valproic acid has been researched along with Drug Overdose in 95 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning." | 8.91 | Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Laliberté, M; Lavergne, V; MacTier, R; Nolin, TD, 2015) |
| "Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications." | 6.45 | Extracorporeal elimination in acute valproic acid poisoning. ( Thanacoody, RH, 2009) |
| " This guideline applies to the acute ingestion and acute-on-chronic ingestion of immediate-release and extended-release dosage forms of valproic acid, divalproex, and valproate sodium alone." | 6.44 | Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management. ( Booze, LL; Caravati, EM; Christianson, G; Chyka, PA; Cobaugh, DJ; Erdman, AR; Manoguerra, AS; Nelson, LS; Scharman, EJ; Troutman, WG; Woolf, AD, 2008) |
| "Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity." | 5.91 | Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. ( Fagiolino, P; Ibarra, M; Maldonado, C; Schiavo, A; Trocóniz, IF; Vázquez, M, 2023) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 5.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| " This case describes a 38 year-old female with a past medical history of epilepsy effectively treated with meropenem to rapidly and safely lower toxic VPA levels after an acute ingestion." | 5.22 | Treatment of valproic acid overdose with meropenem in an epileptic patient. ( Clark, K; Cunningham, D; Lord, K, 2022) |
| "We describe the case of a 56-year-old man who presented to the emergency department after an intentional VPA overdose, was found to have hyperammonemia, and was treated with L-carnitine exclusively." | 5.22 | Valproic Acid Overdose: Case Report and Literature Review. ( Berezowski, I; Frasure, SE; Mazer-Amirshahi, M; Patel, J; Pourmand, A; Tran, QK, 2022) |
| "Valproic acid overdose is a relatively rare and electrocardiographic changes usually consist of tachycardia and nonspecific changes, but ischemic changes may occur and usually transient and require only recognition." | 4.95 | Valproic Acid Overdose Review of a Case With Electrocardiographic Changes. ( Muñiz, AE, 2017) |
| "The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning." | 4.91 | Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Laliberté, M; Lavergne, V; MacTier, R; Nolin, TD, 2015) |
| ", drowsiness, coma) were selected for treatment with l-arginine." | 3.85 | L-Arginine in the treatment of valproate overdose - five clinical cases. ( Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V, 2017) |
| "Two cases of acute valproic acid poisoning with central nervous system depression and raised ammonia level without hepatotoxicity were reported." | 3.74 | Two cases of valproic acid poisoning treated with L-carnitine. ( Chan, YC; Lau, FL; Tse, ML, 2007) |
| "Valproic acid is increasingly used in the treatment of epilepsy, and also prescribed for bipolar affective disorders, schizoaffective disorders, schizophrenia and migraine prophylaxis." | 3.72 | Valproic acid intoxication: sense and non-sense of haemodialysis. ( Boerma, EC; Broekroelofs, J; Egbers, PH; Meek, MF; van der Voort, PH; Yska, JP, 2004) |
| "A 25-year-old white woman with a history of multiple suicide attempts and schizophrenia presented after ingesting an unknown amount of valproic acid." | 3.70 | High-flux hemodialysis without hemoperfusion is effective in acute valproic acid overdose. ( Constantiner, M; Kane, SL; Meinecke, CD; Sedor, JR; Staubus, AE, 2000) |
| "This report presents the first case in which glucagon administration enabled the removal of an impacted orogastric tube in a patient with distal esophageal spasm." | 3.69 | Use of glucagon for removal of an orogastric lavage tube. ( Glauser, JM; Thoma, ME, 1995) |
| "Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications." | 2.45 | Extracorporeal elimination in acute valproic acid poisoning. ( Thanacoody, RH, 2009) |
| " This guideline applies to the acute ingestion and acute-on-chronic ingestion of immediate-release and extended-release dosage forms of valproic acid, divalproex, and valproate sodium alone." | 2.44 | Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management. ( Booze, LL; Caravati, EM; Christianson, G; Chyka, PA; Cobaugh, DJ; Erdman, AR; Manoguerra, AS; Nelson, LS; Scharman, EJ; Troutman, WG; Woolf, AD, 2008) |
| " However, these issues deserve further investigation in controlled, randomized and probably multicentre trials to evaluate the clinical value and the appropriate dosage of L-carnitine in each of these conditions." | 2.43 | Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? ( Gris, M; Lheureux, PE; Penaloza, A; Zahir, S, 2005) |
| "Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
| " Increasing clinical experience will more fully elucidate indications for, and optimal dosing of, naloxone in valproic acid toxic states." | 2.41 | Use of naloxone in valproic acid overdose: case report and review. ( Francis, EH; Roberge, RJ, 2002) |
| "Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity." | 1.91 | Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. ( Fagiolino, P; Ibarra, M; Maldonado, C; Schiavo, A; Trocóniz, IF; Vázquez, M, 2023) |
| "Levocarnitine is the treatment of choice in valproic acid toxicity-related hyperammonaemia." | 1.62 | Managing valproic acid toxicity-related hyperammonaemia: an unpredicted course. ( Edquist, C; O'Rourke, N; Pagali, S, 2021) |
| "Valproic acid (VPA) is a broad-spectrum antiepileptic drug indicated for monotherapy and adjunctive therapy of seizures, and complex manic episodes associated with bipolar disorder [1]." | 1.56 | Meropenem as an antidote for intentional valproic acid overdose. ( Priano, J; Smith, TL; Thomas, C, 2020) |
| "Valproic acid (VPA) is a first-line antiepileptic drug." | 1.46 | Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning. ( Jawień, W; Kłys, M; Piekoszewski, W; Wilimowska, J, 2017) |
| "Drug overdose is a growing problem among adolescents." | 1.40 | Overdose with antiepileptic drugs: the efficacy of extracorporeal removal techniques. ( Dias, A; Estanqueiro, P; Farela Neves, J; Moinho, R, 2014) |
| "Valproic acid (VA) is an antiepileptic drug, and frequently prescribed in pediatrics." | 1.38 | [The clinical course of a three year-old girl after overdose of valproic acid]. ( Blicher, TM; Dalhoff, KP; Vestergaard, ET, 2012) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 1.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| " This case highlights the interplay between pharmacogenetic factors, drug-drug interactions, and dose-related toxicity in a child." | 1.36 | Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions. ( Carleton, BC; Ciszkowski, C; Gong, IY; Hayden, MR; Hildebrandt, D; Koren, G; Lauwers, AE; Madadi, P; Ross, CJ; Schwarz, UI; Sistonen, J, 2010) |
| "1%) had a detectable initial concentration not in the toxic range, and 5 (2." | 1.31 | Delayed valproic acid toxicity: a retrospective case series. ( Beauchamp, J; Clark, RF; Ingels, M; Williams, SR, 2002) |
| "The onset of coma may have been related to inhibition of beta-oxidation in the mitochondria, which was reversible by elimination of plasma VPA by DHP." | 1.30 | Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication. ( Kuhara, T; Maeyama, R; Matsumoto, I; Matsumoto, J; Ogawa, H; Okudaira, K; Shinka, T, 1997) |
| " It has a relatively benign side effect profile, but little data exists on massive overdoses with this agent." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
| " Valproic acid elimination half-life was 3 h during the 190 min hemoperfusion cycle." | 1.29 | Delayed peak serum valproic acid in massive divalproex overdose--treatment with charcoal hemoperfusion. ( Aaron, CK; Graudins, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.05) | 18.7374 |
| 1990's | 16 (16.84) | 18.2507 |
| 2000's | 39 (41.05) | 29.6817 |
| 2010's | 28 (29.47) | 24.3611 |
| 2020's | 11 (11.58) | 2.80 |
| Authors | Studies |
|---|---|
| Cunningham, D | 1 |
| Clark, K | 1 |
| Lord, K | 1 |
| Comstock, G | 1 |
| Kilgallon, K | 1 |
| Wang, GS | 1 |
| Bourne, D | 1 |
| Blanchette, E | 1 |
| Stenson, E | 1 |
| Patel, J | 1 |
| Berezowski, I | 1 |
| Mazer-Amirshahi, M | 1 |
| Frasure, SE | 1 |
| Tran, QK | 1 |
| Pourmand, A | 1 |
| Schiavo, A | 1 |
| Maldonado, C | 1 |
| Vázquez, M | 1 |
| Fagiolino, P | 1 |
| Trocóniz, IF | 1 |
| Ibarra, M | 1 |
| Dreucean, D | 1 |
| Beres, K | 1 |
| McNierney-Moore, A | 1 |
| Gravino, D | 1 |
| Thomas, C | 1 |
| Priano, J | 1 |
| Smith, TL | 1 |
| Muñoz-Pichuante, D | 1 |
| Villa-Zapata, L | 1 |
| Lolas, R | 1 |
| Sidlak, AM | 1 |
| York, SR | 1 |
| Janicki, AJ | 1 |
| Pizon, AF | 1 |
| Stuver, R | 1 |
| Khanna, P | 1 |
| Wischhusen, JW | 1 |
| Cobb, C | 1 |
| Bockorny, B | 1 |
| Boels, D | 1 |
| Mégarbane, B | 1 |
| Bouquié, R | 1 |
| Wong, A | 1 |
| Graudins, A | 2 |
| Pagali, S | 1 |
| Edquist, C | 1 |
| O'Rourke, N | 1 |
| Ge, Y | 1 |
| Xu, B | 1 |
| Zhu, S | 1 |
| Li, C | 1 |
| He, Q | 1 |
| Zhu, T | 1 |
| Fan, R | 1 |
| Gong, D | 1 |
| Das, S | 1 |
| Purushothaman, ST | 1 |
| Bc, M | 1 |
| Chatterjee, SS | 1 |
| Kartha, A | 1 |
| Rajan, V | 1 |
| Muñiz, AE | 1 |
| Gearhart, AM | 1 |
| Guardiola, JJ | 1 |
| El-Kersh, K | 1 |
| Mekonnen, S | 1 |
| Kazim, S | 1 |
| Mohindra, R | 1 |
| Gosselin, S | 2 |
| Larocque, A | 1 |
| Ray, S | 2 |
| Skellett, S | 2 |
| Weiner, D | 1 |
| Nir, V | 1 |
| Klein-Kremer, A | 1 |
| Kassem, E | 1 |
| Tominaga, A | 1 |
| Marusic, S | 1 |
| Obreli Neto, PR | 1 |
| Vuletic, V | 1 |
| Kirin, M | 1 |
| Sarchielli, P | 1 |
| Messina, P | 1 |
| Cupini, LM | 1 |
| Tedeschi, G | 1 |
| Di Piero, V | 1 |
| Livrea, P | 1 |
| Pini, LA | 1 |
| Bernardi, G | 1 |
| Bono, G | 1 |
| Sandrini, G | 1 |
| Caproni, S | 1 |
| Corbelli, I | 1 |
| Pisani, F | 1 |
| Beghi, E | 1 |
| Calabresi, P | 1 |
| Moinho, R | 1 |
| Dias, A | 1 |
| Estanqueiro, P | 1 |
| Farela Neves, J | 1 |
| Sencion Martinez, GL | 1 |
| Samillán, K | 1 |
| Espinosa, JL | 1 |
| Rodriguez Puyol, D | 1 |
| Martinez Miguel, P | 1 |
| Villa, P | 1 |
| Wilimowska, J | 2 |
| Kłys, M | 2 |
| Jawień, W | 2 |
| Ghannoum, M | 1 |
| Laliberté, M | 1 |
| Nolin, TD | 1 |
| MacTier, R | 1 |
| Lavergne, V | 1 |
| Hoffman, RS | 1 |
| Hirose, T | 1 |
| Schrettl, V | 1 |
| Felgenhauer, N | 2 |
| Rabe, C | 1 |
| Fernando, M | 1 |
| Eyer, F | 2 |
| Piekoszewski, W | 1 |
| Manoguerra, AS | 1 |
| Erdman, AR | 1 |
| Woolf, AD | 1 |
| Chyka, PA | 1 |
| Caravati, EM | 1 |
| Scharman, EJ | 1 |
| Booze, LL | 1 |
| Christianson, G | 1 |
| Nelson, LS | 2 |
| Cobaugh, DJ | 1 |
| Troutman, WG | 1 |
| Nixon, AC | 1 |
| Doak, MW | 1 |
| Crozier, H | 1 |
| Crooks, DP | 1 |
| Waring, WS | 1 |
| Mestrović, J | 1 |
| Filipović, T | 1 |
| Polić, B | 1 |
| Stricević, L | 1 |
| Omazić, A | 1 |
| Kuzmanić-Samija, R | 1 |
| Markić, J | 1 |
| Licari, E | 1 |
| Calzavacca, P | 1 |
| Warrillow, SJ | 1 |
| Bellomo, R | 1 |
| Thanacoody, RH | 1 |
| Vannaprasaht, S | 1 |
| Tiamkao, S | 1 |
| Sirivongs, D | 1 |
| Piyavhatkul, N | 1 |
| Madadi, P | 1 |
| Hildebrandt, D | 1 |
| Gong, IY | 1 |
| Schwarz, UI | 1 |
| Ciszkowski, C | 1 |
| Ross, CJ | 1 |
| Sistonen, J | 1 |
| Carleton, BC | 1 |
| Hayden, MR | 1 |
| Lauwers, AE | 1 |
| Koren, G | 1 |
| Dichtwald, S | 1 |
| Dahan, E | 1 |
| Adi, N | 1 |
| Moses, A | 1 |
| Sorkine, P | 1 |
| Rupasinghe, J | 1 |
| Jasinarachchi, M | 1 |
| Min, YG | 1 |
| Tse, ML | 2 |
| Davison, AS | 1 |
| Milan, AM | 1 |
| Roberts, NB | 1 |
| Senthilkumaran, S | 1 |
| Balamurugan, N | 1 |
| Menezes, RG | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Pons, S | 1 |
| Gonzva, J | 1 |
| Prunet, B | 1 |
| Gaillard, T | 1 |
| Brisou, P | 1 |
| Vest, P | 1 |
| Emile, L | 1 |
| Blicher, TM | 1 |
| Vestergaard, ET | 1 |
| Dalhoff, KP | 1 |
| Jain, V | 1 |
| Swartz, CM | 1 |
| Barrueto, F | 1 |
| Su, M | 1 |
| Kay, TD | 1 |
| Playford, HR | 1 |
| Johnson, DW | 1 |
| Isbister, GK | 1 |
| Balit, CR | 1 |
| Whyte, IM | 1 |
| Dawson, A | 1 |
| Houghton, BL | 1 |
| Bowers, JB | 1 |
| Jaffe, R | 1 |
| Leavitt, R | 1 |
| Wind, T | 1 |
| Minville, V | 1 |
| Roche Tissot, C | 1 |
| Samii, K | 1 |
| Engbersen, R | 1 |
| Kramers, C | 1 |
| Meek, MF | 1 |
| Broekroelofs, J | 1 |
| Yska, JP | 1 |
| Egbers, PH | 1 |
| Boerma, EC | 1 |
| van der Voort, PH | 1 |
| Camilleri, C | 1 |
| Albertson, T | 1 |
| Offerman, S | 1 |
| Gempel, K | 1 |
| Steimer, W | 1 |
| Gerbitz, KD | 1 |
| Zilker, T | 1 |
| Robinson, P | 1 |
| Abbott, C | 1 |
| Lheureux, PE | 1 |
| Penaloza, A | 1 |
| Zahir, S | 1 |
| Gris, M | 1 |
| Rajkumar, AP | 1 |
| Jebaraj, P | 1 |
| Tharyan, P | 1 |
| Unal, E | 1 |
| Kaya, U | 1 |
| Aydin, K | 1 |
| Peces, R | 1 |
| Fernández, EJ | 1 |
| Sánchez, RJ | 1 |
| Peces, C | 1 |
| Montero, A | 1 |
| Selgas, R | 1 |
| Sikma, MA | 1 |
| Mier, JC | 1 |
| Meulenbelt, J | 1 |
| Jung, J | 1 |
| Eo, E | 1 |
| Ahn, KO | 1 |
| Chan, YC | 1 |
| Lau, FL | 1 |
| Khan, E | 1 |
| Huggan, P | 1 |
| Celi, L | 1 |
| MacGinley, R | 1 |
| Schollum, J | 1 |
| Walker, R | 1 |
| Thoma, ME | 1 |
| Glauser, JM | 1 |
| Tank, JE | 1 |
| Palmer, BF | 1 |
| Aaron, CK | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Woo, M | 1 |
| Nishida, N | 1 |
| Muro, H | 1 |
| Fernández, MC | 2 |
| Walter, FG | 1 |
| Petersen, LR | 1 |
| Walkotte, SM | 1 |
| Berthelot-Moritz, F | 1 |
| Chadda, K | 1 |
| Chanavaz, I | 1 |
| Leroy, JP | 1 |
| Droy, JM | 1 |
| Bonmarchand, G | 1 |
| Leroy, J | 1 |
| Matsumoto, J | 1 |
| Ogawa, H | 1 |
| Maeyama, R | 1 |
| Okudaira, K | 1 |
| Shinka, T | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Poklis, A | 1 |
| Poklis, JL | 1 |
| Trautman, D | 1 |
| Treece, C | 1 |
| Backer, R | 1 |
| Harvey, CM | 1 |
| Lee, WL | 1 |
| Yang, CC | 1 |
| Deng, JF | 1 |
| Chen, YF | 1 |
| Lin, HD | 1 |
| Wang, PH | 1 |
| Montero, FJ | 1 |
| Johnson, LZ | 1 |
| Martinez, I | 1 |
| Davis, CP | 1 |
| Kasinath, BS | 1 |
| Franssen, EJ | 1 |
| van Essen, GG | 1 |
| Portman, AT | 1 |
| de Jong, J | 1 |
| Go, G | 1 |
| Stegeman, CA | 1 |
| Uges, DR | 1 |
| Verma, A | 1 |
| St Clair, EW | 1 |
| Radtke, RA | 1 |
| Goldberg, JF | 1 |
| Sacks, MH | 1 |
| Kocsis, JH | 1 |
| Azaroual, N | 1 |
| Imbenotte, M | 1 |
| Cartigny, B | 1 |
| Leclerc, F | 1 |
| Vallée, L | 1 |
| Lhermitte, M | 1 |
| Vermeersch, G | 1 |
| Kane, SL | 1 |
| Constantiner, M | 1 |
| Staubus, AE | 1 |
| Meinecke, CD | 1 |
| Sedor, JR | 1 |
| Yoon, Y | 1 |
| Jagoda, A | 1 |
| Rengstorff, DS | 1 |
| Milstone, AP | 1 |
| Seger, DL | 1 |
| Meredith, TJ | 1 |
| Espinoza, O | 1 |
| Maradei, I | 1 |
| Ramírez, M | 1 |
| Pascuzzo-Lima, C | 1 |
| Wasserman, GS | 1 |
| Aldridge, SC | 1 |
| Kelly, JC | 1 |
| Abdel-Rahman, SM | 1 |
| Sbei, M | 1 |
| Campellone, JV | 1 |
| Spahr, L | 1 |
| Negro, F | 1 |
| Rubbia-Brandt, L | 1 |
| Marinescu, O | 1 |
| Goodman, K | 1 |
| Jordan, M | 1 |
| Frossard, JL | 1 |
| Hadengue, A | 1 |
| Roberge, RJ | 1 |
| Francis, EH | 1 |
| Kroll, P | 1 |
| Nand, C | 1 |
| Ingels, M | 1 |
| Beauchamp, J | 1 |
| Clark, RF | 1 |
| Williams, SR | 1 |
| Khoo, SH | 1 |
| Leyland, MJ | 1 |
| Jonville, AP | 1 |
| Gauchez, AS | 1 |
| Autret, E | 1 |
| Billard, C | 1 |
| Barbier, P | 1 |
| Nsabiyumva, F | 1 |
| Breteau, M | 1 |
| Roodhooft, AM | 1 |
| Van Dam, K | 1 |
| Haentjens, D | 1 |
| Verpooten, GA | 1 |
| Van Acker, KJ | 1 |
| Rodat, O | 1 |
| Nicolas, G | 1 |
| Anger, JP | 1 |
| Develay-Legueut, MA | 1 |
| Michaux, P | 1 |
10 reviews available for valproic acid and Drug Overdose
| Article | Year |
|---|---|
Treatment of valproic acid overdose with meropenem in an epileptic patient.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Overdose; Epilepsy; Female; Humans; | 2022 |
Valproic Acid Overdose: Case Report and Literature Review.
Topics: Anticonvulsants; Carnitine; Drug Overdose; Humans; Hyperammonemia; Male; Middle Aged; Valproic Acid | 2022 |
Valproic Acid Overdose Review of a Case With Electrocardiographic Changes.
Topics: Adolescent; Anticonvulsants; Antimanic Agents; Drug Overdose; Electrocardiography; Female; GABA Agen | 2017 |
Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup.
Topics: Anticonvulsants; Drug Overdose; Hemoperfusion; Humans; Poisoning; Renal Dialysis; Treatment Outcome; | 2015 |
Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management.
Topics: Ambulatory Care; Antidotes; Charcoal; Drug Overdose; Humans; Poison Control Centers; Poisoning; Prac | 2008 |
Life-threatening sodium valproate overdose: a comparison of two approaches to treatment.
Topics: Adult; Antimanic Agents; Drug Overdose; Emergency Treatment; Female; Humans; Poisoning; Valproic Aci | 2009 |
Extracorporeal elimination in acute valproic acid poisoning.
Topics: Acute Disease; Anticonvulsants; Databases, Bibliographic; Drug Overdose; Half-Life; Hemoperfusion; H | 2009 |
Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence?
Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalo | 2005 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
Use of naloxone in valproic acid overdose: case report and review.
Topics: Adult; Anticonvulsants; Drug Overdose; Female; Humans; Naloxone; Narcotic Antagonists; Valproic Acid | 2002 |
1 trial available for valproic acid and Drug Overdose
| Article | Year |
|---|---|
Sodium valproate in migraine without aura and medication overuse headache: a randomized controlled trial.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Antimanic Agents; Disability Evaluation; Doubl | 2014 |
84 other studies available for valproic acid and Drug Overdose
| Article | Year |
|---|---|
Management and Associated Toxicokinetics of Massive Valproic Acid Ingestion with High Flow Continuous Venovenous Hemodiafiltration.
Topics: Adolescent; Child; Continuous Renal Replacement Therapy; Drug Overdose; Eating; Female; Hemodiafiltr | 2022 |
Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation.
Topics: Ammonia; Anticonvulsants; Carnitine; Dietary Supplements; Drug Overdose; Drug-Related Side Effects a | 2023 |
Use of meropenem to treat valproic acid overdose.
Topics: Adult; Anti-Bacterial Agents; Antimanic Agents; Drug Overdose; Female; Humans; Meropenem; Valproic A | 2019 |
Meropenem as an antidote for intentional valproic acid overdose.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Antidotes; Drug Overdose; Female; Humans; Meropenem; | 2020 |
Meropenem for management of valproic acid overdose: a case report.
Topics: Administration, Oral; Adult; Anticonvulsants; Drug Overdose; Emergency Service, Hospital; Female; Hu | 2020 |
Highest reported clearance of valproate by hemodialysis in massive overdose.
Topics: Adult; Anticonvulsants; Drug Overdose; Humans; Male; Renal Dialysis; Valproic Acid | 2021 |
Isolated severe thrombocytopenia in the setting of extreme hyperthermia.
Topics: Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Blood Platelets | 2020 |
Delayed and prolonged coma following valpromide poisoning in a 4-year-old girl.
Topics: Anticonvulsants; Child, Preschool; Coma; Drug Overdose; Female; Humans; Intubation; Valproic Acid | 2021 |
Efficacy of sustained low-efficiency dialysis in the management of sodium valproate overdose.
Topics: Anticonvulsants; Drug Overdose; Humans; Hybrid Renal Replacement Therapy; Valproic Acid | 2021 |
Managing valproic acid toxicity-related hyperammonaemia: an unpredicted course.
Topics: Adult; Brain Diseases; Carnitine; Drug Overdose; Female; Humans; Hyperammonemia; Valproic Acid; Youn | 2021 |
Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy.
Topics: Adult; Anticonvulsants; Coma; Drug Overdose; Female; Hemofiltration; Humans; Hypotension; Severity o | 2017 |
Oral Asenapine overdose leading to Neuroleptic Malignant Syndrome (NMS).
Topics: Administration, Oral; Adult; Antipsychotic Agents; Bromocriptine; Diagnosis, Differential; Dibenzocy | 2017 |
A 33-Year-Old Woman With Altered Mental Status and Elevated Ammonia Level.
Topics: Adult; Ammonia; Anticonvulsants; Arrhythmias, Cardiac; Drug Overdose; Female; Glasgow Coma Scale; Hu | 2018 |
Valproic Acid Poisoning.
Topics: Anticonvulsants; Child, Preschool; Drug Overdose; Emergency Service, Hospital; Female; Humans; Valpr | 2019 |
QTc prolongation and valproate toxicity.
Topics: Anticonvulsants; Drug Overdose; Female; Humans; Medication Errors; Neurotoxicity Syndromes; Valproic | 2013 |
Valproate toxicity in a child.
Topics: Anticonvulsants; Drug Overdose; Female; Humans; Medication Errors; Neurotoxicity Syndromes; Valproic | 2013 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
[Case of valproic acid overdose treated by hemodialysis].
Topics: Drug Overdose; Humans; Male; Middle Aged; Monitoring, Physiologic; Renal Dialysis; Suicide, Attempte | 2014 |
Peripheral mononeuropathy associated with valproic acid poisoning in an adult patient.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Drug Overdose; Humans; Male; Mononeuropathies; Neurologic | 2014 |
Overdose with antiepileptic drugs: the efficacy of extracorporeal removal techniques.
Topics: Adolescent; Anticonvulsants; Antidotes; Carbamazepine; Charcoal; Combined Modality Therapy; Drug Ove | 2014 |
[Hemoperfusion with activated charcoal on valproic acid poisoning. A case report].
Topics: Benzodiazepines; Charcoal; Combined Modality Therapy; Depressive Disorder; Drug Overdose; Female; Fl | 2015 |
Analysis of variability of concentrations of valproic acid (VPA) and its selected metabolites in the blood serum of patients treated with VPA and patients hospitalized because of VPA poisoning.
Topics: Anticonvulsants; Bipolar Disorder; Drug Overdose; Epilepsy; Female; Humans; Male; Peripheral Nervous | 2014 |
[Acute valproic acid overdose causing only somnolence and stagger despite the extreme hyperammonemia: A case report].
Topics: Acute Disease; Adult; Anticonvulsants; Disorders of Excessive Somnolence; Drug Overdose; Female; Hum | 2016 |
L-Arginine in the treatment of valproate overdose - five clinical cases.
Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Ove | 2017 |
Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning.
Topics: Adult; Anticonvulsants; Drug Overdose; Female; Humans; Kinetics; Male; Middle Aged; Oxidation-Reduct | 2017 |
Patterns of antiepileptic drug overdose differ between men and women: admissions to the Edinburgh Poisons Unit, 2000-2007.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Overdose; Female; Humans; Lamotrigine; Male; Middle Aged | 2009 |
Life-threatening valproate overdose successfully treated with haemodialysis.
Topics: Adolescent; Drug Overdose; Female; Humans; Renal Dialysis; Suicide, Attempted; Valproic Acid | 2008 |
Acute valproic acid overdose: enhance elimination with multiple-doses activated charcoal.
Topics: Acidosis; Acute Disease; Adult; Antidotes; Charcoal; Drug Overdose; Female; Glasgow Coma Scale; Huma | 2009 |
Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.
Topics: Antitussive Agents; Child, Preschool; Cytochrome P-450 CYP2D6; Drug Interactions; Drug Overdose; Fat | 2010 |
Molecular adsorbent recycling system therapy in the treatment of acute valproic acid intoxication.
Topics: Acute Disease; Adult; Antimanic Agents; Charcoal; Drug Overdose; Fluid Therapy; Hemoperfusion; Hepat | 2010 |
Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.
Topics: Adult; Antimanic Agents; Brain Edema; Brain Infarction; Chemical and Drug Induced Liver Injury; Coma | 2011 |
Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; False Positive Reactions; Humans; Male; Predictive Valu | 2011 |
The consequences of valproate overdose.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anticonvulsants; Carnitine; Drug Overdose; Epilepsy; | 2011 |
Role of Hounsfield units to distinguish pseudo-subarachnoid hemorrhage.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Humans; Subarachnoid Hemorrhage; Time Factors; Valproic | 2011 |
Acute overdose of enteric-coated valproic acid and olanzapine: unusual presentation and delayed toxicity.
Topics: Acute Disease; Adult; Antipsychotic Agents; Benzodiazepines; Drug Overdose; Female; Humans; Olanzapi | 2012 |
[The clinical course of a three year-old girl after overdose of valproic acid].
Topics: Anticonvulsants; Antidotes; Charcoal; Child, Preschool; Drug Overdose; Female; Humans; Valproic Acid | 2012 |
Valproate toxicity in a child: two novel observations.
Topics: Anticonvulsants; Child, Preschool; Coma; Drug Overdose; Female; Half-Life; Hemofiltration; Humans; M | 2013 |
Charcoal enhancement of treatment for tricyclic-induced mania.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depres | 2002 |
Valproic acid is a structural analog of GABA that enters various metabolic pathways and has many clinical effects.
Topics: Anticonvulsants; Drug Overdose; Humans; Naloxone; Narcotic Antagonists; Valproic Acid | 2002 |
Hemodialysis versus continuous veno-venous hemodiafiltration in the management of severe valproate overdose.
Topics: Drug Overdose; Female; Hemodiafiltration; Hemofiltration; Humans; Middle Aged; Renal Dialysis; Sever | 2003 |
Valproate overdose: a comparative cohort study of self poisonings.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Cohort Studies; Critical Care; Drug Ove | 2003 |
Valproic acid overdose: a case report and review of therapy.
Topics: Administration, Oral; Adult; Antimanic Agents; Charcoal; Drug Administration Schedule; Drug Overdose | 2003 |
QTc prolongation in multiple drug overdose.
Topics: Adult; Bupropion; Drug Overdose; Fluoxetine; Humans; Long QT Syndrome; Male; Piperazines; Psychotic | 2004 |
[Haemodialysis, L-carnitine therapy and valproic acid overdose].
Topics: Adult; Anticonvulsants; Antidotes; Brain Edema; Carnitine; Drug Overdose; Humans; Male; Renal Dialys | 2004 |
Pharmaceutical drug overdose case reports. From the World Literature.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine M | 2003 |
Enhanced extracorporeal elimination of valproic acid in overdose.
Topics: Drug Overdose; Gastric Lavage; Hemofiltration; Hemoperfusion; Humans; Valproic Acid | 2004 |
Valproic acid intoxication: sense and non-sense of haemodialysis.
Topics: Adult; Drug Overdose; Epilepsy; Ethanol; Hemodiafiltration; Hemoperfusion; Humans; Male; Mental Diso | 2004 |
Fatal cerebral edema after moderate valproic acid overdose.
Topics: Adult; Ammonia; Brain Edema; Cyclohexanols; Drug Overdose; Fatal Outcome; Humans; Male; Risperidone; | 2005 |
Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.
Topics: Anticonvulsants; Brain Edema; Carnitine; Drug Overdose; Fatty Acids; Female; Humans; Hyperammonemia; | 2005 |
Severe hypothermia in association with sodium valproate overdose.
Topics: Adult; Drug Overdose; GABA Agents; Humans; Hypothermia; Male; Rewarming; Treatment Outcome; Valproic | 2005 |
Multi-drug overdose risperidone, ziprasidone, valproate, trihexyphenidyl, and clonazepam.
Topics: Adult; Antipsychotic Agents; Clonazepam; Drug Overdose; Drug Prescriptions; Female; Humans; Piperazi | 2007 |
Fatal valproate overdose in a newborn baby.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Female; Heart Arrest; Humans; Infant, Ne | 2007 |
[Hemoperfusion in the treatment of acute valproic acid intoxication].
Topics: Adult; Antimanic Agents; Drug Overdose; Female; Hemoperfusion; Humans; Suicide, Attempted; Valproic | 2007 |
Massive valproic acid overdose, a misleading case.
Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; P | 2008 |
A case of hemoperfusion and L-carnitine management in valproic acid overdose.
Topics: Adult; Anticonvulsants; Carnitine; Charcoal; Drug Overdose; Female; Hemoperfusion; Humans; Suicide, | 2008 |
Two cases of valproic acid poisoning treated with L-carnitine.
Topics: Adolescent; Adult; Anticonvulsants; Antidotes; Carnitine; Depression; Drug Overdose; Female; Humans; | 2007 |
Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Drug Overdose; Female; Hemodiafiltration; Humans; Valproi | 2008 |
Use of glucagon for removal of an orogastric lavage tube.
Topics: Adult; Drug Overdose; Esophageal Spasm, Diffuse; Female; Gastric Lavage; Glucagon; Humans; Injection | 1995 |
Simultaneous "in series" hemodialysis and hemoperfusion in the management of valproic acid overdose.
Topics: Adult; Combined Modality Therapy; Drug Overdose; Hemoperfusion; Humans; Male; Renal Dialysis; Valpro | 1993 |
Delayed peak serum valproic acid in massive divalproex overdose--treatment with charcoal hemoperfusion.
Topics: Adult; Anticonvulsants; Charcoal; Chlorpheniramine; Delayed-Action Preparations; Drug Overdose; Fema | 1996 |
Effect of L-carnitine supplementation on acute valproate intoxication.
Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro | 1996 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overd | 1996 |
Fatal sodium valproate poisoning.
Topics: Adult; Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Humans; Male; Valproic Acid | 1997 |
Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication.
Topics: Acute Disease; Adult; Carnitine; Charcoal; Coma; Drug Overdose; Female; Glasgow Coma Scale; Hemoperf | 1997 |
Disposition of valproic acid in a case of fatal intoxication.
Topics: Adult; Anticonvulsants; Drug Overdose; Fatal Outcome; Gas Chromatography-Mass Spectrometry; Humans; | 1998 |
A case of severe hyperammonemia and unconsciousness following sodium valproate intoxication.
Topics: Adolescent; Ammonia; Anion Exchange Resins; Anticonvulsants; Cholestyramine Resin; Drug Overdose; Hu | 1998 |
Naloxone in the reversal of coma induced by sodium valproate.
Topics: Adult; Anticonvulsants; Coma; Drug Overdose; Female; Glasgow Coma Scale; Humans; Naloxone; Narcotic | 1999 |
Successful treatment of valproic acid overdose with hemodialysis.
Topics: Adult; Drug Overdose; Female; Humans; Hypotension; Poisoning; Renal Dialysis; Valproic Acid | 1999 |
Valproic acid toxicokinetics: serial hemodialysis and hemoperfusion.
Topics: Adult; Anticonvulsants; Drug Overdose; Hemoperfusion; Humans; Male; Renal Dialysis; Valproic Acid | 1999 |
A case of sustained massive gabapentin overdose without serious side effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Drug Overdose; Epi | 1999 |
Low-dose lithium augmentation of divalproex in geriatric mania.
Topics: Acute Disease; Aged; Antimanic Agents; Bipolar Disorder; Cognition Disorders; Dose-Response Relation | 2000 |
Valproic acid intoxication identified by 1H and 1H-(13)C correlated NMR spectroscopy of urine samples.
Topics: Adolescent; Adult; Anticonvulsants; Carbon Isotopes; Drug Overdose; Gas Chromatography-Mass Spectrom | 2000 |
High-flux hemodialysis without hemoperfusion is effective in acute valproic acid overdose.
Topics: Acidosis, Lactic; Adult; Algorithms; Anticonvulsants; Drug Overdose; Female; Half-Life; Hemodynamics | 2000 |
Felbamate overdose complicated by massive crystalluria and acute renal failure.
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Chromatography, Gas; Crystallization; Drug Interactions | 2000 |
An unusual presentation of opioid-like syndrome in pediatric valproic acid poisoning.
Topics: Child, Preschool; Diagnosis, Differential; Drug Overdose; Gastric Lavage; Humans; Male; Naloxone; Op | 2001 |
A unique valproic acid ingestion.
Topics: Adult; Antimanic Agents; Behavior; Drug Overdose; Humans; Male; Valproic Acid | 2001 |
Stupor from lamotrigine toxicity.
Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle | 2001 |
Acute valproate-associated microvesicular steatosis: could the [13C]methionine breath test be useful to assess liver mitochondrial function?
Topics: Adult; Antimanic Agents; Breath Tests; Drug Overdose; Female; Hepatocytes; Humans; Liver Failure; Me | 2001 |
Hemodialysis in the treatment of valproic acid overdose.
Topics: Adult; Drug Overdose; Humans; Male; Renal Dialysis; Treatment Outcome; Valproic Acid | 2002 |
Delayed valproic acid toxicity: a retrospective case series.
Topics: Adolescent; Adult; Anticonvulsants; California; Charcoal; Child; Drug Overdose; Gastric Lavage; Huma | 2002 |
Cerebral edema following acute sodium valproate overdose.
Topics: Adult; Brain Diseases; Drug Overdose; Edema; Humans; Hypocalcemia; Kidney; Liver; Male; Valproic Aci | 1992 |
Interaction between isoniazid and valproate: a case of valproate overdosage.
Topics: Child, Preschool; Drug Interactions; Drug Overdose; Female; Humans; Isoniazid; Valproic Acid | 1991 |
Acute sodium valproate intoxication: occurrence of renal failure and treatment with haemoperfusion-haemodialysis.
Topics: Acute Disease; Acute Kidney Injury; Drug Overdose; Female; Hemoperfusion; Humans; Infant; Renal Dial | 1990 |
[Sudden death in epileptics treated with valproic acid].
Topics: Adult; Autopsy; Death, Sudden; Drug Overdose; Epilepsy; Female; Humans; Male; Valproic Acid | 1985 |