valproic acid has been researched along with Disorders of Excessive Somnolence in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| " During the randomization phase, the most common adverse events occurring in > or =5% in the quetiapine group were somnolence, nasopharyngitis, and headache." | 2.73 | Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). ( Brecher, M; Eggens, I; Paulsson, B; Persson, I; Suppes, T; Vieta, E, 2008) |
| "Treatment with valproic acid for bipolar disorder resulted in complete resolution of symptoms." | 1.46 | A Case of Recurrent Hypersomnia With Autonomic Dysfunction. ( Friedman, D; Kothare, SV; Mahmoudi, M; Vendrame, M, 2017) |
| "One of the leading causes of hypersomnia is sleep apnea." | 1.31 | Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. ( Bishop, J; Takhar, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmoudi, M | 1 |
| Friedman, D | 1 |
| Vendrame, M | 1 |
| Kothare, SV | 1 |
| Hirose, T | 1 |
| Vieta, E | 1 |
| Suppes, T | 1 |
| Eggens, I | 1 |
| Persson, I | 1 |
| Paulsson, B | 1 |
| Brecher, M | 1 |
| El Otmani, H | 1 |
| Lahlou, I | 1 |
| Moutaouakil, F | 1 |
| El Moutawakil, B | 1 |
| Rafii, MA | 1 |
| Slassi, I | 1 |
| Berigan, T | 1 |
| Takhar, J | 1 |
| Bishop, J | 1 |
1 trial available for valproic acid and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126).
Topics: Antipsychotic Agents; Bipolar Disorder; Demography; Dibenzothiazepines; Disorders of Excessive Somno | 2008 |
5 other studies available for valproic acid and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
A Case of Recurrent Hypersomnia With Autonomic Dysfunction.
Topics: Antimanic Agents; Autonomic Nervous System Diseases; Bipolar Disorder; Catatonia; Disorders of Exces | 2017 |
[Acute valproic acid overdose causing only somnolence and stagger despite the extreme hyperammonemia: A case report].
Topics: Acute Disease; Adult; Anticonvulsants; Disorders of Excessive Somnolence; Drug Overdose; Female; Hum | 2016 |
[Invasive Kleine-Levin syndrome responding to valproate].
Topics: Adolescent; Anticonvulsants; Disorders of Excessive Somnolence; Humans; Kleine-Levin Syndrome; Male; | 2013 |
Modafinil treatment of excessive sedation associated with divalproex sodium.
Topics: Adult; Antimanic Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimulants; | 2004 |
Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Disorders of Excessive Somnolence; Dose-Response Relations | 2000 |