valproic acid has been researched along with Delirium in 25 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| ""Valproic acid", "valproate", "sodium valproate", "delirium", "acute mania with delirium" in PubMed and Ovid." | 9.22 | Valproic Acid in the Management of Delirium. ( Cuartas, CF; Davis, M, 2022) |
| "Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity." | 7.96 | Delirium Secondary to Lamotrigine Toxicity. ( Catalano, G; Catalano, MC; Fusick, AJ; Gunther, SR; Hernandez, MJ; Sanchez, DL; Sullivan, GA, 2020) |
| "Valproic acid has been proposed as an alternative agent for treatment of agitation and delirium in the intensive care unit (ICU)." | 7.96 | Valproic Acid for the Management of Agitation and Delirium in the Intensive Care Setting: A Retrospective Analysis. ( Crowley, KE; Geiger, KL; Hacobian, G; Urben, L, 2020) |
| "Valproic acid (VPA) is a potential pharmacologic agent that can be utilized to treat ICU delirium, though there is a paucity of evidence for its use, especially in patients with a history of substance abuse." | 6.72 | Prolonged Refractory ICU Delirium Successfully Treated With Valproic Acid: Case Report and Literature Review. ( Louzon, PR; Masood, A; Recksieck, S; Subedi, B, 2021) |
| ""Valproic acid", "valproate", "sodium valproate", "delirium", "acute mania with delirium" in PubMed and Ovid." | 5.22 | Valproic Acid in the Management of Delirium. ( Cuartas, CF; Davis, M, 2022) |
| "Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity." | 3.96 | Delirium Secondary to Lamotrigine Toxicity. ( Catalano, G; Catalano, MC; Fusick, AJ; Gunther, SR; Hernandez, MJ; Sanchez, DL; Sullivan, GA, 2020) |
| "Valproic acid has been proposed as an alternative agent for treatment of agitation and delirium in the intensive care unit (ICU)." | 3.96 | Valproic Acid for the Management of Agitation and Delirium in the Intensive Care Setting: A Retrospective Analysis. ( Crowley, KE; Geiger, KL; Hacobian, G; Urben, L, 2020) |
| "The use of lithium carbonate for the treatment of mood disorders in old age has decreased at a dramatic rate in favor of valproate." | 3.73 | Incidence of delirium in older adults newly prescribed lithium or valproate: a population-based cohort study. ( Anderson, G; Bronskill, S; Gill, S; Mamdani, M; Rochon, P; Shulman, KI; Sykora, K; Wodchis, WP, 2005) |
| "Valproic acid (VPA) is a potential pharmacologic agent that can be utilized to treat ICU delirium, though there is a paucity of evidence for its use, especially in patients with a history of substance abuse." | 2.72 | Prolonged Refractory ICU Delirium Successfully Treated With Valproic Acid: Case Report and Literature Review. ( Louzon, PR; Masood, A; Recksieck, S; Subedi, B, 2021) |
| "Patients with acquired brain injuries who had taken valproate for seizures or quetiapine for delirium for >7 days (N=101)." | 1.43 | Incidence of Neutropenia With Valproate and Quetiapine Combination Treatment in Subjects With Acquired Brain Injuries. ( Kim, JY; Park, HJ, 2016) |
| " A cautious dosing of AMI with VPA comedication is advisable, and therapeutic drug monitoring should be performed because this combination may lead to a remarkable increase of AMI and NOR serum levels." | 1.39 | Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions. ( Burger, R; Deckert, J; Hohage, A; Pfuhlmann, B; Unterecker, S, 2013) |
| "It shows the importance of recognising catatonia as a symptom of delirious mania." | 1.36 | What works for delirious catatonic mania? ( Grunze, H; Vasudev, K, 2010) |
| "The delirium was reversible when all drugs were stopped; however, dyskinesia was found to be persistent after a period of 6 months." | 1.30 | Delirium and persistent dyskinesia induced by a lithium-neuroleptic interaction. ( Berger, M; Brandt, C; Normann, C; Walden, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woolley, B | 1 |
| Mills, J | 1 |
| Sanchez, DL | 1 |
| Fusick, AJ | 1 |
| Gunther, SR | 1 |
| Hernandez, MJ | 1 |
| Sullivan, GA | 1 |
| Catalano, MC | 1 |
| Catalano, G | 1 |
| Crowley, KE | 1 |
| Urben, L | 1 |
| Hacobian, G | 1 |
| Geiger, KL | 1 |
| Subedi, B | 1 |
| Louzon, PR | 1 |
| Masood, A | 1 |
| Recksieck, S | 1 |
| Cuartas, CF | 1 |
| Davis, M | 1 |
| Unterecker, S | 1 |
| Burger, R | 1 |
| Hohage, A | 1 |
| Deckert, J | 1 |
| Pfuhlmann, B | 1 |
| Sher, Y | 1 |
| Miller, AC | 1 |
| Lolak, S | 1 |
| Ament, A | 1 |
| Maldonado, JR | 1 |
| Park, HJ | 1 |
| Kim, JY | 1 |
| Gagnon, DJ | 1 |
| Fontaine, GV | 1 |
| Smith, KE | 1 |
| Riker, RR | 1 |
| Miller, RR | 1 |
| Lerwick, PA | 1 |
| Lucas, FL | 1 |
| Dziodzio, JT | 1 |
| Sihler, KC | 1 |
| Fraser, GL | 1 |
| Gareri, P | 1 |
| Lacava, R | 1 |
| Cotroneo, A | 1 |
| Bambara, V | 1 |
| Marigliano, N | 1 |
| Castagna, A | 1 |
| Costantino, DS | 1 |
| Ruotolo, G | 1 |
| de Sarro, G | 1 |
| Ozen, S | 1 |
| Bülbül, I | 1 |
| Soyuçok, E | 1 |
| Hsu, WY | 1 |
| Kuo, SY | 1 |
| Huang, SS | 1 |
| Chang, TG | 1 |
| Chiu, NY | 1 |
| Pittermann, P | 1 |
| Gabriel, S | 1 |
| Röschke, J | 1 |
| Vasudev, K | 1 |
| Grunze, H | 1 |
| Mueller, TH | 1 |
| Beeber, AR | 1 |
| Shulman, KI | 1 |
| Sykora, K | 1 |
| Gill, S | 1 |
| Mamdani, M | 1 |
| Bronskill, S | 1 |
| Wodchis, WP | 1 |
| Anderson, G | 1 |
| Rochon, P | 1 |
| Bourgeois, JA | 1 |
| Koike, AK | 1 |
| Simmons, JE | 1 |
| Telles, S | 1 |
| Eggleston, C | 1 |
| Chae, BJ | 1 |
| Kang, BJ | 1 |
| Habermeyer, B | 1 |
| Hess, M | 1 |
| Kozomara-Hocke, P | 1 |
| Mager, R | 1 |
| Kawohl, W | 1 |
| Rocha, FF | 1 |
| Tollefson, GD | 1 |
| Zayas, EM | 1 |
| Grossberg, GT | 1 |
| Zarate, CA | 1 |
| Baldessarini, RJ | 1 |
| Siegel, AJ | 1 |
| Nakamura, A | 1 |
| McDonald, J | 1 |
| Muir-Hutchinson, LA | 1 |
| Cherkerzian, T | 1 |
| Tohen, M | 1 |
| Normann, C | 1 |
| Brandt, C | 1 |
| Berger, M | 1 |
| Walden, J | 1 |
2 reviews available for valproic acid and Delirium
| Article | Year |
|---|---|
Prolonged Refractory ICU Delirium Successfully Treated With Valproic Acid: Case Report and Literature Review.
Topics: Adult; Antipsychotic Agents; Delirium; Female; Humans; Intensive Care Units; Psychomotor Agitation; | 2021 |
Valproic Acid in the Management of Delirium.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Delirium; Humans; Male; Middle Aged; Psychomotor Agita | 2022 |
23 other studies available for valproic acid and Delirium
| Article | Year |
|---|---|
Versatile Valproic Acid.
Topics: Brain Injuries, Traumatic; Delirium; Humans; Valproic Acid | 2022 |
Delirium Secondary to Lamotrigine Toxicity.
Topics: Adolescent; Adult; Aged; Delirium; Drug Interactions; Female; Humans; Lamotrigine; Male; Middle Aged | 2020 |
Valproic Acid for the Management of Agitation and Delirium in the Intensive Care Setting: A Retrospective Analysis.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; Benzodiazepines; Critical Care; C | 2020 |
Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chi-Square Distribution; Delirium; Depressive Dis | 2013 |
Adjunctive Valproic Acid in Management-Refractory Hyperactive Delirium: A Case Series and Rationale.
Topics: Adult; Aged; Aged, 80 and over; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Delirium; D | 2015 |
Incidence of Neutropenia With Valproate and Quetiapine Combination Treatment in Subjects With Acquired Brain Injuries.
Topics: Aged; Anticonvulsants; Antipsychotic Agents; Brain Injuries; Cohort Studies; Delirium; Drug Therapy, | 2016 |
Valproate for agitation in critically ill patients: A retrospective study.
Topics: Adult; Aged; Analgesics, Opioid; Critical Illness; Delirium; Dexmedetomidine; Female; Fentanyl; GABA | 2017 |
Valproate-induced delirium in a demented patient.
Topics: Aged; Delirium; Dementia; Electroencephalography; Female; Follow-Up Studies; GABA Agents; Humans; Va | 2009 |
[Valproate induced hypoactive delirium in a bipolar disorder patient with psychotic features].
Topics: Antimanic Agents; Bipolar Disorder; Blood Chemical Analysis; Delirium; Female; Humans; Middle Aged; | 2010 |
Valproate and high dosage of zotepine induced acute delirium: a case report.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Delirium; Dibenzothiepins; Dose-Response Relationship | 2012 |
[Delirium caused by nonconvulsive status epilepticus].
Topics: Affect; Aged; Anticonvulsants; Antipsychotic Agents; Brain Edema; Confusion; Delirium; Dibenzothiaze | 2012 |
What works for delirious catatonic mania?
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Catatonia; Combined Modality Therapy; Deli | 2010 |
Delirium from valproic acid with lamotrigine.
Topics: Anticonvulsants; Delirium; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; | 2004 |
Incidence of delirium in older adults newly prescribed lithium or valproate: a population-based cohort study.
Topics: Adult; Age Distribution; Age Factors; Aged; Anticonvulsants; Antidepressive Agents; Benztropine; Coh | 2005 |
Adjunctive valproic acid for delirium and/or agitation on a consultation-liaison service: a report of six cases.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Delirium; Fever; Humans; Injections, Intra | 2005 |
A case of delirium and subsequent pancytopenia associated with the oral loading of valproic acid.
Topics: Administration, Oral; Anticonvulsants; Delirium; Dose-Response Relationship, Drug; Drug Administrati | 2005 |
[Lithium intoxications at normal serum levels].
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Delirium; Dose-Response Relationship, Drug | 2008 |
[Secondary delirium due to the use of lamotrigine with abrupt increase valproic acid's dose].
Topics: Adult; Anticonvulsants; Bipolar Disorder; Delirium; Drug Interactions; Drug Therapy, Combination; Hu | 2008 |
Delirium induced by the competitive interaction between phenytoin and dipropylacetate.
Topics: Adult; Binding, Competitive; Delirium; Drug Interactions; Humans; Male; Phenytoin; Seizures; Valproi | 1981 |
Treating the agitated Alzheimer patient.
Topics: Adrenergic beta-Antagonists; Aged; Aggression; Alzheimer Disease; Antipsychotic Agents; Buspirone; C | 1996 |
Drugs for psychiatric disorders.
Topics: Aged; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Benzodi | 1997 |
Risperidone in the elderly: a pharmacoepidemiologic study.
Topics: Age Factors; Aged; Aged, 80 and over; Basal Ganglia Diseases; Cardiovascular Diseases; Comorbidity; | 1997 |
Delirium and persistent dyskinesia induced by a lithium-neuroleptic interaction.
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Delirium; Dyskinesia, Drug-Induced; Female | 1998 |