valproic acid has been researched along with Embryopathies in 38 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In utero exposure to valproic acid (VPA) during pregnancy is associated with an increased risk of neural tube defects (NTDs)." | 7.73 | Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. ( Dawson, JE; Raymond, AM; Winn, LM, 2006) |
| "In utero exposure to valproic acid (VPA) during pregnancy is associated with an increased risk of neural tube defects (NTDs)." | 3.73 | Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. ( Dawson, JE; Raymond, AM; Winn, LM, 2006) |
| " Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimated risk, 1 to 2%)." | 3.68 | The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. ( Brandenburg, H; Gaillard, HL; Grobbee, DE; Jahoda, MG; Los, FJ; Omtzigt, JG; Pijpers, L; Sachs, ES; Stewart, PA; Wladimiroff, JW, 1992) |
| "Fetal exposure to valproic acid has recently been associated with an increased incidence of neural tube defects." | 3.67 | Prenatal detection of a neural tube defect after fetal exposure to valproic acid. ( Campbell, WA; Cassidy, SB; Ciarleglio, L; Nochimson, DJ; Vintzileos, AM; Weinbaum, PJ, 1986) |
| "Epilepsy is one of the commonest chronic neurological disorders in developing countries." | 2.50 | [Epilepsy, antiepileptic drugs and disorders of reproductive functions of women]. ( Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P, 2014) |
| "Nasoethmoidal meningocele is considered an uncommon type of cephalocele, and congenital cystic adenomatoid malformation (CCAM) is a rare lung disorder characterized by overgrowth of the terminal bronchioles." | 1.43 | Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( Bellé, NL; Betat, Rda S; da Cunha, AC; da Rosa, EB; Dorfman, LE; Matos, IO; Rogatto, SR; Rosa, RF; Silveira, DB; Targa, LV; Tsugami, LG; Villacis, RA; Zen, PR, 2016) |
| " The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period." | 1.39 | Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013) |
| "Women with epilepsy have a higher risk of having dysmorphic child." | 1.33 | A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. ( Batukan, C; Ceylaner, G; Ceylaner, S; Guven, MA; Uzel, M, 2006) |
| " However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups." | 1.32 | Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004) |
| "VPA-induced exencephaly in mice may provide an animal model to further investigate biochemical markers for prenatal diagnosis of neural tube defects." | 1.27 | Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects. ( Elmazar, MM; Spielmann, H; Vogel, R, 1988) |
| " The incidence of malformations was greater at the higher dosage levels of 340 mg/kg and 560 mg/kg, with a predominance of exencephaly, open eyelids, and gross skeletal defects." | 1.27 | Teratogenic effects of valproate in the CD-1 mouse fetus. ( Hayes, TG; Paulson, GW; Paulson, RB; Sucheston, ME, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.68) | 18.7374 |
| 1990's | 7 (18.42) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 8 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, K | 1 |
| Li, J | 1 |
| Gu, J | 1 |
| Guo, X | 1 |
| Gao, T | 1 |
| Li, D | 1 |
| Vajda, FJ | 5 |
| O'Brien, TJ | 4 |
| Graham, J | 3 |
| Lander, CM | 3 |
| Eadie, MJ | 4 |
| Graham, JE | 1 |
| Sargar, KM | 1 |
| Herman, TE | 1 |
| Siegel, MJ | 1 |
| Grzyb, E | 1 |
| Kwiecińska, P | 1 |
| Gregoraszczuk, EL | 1 |
| da Rosa, EB | 1 |
| Silveira, DB | 1 |
| Tsugami, LG | 1 |
| Bellé, NL | 1 |
| Matos, IO | 1 |
| Targa, LV | 1 |
| Betat, Rda S | 1 |
| da Cunha, AC | 1 |
| Villacis, RA | 1 |
| Rogatto, SR | 1 |
| Dorfman, LE | 1 |
| Rosa, RF | 1 |
| Zen, PR | 1 |
| Pearlstein, T | 1 |
| Hitchcock, AA | 1 |
| Alessandri, JL | 1 |
| Isidor, B | 1 |
| David, A | 1 |
| Martin-Coignard, D | 1 |
| Ghazouani, J | 1 |
| Ramful, D | 1 |
| Laville, JM | 1 |
| Le Caignec, C | 1 |
| Crawford, P | 1 |
| Wide, K | 1 |
| Winbladh, B | 1 |
| Källén, B | 1 |
| Yonkers, KA | 1 |
| Wisner, KL | 1 |
| Stowe, Z | 1 |
| Leibenluft, E | 1 |
| Cohen, L | 1 |
| Miller, L | 1 |
| Manber, R | 1 |
| Viguera, A | 1 |
| Suppes, T | 1 |
| Altshuler, L | 1 |
| Hitchcock, A | 1 |
| Cook, M | 1 |
| Lander, C | 1 |
| O'Brien, MD | 1 |
| Gilmour-White, SK | 1 |
| Solinas, C | 1 |
| Dawson, JE | 1 |
| Raymond, AM | 1 |
| Winn, LM | 1 |
| Guven, MA | 1 |
| Batukan, C | 1 |
| Ceylaner, S | 1 |
| Ceylaner, G | 1 |
| Uzel, M | 1 |
| Nau, H | 2 |
| Spielmann, H | 2 |
| Löscher, W | 1 |
| Schäfer, H | 1 |
| Sharony, R | 1 |
| Garber, A | 1 |
| Viskochil, D | 1 |
| Schreck, R | 1 |
| Platt, LD | 1 |
| Ward, R | 1 |
| Buehler, BA | 1 |
| Graham, JM | 1 |
| Michaud, L | 1 |
| Gottrand, F | 1 |
| Turck, D | 1 |
| Poher, M | 1 |
| Lecomte-Houcke, M | 1 |
| Farriaux, JP | 2 |
| Wood, BP | 1 |
| Espinasse, M | 1 |
| Manouvrier, S | 1 |
| Boute, O | 1 |
| Chabrolle, JP | 1 |
| Poinsot, J | 1 |
| Bruel, H | 1 |
| Amussini, P | 1 |
| Sharief, N | 1 |
| Adams, T | 1 |
| Butler, L | 1 |
| Gnanaratnam, J | 1 |
| Moore, SJ | 2 |
| Turnpenny, P | 1 |
| Quinn, A | 1 |
| Glover, S | 1 |
| Lloyd, DJ | 1 |
| Montgomery, T | 1 |
| Dean, JC | 2 |
| Sonoda, T | 1 |
| Gardner, RJ | 1 |
| Savarirayan, R | 1 |
| Dunne, KB | 1 |
| McLellan, JA | 1 |
| Coleman, LT | 1 |
| Suthers, GK | 1 |
| Nagai, T | 1 |
| Glover, SJ | 1 |
| Quinn, AG | 1 |
| Barter, P | 1 |
| Hart, J | 1 |
| Turnpenny, PD | 1 |
| Omtzigt, JG | 1 |
| Los, FJ | 1 |
| Grobbee, DE | 1 |
| Pijpers, L | 1 |
| Jahoda, MG | 1 |
| Brandenburg, H | 1 |
| Stewart, PA | 1 |
| Gaillard, HL | 1 |
| Sachs, ES | 1 |
| Wladimiroff, JW | 1 |
| Orrell, RW | 1 |
| Guibaud, S | 2 |
| Simplot, A | 1 |
| Boisson, C | 1 |
| Pison, H | 1 |
| Serville, F | 1 |
| Carles, D | 1 |
| Dallay, D | 1 |
| Oakeshott, P | 1 |
| Hunt, GM | 1 |
| Chevallier, B | 1 |
| Nègre, V | 1 |
| Bidat, E | 1 |
| Lagardère, B | 1 |
| Weinbaum, PJ | 1 |
| Cassidy, SB | 1 |
| Vintzileos, AM | 1 |
| Campbell, WA | 1 |
| Ciarleglio, L | 1 |
| Nochimson, DJ | 1 |
| Elmazar, MM | 1 |
| Vogel, R | 1 |
| Paulson, RB | 1 |
| Sucheston, ME | 1 |
| Hayes, TG | 1 |
| Paulson, GW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Homeopathic Treatment in Pregnant Women With Overweight and Mental Disorder: a Double Blinded Controlled Clinical Trial[NCT00942097] | Phase 2/Phase 3 | 134 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for valproic acid and Embryopathies
| Article | Year |
|---|---|
[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women].
Topics: Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infertility, Female; Polycystic Ovary Syn | 2014 |
Perinatal depression: treatment options and dilemmas.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Control Studies; Cyclohexan | 2008 |
The teratogenic risk of antiepileptic drug polytherapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Drug Therapy, Combination; Female; Fetal Di | 2010 |
Epilepsy and pregnancy.
Topics: Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fetal Diseases; Folic Acid; Huma | 2002 |
Management of bipolar disorder during pregnancy and the postpartum period.
Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbam | 2004 |
Management of epilepsy in women.
Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilitie | 2005 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Pregn | 2001 |
30 other studies available for valproic acid and Embryopathies
| Article | Year |
|---|---|
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic | 2018 |
Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Fetal Diseases; Fructose; | 2013 |
Dose dependence of fetal malformations associated with valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F | 2013 |
Valproate fetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnostic Imaging; Epilepsy; Female; Fetal Di | 2015 |
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures?
Topics: Adolescent; ATPases Associated with Diverse Cellular Activities; Cystic Adenomatoid Malformation of | 2016 |
Tibial developmental field defect in valproic acid embryopathy: Report on three cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Comparative Genomic Hybridization; Female; Fetal Disease | 2010 |
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu | 2004 |
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Potential risks associated with high-dose valproate in pregnancy in psychiatric patients.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Depressive Disorder, Major; Dose-Response Relationship, D | 2005 |
Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Dose-Response Relationship, Drug; Female; Feta | 2006 |
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases | 2006 |
Embryotoxicity testing of valproic acid.
Topics: Animals; Drug Evaluation, Preclinical; Embryo, Mammalian; Female; Fetal Diseases; Humans; Methods; P | 1983 |
Anticonvulsant activity and embryotoxicity of valproic acid.
Topics: Animals; Female; Fetal Diseases; Humans; Muridae; Pregnancy; Valproic Acid | 1984 |
Preaxial ray reduction defects as part of valproic acid embryofetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Therapeutic; Adolescent; Adult; Extr | 1993 |
Radiological case of the month. In utero ultrasonographic demonstration of a lymphangioma.
Topics: Adult; Epilepsy; Female; Fetal Diseases; Humans; Infant, Newborn; Liver Neoplasms; Lymphangioma, Cys | 1996 |
[Embryofetopathy due to valproate: a pathology only little known. Apropos of 4 cases].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Epilepsy; Face; Female; F | 1996 |
[Embryo-fetopathy due to valproate].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Central Nervous System; Female; Fetal Diseases; Humans | 1997 |
A child with a DIC (15p; 22p) centric fusion and fetal Valproate syndrome.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosomes, Human, Pair 15; Chromosomes, Hu | 1999 |
A clinical study of 57 children with fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Microlissencephaly with cardiac, spinal and urogenital defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Fetal Diseases; Heart | 2001 |
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2002 |
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Male; Pre | 1992 |
Sodium valproate in pregnancy.
Topics: Epilepsy; Female; Fetal Diseases; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; V | 1991 |
[Prenatal diagnosis of 4 cases of spina bifida in mothers treated with valproate].
Topics: Adult; alpha-Fetoproteins; Amniocentesis; Female; Fetal Diseases; Humans; Pregnancy; Pregnancy Trime | 1987 |
Fetal valproate phenotype is recognisable by mid pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Diseases; Humans; Meningomyelocele; Phenotype; Pre | 1989 |
Valproate and spina bifida.
Topics: Adult; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Pr | 1989 |
[Valproate induced fetopathy and somatic and psychomotor development].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Preg | 1989 |
Prenatal detection of a neural tube defect after fetal exposure to valproic acid.
Topics: Abortion, Therapeutic; Adolescent; Epilepsy; Female; Fetal Diseases; Humans; Hydrocephalus; Meningom | 1986 |
Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects.
Topics: Amniotic Fluid; Animals; Brain; Cholinesterases; Disease Models, Animal; Female; Fetal Diseases; Mic | 1988 |
Teratogenic effects of valproate in the CD-1 mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Female; Fetal Diseases; Mice; Mice, Inbred Strains; Pre | 1985 |