valproic acid has been researched along with Diathesis in 18 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 7.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| " Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy in human, has long been considered a risk factor to contribute to ASD susceptibility in offspring from epidemiological studies in humans." | 3.91 | Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates. ( Guo, X; Jiang, YH; Li, XJ; Tu, Z; Wang, Q; Xu, HJ; Yan, T; Yu, HP; Zhang, Y; Zhang, YQ; Zhao, H; Zhou, H, 2019) |
| "The effects of valproate on CNS concentrations of gamma-aminobutyric acid (GABA), glulamate (GLU), glutamine (GLN); dopamine (DA), serotonin (5-HT), and metabolites were examined in tissue extracts of caudate nucleus of genetic substrains of Balb/c mice susceptible (EP) or resistant (ER) to audiogenic seizures." | 3.69 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 3.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| "Valproic acid (VPA) is a drug commonly used for epileptic seizure control." | 1.56 | Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection. ( Chacón-Salinas, R; Chávez-Blanco, AD; Estrada-García, I; Estrada-Parra, S; Flores-Borja, F; Flores-Mejía, R; García-Pérez, BE; Serafín-López, J; Soria-Castro, R; Wong-Baeza, I, 2020) |
| "A relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown." | 1.42 | A new model to study sleep deprivation-induced seizure. ( Leahy, A; Lucey, BP; Rosas, R; Shaw, PJ, 2015) |
| "Thus, the seizure-facilitating nigral efferents may be subject to inhibition by both GABA and opiates and may normally be driven by substance P." | 1.27 | Role of the substantia nigra in GABA-mediated anticonvulsant actions. ( Gale, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kazlauskas, N | 1 |
| Seiffe, A | 1 |
| Campolongo, M | 1 |
| Zappala, C | 1 |
| Depino, AM | 1 |
| Zhao, H | 1 |
| Wang, Q | 1 |
| Yan, T | 1 |
| Zhang, Y | 1 |
| Xu, HJ | 1 |
| Yu, HP | 1 |
| Tu, Z | 1 |
| Guo, X | 1 |
| Jiang, YH | 1 |
| Li, XJ | 1 |
| Zhou, H | 1 |
| Zhang, YQ | 1 |
| Andrade, FO | 1 |
| Nguyen, NM | 1 |
| Warri, A | 1 |
| Hilakivi-Clarke, L | 1 |
| Soria-Castro, R | 1 |
| Chávez-Blanco, AD | 1 |
| García-Pérez, BE | 1 |
| Wong-Baeza, I | 1 |
| Flores-Mejía, R | 1 |
| Flores-Borja, F | 1 |
| Estrada-Parra, S | 1 |
| Estrada-García, I | 1 |
| Serafín-López, J | 1 |
| Chacón-Salinas, R | 1 |
| Lefkopoulos, S | 1 |
| Polyzou, A | 1 |
| Derecka, M | 1 |
| Bergo, V | 1 |
| Clapes, T | 1 |
| Cauchy, P | 1 |
| Jerez-Longres, C | 1 |
| Onishi-Seebacher, M | 1 |
| Yin, N | 1 |
| Martagon-Calderón, NA | 1 |
| Potts, KS | 1 |
| Klaeylé, L | 1 |
| Liu, F | 1 |
| Bowman, TV | 1 |
| Jenuwein, T | 1 |
| Mione, MC | 1 |
| Trompouki, E | 1 |
| Gąssowska-Dobrowolska, M | 1 |
| Kolasa-Wołosiuk, A | 1 |
| Cieślik, M | 1 |
| Dominiak, A | 1 |
| Friedland, K | 1 |
| Adamczyk, A | 1 |
| Jahan, K | 1 |
| Pillai, KK | 1 |
| Vohora, D | 1 |
| Lucey, BP | 1 |
| Leahy, A | 1 |
| Rosas, R | 1 |
| Shaw, PJ | 1 |
| Tremolizzo, L | 1 |
| Carboni, G | 1 |
| Ruzicka, WB | 1 |
| Mitchell, CP | 1 |
| Sugaya, I | 1 |
| Tueting, P | 1 |
| Sharma, R | 1 |
| Grayson, DR | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Swann, AC | 1 |
| Vriend, JP | 1 |
| Alexiuk, NA | 1 |
| Hall, JL | 1 |
| Harris, MJ | 1 |
| Juriloff, DM | 1 |
| Pavlakis, SG | 1 |
| Chusid, RL | 1 |
| Roye, DP | 1 |
| Nordli, DR | 1 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Sharma, SK | 1 |
| Behari, M | 1 |
| Maheshwari, MC | 1 |
| Selvamurthy, W | 1 |
| Gale, K | 1 |
| Crabbe, JC | 1 |
| Young, ER | 1 |
| Tam, B | 1 |
| Kosobud, A | 1 |
| Belknap, JK | 1 |
| Laursen, SE | 1 |
| Finnell, RH | 1 |
| Bennett, GD | 1 |
| Karras, SB | 1 |
| Mohl, VK | 1 |
18 other studies available for valproic acid and Diathesis
| Article | Year |
|---|---|
Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism.
Topics: Animals; Animals, Outbred Strains; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Anima | 2019 |
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Disease Susceptibility; | 2019 |
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Topics: Animals; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Diet, | 2019 |
Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Female; Humans; Immunomodu | 2020 |
Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells.
Topics: Animals; Biomarkers; Chromatin Assembly and Disassembly; Disease Susceptibility; DNA Transposable El | 2020 |
Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid.
Topics: Animals; Autistic Disorder; Biomarkers; Brain; Disease Susceptibility; Enzyme Activation; Female; Im | 2021 |
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug | 2018 |
A new model to study sleep deprivation-induced seizure.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Disease Susceptibility; Drosophila melanoga | 2015 |
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.
Topics: Acetylation; Animals; Cell Adhesion Molecules, Neuronal; CpG Islands; Disease Models, Animal; Diseas | 2002 |
What is bipolar disorder?
Topics: Bipolar Disorder; Disease Susceptibility; Frontal Lobe; Humans; Lithium; Recurrence; Regional Blood | 2006 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; D | 1996 |
Effect of multifactorial genetic liability to exencephaly on the teratogenic effect of valproic acid in mice.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Susceptibility; Female; Fetal Death; Mice; Mice | 1997 |
Valproate therapy: predisposition to bone fracture?
Topics: Adolescent; Bone and Bones; Disease Susceptibility; Epilepsy; Female; Femoral Fractures; Foot; Fract | 1998 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Seizure susceptibility & intra rectal sodium valproate induced recovery in developing undernourished rats.
Topics: Administration, Rectal; Animals; Animals, Newborn; Differential Threshold; Disease Susceptibility; N | 1990 |
Role of the substantia nigra in GABA-mediated anticonvulsant actions.
Topics: Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Brain Diseases; Denervation; D | 1986 |
Genetic differences in anticonvulsant sensitivity in mouse lines selectively bred for ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcohols; Animals; Anticonvulsants; Diazepam; Disease Susceptibility; E | 1986 |
Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite.
Topics: Animals; Disease Susceptibility; Fatty Acids, Monounsaturated; Female; Fetal Resorption; Male; Mice; | 1988 |