valproic acid has been researched along with Drug Refractory Epilepsy in 30 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 7.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)." | 7.83 | Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 7.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate receptor antagonist that has been safely used for the treatment of refractory SE in adults and children." | 7.01 | Ketamine as advanced second-line treatment in benzodiazepine-refractory convulsive status epilepticus in children. ( Brisca, G; Buratti, S; Giacheri, E; Mancardi, MM; Moscatelli, A; Nobili, L; Palmieri, A; Riva, A; Striano, P; Tibaldi, J, 2023) |
| " The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy." | 4.98 | Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018) |
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 3.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)." | 3.83 | Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 3.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate receptor antagonist that has been safely used for the treatment of refractory SE in adults and children." | 3.01 | Ketamine as advanced second-line treatment in benzodiazepine-refractory convulsive status epilepticus in children. ( Brisca, G; Buratti, S; Giacheri, E; Mancardi, MM; Moscatelli, A; Nobili, L; Palmieri, A; Riva, A; Striano, P; Tibaldi, J, 2023) |
| " In order to name some, the administration of once-daily dosing of phenytoin or the coadministration of carnitine with valproic acid would be preferable to avoid iatrogenic refractoriness." | 2.82 | The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug-resistant epilepsy. ( Fagiolino, P; Vázquez, M, 2022) |
| "The drug-refractory epilepsy (DRE) in children is commonly observed but the underlying mechanisms remain elusive." | 1.91 | Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy. ( Chen, F; Dai, HR; Dong, N; Guo, HL; Hu, YH; Lu, XP; Qiu, JC; Wang, J; Wang, WJ; Zhang, YY; Zhao, YT, 2023) |
| "The most common syndrome was juvenile myoclonic epilepsy (JME), diagnosed in 44." | 1.56 | Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center. ( Barone, FA; Cerulli Irelli, E; Di Bonaventura, C; Fanella, M; Fattouch, J; Fisco, G; Giallonardo, AT; Manfredi, M; Morano, A; Orlando, B, 2020) |
| "Juvenile myoclonic epilepsy is often regarded as a benign epileptic syndrome, but in this setting, half of the individuals with JME have refractory epilepsy with only about a quarter of those seizure-free in the previous year." | 1.48 | Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center. ( Cação, G; Mannan, S; Parra, J; Sander, JW; Sisodiya, SM, 2018) |
| "A total of 174 children with generalized seizures on VPA therapy were enrolled." | 1.48 | Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2018) |
| "Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE])." | 1.46 | Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy. ( Aroni, S; Marrosu, F; Melis, M; Milioli, G; Muntoni, AL; Parrino, L; Pillolla, G; Pistis, M; Puligheddu, M; Sagheddu, C; Terzano, GM, 2017) |
| " We sought to determine whether there were regions in the dosage range of commonly used AEDs that were associated with superior efficacy in patients with refractory epilepsy." | 1.46 | Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. ( Castagna, CE; Miller, AB; Poolos, NP; Story, TJ; Williams, S, 2017) |
| "Lamotrigine and valproate were rated most successful with good or partial response rates in 88-100% of the patients." | 1.43 | LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs. ( Beaud, N; Borggraefe, I; Budde, J; Debus, O; Ensslen, M; Geis, T; Gilbert, M; Haeussler, M; Hahn, A; Hehr, U; Heiming, R; Herbst, SM; Kurlemann, G; Morgner, R; Morris-Rosendahl, DJ; Muelleder, K; Philippi, H; Proepper, CR; Ross, S; Schuierer, G; Strobl-Wildemann, G; von Gersdorff, G; Vosschulte, P, 2016) |
| "Our patient presented with intractable epilepsy at 2 months of age." | 1.43 | Early-life epileptic encephalopathy secondary to SZT2 pathogenic recessive variants. ( Angle, B; Millichap, JJ; Venkatesan, C, 2016) |
| "Valproic acid (VPA) has been associated with coagulation factors deficiency, platelet dysfunction and hemorrhagic complications." | 1.43 | Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon? ( Arora, A; Chandra, PS; Garg, K; Kurwale, N; Tripathi, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (60.00) | 24.3611 |
| 2020's | 12 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vázquez, M | 1 |
| Fagiolino, P | 1 |
| van der Meer, PB | 1 |
| Dirven, L | 1 |
| Fiocco, M | 1 |
| Vos, MJ | 1 |
| Kouwenhoven, MCM | 1 |
| van den Bent, MJ | 1 |
| Taphoorn, MJB | 1 |
| Koekkoek, JAF | 1 |
| Buratti, S | 1 |
| Giacheri, E | 1 |
| Palmieri, A | 1 |
| Tibaldi, J | 1 |
| Brisca, G | 1 |
| Riva, A | 1 |
| Striano, P | 1 |
| Mancardi, MM | 1 |
| Nobili, L | 1 |
| Moscatelli, A | 1 |
| Guo, HL | 1 |
| Wang, WJ | 1 |
| Dong, N | 1 |
| Zhao, YT | 1 |
| Dai, HR | 1 |
| Hu, YH | 1 |
| Zhang, YY | 1 |
| Wang, J | 1 |
| Qiu, JC | 1 |
| Lu, XP | 1 |
| Chen, F | 1 |
| Niquet, J | 1 |
| Lumley, L | 1 |
| Baldwin, R | 1 |
| Rossetti, F | 1 |
| Schultz, M | 1 |
| de Araujo Furtado, M | 1 |
| Suchomelova, L | 1 |
| Naylor, D | 1 |
| Franco-Estrada, I | 1 |
| Wasterlain, CG | 1 |
| Reindl, C | 1 |
| Sprügel, MI | 1 |
| Sembill, JA | 1 |
| Mueller, TM | 1 |
| Hagen, M | 1 |
| Gerner, ST | 1 |
| Kuramatsu, JB | 1 |
| Hamer, HM | 1 |
| Huttner, HB | 1 |
| Madžar, D | 1 |
| Altenmüller, DM | 1 |
| Hebel, JM | 1 |
| Deniz, C | 1 |
| Volz, S | 1 |
| Zentner, J | 1 |
| Feuerstein, TJ | 1 |
| Moser, A | 1 |
| Yamamoto, A | 1 |
| Saito, Y | 1 |
| Oyama, Y | 1 |
| Watanabe, Y | 1 |
| Ikeda, A | 1 |
| Takayama, R | 1 |
| Ikeda, H | 1 |
| Takeshita, S | 1 |
| Takumi, I | 1 |
| Itai, T | 1 |
| Miyatake, S | 1 |
| Matsumoto, N | 1 |
| McNamara, NA | 1 |
| Dang, LT | 1 |
| Sturza, J | 1 |
| Ziobro, JM | 1 |
| Fedak Romanowski, EM | 1 |
| Smith, GC | 1 |
| Joshi, SM | 1 |
| Leber, SM | 1 |
| Carlson, M | 1 |
| Robertson, P | 1 |
| Shellhaas, RA | 1 |
| Koneval, Z | 1 |
| Knox, KM | 1 |
| Memon, A | 1 |
| Zierath, DK | 1 |
| White, HS | 1 |
| Barker-Haliski, M | 1 |
| Cerulli Irelli, E | 1 |
| Morano, A | 1 |
| Barone, FA | 1 |
| Fisco, G | 1 |
| Fanella, M | 1 |
| Orlando, B | 1 |
| Fattouch, J | 1 |
| Manfredi, M | 1 |
| Giallonardo, AT | 1 |
| Di Bonaventura, C | 1 |
| Wabl, R | 1 |
| Terman, SW | 1 |
| Kwok, M | 1 |
| Elm, J | 1 |
| Chamberlain, J | 1 |
| Silbergleit, R | 1 |
| Hill, CE | 1 |
| Cho, SJ | 1 |
| Park, E | 1 |
| Baker, A | 1 |
| Reid, AY | 1 |
| Puligheddu, M | 1 |
| Melis, M | 1 |
| Pillolla, G | 1 |
| Milioli, G | 1 |
| Parrino, L | 1 |
| Terzano, GM | 1 |
| Aroni, S | 1 |
| Sagheddu, C | 1 |
| Marrosu, F | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Rosati, A | 1 |
| Ilvento, L | 1 |
| Lucenteforte, E | 1 |
| Pugi, A | 1 |
| Crescioli, G | 1 |
| McGreevy, KS | 1 |
| Virgili, G | 1 |
| Mugelli, A | 1 |
| De Masi, S | 1 |
| Guerrini, R | 1 |
| Cação, G | 1 |
| Parra, J | 1 |
| Mannan, S | 1 |
| Sisodiya, SM | 1 |
| Sander, JW | 1 |
| Feng, W | 1 |
| Mei, S | 1 |
| Zhu, L | 1 |
| Yu, Y | 1 |
| Yang, W | 1 |
| Gao, B | 1 |
| Wu, X | 1 |
| Zhao, Z | 1 |
| Fang, F | 1 |
| Jahan, K | 1 |
| Pillai, KK | 1 |
| Vohora, D | 1 |
| Huang, Q | 1 |
| Yu, L | 1 |
| Ma, M | 1 |
| Qi, H | 1 |
| Wu, Y | 1 |
| Lee, BI | 1 |
| Park, KM | 1 |
| Kim, SE | 1 |
| Heo, K | 1 |
| Trivisano, M | 1 |
| Specchio, N | 1 |
| Vigevano, F | 1 |
| Herbst, SM | 1 |
| Proepper, CR | 1 |
| Geis, T | 1 |
| Borggraefe, I | 1 |
| Hahn, A | 1 |
| Debus, O | 1 |
| Haeussler, M | 1 |
| von Gersdorff, G | 1 |
| Kurlemann, G | 1 |
| Ensslen, M | 1 |
| Beaud, N | 1 |
| Budde, J | 1 |
| Gilbert, M | 1 |
| Heiming, R | 1 |
| Morgner, R | 1 |
| Philippi, H | 1 |
| Ross, S | 1 |
| Strobl-Wildemann, G | 1 |
| Muelleder, K | 1 |
| Vosschulte, P | 1 |
| Morris-Rosendahl, DJ | 1 |
| Schuierer, G | 1 |
| Hehr, U | 1 |
| Chowdhury, A | 1 |
| Brodie, MJ | 1 |
| Stevens, CE | 1 |
| Turner, Z | 1 |
| Kossoff, EH | 1 |
| Bektaş, G | 1 |
| Çalışkan, M | 1 |
| Aydın, A | 1 |
| Pembegül Yıldız, E | 1 |
| Tatlı, B | 1 |
| Aydınlı, N | 1 |
| Özmen, M | 1 |
| Venkatesan, C | 1 |
| Angle, B | 1 |
| Millichap, JJ | 1 |
| London, F | 1 |
| Hadhoum, N | 1 |
| Outteryck, O | 1 |
| Vermersch, P | 1 |
| Zéphir, H | 1 |
| Kurwale, N | 1 |
| Garg, K | 1 |
| Arora, A | 1 |
| Chandra, PS | 1 |
| Tripathi, M | 1 |
| Gesche, J | 1 |
| Khanevski, M | 1 |
| Solberg, C | 1 |
| Beier, CP | 1 |
| Poolos, NP | 1 |
| Castagna, CE | 1 |
| Williams, S | 1 |
| Miller, AB | 1 |
| Story, TJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for valproic acid and Drug Refractory Epilepsy
| Article | Year |
|---|---|
The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug-resistant epilepsy.
Topics: Brain; Drug Resistant Epilepsy; Humans; Membrane Transport Proteins; Phenytoin; Valproic Acid | 2022 |
Ketamine as advanced second-line treatment in benzodiazepine-refractory convulsive status epilepticus in children.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Resistant Epilepsy; Ketamine; Status Epilepticus; Va | 2023 |
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch | 2018 |
Clinical opinion: Earlier employment of polytherapy in sequential pharmacotherapy of epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; | 2019 |
1 trial available for valproic acid and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Efficacy of Home Anticonvulsant Administration for Second-Line Status Epilepticus Treatment.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Comparative Effectiveness Research; Doub | 2021 |
24 other studies available for valproic acid and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Effectiveness of Antiseizure Medication Triple Therapy in Patients With Glioma With Refractory Epilepsy: An Observational Cohort Study.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Epilepsy, Generalized; Glioma; Humans; Retrospective Studi | 2023 |
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy.
Topics: Child; Drug Resistant Epilepsy; Fatty Acids; Humans; Lipidomics; Retrospective Studies; Triglyceride | 2023 |
Influence of new versus traditional antiepileptic drugs on course and outcome of status epilepticus.
Topics: Aged; Anticonvulsants; Cohort Studies; Drug Prescriptions; Drug Resistant Epilepsy; Female; Humans; | 2020 |
Electrocorticographic and neurochemical findings after local cortical valproate application in patients with pharmacoresistant focal epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Electrocorticography; Epilepsies, Partial; Female; Humans; | 2020 |
Effect of total callosotomy on KCNQ2-related intractable epilepsy.
Topics: Carbamazepine; Child; Corpus Callosum; Drug Resistant Epilepsy; Electroencephalography; Female; Huma | 2020 |
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Resistant Epilepsy; Drug The | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center.
Topics: Adult; Anticonvulsants; Cohort Studies; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, G | 2020 |
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista | 2021 |
Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Disease Models, Animal; D | 2017 |
Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Resistant Epilepsy; Electroencephalography; Female; | 2018 |
Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP3A; Drug Resistant Epileps | 2018 |
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug | 2018 |
Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report.
Topics: Adult; Anticonvulsants; Ataxia; Carbamazepine; Disease Progression; Drug Resistant Epilepsy; Electro | 2019 |
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni | 2015 |
LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Anticonvulsants; Brain; Child; Ch | 2016 |
Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Drug Resistant Epilepsy; Female; Follow-Up S | 2016 |
Hepatic Dysfunction as a Complication of Combined Valproate and Ketogenic Diet.
Topics: Anticonvulsants; Combined Modality Therapy; Diet, Ketogenic; Drug Resistant Epilepsy; Female; Follow | 2016 |
Aggravation of atonic seizures by rufinamide: A case report.
Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Com | 2016 |
Early-life epileptic encephalopathy secondary to SZT2 pathogenic recessive variants.
Topics: Anticonvulsants; Brain; Child, Preschool; Drug Resistant Epilepsy; Electroencephalography; Humans; I | 2016 |
Late-onset of Alpers-Huttenlocher syndrome: an unusual cause of refractory epilepsy and liver failure.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Diffusion Magnetic Resonance Im | 2017 |
Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon?
Topics: Adolescent; Anticonvulsants; Blood Loss, Surgical; Clinical Decision-Making; Drug Resistant Epilepsy | 2016 |
Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies.
Topics: Adult; Anticonvulsants; Cohort Studies; Delta Rhythm; Demography; Drug Resistant Epilepsy; Electroen | 2017 |
Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul | 2017 |