valproic acid has been researched along with Deficiency Disease, Ornithine Carbamoyltransferase in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this report, we describe the diagnosis, investigation and management of a patient presenting with refractory status epilepticus secondary to a previously unrecognised urea cycle defect, ornithine transcarbamylase deficiency, causing a hyperammonaemic encephalopathy." | 8.02 | Status epilepticus secondary to hyperammonaemia: a late presentation of an undiagnosed urea cycle defect. ( Beddoes, P; Nerone, G; Tai, C, 2021) |
| "In this report, we describe the diagnosis, investigation and management of a patient presenting with refractory status epilepticus secondary to a previously unrecognised urea cycle defect, ornithine transcarbamylase deficiency, causing a hyperammonaemic encephalopathy." | 4.02 | Status epilepticus secondary to hyperammonaemia: a late presentation of an undiagnosed urea cycle defect. ( Beddoes, P; Nerone, G; Tai, C, 2021) |
| "The aims of this report are to 1) present a rare case of fatal cerebral edema associated with late-onset ornithine transcarbamylase (OTC) deficiency in a juvenile male patient receiving valproic acid and 2) review the neuropathologic changes associated with the hyperammonemia." | 3.73 | Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid. ( Fraser, DD; Ramsay, DA; Rupar, CA; Singh, R; Thakur, V, 2006) |
| "Specific treatment for hyperammonemia must be implemented promptly." | 1.48 | Valproate-induced hyperammonemia - uncovering an underlying inherited metabolic disorder: a case report. ( Lachmann, R; Mehta, S; Tayabali, S, 2018) |
| "Acute hyperammonemia is a medical emergency for which immediate steps must be taken to minimize permanent brain damage." | 1.32 | Unusual causes of hyperammonemia in the ED. ( Chen, WJ; Shih, FF; Weng, TI, 2004) |
| "Ornithine transcarbamylase deficiency is an X linked disorder and the most common inherited cause of hyperammonaemia." | 1.30 | Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. ( Kohlschütter, A; Oechsner, M; Steen, C; Stürenburg, HJ, 1998) |
| "Women with heterozygous ornithine transcarbamylase deficiency may have no symptoms or have episodic, symptomatic hyperammonemia, which can be fatal." | 1.28 | Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy. ( Callahan, K; Evans, B; Honeycutt, D; Rutledge, L, 1992) |
| " It is postulated that the idiosyncratic response in OTC-deficient mice may be caused by an interaction between a metabolic aberration of mitochondria and toxic metabolites of valproate." | 1.27 | Hepatotoxicity of sodium valproate in ornithine transcarbamylase-deficient mice. ( Letarte, J; Qureshi, IA; Qureshi, SR; Tuchweber, B; Yousef, I, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kazmierski, D | 1 |
| Sharma, N | 1 |
| O'Leary, K | 1 |
| Ochieng, P | 1 |
| Beddoes, P | 1 |
| Nerone, G | 1 |
| Tai, C | 1 |
| Mehta, S | 1 |
| Tayabali, S | 1 |
| Lachmann, R | 1 |
| Weng, TI | 1 |
| Shih, FF | 1 |
| Chen, WJ | 1 |
| Thakur, V | 1 |
| Rupar, CA | 1 |
| Ramsay, DA | 1 |
| Singh, R | 1 |
| Fraser, DD | 1 |
| Tripp, JH | 1 |
| Hargreaves, T | 1 |
| Anthony, PP | 1 |
| Searle, JF | 1 |
| Miller, P | 1 |
| Leonard, JV | 1 |
| Patrick, AD | 1 |
| Oberholzer, VG | 1 |
| Jaeken, J | 1 |
| Corbeel, L | 1 |
| Leão, M | 1 |
| Oechsner, M | 1 |
| Steen, C | 1 |
| Stürenburg, HJ | 1 |
| Kohlschütter, A | 1 |
| Padilla, Mde L | 1 |
| Miguélez, M | 1 |
| Riverola, A | 1 |
| Bueno, J | 1 |
| Honeycutt, D | 1 |
| Callahan, K | 1 |
| Rutledge, L | 1 |
| Evans, B | 1 |
| Tokatli, A | 1 |
| Coşkun, T | 1 |
| Cataltepe, S | 1 |
| Ozalp, I | 1 |
| Kennedy, CR | 1 |
| Cogswell, JJ | 1 |
| Kay, JD | 1 |
| Hilton-Jones, D | 1 |
| Hyman, N | 1 |
| Qureshi, IA | 1 |
| Letarte, J | 1 |
| Tuchweber, B | 1 |
| Yousef, I | 1 |
| Qureshi, SR | 1 |
15 other studies available for valproic acid and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
Valproate-induced fatal acute hyperammonaemia-related encephalopathy in late-onset ornithine transcarbamylase deficiency.
Topics: Adult; Brain Diseases; Humans; Hyperammonemia; Male; Ornithine Carbamoyltransferase Deficiency Disea | 2021 |
Status epilepticus secondary to hyperammonaemia: a late presentation of an undiagnosed urea cycle defect.
Topics: Adult; Child; Humans; Hyperammonemia; Ornithine Carbamoyltransferase Deficiency Disease; Status Epil | 2021 |
Valproate-induced hyperammonemia - uncovering an underlying inherited metabolic disorder: a case report.
Topics: Anticonvulsants; Critical Illness; Dietary Proteins; Humans; Hyperammonemia; Male; Ornithine Carbamo | 2018 |
Unusual causes of hyperammonemia in the ED.
Topics: Adult; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Emergency Service, Hospital; Female; | 2004 |
Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid.
Topics: Adolescent; Brain Edema; Fatal Outcome; GABA Agents; Humans; Hyperammonemia; Male; Ornithine Carbamo | 2006 |
Sodium valproate and ornithine carbamyl transferase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Humans; Infant; Liver; Male; Mitochondria, Liver; Orn | 1981 |
Sodium valproate and the development of acute hepatic failure.
Topics: Chemical and Drug Induced Liver Injury; Humans; Infant; Male; Ornithine Carbamoyltransferase Deficie | 1984 |
Valproate as a cause of hyperammonemia in heterozygotes with ornithine-transcarbamylase deficiency.
Topics: Ammonia; Child; Epilepsy, Tonic-Clonic; Female; Heterozygote; Humans; Ornithine Carbamoyltransferase | 1995 |
Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Diseases, Metaboli | 1998 |
[Hyperammonaemic coma after valproate therapy as adult onset of ornithine transcarbamylase deficiency].
Topics: Coma; Female; Humans; Hyperammonemia; Middle Aged; Ornithine Carbamoyltransferase Deficiency Disease | 2002 |
Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy.
Topics: Adult; Ammonia; Female; Heterozygote; Humans; Metabolic Diseases; Ornithine Carbamoyltransferase Def | 1992 |
Valproate-induced lethal hyperammonaemic coma in a carrier of ornithine carbamoyltransferase deficiency.
Topics: Ammonia; Child, Preschool; Coma; Epilepsy; Female; Heterozygote; Humans; Ornithine Carbamoyltransfer | 1991 |
Late onset ornithine carbamoyl transferase deficiency in males.
Topics: Child; Humans; Male; Ornithine Carbamoyltransferase Deficiency Disease; Photosensitivity Disorders; | 1989 |
Valproate toxicity and ornithine carbamoyltransferase deficiency.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Female; Humans; Ornithine Carbamoyltransferase Deficien | 1986 |
Hepatotoxicity of sodium valproate in ornithine transcarbamylase-deficient mice.
Topics: Animals; Dose-Response Relationship, Drug; Liver; Male; Mice; Mice, Mutant Strains; Ornithine Carbam | 1985 |