valproic acid has been researched along with Dermatitis Medicamentosa in 36 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 8.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 7.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 4.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 3.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| " The adverse effect (AE) profile of this combination needs clarification." | 2.69 | Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. ( Faught, E; French, J; Harden, C; Jacobson, M; Montouris, G; Morris, G; Rosenfeld, W, 1999) |
| " Recommendations are made for a higher initial dosage regime for sodium valproate in partial seizures." | 2.67 | A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group. ( Cartlidge, NE; Davidson, DL; Easter, DJ; Richens, A, 1994) |
| "Valproate (VPA)-induced encephalopathy is a rare but serious complication, presenting with impaired consciousness, with or without hyperammonemia, normal liver enzymes, and normal serum level of VPA." | 1.40 | Valproate-related erythrodermia with reversible encephalopathy: a rare but serious adverse reaction, case report. ( Balkovec, V; Rener-Primec, Z, 2014) |
| "DRESS syndrome is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, lymph node enlargement, and liver or renal dysfunctions." | 1.38 | DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. ( Albayrak, A; Albayrak, F; Cerrah, S; Dursun, H; Uyanik, A; Yildirim, R, 2012) |
| "Antiepileptic drugs (AEDs) have been widely used in patients with epilepsy but the adverse effects in adult Chinese patients have not been investigated." | 1.36 | Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients. ( Wang, X; Xi, Z; Yan, Y; Zeng, K, 2010) |
| "This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs." | 1.32 | [Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004) |
| "Carbamazepine was stopped and the lesions disappeared without relapse over a 4-year follow-up." | 1.31 | Sodium valproate-induced cutaneous pseudolymphoma followed by recurrence with carbamazepine. ( Beylot, C; Beylot-Barry, M; Cogrel, O; Doutre, MS; Dubus, P; Merlio, JP; Vergier, B, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 14 (38.89) | 29.6817 |
| 2010's | 10 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caillot, F | 1 |
| Andrieu, E | 1 |
| Houivet, E | 1 |
| Duvert-Lehembre, S | 1 |
| Calbo, S | 1 |
| Sabbah, B | 1 |
| Maltete, D | 1 |
| Martinaud, O | 1 |
| Le Goff, F | 1 |
| Malekpour, P | 1 |
| Berard, M | 1 |
| Rogez, S | 1 |
| Joly, P | 1 |
| Picard, D | 1 |
| Musette, P | 1 |
| Brizendine, CE | 1 |
| Naik, PJ | 1 |
| Papadavid, E | 1 |
| Evangelia, P | 1 |
| Panayiotides, I | 1 |
| Ioannis, P | 1 |
| Makris, M | 1 |
| Michael, M | 1 |
| Giatrakou, S | 1 |
| Sophia, G | 1 |
| Dalamaga, M | 1 |
| Maria, D | 1 |
| Stavrianeas, N | 2 |
| Rigopoulos, D | 1 |
| Dimitrios, R | 1 |
| Chou, YC | 1 |
| Chao, FH | 1 |
| Chou, YH | 1 |
| Rener-Primec, Z | 1 |
| Balkovec, V | 1 |
| Kwan, Z | 1 |
| Che Ismail, RB | 1 |
| Wong, SM | 1 |
| Tan, LL | 1 |
| Robinson, S | 1 |
| Lim, KS | 1 |
| Gau, SS | 1 |
| Chao, PF | 1 |
| Lin, YJ | 1 |
| Chang, CJ | 1 |
| Gau, CS | 1 |
| Mardivirin, L | 1 |
| Descamps, V | 1 |
| Lacroix, A | 1 |
| Delebassée, S | 1 |
| Ranger-Rogez, S | 1 |
| Zeng, K | 1 |
| Wang, X | 1 |
| Xi, Z | 1 |
| Yan, Y | 1 |
| Albayrak, F | 1 |
| Cerrah, S | 1 |
| Albayrak, A | 1 |
| Dursun, H | 1 |
| Yildirim, R | 1 |
| Uyanik, A | 1 |
| Lin, YH | 1 |
| Chien, YL | 1 |
| Coulter, DW | 1 |
| Walko, C | 1 |
| Patel, J | 1 |
| Moats-Staats, BM | 1 |
| McFadden, A | 1 |
| Smith, SV | 1 |
| Khan, WA | 1 |
| Bridges, AS | 1 |
| Deal, AM | 1 |
| Oesterheld, J | 1 |
| Davis, IJ | 1 |
| Blatt, J | 1 |
| Arévalo-Lorido, JC | 1 |
| Carretero-Gómez, J | 1 |
| Bureo-Dacal, JC | 1 |
| Montero-Leal, C | 1 |
| Bureo-Dacal, P | 1 |
| Roepke, S | 1 |
| Treudler, R | 1 |
| Anghelescu, I | 1 |
| Orfanos, CE | 1 |
| Tebbe, B | 1 |
| Papp, Z | 1 |
| Török, L | 1 |
| Hirsch, LJ | 1 |
| Weintraub, D | 1 |
| Du, Y | 1 |
| Buchsbaum, R | 1 |
| Spencer, HT | 1 |
| Hager, M | 1 |
| Straka, T | 1 |
| Bazil, CW | 1 |
| Adams, DJ | 1 |
| Resor, SR | 1 |
| Morrell, MJ | 1 |
| Bhatti, MA | 1 |
| Zander, J | 1 |
| Reeve, E | 1 |
| Yun, SJ | 1 |
| Lee, JB | 1 |
| Kim, EJ | 1 |
| Quan, G | 1 |
| Kim, SJ | 1 |
| Won, YH | 1 |
| Lee, SC | 1 |
| Gélisse, P | 1 |
| Crespel, A | 1 |
| Zaccara, G | 1 |
| Franciotta, D | 1 |
| Perucca, E | 1 |
| Periole, B | 2 |
| el Sayed, F | 1 |
| Moreau-Cabarrot, A | 1 |
| Bazex, J | 1 |
| Richens, A | 1 |
| Davidson, DL | 1 |
| Cartlidge, NE | 1 |
| Easter, DJ | 1 |
| Brenner, S | 1 |
| Wolf, R | 1 |
| Landau, M | 1 |
| Politi, Y | 1 |
| Li, LM | 1 |
| Russo, M | 1 |
| O'Donoghue, MF | 1 |
| Duncan, JS | 1 |
| Sander, JW | 1 |
| Chan, HL | 1 |
| Tan, KC | 1 |
| Kusumakar, V | 1 |
| Yatham, LN | 1 |
| Sachs, B | 1 |
| Rönnau, AC | 1 |
| von Schmiedeberg, S | 1 |
| Ruzicka, T | 1 |
| Gleichmann, E | 1 |
| Schuppe, HC | 1 |
| Scheen, AJ | 1 |
| Lovell, RW | 1 |
| Faught, E | 1 |
| Morris, G | 1 |
| Jacobson, M | 1 |
| French, J | 1 |
| Harden, C | 1 |
| Montouris, G | 1 |
| Rosenfeld, W | 1 |
| Matsuo, F | 1 |
| Picart, N | 1 |
| Mazereeuw, J | 1 |
| Bonafé, JL | 1 |
| Scott, S | 1 |
| Cogrel, O | 1 |
| Beylot-Barry, M | 1 |
| Vergier, B | 1 |
| Dubus, P | 1 |
| Doutre, MS | 1 |
| Merlio, JP | 1 |
| Beylot, C | 1 |
| Anderson, GD | 1 |
| Ohtani, K | 1 |
| Tagawa, T | 1 |
| Niki, Y | 1 |
| Okamoto, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for valproic acid and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy, | 2004 |
Idiosyncratic adverse reactions to antiepileptic drugs.
Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem | 2007 |
Lamotrigine.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Diplopia; Dizziness; D | 1999 |
Children versus adults: pharmacokinetic and adverse-effect differences.
Topics: Adolescent; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 2002 |
3 trials available for valproic acid and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine | 2013 |
A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group.
Topics: Administration, Oral; Adult; Ambulatory Care Facilities; Carbamazepine; Clinical Protocols; Drug Eru | 1994 |
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
Topics: Adolescent; Adult; Child; Dizziness; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combinatio | 1999 |
29 other studies available for valproic acid and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Anti-epileptic drugs induce cutaneous lymphocyte-associated antigen downregulation leading to potential human herpes virus-7 reactivation in clinically asymptomatic patients.
Topics: Adult; Aged; Anticonvulsants; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cells, Cultured; Dow | 2018 |
Drug rash with eosinophilia and systemic symptoms syndrome associated with use of phenytoin, divalproex sodium, and phenobarbital.
Topics: Adult; Drug Eruptions; Drug Substitution; Eosinophilia; Female; Humans; Phenobarbital; Phenytoin; Va | 2013 |
Pityriasis rosea-like eruption associated with lamotrigine.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Lamotrigine; Myocloni | 2013 |
Rapid development of severe skin rash after adding valproic acid in a case of bipolar depression treated with low-dose lamotrigine.
Topics: Antimanic Agents; Bipolar Disorder; Drug Eruptions; Drug Interactions; Drug Therapy, Combination; Fe | 2014 |
Valproate-related erythrodermia with reversible encephalopathy: a rare but serious adverse reaction, case report.
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Humans; | 2014 |
Sodium valproate-aggravated psoriasiform eruption.
Topics: Adolescent; Anticonvulsants; Disease Progression; Drug Eruptions; Humans; Male; Psoriasis; Valproic | 2014 |
The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study.
Topics: Acetaminophen; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Contr | 2008 |
Early effects of drugs responsible for DRESS on HHV-6 replication in vitro.
Topics: Carbamazepine; Cell Line, Transformed; Drug Eruptions; Eosinophilia; Herpesvirus 6, Human; Humans; V | 2009 |
Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Drug Eruptions; Epilepsy; Female; Hu | 2010 |
DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result.
Topics: Anti-Bacterial Agents; Antibodies, Antineutrophil Cytoplasmic; Anticonvulsants; Brucellosis; Drug Er | 2012 |
Valproic Acid-related anticonvulsant hypersensitivity syndrome and subsequent olanzapine-related neutropenia and thrombocytopenia: a case report.
Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; C | 2012 |
Antiepileptic drug hypersensitivity syndrome in a patient treated with valproate.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Humans; Hyperplasia; Lymph | 2003 |
Valproic Acid and hypersensitivity syndrome.
Topics: Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combination; | 2004 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug | 2004 |
Clozapine-induced pericarditis, pericardial tamponade, polyserositis, and rash.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Cardiac Tamponade; Clozapine; Drug Eruptions; Drug The | 2005 |
Drug rash with eosinophilia and systemic symptoms induced by valproate and carbamazepine: formation of circulating auto-antibody against 190-kDa antigen.
Topics: Adult; Anticonvulsants; Autoantibodies; Carbamazepine; Cross Reactions; Diagnosis, Differential; Dru | 2006 |
[Reintroduction of treatment with lamotrigine in combination with valproate after an initial allergic skin reaction].
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Therapy, Combination; Epilepsy, Absence; Female; Humans | 2006 |
[A case for diagnosis: syndrome of hypersensitivity to carbamazepine].
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Skin T | 1995 |
Psoriasiform eruption induced by anticonvulsants.
Topics: Adult; Carbamazepine; Drug Eruptions; Epilepsy; Female; Humans; Male; Middle Aged; Psoriasis; Valpro | 1994 |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk.
Topics: Adolescent; Adult; Anticonvulsants; Drug Eruptions; Female; Humans; Lamotrigine; Male; Middle Aged; | 1996 |
Fixed drug eruption to three anticonvulsant drugs: an unusual case of polysensitivity.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Humans; Male; Phenytoin; Valproic Acid | 1997 |
Lamotrigine treatment of rapid cycling bipolar disorder.
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Drug Administration Schedule; Drug Eruptions; Drug T | 1997 |
Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro.
Topics: Adult; Anticonvulsants; Concanavalin A; Drug Eruptions; Drug Therapy, Combination; Half-Life; Humans | 1997 |
[Lamotrigine (Lamictal)].
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Drug Combinations; Drug Eruptions; Epilepsies, Part | 1997 |
Mood stabilizer combinations for bipolar disorder.
Topics: Acetates; Adolescent; Age Factors; Amines; Antimanic Agents; Bipolar Disorder; Child; Cyclohexanecar | 1999 |
[Drug hypersensitivity syndrome to valproic acid].
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Patch Tests; Valproic | 2000 |
Fracture blisters and sodium valproate: two case reports.
Topics: Adult; Ankle Injuries; Anticonvulsants; Blister; Drug Eruptions; Fractures, Bone; Humans; Male; Valp | 2000 |
Sodium valproate-induced cutaneous pseudolymphoma followed by recurrence with carbamazepine.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Humans; Male; Pseudolymphoma; Recurrence; Val | 2001 |
[Disseminated intravascular coagulation in an epileptic infant under the treatment with sodium valproate].
Topics: Disseminated Intravascular Coagulation; Drug Eruptions; Epilepsy; Female; Humans; Infant; Valproic A | 1992 |