valproic acid has been researched along with Down Syndrome in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| " We report a 17-year-old man with epilepsy and Down's syndrome who experienced tremor during the treatment with a low dosage of sodium valproate." | 1.39 | Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome. ( De Sarro, G; Gallelli, L; Loizzo, S; Russo, E; Siniscalchi, A; Tiziana, A, 2013) |
| "Children with Down syndrome are highly susceptible to infantile spasms." | 1.35 | Infantile spasms and Down syndrome: a new animal model. ( Aleem, IS; Ashraf, A; Cortez, MA; Kanawaty, A; Liu, CC; Sadeghnia, HR; Shen, L; Snead, OC; Stewart, L; Trepanier, CH; Wu, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siniscalchi, A | 1 |
| Gallelli, L | 1 |
| Loizzo, S | 1 |
| Tiziana, A | 1 |
| Russo, E | 1 |
| De Sarro, G | 1 |
| Aller-Alvarez, JS | 1 |
| Menéndez-González, M | 1 |
| Ribacoba-Montero, R | 1 |
| Salvado, M | 1 |
| Vega, V | 1 |
| Suárez-Moro, R | 1 |
| Sueiras, M | 1 |
| Toledo, M | 1 |
| Salas-Puig, J | 1 |
| Álvarez-Sabin, J | 1 |
| Cortez, MA | 1 |
| Shen, L | 1 |
| Wu, Y | 1 |
| Aleem, IS | 1 |
| Trepanier, CH | 1 |
| Sadeghnia, HR | 1 |
| Ashraf, A | 1 |
| Kanawaty, A | 1 |
| Liu, CC | 1 |
| Stewart, L | 1 |
| Snead, OC | 1 |
| Darling, A | 1 |
| Poo, P | 1 |
| Perez-Duenas, B | 1 |
| Campistol, J | 1 |
| The, T | 1 |
| Kolla, R | 1 |
| Dawkins, F | 1 |
| Trouth, AJ | 1 |
| Cooper, SA | 1 |
| Collacott, RA | 1 |
| Vanstraelen, M | 1 |
| Tyrer, SP | 1 |
| Kane, RE | 1 |
| Kotagel, S | 1 |
| Bacon, BR | 1 |
| Vogler, CA | 1 |
3 reviews available for valproic acid and Down Syndrome
| Article | Year |
|---|---|
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
Mania and Down's syndrome.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Down Syndrome; Humans; Lithium; Male; Middle Aged; Va | 1993 |
Rapid cycling bipolar affective disorder in people with intellectual disability: a systematic review.
Topics: Antimanic Agents; Bipolar Disorder; Carbamazepine; Down Syndrome; Humans; Intellectual Disability; L | 1999 |
5 other studies available for valproic acid and Down Syndrome
| Article | Year |
|---|---|
Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome.
Topics: Adolescent; Anticonvulsants; Down Syndrome; Epilepsy; GABA Agents; Humans; Male; Tremor; Valproic Ac | 2013 |
Myoclonic epilepsy in Down syndrome and Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Anticonvulsants; Down Syndrome; Electroencephalography; Epilepsies, | 2017 |
Infantile spasms and Down syndrome: a new animal model.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Brain; Disease Models, Animal; Down Syndrome; E | 2009 |
Pure red cell aplasia after 13 years of sodium valproate, and bone marrow suppression after 17 years of carbamazepine.
Topics: Adult; Anticonvulsants; Bone Marrow; Carbamazepine; Down Syndrome; Drug Administration Schedule; Fem | 2004 |
Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome.
Topics: Ammonia; Bone Marrow; Child, Preschool; Down Syndrome; Follow-Up Studies; Humans; Liver; Male; Mitoc | 1992 |