valproic acid has been researched along with Diabetes Mellitus, Type 1 in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We accepted him as type 1 diabetes mellitus (DM type 1)." | 5.33 | Risperidone-associated transient diabetic ketoacidosis and diabetes mellitus type 1 in a patient treated with valproate and lithium. ( Alpaslan, T; Bulent, C; Cengiz, T; Mithat, B, 2005) |
| " A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium." | 3.85 | Second-generation antipsychotic and diabetes mellitus in children and adolescents. ( Nurchi, AM; Pinna, AP; Podda, F; Ripoli, C; Tronci, MG; Zanni, R, 2017) |
| "Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues." | 1.48 | Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors. ( Bhadada, S; Dudhrejiya, A; Patel, B; Rabadiya, S; Vaishnav, D, 2018) |
| "We accepted him as type 1 diabetes mellitus (DM type 1)." | 1.33 | Risperidone-associated transient diabetic ketoacidosis and diabetes mellitus type 1 in a patient treated with valproate and lithium. ( Alpaslan, T; Bulent, C; Cengiz, T; Mithat, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabadiya, S | 1 |
| Bhadada, S | 1 |
| Dudhrejiya, A | 1 |
| Vaishnav, D | 1 |
| Patel, B | 1 |
| Ripoli, C | 1 |
| Pinna, AP | 1 |
| Podda, F | 1 |
| Zanni, R | 1 |
| Tronci, MG | 1 |
| Nurchi, AM | 1 |
| Hesemann, J | 1 |
| Lauer, E | 1 |
| Ziska, S | 1 |
| Noonan, K | 1 |
| Nemeth, B | 1 |
| Scott-Schwoerer, J | 1 |
| McCarty, C | 1 |
| Rasmussen, K | 1 |
| Goldberg, JM | 1 |
| Sund, S | 1 |
| Eickhoff, J | 1 |
| Raggio, CL | 1 |
| Giampietro, PF | 1 |
| Khan, S | 1 |
| Jena, G | 1 |
| Noh, H | 1 |
| Oh, EY | 1 |
| Seo, JY | 1 |
| Yu, MR | 1 |
| Kim, YO | 1 |
| Ha, H | 1 |
| Lee, HB | 1 |
| Young, L | 1 |
| Coffey, BJ | 1 |
| Sakai, K | 2 |
| Tavakoli, SA | 1 |
| Arguisola, MS | 1 |
| Mithat, B | 1 |
| Alpaslan, T | 1 |
| Bulent, C | 1 |
| Cengiz, T | 1 |
| Averbuch-Heller, L | 1 |
| Ben-Hur, T | 1 |
| Reches, A | 1 |
| Doucet, J | 1 |
| Fresel, J | 1 |
| Hue, G | 1 |
| Moore, N | 1 |
| Finnerty, M | 1 |
| Levin, Z | 1 |
| Miller, LJ | 1 |
| Schmid, RD | 1 |
| Coiro, V | 1 |
| Capretti, L | 1 |
| Bianconi, L | 1 |
| Castelli, A | 1 |
| Cerri, L | 1 |
| Roberti, G | 1 |
| Marcato, A | 1 |
| Volpi, R | 1 |
| Chiodera, P | 1 |
| Gatti, G | 1 |
| Crema, F | 1 |
| Attardo-Parrinello, G | 1 |
| Fratino, P | 1 |
| Aguzzi, F | 1 |
| Perucca, E | 1 |
| Turnbull, DM | 1 |
| Bone, AJ | 1 |
| Tames, FJ | 1 |
| Wilson, L | 1 |
| Baird, JD | 1 |
| Sherratt, HS | 1 |
2 reviews available for valproic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
[Stiff-person syndrome].
Topics: Animals; Autoantibodies; Autoimmunity; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; | 2002 |
[Stiff-man syndrome].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Ami | 2000 |
1 trial available for valproic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Reduction of baclofen-, but not sodium valproate-induced growth hormone release in type I diabetic men.
Topics: Adult; Baclofen; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; R | 1991 |
14 other studies available for valproic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors.
Topics: Animals; Cardiomegaly; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Cardiomy | 2018 |
Second-generation antipsychotic and diabetes mellitus in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Blood Glucose; Clomipramine; D | 2017 |
Analysis of maternal risk factors associated with congenital vertebral malformations.
Topics: Abnormalities, Multiple; Adolescent; Adult; Alcohol Drinking; Child; Clomiphene; Diabetes Mellitus, | 2013 |
Valproic Acid Improves Glucose Homeostasis by Increasing Beta-Cell Proliferation, Function, and Reducing its Apoptosis through HDAC Inhibition in Juvenile Diabetic Rat.
Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mel | 2016 |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiat | 2009 |
Bipolar disorder and valproate-induced hyperammonemic encephalopathy in an adolescent with diabetes.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Diabetes Mellitus, Type 1; Humans; Hyperammonemia; M | 2010 |
Diabetic ketoacidosis in a patient treated with olanzapine, valproic acid, and venlafaxine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepi | 2003 |
Risperidone-associated transient diabetic ketoacidosis and diabetes mellitus type 1 in a patient treated with valproate and lithium.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Ke | 2005 |
Valproate encephalopathy and hypocarnitinaemia in diabetic patients.
Topics: Adolescent; Adult; Brain Diseases; Carnitine; Diabetes Mellitus, Type 1; Electroencephalography; Epi | 1994 |
Protein binding of digitoxin, valproate and phenytoin in sera from diabetics.
Topics: Adult; Blood Proteins; Diabetes Mellitus, Type 1; Digitoxin; Female; Humans; Male; Phenytoin; Protei | 1993 |
Acute manic episodes in pregnancy.
Topics: Adult; Bipolar Disorder; Chlorpromazine; Comorbidity; Diabetes Mellitus, Type 1; Drug Therapy, Combi | 1996 |
Propionic acid and dipropylacetic acid in the urine of patients treated with dipropylacetic acid.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Gas; Diabetes Mellitus, Type 1; Female; Humans; | 1977 |
Serum protein binding of phenytoin and valproic acid in insulin-dependent diabetes mellitus.
Topics: Adolescent; Adult; Blood Proteins; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Female; Gl | 1987 |
The effect of valproate on blood metabolite concentrations in spontaneously diabetic, ketoacidotic, BB/E Wistar rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Drug Evaluation, Preclinic | 1985 |