valproic acid has been researched along with Developmental Psychomotor Disorders in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 7.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use." | 4.84 | Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 3.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "There is no effective therapy for early myoclonic encephalopathy." | 1.38 | [The clinical and electroencephalographic characteristics of early myoclonic encephalopathy]. ( Huang, R; Li, B; Liu, CT; Yin, F, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, CT | 1 |
| Yin, F | 1 |
| Huang, R | 1 |
| Li, B | 1 |
| Krsek, P | 1 |
| Sebronová, V | 1 |
| Procházka, T | 1 |
| Maulisová, A | 1 |
| Komárek, V | 1 |
| Veggiotti, P | 1 |
| Cardinali, S | 1 |
| Granocchio, E | 1 |
| Avantaggiato, P | 1 |
| Papalia, G | 1 |
| Cagnana, A | 1 |
| Lanzi, G | 1 |
| Konovalov, S | 1 |
| Muralee, S | 1 |
| Tampi, RR | 1 |
| Coccurello, R | 1 |
| Caprioli, A | 1 |
| Ghirardi, O | 1 |
| Virmani, A | 1 |
| Kiul'ts, I | 1 |
| Klaĭf, F | 1 |
| Sommerbeck, KW | 1 |
| Theilgaard, A | 1 |
| Rasmussen, KE | 1 |
| Løhren, V | 1 |
| Gram, L | 1 |
| Wulff, K | 1 |
| Christmann, D | 1 |
| Hirsch, E | 1 |
| Mutschler, V | 1 |
| Collard, M | 1 |
| Marescaux, C | 1 |
| Colombo, JP | 1 |
| Gobbi, G | 1 |
| Bureau, M | 1 |
| Roger, J | 1 |
| Giovanardi-Rossi, P | 1 |
| Chevallier, B | 1 |
| Nègre, V | 1 |
| Bidat, E | 1 |
| Lagardère, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids | 2008 |
[Late diagnosis of congenital argininemia during administration of sodium valproate].
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psych | 1990 |
1 trial available for valproic acid and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
[Sodium di-n-propylacetate: evaluation of its so-called psychotropic effect. A controlled study].
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Humans; Male; | 1977 |
8 other studies available for valproic acid and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
[The clinical and electroencephalographic characteristics of early myoclonic encephalopathy].
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Infant; Infant, Newb | 2012 |
Successful treatment of Ohtahara syndrome with chloral hydrate.
Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans; | 2002 |
Motor impairment on awakening in a patient with an EEG pattern of "unilateral, continuous spikes and waves during slow sleep".
Topics: Anticonvulsants; Arm; Benzodiazepines; Child; Clobazam; Electroencephalography; Epilepsy; Ethosuximi | 2005 |
Valproate and acetyl-L-carnitine prevent methamphetamine-induced behavioral sensitization in mice.
Topics: Acetylcarnitine; Analysis of Variance; Animals; Behavior, Animal; Drug Administration Schedule; Drug | 2007 |
[Treatment of rapid nodding "salaam" spasms in childhood].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Clonazepam; Electroencephalography; Female; Humans; I | 1980 |
[Case of epilepsy in an infant with fatal outcome during the 1st year of unknown etiology].
Topics: Developmental Disabilities; Drug Resistance; Electroencephalography; Epilepsy; Humans; Infant; Infan | 1985 |
[Valproate induced fetopathy and somatic and psychomotor development].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Preg | 1989 |