valproic acid has been researched along with Demyelinating Diseases in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 8.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 4.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| "In order to produce this demyelination model, LPC (1%, 2 μL) was injected into the rat optic chiasm." | 1.51 | Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm. ( Ghasemi-Kasman, M; Hashemian, M; Parsian, H; Sadeghi, F, 2019) |
| "Multiple sclerosis is a demyelinating disease with severe neurological symptoms due to blockage of signal conduction in affected axons." | 1.43 | Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. ( Dehghan, S; Fathollahi, Y; Hesaraki, M; Javan, M; Mirnajafi-Zadeh, J; Soleimani, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, X | 1 |
| Yao, Y | 1 |
| Hu, Y | 1 |
| Yang, J | 1 |
| Zhang, C | 2 |
| He, Y | 1 |
| Zhang, A | 1 |
| Liu, X | 1 |
| Gan, G | 1 |
| Hashemian, M | 1 |
| Ghasemi-Kasman, M | 1 |
| Parsian, H | 1 |
| Sadeghi, F | 1 |
| Ding, L | 1 |
| Zhou, J | 1 |
| Ye, L | 1 |
| Sun, Y | 1 |
| Jiang, Z | 1 |
| Gan, D | 1 |
| Xu, L | 1 |
| Luo, Q | 1 |
| Wang, G | 1 |
| Dehghan, S | 1 |
| Hesaraki, M | 1 |
| Soleimani, M | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Fathollahi, Y | 1 |
| Javan, M | 1 |
| Yang, Y | 1 |
| Cheng, Z | 1 |
| Tang, H | 1 |
| Jiao, H | 1 |
| Sun, X | 1 |
| Cui, Q | 1 |
| Luo, F | 1 |
| Pan, H | 1 |
| Ma, C | 1 |
| Li, B | 1 |
| Shen, S | 1 |
| Sandoval, J | 1 |
| Swiss, VA | 1 |
| Li, J | 1 |
| Dupree, J | 1 |
| Franklin, RJ | 1 |
| Casaccia-Bonnefil, P | 1 |
| Blindauer, KA | 1 |
| Harrington, G | 1 |
| Morris, GL | 1 |
| Ho, KC | 1 |
7 other studies available for valproic acid and Demyelinating Diseases
| Article | Year |
|---|---|
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis.
Topics: Animals; Anxiety; Cholesterol; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inb | 2021 |
Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Histone Deacetyla | 2019 |
PPAR-γ Is Critical for HDAC3-Mediated Control of Oligodendrocyte Progenitor Cell Proliferation and Differentiation after Focal Demyelination.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cognition; Demyelinating Disease | 2020 |
Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.
Topics: Animals; Cell Differentiation; Cell Transdifferentiation; Demyelinating Diseases; Male; Mice, Inbred | 2016 |
Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling.
Topics: Animals; Animals, Newborn; Anxiety; Cognition Disorders; Demyelinating Diseases; Enzyme Inhibitors; | 2017 |
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Topics: Aging; Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Diff | 2008 |
Fulminant progression of demyelinating disease after valproate-induced encephalopathy.
Topics: Adult; Anticonvulsants; Brain Stem; Cerebral Cortex; Contraindications; Demyelinating Diseases; Ence | 1998 |