valproic acid has been researched along with Diarrhea in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the study was to compare the antiaggressive efficacy of risperidone monotherapy versus risperidone plus valproate in patients with schizophrenia." | 9.12 | Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility. ( Citrome, L; Czobor, P; Nolan, KA; Shope, CB; Volavka, J, 2007) |
| "A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients." | 7.68 | Excipients in valproic acid syrup may cause diarrhea: a case report. ( Veerman, MW, 1990) |
| "The objective of the study was to compare the antiaggressive efficacy of risperidone monotherapy versus risperidone plus valproate in patients with schizophrenia." | 5.12 | Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility. ( Citrome, L; Czobor, P; Nolan, KA; Shope, CB; Volavka, J, 2007) |
| "A case of rapid cycling bipolar disorder in a person with Down's syndrome, responsive to divalproex sodium, a valproic acid derivative, is presented." | 3.68 | Divalproex-responsive rapid cycling bipolar disorder in a patient with Down's syndrome: implications for the Down's syndrome-mania hypothesis. ( Sovner, R, 1991) |
| "A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients." | 3.68 | Excipients in valproic acid syrup may cause diarrhea: a case report. ( Veerman, MW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Omar, MI | 1 |
| Alexander, CE | 1 |
| Citrome, L | 1 |
| Shope, CB | 1 |
| Nolan, KA | 1 |
| Czobor, P | 1 |
| Volavka, J | 1 |
| Hassan, MN | 1 |
| Laljee, HC | 1 |
| Parsonage, MJ | 1 |
| Sovner, R | 1 |
| Veerman, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Psyllium (Agio®) for the Treatment of Fecal Incontinence: Multicenter Randomized Trial (SERAFI)[NCT06166615] | Phase 2/Phase 3 | 148 participants (Anticipated) | Interventional | 2023-12-15 | Not yet recruiting | ||
| Phase 1 Treatment Study to Assess Safety and Proof of Concept to Assess Potential Efficacy of the Implanted Internal Anal Sphincter BioSphincterTM Bioengineered From Autologous Cells to Treat Patients With Severe Passive Fecal Incontinence[NCT05616208] | Phase 1 | 10 participants (Anticipated) | Interventional | 2022-11-02 | Recruiting | ||
| Risperidone Alone Vs. Risperidone Plus Valproate in the Treatment of Patients With Schizophrenia and Hostility[NCT00308360] | Phase 4 | 46 participants | Interventional | 1999-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Diarrhea
| Article | Year |
|---|---|
Drug treatment for faecal incontinence in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Epinephrine; Fecal Incontinence; Gastrointestinal Agents; Humans; L | 2013 |
Drug treatment for faecal incontinence in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Epinephrine; Fecal Incontinence; Gastrointestinal Agents; Humans; L | 2013 |
Drug treatment for faecal incontinence in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Epinephrine; Fecal Incontinence; Gastrointestinal Agents; Humans; L | 2013 |
Drug treatment for faecal incontinence in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Epinephrine; Fecal Incontinence; Gastrointestinal Agents; Humans; L | 2013 |
1 trial available for valproic acid and Diarrhea
| Article | Year |
|---|---|
Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility.
Topics: Adult; Aggression; Anticonvulsants; Antipsychotic Agents; Diarrhea; Drug Therapy, Combination; Femal | 2007 |
3 other studies available for valproic acid and Diarrhea
| Article | Year |
|---|---|
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Divalproex-responsive rapid cycling bipolar disorder in a patient with Down's syndrome: implications for the Down's syndrome-mania hypothesis.
Topics: Adult; Affect; Bipolar Disorder; Diarrhea; Humans; Intellectual Disability; Male; Valproic Acid | 1991 |
Excipients in valproic acid syrup may cause diarrhea: a case report.
Topics: Child, Preschool; Diarrhea; Excipients; Humans; Male; Seizures; Tablets, Enteric-Coated; Valproic Ac | 1990 |