor-α (TNF-α) levels, hot plate and tail-flick latencies, lesion size, and body weight." | 7.78 | Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, M; Liu, X; Zhang, Y, 2012) |
| "One primary goal of medical treatment of endometriosis is to alleviate pain and there is a pressing need for new therapeutics for endometriosis with better efficacy and side-effect profiles." | 5.37 | Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, X; Zhao, T; Zhen, X, 2011) |
| "Following on the heels of the discovery that endometriosis is an epigenetic disease, we conducted a pilot study on the off-label use of valproic acid to treat adenomyosis." | 5.13 | A pilot study on the off-label use of valproic acid to treat adenomyosis. ( Guo, SW; Liu, X, 2008) |
| " This study was designed to evaluate the effect of valproic acid (VPA) and progesterone (P4) in a rat model of endometriosis on serum tumor necrosis factor-α (TNF-α) levels, hot plate and tail-flick latencies, lesion size, and body weight." | 3.78 | Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, M; Liu, X; Zhang, Y, 2012) |
| "Endometriosis is a common type of estrogen‑dependent, gynecological and chronic inflammatory disease." | 1.42 | Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells. ( Cai, S; Chen, Y; Wang, J; Xu, M, 2015) |
| "One primary goal of medical treatment of endometriosis is to alleviate pain and there is a pressing need for new therapeutics for endometriosis with better efficacy and side-effect profiles." | 1.37 | Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. ( Guo, SW; Liu, X; Zhao, T; Zhen, X, 2011) |
| " Adenomyosis was induced in 55 female ICR mice neonatally dosed with tamoxifen, while another 8 (group C) were dosed with solvent only." | 1.37 | The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide. ( Carter, AV; Guo, SW; Mao, X; Wang, Y; Zhen, X, 2011) |
| " In this study, we evaluated the effect of valproic acid (VPA) in ICR mice with adenomyosis, induced by neonatal dosing with tamoxifen." | 1.37 | Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis. ( Guo, SW; Liu, X, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barra, F | 1 |
| Ferrero, S | 1 |
| Kawano, Y | 2 |
| Nasu, K | 2 |
| Hijiya, N | 1 |
| Tsukamoto, Y | 1 |
| Amada, K | 1 |
| Abe, W | 2 |
| Kai, K | 1 |
| Moriyama, M | 1 |
| Narahara, H | 2 |
| Chen, Y | 1 |
| Cai, S | 1 |
| Wang, J | 1 |
| Xu, M | 1 |
| Chandrareddy, A | 1 |
| Muneyyirci-Delale, O | 1 |
| Guo, SW | 6 |
| Zhao, T | 1 |
| Liu, X | 4 |
| Zhen, X | 2 |
| Mao, X | 1 |
| Wang, Y | 1 |
| Carter, AV | 1 |
| Li, H | 1 |
| Tsuno, A | 1 |
| Takai, N | 1 |
| Liu, M | 1 |
| Zhang, Y | 1 |
1 trial available for valproic acid and Endometrioma
| Article | Year |
|---|---|
A pilot study on the off-label use of valproic acid to treat adenomyosis.
Topics: Administration, Oral; Adult; Analgesics; Drug Labeling; Dysmenorrhea; Endometriosis; Enzyme Inhibito | 2008 |
10 other studies available for valproic acid and Endometrioma
| Article | Year |
|---|---|
Epigenetic Drugs in the Treatment of Endometriosis.
Topics: Endometriosis; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids | 2019 |
CCAAT/enhancer-binding protein α is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis.
Topics: Acetylation; Adult; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Caspases; CCAA | 2013 |
Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells.
Topics: Acetylation; Aromatase; Cell Line; Cell Proliferation; Down-Regulation; Endometriosis; Endometrium; | 2015 |
Risks versus benefits of valproic acid?
Topics: 3-Hydroxysteroid Dehydrogenases; Analgesics; Endometriosis; Enzyme Inhibitors; Female; Humans; Hyper | 2008 |
Valproic acid as a therapy for adenomyosis: a comparative case series.
Topics: Adult; Dysmenorrhea; Endometriosis; Female; Humans; Intrauterine Devices, Medicated; Levonorgestrel; | 2010 |
Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats.
Topics: Acid Sensing Ion Channels; Analgesics, Non-Narcotic; Animals; Berberine Alkaloids; Calcitonin Gene-R | 2011 |
The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine Alkaloids; Dit | 2011 |
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Endometriosis; Female; Hyperalgesia; Mice; Mice | 2011 |
Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.
Topics: Acetylation; Adult; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Checkpoint Kinase 2; Cycl | 2011 |
Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Endometriosis; Female; Histone Deacetylase Inhibitors; | 2012 |