valproic acid has been researched along with Depressive Disorder, Treatment-Resistant in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnoses were major depressive disorder (n = 15), bipolar I disorder (n = 6), and bipolar II disorder (n = 16)." | 2.82 | Prediction of an Optimal Dose of Lamotrigine for Augmentation Therapy in Treatment-Resistant Depressive Disorder From Plasma Lamotrigine Concentration at Week 2. ( Kagawa, S; Kondo, T; Mihara, K; Nagai, G; Nakamura, A; Nemoto, K; Suzuki, T, 2016) |
| " A cautious dosing of AMI with VPA comedication is advisable, and therapeutic drug monitoring should be performed because this combination may lead to a remarkable increase of AMI and NOR serum levels." | 1.39 | Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions. ( Burger, R; Deckert, J; Hohage, A; Pfuhlmann, B; Unterecker, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Unterecker, S | 1 |
| Burger, R | 1 |
| Hohage, A | 1 |
| Deckert, J | 1 |
| Pfuhlmann, B | 1 |
| Villaseñor, A | 1 |
| Ramamoorthy, A | 1 |
| Silva dos Santos, M | 1 |
| Lorenzo, MP | 1 |
| Laje, G | 1 |
| Zarate, C | 1 |
| Barbas, C | 1 |
| Wainer, IW | 1 |
| Xu, AJ | 1 |
| Niciu, MJ | 1 |
| Lundin, NB | 1 |
| Luckenbaugh, DA | 1 |
| Ionescu, DF | 1 |
| Richards, EM | 1 |
| Vande Voort, JL | 1 |
| Ballard, ED | 1 |
| Brutsche, NE | 1 |
| Machado-Vieira, R | 1 |
| Zarate, CA | 1 |
| Ghabrash, MF | 1 |
| Comai, S | 1 |
| Tabaka, J | 1 |
| Saint-Laurent, M | 1 |
| Booij, L | 1 |
| Gobbi, G | 1 |
| Nakamura, A | 1 |
| Mihara, K | 1 |
| Nagai, G | 1 |
| Kagawa, S | 1 |
| Suzuki, T | 1 |
| Nemoto, K | 1 |
| Kondo, T | 1 |
| Kasper, S | 1 |
| McSkimming, AJ | 1 |
| Dham, P | 1 |
| Alexander, J | 1 |
| Dinesh, A | 1 |
3 trials available for valproic acid and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks.
Topics: Adult; Antidepressive Agents; Biomarkers, Pharmacological; Bipolar Disorder; Cross-Over Studies; Dep | 2014 |
Lithium and Valproate Levels Do Not Correlate with Ketamine's Antidepressant Efficacy in Treatment-Resistant Bipolar Depression.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Cross-Over Studies; Depressive Disorder, Treatment-R | 2015 |
Prediction of an Optimal Dose of Lamotrigine for Augmentation Therapy in Treatment-Resistant Depressive Disorder From Plasma Lamotrigine Concentration at Week 2.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Chromatograp | 2016 |
4 other studies available for valproic acid and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chi-Square Distribution; Delirium; Depressive Dis | 2013 |
Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression.
Topics: Adult; Antidepressive Agents; Canada; Depressive Disorder, Treatment-Resistant; Female; Humans; Male | 2016 |
Editorial.
Topics: Bipolar Disorder; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Humans; Psych | 2016 |
Peripheral oedema in quetiapine therapy.
Topics: Antimanic Agents; Antipsychotic Agents; Depressive Disorder, Treatment-Resistant; Dibenzothiazepines | 2012 |