valproic acid has been researched along with Dysembryoma in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therapy with the antiepileptic drug valproic acid (2-propylpentanoic acid, VPA) during early pregnancy can cause similar teratogenic effects (neural tube defects) in human and mice." | 3.71 | Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods. ( Göttlicher, M; Lampen, A; Nau, H, 2001) |
| "Significant decreases in pregnancy weight gain and the number of live fetuses were observed when VPA was administered at the high dose, whereas the percentage of exencephalic fetuses was significantly increased in VPA treated compared with an equivalent VCD dosage group." | 1.51 | Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. ( Bialer, M; Cabrera, RM; Finnell, RH; Lin, YL; Wlodarczyk, BJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, YL | 1 |
| Bialer, M | 1 |
| Cabrera, RM | 1 |
| Finnell, RH | 1 |
| Wlodarczyk, BJ | 1 |
| Chanda, S | 1 |
| Ang, CE | 1 |
| Lee, QY | 1 |
| Ghebrial, M | 1 |
| Haag, D | 1 |
| Shibuya, Y | 1 |
| Wernig, M | 1 |
| Südhof, TC | 1 |
| Heo, YT | 1 |
| Quan, X | 1 |
| Xu, YN | 1 |
| Baek, S | 1 |
| Choi, H | 1 |
| Kim, NH | 1 |
| Kim, J | 1 |
| Dehghan, S | 1 |
| Asadi, S | 1 |
| Hajikaram, M | 1 |
| Soleimani, M | 1 |
| Mowla, SJ | 1 |
| Fathollahi, Y | 1 |
| Ahmadiani, A | 1 |
| Javan, M | 1 |
| Yusa, K | 1 |
| Rad, R | 1 |
| Takeda, J | 1 |
| Bradley, A | 1 |
| Belaizi, M | 1 |
| Mehssani, J | 1 |
| Yahyaoui, M | 1 |
| Fajri, A | 1 |
| Moschidou, D | 1 |
| Mukherjee, S | 1 |
| Blundell, MP | 1 |
| Jones, GN | 1 |
| Atala, AJ | 1 |
| Thrasher, AJ | 1 |
| Fisk, NM | 1 |
| De Coppi, P | 1 |
| Guillot, PV | 1 |
| Lampen, A | 1 |
| Göttlicher, M | 1 |
| Nau, H | 1 |
8 other studies available for valproic acid and Dysembryoma
| Article | Year |
|---|---|
Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Female; Fetal Death; Fetus; Mice; Neu | 2019 |
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.
Topics: Animals; Calmodulin-Binding Proteins; Carcinogenesis; Cells, Cultured; Cellular Reprogramming; Elect | 2019 |
CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells.
Topics: Animals; Animals, Genetically Modified; Benzamides; Blastocyst; Cattle; Cells, Cultured; CRISPR-Cas | 2015 |
Exogenous Oct4 in combination with valproic acid increased neural progenitor markers: an approach for enhancing the repair potential of the brain.
Topics: Animals; Anticonvulsants; Biomarkers; Blotting, Western; Brain; Cell Differentiation; Cells, Culture | 2015 |
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.
Topics: Alkaline Phosphatase; Animals; Cell Dedifferentiation; Cell Differentiation; Chimera; Chromosomal Pr | 2009 |
[Psychotic disorder revealing epilepsy linked to a dysembryoma of the left hippocampus].
Topics: Acute Disease; Adult; Anticonvulsants; Antipsychotic Agents; Diagnosis, Differential; Electroencepha | 2011 |
Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics.
Topics: Amniotic Fluid; Animals; Antigens, Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; | 2013 |
Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods.
Topics: Animals; Anticonvulsants; Cell Differentiation; Drug Evaluation, Preclinical; Female; Humans; Pregna | 2001 |