valproic acid has been researched along with Drug-Induced Stevens Johnson Syndrome in 32 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 7.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 6.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures." | 5.31 | Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000) |
| "We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions." | 4.91 | Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014. ( Huang, XS; Lang, SY; Lv, B; Tian, CL; Wang, HF; Wang, XQ; Yu, SY; Zhang, JT; Zhang, X, 2015) |
| "We systematically reviewed and analyzed published and unpublished cases of Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN) associated with lamotrigine (LTG) therapy to identify characteristics of these reactions." | 4.80 | Lamotrigine-induced severe cutaneous adverse reactions. ( Schlienger, RG; Shapiro, LE; Shear, NH, 1998) |
| "We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine." | 3.85 | Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy. ( Buckley, D; Maduemem, K; O'Neill, T; Vatca, A, 2017) |
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 3.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 2.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "This study was undertaken to determine the impact of dosage in new users of lamotrigine (LTG) and the concomitant intake of valproic acid (VPA) on epidermal necrolysis (EN)." | 1.91 | Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions. ( Diederich, S; Hemmeter, U; Mockenhaupt, M; Paulmann, M, 2023) |
| "Epilepsy is very difficult to treat and often involves the combination of two or more AEDs." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "Previously, we reported a fatal case of toxic epidermal necrolysis with hyperbilirubinemia, and more than 60% of body surface areas had been eroded for 9 weeks." | 1.36 | Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies. ( Hirasawa, H; Kamada, N; Matsuda, K; Matsue, H; Oda, S; Shinkai, H; Suehiro, K; Togawa, Y; Yokota, M; Yoneyama, K, 2010) |
| "Most cases of toxic epidermal necrolysis are drug induced." | 1.32 | Suspected lamotrigine-induced toxic epidermal necrolysis. ( Demiralay, E; Kilinç, M; Söğüt, A; Söğüt, AG; Uzar, H; Yilmaz, A, 2003) |
| "Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures." | 1.31 | Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Almuhana, G | 1 |
| Alsalhi, A | 1 |
| Alsalhi, H | 1 |
| Al-Hoqail, IA | 1 |
| Diederich, S | 1 |
| Hemmeter, U | 1 |
| Paulmann, M | 1 |
| Mockenhaupt, M | 2 |
| Noguchi, Y | 1 |
| Takaoka, M | 1 |
| Hayashi, T | 1 |
| Tachi, T | 1 |
| Teramachi, H | 1 |
| Maduemem, K | 1 |
| Vatca, A | 1 |
| O'Neill, T | 1 |
| Buckley, D | 1 |
| Rashid, M | 1 |
| Kashyap, A | 1 |
| Undela, K | 1 |
| Barbour, KK | 1 |
| Umfrid, CP | 1 |
| Brinton, BA | 1 |
| Avery, JD | 1 |
| Snow, CE | 1 |
| Saaiq, M | 1 |
| Iqbal, T | 1 |
| Wang, XQ | 1 |
| Lv, B | 1 |
| Wang, HF | 1 |
| Zhang, X | 1 |
| Yu, SY | 1 |
| Huang, XS | 1 |
| Zhang, JT | 1 |
| Tian, CL | 1 |
| Lang, SY | 1 |
| Ordoñez, L | 1 |
| Salgueiro, E | 1 |
| Jimeno, FJ | 1 |
| Manso, G | 1 |
| Gau, SS | 1 |
| Chao, PF | 1 |
| Lin, YJ | 1 |
| Chang, CJ | 1 |
| Gau, CS | 1 |
| Ertam, I | 1 |
| Sezgin, AO | 1 |
| Unal, I | 1 |
| Franciotta, D | 1 |
| Kwan, P | 1 |
| Perucca, E | 1 |
| Guevara-Campos, J | 1 |
| González-De Guevara, L | 1 |
| Berardi-Lorenzón, ML | 1 |
| Ibrahim, G | 1 |
| Mejías, P | 1 |
| Agelvis, MC | 1 |
| Kamada, N | 1 |
| Yoneyama, K | 1 |
| Togawa, Y | 1 |
| Suehiro, K | 1 |
| Shinkai, H | 1 |
| Yokota, M | 1 |
| Matsuda, K | 1 |
| Oda, S | 1 |
| Hirasawa, H | 1 |
| Matsue, H | 1 |
| Söğüt, A | 1 |
| Yilmaz, A | 1 |
| Kilinç, M | 1 |
| Söğüt, AG | 1 |
| Demiralay, E | 1 |
| Uzar, H | 1 |
| Hashim, N | 1 |
| Bandara, D | 1 |
| Tan, E | 1 |
| Ilchyshyn, A | 1 |
| Famularo, G | 1 |
| De Simone, C | 1 |
| Minisola, G | 1 |
| Messenheimer, J | 1 |
| Tennis, P | 1 |
| Schlingmann, J | 1 |
| Fein, JD | 1 |
| Hamann, KL | 1 |
| Chang, CC | 1 |
| Shiah, IS | 1 |
| Chang, HA | 1 |
| Huang, SY | 1 |
| Kocak, S | 1 |
| Girisgin, SA | 1 |
| Gul, M | 1 |
| Cander, B | 1 |
| Kaya, H | 1 |
| Kaya, E | 1 |
| Keating, A | 1 |
| Blahunka, P | 1 |
| Duval, X | 1 |
| Chosidow, O | 1 |
| Semah, F | 1 |
| Lipsker, D | 1 |
| Francès, C | 1 |
| Herson, S | 1 |
| Sachs, B | 1 |
| Rönnau, AC | 1 |
| von Schmiedeberg, S | 1 |
| Ruzicka, T | 1 |
| Gleichmann, E | 1 |
| Schuppe, HC | 1 |
| Vukelíc, D | 1 |
| Bozinović, D | 1 |
| Tesović, G | 1 |
| Dobrić, I | 1 |
| Loncarić, D | 1 |
| Knezović, I | 1 |
| Skerlev, M | 1 |
| Tsai, SJ | 1 |
| Chen, YS | 1 |
| Schlienger, RG | 1 |
| Shapiro, LE | 1 |
| Shear, NH | 1 |
| Elston, DM | 1 |
| Dunn, N | 1 |
| Wilton, L | 1 |
| Shakir, S | 1 |
| Bhushan, M | 1 |
| Brooke, R | 1 |
| Hewitt-Symonds, M | 1 |
| Craven, NM | 1 |
| August, PJ | 1 |
| Yalçin, B | 1 |
| Karaduman, A | 1 |
4 reviews available for valproic acid and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy; Hum | 2019 |
Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.
Topics: Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle A | 2015 |
Genetic basis for idiosyncratic reactions to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epile | 2009 |
Lamotrigine-induced severe cutaneous adverse reactions.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combin | 1998 |
28 other studies available for valproic acid and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
New insight into the management of toxic epidermal necrolysis following the coadministration of lamotrigine and valproic acid.
Topics: Anticonvulsants; Humans; Lamotrigine; Stevens-Johnson Syndrome; Triazines; Valproic Acid | 2023 |
Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Registries; Stevens-Johnson Syn | 2023 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Humans; Lamotrigine; Male; Stevens-Johnson Syndro | 2017 |
A Case of Stevens-Johnson Syndrome After Exposure to Valproic Acid.
Topics: Antipsychotic Agents; Bipolar Disorder; Female; Humans; Stevens-Johnson Syndrome; Valproic Acid | 2019 |
Report: Fatal toxic epidermal necrolysis induced by sodium valproate.
Topics: Adult; Epilepsy; Fatal Outcome; Humans; Male; Stevens-Johnson Syndrome; Valproic Acid | 2013 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Pr | 2015 |
The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study.
Topics: Acetaminophen; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Contr | 2008 |
A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Drug Therapy, Combination; Follow-Up S | 2009 |
[Toxic epidermal necrolysis associated to the use of valproic acid].
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Stevens-Johnson Syndrome; Valproic Acid | 2010 |
Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies.
Topics: Aged; Anticonvulsants; Fatal Outcome; Female; Humans; Hyperbilirubinemia; Plasma Exchange; Sorption | 2010 |
Suspected lamotrigine-induced toxic epidermal necrolysis.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Myoclonic Epilepsy, | 2003 |
Early cyclosporine treatment of incipient toxic epidermal necrolysis induced by concomitant use of lamotrigine and sodium valproate.
Topics: Adult; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Epilepsy, Comp | 2004 |
Stevens-Johnson syndrome associated with single high dose of lamotrigine in a patient taking valproate.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Male; Steven | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Images in clinical medicine. Stevens-Johnson syndrome.
Topics: Adult; Anticonvulsants; Drug Synergism; Female; Humans; Lamotrigine; Stevens-Johnson Syndrome; Triaz | 2005 |
Toxic epidermal necrolysis with combination lamotrigine and valproate in bipolar disorder.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Lamotrigine; St | 2006 |
Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrig | 2007 |
Carbamazepine-induced Stevens-Johnson syndrome in a child.
Topics: Anti-Bacterial Agents; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy, Generalized; Human | 1995 |
Lamotrigine versus carbamazepine in epilepsy.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1995 |
Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro.
Topics: Adult; Anticonvulsants; Concanavalin A; Drug Eruptions; Drug Therapy, Combination; Half-Life; Humans | 1997 |
Lamotrigine and toxic epidermal necrolysis.
Topics: Anticonvulsants; Drug Therapy, Combination; Humans; Infant; Lamotrigine; Male; Stevens-Johnson Syndr | 1997 |
Valproic acid-induced Stevens-Johnson syndrome.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Male; Stevens-John | 1998 |
Photo Quiz.
Topics: Aged; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Skin; Stevens-Johns | 1999 |
Stevens-Johnson syndrome and antiepileptics.
Topics: Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; Stevens-Joh | 1999 |
Prolonged toxic epidermal necrolysis due to Lamotrigine.
Topics: Adult; Anticonvulsants; Drug Interactions; Humans; Lamotrigine; Male; Seizures; Stevens-Johnson Synd | 2000 |
Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid.
Topics: Adult; Anticonvulsants; Antimanic Agents; Drug Therapy, Combination; Female; Humans; Lamotrigine; Ps | 2000 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |