valproic acid has been researched along with Developmental Disabilities in 65 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG." | 9.09 | Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000) |
| "We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay." | 9.08 | Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997) |
| "We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity." | 7.74 | Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008) |
| "Valproic acid (VPA) is a known teratogenic drug." | 5.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG." | 5.09 | Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000) |
| "We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay." | 5.08 | Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997) |
| "The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5." | 4.90 | Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014) |
| " Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15." | 3.83 | Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. ( Filipović, L; Kanazir, S; Martać, L; Pavković, Ž; Pešić, V; Podgorac, J; Sekulić, S, 2016) |
| "The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine." | 3.76 | Growth hormone levels in children and adolescents with epilepsy. ( Al-Badani, AK; Aly, GS; El-Khayat, HA; Mamdouh, RM; Mohamed, EI; Tomoum, HY, 2010) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| "We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity." | 3.74 | Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008) |
| "Valproate embryopathy is a well recognized syndrome caused by prenatal exposure to the anticonvulsant valproic acid (Depakote)." | 3.73 | Valproate embryopathy: clinical and cognitive profile in 5 siblings. ( Oppenheimer, SG; Saal, HM; Schorry, EK, 2005) |
| "Twenty patients with West syndrome were initially treated with high-dose vitamin B6 (40 to 50 mg/kg/day) and valproate (40 to 50 mg/kg/day)." | 2.70 | [Seizure and developmental prognosis of West syndrome--combination therapy with high-dose vitamin B6, valproate and low-dose ACTH]. ( Fujii, T; Ito, M; Miyajima, T; Okuno, T, 2001) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0." | 1.40 | Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014) |
| "Valproic acid (VPA) is a known teratogenic drug." | 1.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "Epilepsy was diagnosed in 37% (375/1014) of the study participants." | 1.36 | Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). ( Yasuhara, A, 2010) |
| "BMEI may be followed by juvenile myoclonic epilepsy." | 1.33 | Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients. ( Auvin, S; Badinand, N; De Bellecize, J; Isnard, H; Lamblin, MD; Motte, J; Pandit, F; Vallée, L; Villeneuve, N, 2006) |
| "Nonconvulsive status epilepticus is characterized by continuous or near continuous epileptiform discharges on electroencephalography without overt motor or sensory phenomena." | 1.33 | Nonconvulsive status epilepticus and neurodevelopmental delay. ( Dirik, E; Hüdaoglu, O; Kurul, S; Yiş, U, 2006) |
| "The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome." | 1.31 | Prognosis of seizures occurring in the first year. ( Datta, AN; Wirrell, EC, 2000) |
| "Autism has been described in association with a variety of medical and genetic conditions." | 1.31 | Fetal valproate syndrome and autism: additional evidence of an association. ( Cunningham, M; Hersh, JH; Kerr, B; King, J; Stephan, M; Williams, G, 2001) |
| "A possible causal relationship between autism and absence seizures in these children is explored." | 1.30 | Valproic acid treatment of epilepsy in autistic twins. ( Blair, JL; Childs, JA, 1997) |
| "The two patients with mental retardation have been treated with polytherapy." | 1.30 | Epilepsy with myoclonic absences with early onset: a follow-up study. ( Chiarelli, F; Domizio, S; Greco, R; Morgese, G; Sabatino, G; Verrotti, A, 1999) |
| "One also had features of infantile autism." | 1.29 | Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994) |
| "The prognosis of infantile spasms is grim when a detectable brain lesion is present." | 1.28 | [A prognostic study of cryptogenic infantile spasms]. ( Boulloche, J; Dautreme, P; Le Luyer, B; Mallet, E; Tron, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.54) | 18.7374 |
| 1990's | 10 (15.38) | 18.2507 |
| 2000's | 26 (40.00) | 29.6817 |
| 2010's | 23 (35.38) | 24.3611 |
| 2020's | 5 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Jackson, A | 1 |
| Ward, H | 1 |
| Bromley, RL | 3 |
| Deshpande, C | 1 |
| Vasudevan, P | 1 |
| Scurr, I | 1 |
| Dean, J | 1 |
| Shannon, N | 1 |
| Berg, J | 1 |
| Holder, S | 1 |
| Baralle, D | 1 |
| Clayton-Smith, J | 6 |
| Devries, S | 1 |
| Mulder, M | 1 |
| Charron, JG | 1 |
| Prokop, JW | 1 |
| Mark, PR | 1 |
| Colijn, MA | 1 |
| Daugaard, CA | 1 |
| Pedersen, L | 1 |
| Sun, Y | 1 |
| Dreier, JW | 1 |
| Christensen, J | 1 |
| Nickels, K | 1 |
| Kossoff, EH | 1 |
| Eschbach, K | 1 |
| Joshi, C | 1 |
| Wise, J | 1 |
| Angus-Leppan, H | 1 |
| Liu, RSN | 1 |
| Weiner, D | 1 |
| Nir, V | 1 |
| Klein-Kremer, A | 1 |
| Kassem, E | 1 |
| Patil, RB | 1 |
| Urs, P | 1 |
| Kiran, S | 1 |
| Bargale, SD | 1 |
| Baek, JH | 1 |
| Seo, YH | 1 |
| Kim, GH | 1 |
| Kim, MK | 1 |
| Eun, BL | 1 |
| Verrotti, A | 2 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 2 |
| Tiboni, GM | 1 |
| Van Houtte, E | 1 |
| Casselman, J | 1 |
| Janssens, S | 1 |
| De Kegel, A | 1 |
| Maes, L | 1 |
| Dhooge, I | 1 |
| Bromley, R | 1 |
| Weston, J | 1 |
| Adab, N | 3 |
| Greenhalgh, J | 1 |
| Sanniti, A | 1 |
| McKay, AJ | 1 |
| Tudur Smith, C | 1 |
| Marson, AG | 1 |
| James, EJ | 1 |
| Gu, J | 1 |
| Ramirez-Vizcarrondo, CM | 1 |
| Hasan, M | 1 |
| Truszkowski, TL | 1 |
| Tan, Y | 1 |
| Oupravanh, PM | 1 |
| Khakhalin, AS | 1 |
| Aizenman, CD | 1 |
| Podgorac, J | 1 |
| Pešić, V | 1 |
| Pavković, Ž | 1 |
| Martać, L | 1 |
| Kanazir, S | 1 |
| Filipović, L | 1 |
| Sekulić, S | 1 |
| Kmietowicz, Z | 1 |
| Deng, XL | 1 |
| Yin, F | 1 |
| Zhang, CL | 1 |
| Ma, YP | 1 |
| He, F | 1 |
| Wu, LW | 1 |
| Peng, J | 1 |
| Main, SL | 1 |
| Kulesza, RJ | 1 |
| Sabers, A | 1 |
| Larsen, K | 1 |
| Blichfeldt, S | 1 |
| Sahlholdt, L | 1 |
| Rasmussen, JO | 1 |
| Meador, KJ | 1 |
| Baker, GA | 3 |
| Browning, N | 1 |
| Combs-Cantrell, DT | 1 |
| Cohen, M | 1 |
| Kalayjian, LA | 1 |
| Kanner, A | 1 |
| Liporace, JD | 1 |
| Pennell, PB | 1 |
| Privitera, M | 1 |
| Loring, DW | 1 |
| Liu, YH | 1 |
| Wang, L | 1 |
| Huang, YG | 1 |
| Lagae, L | 1 |
| Verhelst, H | 1 |
| Ceulemans, B | 2 |
| De Meirleir, L | 1 |
| Nassogne, MC | 1 |
| De Borchgrave, V | 1 |
| D'Hooghe, M | 1 |
| Foulon, M | 1 |
| Van Bogaert, P | 1 |
| El-Khayat, HA | 1 |
| Aly, GS | 1 |
| Tomoum, HY | 1 |
| Mamdouh, RM | 1 |
| Al-Badani, AK | 1 |
| Mohamed, EI | 1 |
| Mawer, G | 2 |
| Love, J | 1 |
| Kelly, J | 1 |
| Purdy, L | 1 |
| McEwan, L | 1 |
| Briggs, M | 2 |
| Shi, X | 1 |
| Sin, X | 1 |
| Yasuhara, A | 1 |
| Cummings, C | 1 |
| Stewart, M | 1 |
| Stevenson, M | 1 |
| Morrow, J | 1 |
| Nelson, J | 1 |
| Tureci, E | 1 |
| Asan, Z | 1 |
| Eser, M | 1 |
| Tanriverdi, T | 1 |
| Alkan, F | 1 |
| Erdincler, P | 1 |
| Poolos, NP | 1 |
| Warner, LN | 1 |
| Humphreys, SZ | 1 |
| Williams, S | 1 |
| Lance, EI | 1 |
| Shapiro, BK | 1 |
| Kozhokaru, AB | 1 |
| Karlov, VA | 1 |
| Zhidkova, IA | 1 |
| Serkina, AV | 1 |
| Mawer, GE | 1 |
| Cheyne, C | 1 |
| García-Fiñana, M | 1 |
| Kneen, R | 1 |
| Lucas, SB | 1 |
| Shallcross, R | 1 |
| Malm, H | 1 |
| Kajantie, E | 1 |
| Kivirikko, S | 1 |
| Kääriäinen, H | 1 |
| Peippo, M | 1 |
| Somer, M | 1 |
| Duchowny, M | 1 |
| Kini, U | 2 |
| Vinten, J | 2 |
| Ayres, J | 1 |
| Baker, G | 1 |
| Coyle, H | 1 |
| Fryer, A | 2 |
| Gorry, J | 1 |
| Gregg, J | 1 |
| Nicolaides, P | 1 |
| Pickering, L | 1 |
| Tunnicliffe, L | 1 |
| Chadwick, DW | 1 |
| Schorry, EK | 1 |
| Oppenheimer, SG | 1 |
| Saal, HM | 1 |
| O'Brien, MD | 1 |
| Gilmour-White, SK | 1 |
| Eriksson, K | 1 |
| Viinikainen, K | 1 |
| Mönkkönen, A | 1 |
| Aikiä, M | 1 |
| Nieminen, P | 1 |
| Heinonen, S | 1 |
| Kälviäinen, R | 1 |
| Auvin, S | 1 |
| Pandit, F | 1 |
| De Bellecize, J | 1 |
| Badinand, N | 1 |
| Isnard, H | 1 |
| Motte, J | 1 |
| Villeneuve, N | 1 |
| Lamblin, MD | 1 |
| Vallée, L | 1 |
| Koren, G | 1 |
| Nava-Ocampo, AA | 1 |
| Moretti, ME | 1 |
| Sussman, R | 1 |
| Nulman, I | 1 |
| Hellings, JA | 1 |
| Ben-Menachem, E | 1 |
| Schmitz, B | 1 |
| Tomson, T | 1 |
| Vajda, F | 1 |
| Vorbrodt, AW | 1 |
| Dobrogowska, DH | 1 |
| Kozlowski, PB | 1 |
| Rabe, A | 1 |
| Tarnawski, M | 1 |
| Lee, MH | 1 |
| Dirik, E | 1 |
| Yiş, U | 1 |
| Hüdaoglu, O | 1 |
| Kurul, S | 1 |
| Galimberti, CA | 1 |
| Diegoli, M | 1 |
| Sartori, I | 1 |
| Uggetti, C | 1 |
| Brega, A | 1 |
| Tartara, A | 1 |
| Arbustini, E | 1 |
| Ivanov, I | 1 |
| Klein, M | 1 |
| Green, WH | 1 |
| Coffey, B | 1 |
| Piantino, JA | 1 |
| Torres, A | 1 |
| Duncan, S | 1 |
| Nicolai, J | 1 |
| Gunning, B | 1 |
| Leroy, PL | 1 |
| Vles, JS | 1 |
| Christianson, AL | 1 |
| Chesler, N | 1 |
| Kromberg, JG | 1 |
| Laegreid, L | 1 |
| Kyllerman, M | 1 |
| Hedner, T | 1 |
| Hagberg, B | 1 |
| Viggedahl, G | 1 |
| Lande, MB | 1 |
| Kim, MS | 1 |
| Bartlett, C | 1 |
| Guay-Woodford, LM | 1 |
| Childs, JA | 1 |
| Blair, JL | 1 |
| Coppola, G | 1 |
| Pascotto, A | 1 |
| Williams, PG | 1 |
| Hersh, JH | 2 |
| Greco, R | 1 |
| Domizio, S | 1 |
| Sabatino, G | 1 |
| Morgese, G | 1 |
| Jung, M | 1 |
| Gabriel, KH | 1 |
| Stolle, D | 1 |
| Datta, AN | 1 |
| Wirrell, EC | 1 |
| Gidal, BE | 1 |
| Anderson, GD | 1 |
| Rutecki, PR | 1 |
| Shaw, R | 1 |
| Lanning, A | 1 |
| Williams, G | 1 |
| King, J | 1 |
| Cunningham, M | 1 |
| Stephan, M | 1 |
| Kerr, B | 1 |
| Miyajima, T | 1 |
| Ito, M | 1 |
| Fujii, T | 1 |
| Okuno, T | 1 |
| Kulkarni, ML | 1 |
| Bratton, SL | 1 |
| Garden, AL | 1 |
| Bohan, TP | 1 |
| French, JW | 1 |
| Clarke, WR | 1 |
| Boulloche, J | 1 |
| Dautreme, P | 1 |
| Le Luyer, B | 1 |
| Mallet, E | 1 |
| Tron, P | 1 |
| Gobbi, G | 1 |
| Bureau, M | 1 |
| Roger, J | 1 |
| Giovanardi-Rossi, P | 1 |
8 reviews available for valproic acid and Developmental Disabilities
| Article | Year |
|---|---|
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety | 2020 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu | 2014 |
[Dynamin-1-related infantile spasms: a case report and review of literature].
Topics: Child; Child, Preschool; Developmental Disabilities; Dynamin I; Electroencephalography; Epilepsy; Fe | 2016 |
Management of epilepsy in women.
Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilitie | 2005 |
Major malformations with valproic acid.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Developmental Disabilities; Dose-Res | 2006 |
Role of valproate across the ages. Treatment of epilepsy in adults.
Topics: Adult; Age Factors; Anticonvulsants; Child; Developmental Disabilities; Epilepsy; Female; Fertility; | 2006 |
Teratogenesis of sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; Infant, Newborn; Intellectual | 2007 |
5 trials available for valproic acid and Developmental Disabilities
| Article | Year |
|---|---|
Much improved outcome with gabapentin-divalproex combination in adults with bipolar disorders and developmental disabilities.
Topics: Adolescent; Adult; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Developm | 2006 |
Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Drug Resist | 1997 |
[ESES-syndrome in child- and adolescent psychiatry].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Developmen | 2000 |
Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Chromatography, Gas; Chromatography, High Pre | 2000 |
[Seizure and developmental prognosis of West syndrome--combination therapy with high-dose vitamin B6, valproate and low-dose ACTH].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Developmental Disabilities; Drug Administratio | 2001 |
52 other studies available for valproic acid and Developmental Disabilities
| Article | Year |
|---|---|
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2020 |
SLC6A1 G443D associated with developmental delay and epilepsy.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; GABA Plasma Membrane Transport Prote | 2020 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Developmental Disabilities; Diet, Ketogeni | 2021 |
Women still not being told about pregnancy risks of valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; | 2017 |
Weighing the risks of valproate in women who could become pregnant.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Contraindications, Drug; Developmental Disabilities; E | 2018 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
Global developmental delay with sodium valproate-induced gingival hyperplasia.
Topics: Child; Child, Preschool; Combined Modality Therapy; Developmental Disabilities; Female; Follow-Up St | 2014 |
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr | 2014 |
Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2014 |
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Avoidance Learning; Convulsants; Dendrites; | 2015 |
Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development.
Topics: Analysis of Variance; Animals; Anticonvulsants; Body Weight; Developmental Disabilities; Dose-Respon | 2016 |
Women are unaware of pregnancy risks linked with sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Health Knowledge, Attitudes, Practice | 2016 |
Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia.
Topics: Administration, Oral; Animals; Ataxia; Calbindins; Cell Size; Cerebellum; Developmental Disabilities | 2017 |
[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Cognitive function after fetal exposure to antiepileptic drugs.
Topics: Anticonvulsants; Child, Preschool; Confounding Factors, Epidemiologic; Developmental Disabilities; E | 2009 |
Treatment and long term outcome in West syndrome: the clinical reality. A multicentre follow up study.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Developmental Disabilities; F | 2010 |
Growth hormone levels in children and adolescents with epilepsy.
Topics: Adolescent; Anthropometry; Body Weight; Carbamazepine; Chi-Square Distribution; Child; Developmental | 2010 |
Early cognitive development in children born to women with epilepsy: a prospective report.
Topics: Age Factors; Anticonvulsants; Child; Child of Impaired Parents; Cognition; Cognition Disorders; Deve | 2010 |
Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD).
Topics: Adolescent; Age of Onset; Aging; Anticonvulsants; Asperger Syndrome; Autistic Disorder; Brain Mappin | 2010 |
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities; | 2011 |
The effects of valproic acid and levetiracetam on chicken embryos.
Topics: Animals; Anticonvulsants; Chick Embryo; Developmental Disabilities; Dose-Response Relationship, Drug | 2011 |
Comparative efficacy of combination drug therapy in refractory epilepsy.
Topics: Anticonvulsants; Developmental Disabilities; Drug Therapy, Combination; Epilepsy; Female; Humans; La | 2012 |
Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Audiometry, Pure-Tone; Central Nervo | 2013 |
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Dis | 2011 |
The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child Development Disorders, Per | 2013 |
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2002 |
Neurobehavioral teratogenicity in antiepileptic drugs: the new Pandora's box.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Developmental Disabilities; Dose-Respons | 2004 |
The longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition Disorde | 2004 |
Valproate embryopathy: clinical and cognitive profile in 5 siblings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child Behavior; Child, | 2005 |
Children exposed to valproate in utero--population based evaluation of risks and confounding factors for long-term neurocognitive development.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cognition Disorders; Confounding Factors, Epidemiologic; | 2005 |
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child | 2006 |
Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Comorbid | 2006 |
Immunogold study of effects of prenatal exposure to lipopolysaccharide and/or valproic acid on the rat blood-brain barrier vessels.
Topics: Albumins; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane; Cerebral Arteries; Child; Dev | 2005 |
Nonconvulsive status epilepticus and neurodevelopmental delay.
Topics: Anticonvulsants; Developmental Disabilities; Electroencephalography; Humans; Infant; Male; Status Ep | 2006 |
Brain pseudoatrophy and mental regression on valproate and a mitochondrial DNA mutation.
Topics: Adult; Aged; Anticonvulsants; Atrophy; Brain; Child; Cognition Disorders; Developmental Disabilities | 2006 |
The challenges of psychopharmacological management of children with severe developmental disabilities.
Topics: Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Caregivers; Child; Developmental Disabilit | 2006 |
Myoclonic seizures in a patient with Charcot-Marie-tooth disease.
Topics: Anticonvulsants; Carbamazepine; Charcot-Marie-Tooth Disease; Child; Developmental Disabilities; Drug | 2007 |
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; De | 2008 |
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family | 1994 |
Benzodiazepine amplification of valproate teratogenic effects in children of mothers with absence epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Benzodiazepines; Brain; Child; Child, Preschool; Developmental D | 1993 |
Reversible Fanconi syndrome associated with valproate therapy.
Topics: Child; Child, Preschool; Developmental Disabilities; Fanconi Syndrome; Female; Humans; Male; Valproi | 1993 |
Valproic acid treatment of epilepsy in autistic twins.
Topics: Anticonvulsants; Autistic Disorder; Child, Preschool; Developmental Disabilities; Diseases in Twins; | 1997 |
A male with fetal valproate syndrome and autism.
Topics: Anticonvulsants; Audiology; Autistic Disorder; Child, Preschool; Developmental Disabilities; Female; | 1997 |
Epilepsy with myoclonic absences with early onset: a follow-up study.
Topics: Anticonvulsants; Child, Preschool; Developmental Disabilities; Drug Therapy, Combination; Epilepsies | 1999 |
Prognosis of seizures occurring in the first year.
Topics: Anticonvulsants; Brain; Child, Preschool; Developmental Disabilities; Diagnosis, Differential; Elect | 2000 |
Fetal valproate syndrome and autism: additional evidence of an association.
Topics: Autistic Disorder; Child; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Follow-Up | 2001 |
Sodium valproate controls choreoathetoid movements of kernicterus.
Topics: Blood Transfusion; Child, Preschool; Chorea; Developmental Disabilities; Female; Humans; Kernicterus | 1992 |
A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction.
Topics: Carnitine; Child; Developmental Disabilities; Heart Diseases; Humans; Male; Metabolic Diseases; Myoc | 1992 |
[A prognostic study of cryptogenic infantile spasms].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Cosyntropin; Developmental Disabilities; Electroencep | 1991 |
[Case of epilepsy in an infant with fatal outcome during the 1st year of unknown etiology].
Topics: Developmental Disabilities; Drug Resistance; Electroencephalography; Epilepsy; Humans; Infant; Infan | 1985 |