valproic acid has been researched along with Dystonia in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| "We have observed acute dystonias in the absence of antipsychotic treatment and in the context of seizure activity (or paroxysmal dyskinetic activity)." | 1.33 | High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. ( Botts, SR; Coffey, GL; de Leon, J, 2005) |
| "Myoclonic dystonia is a rare disorder that occurs in an hereditary and a sporadic form." | 1.28 | Myoclonic dystonia. ( Friedman, JH; Pueschel, SM; Shetty, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coffey, GL | 1 |
| Botts, SR | 1 |
| de Leon, J | 1 |
| Yohanan, M | 1 |
| Aulakh, JS | 1 |
| Weith, J | 1 |
| Hawkins, JW | 1 |
| Brennan, MJ | 1 |
| Ruff, P | 1 |
| Sandyk, R | 1 |
| Auchus, AP | 1 |
| Freeman, A | 1 |
| Green, RC | 1 |
| Godwin-Austen, RB | 1 |
| Pueschel, SM | 1 |
| Friedman, JH | 1 |
| Shetty, T | 1 |
| Fredow, G | 1 |
| Löscher, W | 1 |
| Maccario, M | 1 |
| Lustman, LI | 1 |
| Reynolds, EH | 1 |
| Trimble, MR | 1 |
1 review available for valproic acid and Dystonia
| Article | Year |
|---|---|
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
8 other studies available for valproic acid and Dystonia
| Article | Year |
|---|---|
High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.
Topics: Anticonvulsants; Antipsychotic Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Dibenzothiazepines; | 2005 |
Pisa syndrome in a patient in a wheelchair taking valproic acid.
Topics: Aged; Anticonvulsants; Antipsychotic Agents; Drug Therapy, Combination; Dystonia; Humans; Male; Psyc | 2006 |
Efficacy of a combination of sodium valproate and baclofen in Meige's disease (idiopathic orofacial dystonia).
Topics: Baclofen; Drug Therapy, Combination; Dystonia; Facial Muscles; Humans; Male; Middle Aged; Valproic A | 1982 |
Agitated behavior relieved following treatment of cervical dystonia in dementia.
Topics: Alzheimer Disease; Botulinum Toxins; Chlorpromazine; Dystonia; Female; Humans; Isoxazoles; Middle Ag | 1995 |
The treatment of the choreas and athetotic dystonias.
Topics: Adult; Athetosis; Benzodiazepines; Child; Chorea; Dystonia; Haloperidol; Humans; Levodopa; Movement | 1979 |
Myoclonic dystonia.
Topics: Adult; Biopsy; Cerebellum; Diseases in Twins; Drug Therapy, Combination; Dystonia; Epilepsies, Myocl | 1992 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Paroxysmal nocturnal dystonia presenting as excessive daytime somnolence.
Topics: Adult; Carbamazepine; Diagnosis, Differential; Dystonia; Electroencephalography; Evaluation Studies | 1990 |