valproic acid has been researched along with Dyskinesia, Drug-Induced in 45 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ)." | 3.73 | Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. ( Baldy-Moulinier, M; Berramdane, M; Coubes, P; Crespel, A; Gelisse, P; Genton, P; Monicard, C, 2005) |
| " We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid." | 3.70 | Adverse response to methylphenidate in combination with valproic acid. ( Gara, L; Roberts, W, 2000) |
| "Valproic acid is used in first case as an antiepileptic; own clinical observance and references from the literature show other indication-fields outside of the group of cerebral fits; so Convulex was employed successfully also in the therapy of perioral dyskinesia of variable etiology and in the medical treatment of therapy-resistant pains within the bounds of Polyneuropathy-Polyneuritis Syndrome." | 3.67 | [Further therapeutic possibilities with valproic acid (Convulex)]. ( Auff, E; Holzner, F; Wessely, P, 1985) |
| "We made accelerometric recordings of the tremor induced by valproic acid." | 3.66 | Valproate tremors. ( Bauman, AW; Hammond, EJ; Karas, BJ; Wilder, BJ, 1982) |
| "Risperidone was shown to have significant anti-manic effects which was observed as early as week 1, following start of treatment." | 2.77 | Efficacy and safety of combination of risperidone and haloperidol with divalproate in patients with acute mania. ( Hsu, MC; Kuo, CC; Ouyang, WC; Yeh, IN, 2012) |
| "Aripiprazole is an effective treatment for mania in a population that includes adults, children and adolescents, although its use leads to gastrointestinal disturbances and movement disorders." | 2.49 | Aripiprazole alone or in combination for acute mania. ( Brown, R; Geddes, J; Taylor, MJ, 2013) |
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| " Neuroleptic dosing of manic patients is probably too high and exposes patients to an unnecessary risk of side effects including tardive dyskinesia." | 2.38 | Treatment approaches for acute mania. ( Chou, JC; Sweeney, EA; Tuma, I, 1993) |
| "Among psychiatric disorders the acute symptoms of schizophrenia are exacerbated by enhanced GABA-ergic function." | 2.36 | Pharmacology of GABA. ( Meldrum, B, 1982) |
| "LTG, amantadine, and VPA were withdrawn, the remaining 2 drugs, benzhexol and compound preparation (flupentixol and melitracen), were continued to use, and the patient improved in 2." | 1.46 | Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report. ( Chen, J; He, ZF; Rao, Z; Wang, XH; Zhou, CN, 2017) |
| "Valproic acid is a drug used for the treatment of a variety of psychiatric and neurological disorders." | 1.39 | Valproic acid-induced parkinsonism: levodopa responsiveness with dyskinesia. ( Factor, SA; Silver, M, 2013) |
| "Methylphenidate is a short-acting stimulant." | 1.39 | Methylphenidate-induced acute orofacial and extremity dyskinesia. ( Donmez, A; Isik, B; Orun, E; Sonmez, FM; Tas, T; Yilmaz, AE, 2013) |
| "Haloperidol-induced TD was also attenuated by the antioxidant, vitamin E (400 and 800 mg/kg, p." | 1.31 | Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia. ( Bhattacharya, D; Bhattacharya, SK; Ghosal, S; Sairam, K, 2002) |
| "The delirium was reversible when all drugs were stopped; however, dyskinesia was found to be persistent after a period of 6 months." | 1.30 | Delirium and persistent dyskinesia induced by a lithium-neuroleptic interaction. ( Berger, M; Brandt, C; Normann, C; Walden, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (53.33) | 18.7374 |
| 1990's | 3 (6.67) | 18.2507 |
| 2000's | 8 (17.78) | 29.6817 |
| 2010's | 10 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, ZF | 1 |
| Chen, J | 1 |
| Zhou, CN | 1 |
| Rao, Z | 1 |
| Wang, XH | 1 |
| Alabed, S | 1 |
| Latifeh, Y | 1 |
| Mohammad, HA | 1 |
| Bergman, H | 1 |
| Silver, M | 1 |
| Factor, SA | 1 |
| Brown, R | 1 |
| Taylor, MJ | 1 |
| Geddes, J | 1 |
| Sekhar, S | 1 |
| Kalra, B | 1 |
| Mendhekar, DN | 1 |
| Tekur, U | 1 |
| Lee, Y | 1 |
| Kim, D | 1 |
| Kim, YH | 1 |
| Lee, H | 1 |
| Lee, CJ | 1 |
| Ouyang, WC | 1 |
| Hsu, MC | 1 |
| Yeh, IN | 1 |
| Kuo, CC | 1 |
| Chung, AK | 1 |
| Yilmaz, AE | 1 |
| Donmez, A | 1 |
| Orun, E | 1 |
| Tas, T | 1 |
| Isik, B | 1 |
| Sonmez, FM | 1 |
| Darling, A | 1 |
| Poo, P | 1 |
| Perez-Duenas, B | 1 |
| Campistol, J | 1 |
| Bhattachary, SK | 1 |
| Bhattacharya, D | 2 |
| Muruganandam, AV | 1 |
| Peixoto, MF | 1 |
| Abílio, VC | 1 |
| Silva, RH | 1 |
| Frussa-Filho, R | 1 |
| Witschy, JK | 1 |
| Winter, AS | 1 |
| Luszczki, JJ | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Czuczwar, SJ | 1 |
| Crespel, A | 1 |
| Genton, P | 1 |
| Berramdane, M | 1 |
| Coubes, P | 1 |
| Monicard, C | 1 |
| Baldy-Moulinier, M | 1 |
| Gelisse, P | 1 |
| Tahiroglu, AY | 1 |
| Avci, A | 1 |
| Ogawa, T | 1 |
| Nagao, T | 2 |
| Kashiwabara, K | 1 |
| Fujiwara, Y | 1 |
| Harada, T | 1 |
| Otsuki, S | 2 |
| Friis, T | 1 |
| Christensen, TR | 1 |
| Gerlach, J | 1 |
| Tegeler, J | 1 |
| Wöller, W | 1 |
| Meldrum, B | 1 |
| Hammond, EJ | 2 |
| Wilder, BJ | 2 |
| Bruni, J | 1 |
| Crowe, BM | 1 |
| Thaker, GK | 1 |
| Hare, TA | 1 |
| Tamminga, CA | 1 |
| Ames, D | 1 |
| Webber, J | 1 |
| Marsden, CD | 2 |
| Sheehy, MP | 1 |
| Nair, NP | 1 |
| Lal, S | 1 |
| Schwartz, G | 1 |
| Thavundayil, JX | 1 |
| Karas, BJ | 1 |
| Bauman, AW | 1 |
| Chou, JC | 1 |
| Tuma, I | 1 |
| Sweeney, EA | 1 |
| Kazamatsuri, H | 1 |
| Normann, C | 1 |
| Brandt, C | 1 |
| Berger, M | 1 |
| Walden, J | 1 |
| Gara, L | 1 |
| Roberts, W | 1 |
| Bhattacharya, SK | 1 |
| Sairam, K | 1 |
| Ghosal, S | 1 |
| Chien, C | 1 |
| Jung, K | 1 |
| Ross-Townsend, A | 1 |
| Ohshimo, T | 1 |
| Mitsunobu, K | 1 |
| Sato, M | 1 |
| Campanini, T | 1 |
| Catalano, A | 1 |
| De Risio, C | 1 |
| Forino, V | 1 |
| Gibson, AC | 1 |
| Price, PA | 1 |
| Parkes, JD | 1 |
| Linnoila, M | 1 |
| Viukari, M | 1 |
| Casey, DE | 1 |
| Hammerstad, JP | 1 |
| Gram, L | 1 |
| Bentsen, KD | 1 |
| Nasrallah, HA | 2 |
| Dunner, FJ | 2 |
| McCalley-Whitters, M | 2 |
| Smith, RE | 1 |
| Fisk, GG | 1 |
| York, SM | 1 |
| Monteleone, P | 1 |
| Maj, M | 1 |
| Ariano, MG | 1 |
| Iovino, M | 1 |
| Fiorenza, L | 1 |
| Steardo, L | 1 |
| Auff, E | 1 |
| Holzner, F | 1 |
| Wessely, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aripiprazole for Pre-Existing Neuroleptic-Induced Tardive Dyskinesia: a Prospective 26-Week Observational Study[NCT00837707] | Phase 4 | 25 participants (Anticipated) | Interventional | 2008-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for valproic acid and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Dyskinesia, Drug-Induced; GABA Agonists; gamma-Aminobutyric Acid; Hu | 2018 |
Aripiprazole alone or in combination for acute mania.
Topics: Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Child; Dr | 2013 |
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
Pharmacology of GABA.
Topics: 4-Aminobutyrate Transaminase; Anxiety Disorders; Autonomic Nervous System; Barbiturates; Benzodiazep | 1982 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
Treatment approaches for acute mania.
Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Dyskinesia, Drug-Induced; Fe | 1993 |
[Tardive dyskinesia--diagnosis and treatment].
Topics: Clonidine; Diagnosis, Differential; Dyskinesia, Drug-Induced; Humans; Middle Aged; Psychotropic Drug | 1993 |
Valproate: an updated review.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi | 1985 |
10 trials available for valproic acid and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Efficacy of sodium valproate and haloperidol in the management of acute mania: a randomized open-label comparative study.
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Dyskinesia, Drug-Induced; Female; Haloperidol | 2010 |
Efficacy and safety of combination of risperidone and haloperidol with divalproate in patients with acute mania.
Topics: Acute Disease; Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Body Wei | 2012 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; | 1981 |
Efficacies of agents related to GABA, dopamine, and acetylcholine in the treatment of tardive dyskinesia [proceedings].
Topics: Acetylcholine; Clinical Trials as Topic; Deanol; Dopamine; Dyskinesia, Drug-Induced; Ethanolamines; | 1978 |
Sodium valproate in the treatment of levodopa-induced dyskinesia.
Topics: Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; M | 1978 |
Pharmacologic probes of neurotransmitter systems in tardive dyskinesia: implications for clinical management.
Topics: 5-Hydroxytryptophan; Adult; Aged; Choline; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamin | 1986 |
The effect of sodium valproate on tardive dyskinesia--revisited.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans | 1987 |
Prolactin response to sodium valproate in schizophrenics with and without tardive dyskinesia.
Topics: Adult; Aged; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Prolactin; Psychiatric Status Rati | 1988 |
A placebo-controlled trial of valproate in tardive dyskinesia.
Topics: Adult; Aged; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; | 1985 |
27 other studies available for valproic acid and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report.
Topics: Amantadine; Anticonvulsants; Antiparkinson Agents; Dyskinesia, Drug-Induced; Dyskinesias; Humans; La | 2017 |
Valproic acid-induced parkinsonism: levodopa responsiveness with dyskinesia.
Topics: Adult; Aged; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Diseas | 2013 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, D | 2010 |
Atypical presentation of tardive dyskinesia associated with risperidone long-acting injection as maintenance treatment in bipolar affective disorder: a case report.
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Delayed-Action Preparations; Drug Therapy, | 2012 |
Methylphenidate-induced acute orofacial and extremity dyskinesia.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; C | 2013 |
Effect of Emblica officinalis tannoids on a rat model of tardive dyskinesia.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dyski | 2000 |
Effects of valproic acid on an animal model of tardive dyskinesia.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, | 2003 |
Improvement in tardive dyskinesia with aripiprazole use.
Topics: Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Drug Interactions; Drug Therapy, Combination; | 2005 |
1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Electroshoc | 2006 |
Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
Topics: Adult; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Epilepsie | 2005 |
Polypharmacy and EPS in a child; a case report.
Topics: Attention Deficit Disorder with Hyperactivity; Benztropine; Bipolar Disorder; Child; Comorbidity; Do | 2007 |
Tardive dyskinesia and neurotransmitters: effects of sodium valproate, cyproheptadine, oxypertine, hydroxyzine pamoate and Ca-hopantenate on monoamine metabolites, cyclic nucleotides and gamma-aminobutyric acid in human cerebrospinal fluid.
Topics: Adult; Aged; Cyclic AMP; Cyclic GMP; Cyproheptadine; Dyskinesia, Drug-Induced; Female; Homovanillic | 1984 |
Sodium valproate and biperiden in neuroleptic-induced akathisia, parkinsonism and hyperkinesia. A double-blind cross-over study with placebo.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Biperiden; Double-Blind Method; Drug Therapy, Combina | 1983 |
[Therapeutic measures in tardive dyskinesia].
Topics: Age Factors; Amantadine; Antipsychotic Agents; Baclofen; Benzodiazepines; Bromocriptine; Deanol; Dih | 1983 |
Symptom control in tardive dyskinesia.
Topics: Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Valpr | 1983 |
Sodium valproate and tardive dyskinesia.
Topics: Aged; Dyskinesia, Drug-Induced; Female; Humans; Valproic Acid | 1984 |
Effect of sodium valproate and baclofen in tardive dyskinesia: clinical and neuroendocrine studies.
Topics: Adult; Baclofen; Chronic Disease; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Halop | 1980 |
Valproate tremors.
Topics: Adolescent; Adult; Diagnosis, Differential; Dyskinesia, Drug-Induced; Humans; Middle Aged; Parkinson | 1982 |
Delirium and persistent dyskinesia induced by a lithium-neuroleptic interaction.
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Delirium; Dyskinesia, Drug-Induced; Female | 1998 |
Adverse response to methylphenidate in combination with valproic acid.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bruxism; Central Nervous System Stim | 2000 |
Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Antioxidants; Disease Models, Animal; Dyskinesia, | 2002 |
Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor.
Topics: Adult; Chronic Disease; Cyclic AMP; Cyclic GMP; Cyproheptadine; Dyskinesia, Drug-Induced; Female; Ho | 1979 |
[Tardive dyskinesia. Synthetic-critical review and case contribution].
Topics: Adult; Aged; Baclofen; Dyskinesia, Drug-Induced; Female; Humans; Iatrogenic Disease; Male; Mental Di | 1977 |
Sodium valproate and tardive dyskinesia.
Topics: Adult; Aged; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Schiz | 1978 |
Sodium valproate and tardive dyskinesia.
Topics: Aged; Dyskinesia, Drug-Induced; Humans; Research Design; Valproic Acid | 1979 |
Sodium valproate in tardive dyskinesia.
Topics: Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Valproic Acid | 1979 |
[Further therapeutic possibilities with valproic acid (Convulex)].
Topics: Aged; Blepharospasm; Dyskinesia, Drug-Induced; Female; Foot Diseases; Humans; Male; Middle Aged; Myo | 1985 |