valproic acid has been researched along with Deficiency, Mental in 86 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first multicenter Italian experience with rufinamide as an adjunctive drug in children, adolescents and adults with Lennox-Gastaut syndrome." | 9.14 | Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience. ( Balestri, A; Capovilla, G; Coppola, G; Curatolo, P; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N, 2010) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 7.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 7.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording." | 7.72 | [A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 5.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| "This is the first multicenter Italian experience with rufinamide as an adjunctive drug in children, adolescents and adults with Lennox-Gastaut syndrome." | 5.14 | Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience. ( Balestri, A; Capovilla, G; Coppola, G; Curatolo, P; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N, 2010) |
| "Under the medicine treatment of magnesium valproate with carbamazepine, the patient experienced partial seizures approximately once per month that lasted 30 to 60 seconds each without any complications observed during a follow-up period of 24 months." | 5.01 | A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report. ( Jiang, Z; Li, B; Li, J; Li, Y; Wang, L; Zhang, T, 2019) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 3.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| " Seizures were controlled in a few weeks with intramuscular synthetic ACTH, followed by valproic acid." | 3.81 | LAMA2-related congenital muscular dystrophy complicated by West syndrome. ( Camacho, A; de Aragón, AM; Dekomien, G; Hernández-Laín, A; Núñez, N; Simón, R, 2015) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 3.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Rufinamide (RUF) is an orphan drug for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in persons aged 4 years and older." | 3.77 | Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication. ( Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B, 2011) |
| "To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy." | 3.72 | Normal intelligence in children with prenatal exposure to carbamazepine. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V; Isoaho, M; Kaaja, E; Kantola-Sorsa, E; Kotila, M; Matila, R; Nylund, T, 2004) |
| "Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording." | 3.72 | [A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003) |
| " Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE." | 3.69 | Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996) |
| "A case of rapid cycling bipolar disorder in a person with Down's syndrome, responsive to divalproex sodium, a valproic acid derivative, is presented." | 3.68 | Divalproex-responsive rapid cycling bipolar disorder in a patient with Down's syndrome: implications for the Down's syndrome-mania hypothesis. ( Sovner, R, 1991) |
| "The case of a mentally handicapped female patient is presented who developed typical pellagra with dermatitis, diarrhoea and mental alteration following a long-term antiepileptic treatment with phenytoin, ethosuximide and valproic acid." | 3.68 | [Pellagra in anticonvulsive therapy]. ( Bartels, H; Hebestreit, H; Mingers, AM; Pannenbecker, J, 1990) |
| "Blood levels and seizures were monitored." | 2.68 | Effects of switching from Depakene to generic valproic acid on individuals with mental retardation. ( Kraushaar, KW; Vadney, VJ, 1997) |
| "Developmental retardation (speech, motor or global) was almost always present in children exposed to valproic acid." | 2.61 | Recent advances in trigonocephaly. ( Aillet, S; Mocquard, C; Riffaud, L, 2019) |
| "In patients with EAST syndrome, seizure is the first symptom occurring around 3-4 months of age." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X." | 2.50 | Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014) |
| "Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy." | 2.50 | Treating epilepsy in pregnant women. ( Eadie, MJ, 2014) |
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| "Epilepsy was controlled with valproate at the age of 6 years." | 2.42 | A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders. ( Fiore, LA; Freitas, A; Kim, CA; Valente, KD, 2003) |
| "Over two-thirds of women/girls with intellectual disability (ID) may have treatment-resistant epilepsy that could benefit from VPA treatment." | 1.62 | Valproate prescribing practices for women with intellectual disability across Europe. ( Angus-Leppan, H; Banks, R; Courtenay, K; Murphy, E; Perera, B; Reuber, M; Shankar, R; Watkins, L, 2021) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment." | 1.51 | ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019) |
| "Ataxia was observed in 7/34 cases." | 1.48 | Defining the phenotypic spectrum of SLC6A1 mutations. ( Abi-Warde, MT; Afenjar, A; Bird, LM; Carvill, GL; Chae, JH; Chelly, J; Choi, M; Christensen, J; Courage, C; Czapansky-Beilman, D; de Saint Martin, A; Devinsky, O; Doummar, D; Dubbs, H; Gardella, E; Gleeson, JG; Helbig, I; Helbig, KL; Hopkins, S; Johannesen, KM; Keren, B; Lehesjoki, AE; Lesca, G; Linnankivi, T; Mecarelli, O; Mefford, HC; Merritt, JL; Mignot, C; Millichap, JJ; Myers, CT; Møller, RS; Nava, C; Nespeca, M; Pal, DK; Pendziwiat, M; Pisani, L; Piton, A; Reichert, SC; Rodan, LH; Rubboli, G; Schaefer, E; Schelhaas, HJ; Shaw, JE; Specchio, N; Striano, P; Tan, WH; Tang, S; Trivisano, M; Verhoeven, JS; Weber, YG; Yoo, Y, 2018) |
| "Epilepsy is common in individuals with autism spectrum disorder (ASD) and intellectual disabilities (ID)." | 1.42 | Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities. ( Katz, N; Moses, L; Weizman, A, 2015) |
| "For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0." | 1.40 | Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014) |
| "Focal seizures were more frequent during drowsiness and sleep." | 1.39 | Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype. ( Bianchi, P; Bonetti, S; Boni, A; Buoni, S; Cecconi, I; Cerruti Mainardi, P; Cordelli, DM; Della Giustina, E; Doz, M; Epifanio, R; Faravelli, F; Ferrari, AR; Franzoni, E; Garavelli, L; Gelmini, C; Giordano, L; Grasso, M; Grioni, D; Grosso, S; Guerra, A; Licata, F; Malbora, B; Mammi, I; Mari, F; Mazzanti, L; Mostardini, R; Pantaleoni, C; Pellicciari, A; Poch-Olivé, ML; Rivieri, F; Rosato, S; Savasta, S; Seri, M; Simonte, G; Sorge, G; Tarani, L; Terazzi, E; Wischmeijer, A; Zanotta, N; Zollino, M, 2013) |
| "Propofol was infused, and sedation was maintained at the same level in all patients using a bispectral index (BIS) monitor." | 1.38 | The influence of oral VPA on the required dose of propofol for sedation during dental treatment in patients with mental retardation: a prospective observer-blinded cohort study. ( Egusa, M; Higuchi, H; Ishii, M; Maeda, S; Miyawaki, T; Tomoyasu, Y, 2012) |
| "The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively." | 1.37 | Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| "Epilepsy is one of the most frequent neurological diseases in the pediatric population." | 1.36 | [Characteristics of the children with epilepsy followed in the Marrakech University Hospital]. ( Amine, M; Bourrous, M; Bouskraoui, M; Draiss, G; Elibrahimi, I; Safini, F, 2010) |
| "This article describes a girl with mental retardation, probably due to a perinatal complication, who had typical absence seizures with characteristic electroencephalographic findings of childhood absence epilepsy, including normal background activity." | 1.35 | Childhood absence epilepsy with clinically apparent genetic and acquired burdens: a diagnostic consideration. ( Wakamoto, H, 2008) |
| "Minor motor seizures from the 10th month onwards are successfully treated with Valproate." | 1.35 | Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature. ( Creemers, JW; Mullaart, RA; Reimer, A; Wortmann, SB, 2008) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 1.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| "Epilepsy is often the most important clinical manifestation of the syndrome, even if its appearance is not constantly precocious." | 1.35 | Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children. ( Canevini, MP; Dalla Bernardina, B; Darra, F; Fiorini, E; La Selva, L; Lazzarotto, F; Piazzini, A; Vignoli, A; Zucca, C, 2009) |
| "A 25-year-old girl with mild mental retardation had a 6-year history of absence seizures, with occasional head drop." | 1.31 | Mild generalized epilepsy and developmental disorder associated with large inv dup(15). ( Canevini, MP; Canger, R; Cavani, S; Chifari, R; Elia, M; Guerrini, R; Pierluigi, M; Sgrò, V, 2002) |
| " Reduction of VPA dosage and subsequent discontinuation 4 months later resulted in disappearance of clinical symptoms with a 20-point improvement at IQ testing and recovery of previous PM score." | 1.30 | Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment. ( Belmonte, A; Canapicchi, R; Casalini, C; Guerrini, R; Perucca, E, 1998) |
| "Mental retardation is present only in patients with poor seizure control." | 1.30 | Epilepsy with myoclonic absences with early onset: a follow-up study. ( Chiarelli, F; Domizio, S; Greco, R; Morgese, G; Sabatino, G; Verrotti, A, 1999) |
| " VPA dosage was tapered and discontinued, with accompanying resolution of clinical, immunological and hematological signs of SLE 6 weeks after VPA discontinuation." | 1.29 | Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy. ( Diomedi, M; Gigli, GL; Grazia Pomponi, M; Masala, C; Pauri, F; Placidi, F; Scalise, A; Silvestri, G, 1996) |
| "Pancreatitis is usually considered a rare side effect of valproate." | 1.29 | Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults. ( Buzan, RD; Dubovsky, SL; Firestone, D; Thomas, M, 1995) |
| "The case of an adolescent with severe mental retardation, blindness, and a complex of behavioral symptoms consistent with mania is reported." | 1.28 | Verapamil and valproic acid treatment of prolonged mania. ( Friedman, DL; Kastner, T, 1992) |
| "In contrast, cryptogenic infantile spasms, in which there is no identifiable brain lesion, usually run a favorable course under treatment." | 1.28 | [A prognostic study of cryptogenic infantile spasms]. ( Boulloche, J; Dautreme, P; Le Luyer, B; Mallet, E; Tron, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.65) | 18.7374 |
| 1990's | 23 (26.74) | 18.2507 |
| 2000's | 18 (20.93) | 29.6817 |
| 2010's | 29 (33.72) | 24.3611 |
| 2020's | 12 (13.95) | 2.80 |
| Authors | Studies |
|---|---|
| Lhamu, T | 1 |
| Sadh, K | 1 |
| Dahale, AB | 1 |
| Mohan, V | 1 |
| Loganathan, S | 1 |
| Bjørk, MH | 1 |
| Zoega, H | 1 |
| Leinonen, MK | 1 |
| Cohen, JM | 1 |
| Dreier, JW | 2 |
| Furu, K | 1 |
| Gilhus, NE | 1 |
| Gissler, M | 1 |
| Hálfdánarson, Ó | 1 |
| Igland, J | 1 |
| Sun, Y | 2 |
| Tomson, T | 1 |
| Alvestad, S | 1 |
| Christensen, J | 3 |
| Ju, Y | 1 |
| Ji, TY | 1 |
| Kessi, M | 1 |
| Chen, B | 2 |
| Shan, LD | 1 |
| Wang, Y | 1 |
| Yang, L | 2 |
| Yin, F | 1 |
| He, F | 1 |
| Peng, J | 2 |
| Wang, G | 1 |
| Wang, XL | 1 |
| Tian, YN | 1 |
| Chen, C | 1 |
| Hofmeister, B | 2 |
| von Stülpnagel, C | 2 |
| Berweck, S | 2 |
| Abicht, A | 1 |
| Kluger, G | 2 |
| Weber, P | 2 |
| Mocquard, C | 1 |
| Aillet, S | 1 |
| Riffaud, L | 1 |
| Calle-Lopez, Y | 1 |
| Kotagal, P | 1 |
| Knight, EP | 1 |
| Li, Y | 1 |
| Zhang, T | 1 |
| Li, B | 1 |
| Li, J | 1 |
| Wang, L | 1 |
| Jiang, Z | 1 |
| Finsterer, J | 2 |
| Devries, S | 1 |
| Mulder, M | 1 |
| Charron, JG | 1 |
| Prokop, JW | 1 |
| Mark, PR | 1 |
| Watkins, L | 1 |
| Reuber, M | 1 |
| Perera, B | 1 |
| Courtenay, K | 1 |
| Banks, R | 1 |
| Murphy, E | 1 |
| Angus-Leppan, H | 1 |
| Shankar, R | 1 |
| Daugaard, CA | 1 |
| Pedersen, L | 1 |
| Kang, Q | 1 |
| Liao, H | 1 |
| Wu, L | 1 |
| Yang, S | 1 |
| Kuang, X | 1 |
| Yang, H | 1 |
| Liao, C | 1 |
| Johannesen, KM | 1 |
| Gardella, E | 1 |
| Linnankivi, T | 1 |
| Courage, C | 1 |
| de Saint Martin, A | 1 |
| Lehesjoki, AE | 1 |
| Mignot, C | 1 |
| Afenjar, A | 1 |
| Lesca, G | 1 |
| Abi-Warde, MT | 1 |
| Chelly, J | 1 |
| Piton, A | 1 |
| Merritt, JL | 1 |
| Rodan, LH | 1 |
| Tan, WH | 1 |
| Bird, LM | 1 |
| Nespeca, M | 1 |
| Gleeson, JG | 1 |
| Yoo, Y | 1 |
| Choi, M | 1 |
| Chae, JH | 1 |
| Czapansky-Beilman, D | 1 |
| Reichert, SC | 1 |
| Pendziwiat, M | 1 |
| Verhoeven, JS | 1 |
| Schelhaas, HJ | 1 |
| Devinsky, O | 1 |
| Specchio, N | 2 |
| Trivisano, M | 2 |
| Weber, YG | 1 |
| Nava, C | 1 |
| Keren, B | 1 |
| Doummar, D | 1 |
| Schaefer, E | 1 |
| Hopkins, S | 1 |
| Dubbs, H | 1 |
| Shaw, JE | 1 |
| Pisani, L | 1 |
| Myers, CT | 1 |
| Tang, S | 2 |
| Pal, DK | 1 |
| Millichap, JJ | 1 |
| Carvill, GL | 1 |
| Helbig, KL | 1 |
| Mecarelli, O | 1 |
| Striano, P | 1 |
| Helbig, I | 1 |
| Rubboli, G | 1 |
| Mefford, HC | 1 |
| Møller, RS | 1 |
| Ono, H | 1 |
| Arora, V | 1 |
| Joshi, A | 1 |
| Lall, M | 1 |
| Agarwal, S | 1 |
| Bijarnia Mahay, S | 1 |
| Dua Puri, R | 1 |
| Chander Verma, I | 1 |
| Mir, A | 1 |
| Chaudhary, M | 1 |
| Alkhaldi, H | 1 |
| Alhazmi, R | 1 |
| Albaradie, R | 1 |
| Housawi, Y | 1 |
| Clayton-Smith, J | 1 |
| Bromley, R | 1 |
| Dean, J | 1 |
| Journel, H | 1 |
| Odent, S | 1 |
| Wood, A | 1 |
| Williams, J | 1 |
| Cuthbert, V | 1 |
| Hackett, L | 1 |
| Aslam, N | 1 |
| Malm, H | 1 |
| James, G | 1 |
| Westbom, L | 1 |
| Day, R | 1 |
| Ladusans, E | 1 |
| Jackson, A | 1 |
| Bruce, I | 1 |
| Walker, R | 1 |
| Sidhu, S | 1 |
| Dyer, C | 1 |
| Ashworth, J | 1 |
| Hindley, D | 1 |
| Diaz, GA | 1 |
| Rawson, M | 1 |
| Turnpenny, P | 1 |
| Kwong, AK | 1 |
| Chu, VL | 1 |
| Rodenburg, RJT | 1 |
| Smeitink, J | 1 |
| Fung, CW | 1 |
| Mori, T | 1 |
| Goji, A | 1 |
| Toda, Y | 1 |
| Ito, H | 1 |
| Mori, K | 1 |
| Kohmoto, T | 1 |
| Imoto, I | 1 |
| Kagami, S | 1 |
| Ennaim, N | 1 |
| Bourrous, M | 2 |
| Rada, N | 1 |
| Draiss, G | 2 |
| Bouskraoui, M | 2 |
| Baek, JH | 1 |
| Seo, YH | 1 |
| Kim, GH | 1 |
| Kim, MK | 1 |
| Eun, BL | 1 |
| Gentile, S | 1 |
| Eadie, MJ | 1 |
| Camacho, A | 1 |
| Núñez, N | 1 |
| Dekomien, G | 1 |
| Hernández-Laín, A | 1 |
| de Aragón, AM | 1 |
| Simón, R | 1 |
| Vigevano, F | 1 |
| Maeda, S | 2 |
| Tomoyasu, Y | 2 |
| Higuchi, H | 2 |
| Ishii-Maruhama, M | 1 |
| Egusa, M | 2 |
| Miyawaki, T | 2 |
| Moses, L | 1 |
| Katz, N | 1 |
| Weizman, A | 1 |
| Vignoli, A | 1 |
| Canevini, MP | 2 |
| Darra, F | 1 |
| La Selva, L | 1 |
| Fiorini, E | 1 |
| Piazzini, A | 1 |
| Lazzarotto, F | 1 |
| Zucca, C | 1 |
| Dalla Bernardina, B | 1 |
| Hellings, JA | 1 |
| Barth, FX | 1 |
| Logan, M | 1 |
| Cook-Wiens, G | 1 |
| Osorio, I | 1 |
| Reed, RC | 1 |
| Elibrahimi, I | 1 |
| Safini, F | 1 |
| Amine, M | 1 |
| Coppola, G | 1 |
| Grosso, S | 2 |
| Franzoni, E | 2 |
| Veggiotti, P | 1 |
| Zamponi, N | 1 |
| Parisi, P | 1 |
| Spalice, A | 1 |
| Habetswallner, F | 1 |
| Fels, A | 1 |
| Capovilla, G | 1 |
| Verrotti, A | 2 |
| Mangano, S | 1 |
| Balestri, A | 1 |
| Curatolo, P | 1 |
| Pascotto, A | 1 |
| Chen, K | 1 |
| Mi, YJ | 1 |
| Ma, Y | 1 |
| Fu, HL | 1 |
| Jin, WL | 1 |
| Velizarova, R | 1 |
| Gelisse, P | 1 |
| Pageaux, GP | 1 |
| Genton, P | 2 |
| Crespel, A | 1 |
| May, TW | 1 |
| Boor, R | 1 |
| Rambeck, B | 1 |
| Jürgens, U | 1 |
| Korn-Merker, E | 1 |
| Brandt, C | 1 |
| Visser, WE | 1 |
| de Rijke, YB | 1 |
| van Toor, H | 1 |
| Visser, TJ | 1 |
| Ishii, M | 1 |
| Brownstone, E | 1 |
| Voigtländer, T | 1 |
| Baumhackl, U | 1 |
| Cordelli, DM | 1 |
| Garavelli, L | 1 |
| Savasta, S | 1 |
| Guerra, A | 1 |
| Pellicciari, A | 1 |
| Giordano, L | 1 |
| Bonetti, S | 1 |
| Cecconi, I | 1 |
| Wischmeijer, A | 1 |
| Seri, M | 1 |
| Rosato, S | 1 |
| Gelmini, C | 1 |
| Della Giustina, E | 1 |
| Ferrari, AR | 1 |
| Zanotta, N | 1 |
| Epifanio, R | 1 |
| Grioni, D | 1 |
| Malbora, B | 1 |
| Mammi, I | 1 |
| Mari, F | 1 |
| Buoni, S | 1 |
| Mostardini, R | 1 |
| Pantaleoni, C | 1 |
| Doz, M | 1 |
| Poch-Olivé, ML | 1 |
| Rivieri, F | 1 |
| Sorge, G | 1 |
| Simonte, G | 1 |
| Licata, F | 1 |
| Tarani, L | 1 |
| Terazzi, E | 1 |
| Mazzanti, L | 1 |
| Cerruti Mainardi, P | 1 |
| Boni, A | 1 |
| Faravelli, F | 1 |
| Grasso, M | 1 |
| Bianchi, P | 1 |
| Zollino, M | 1 |
| Darling, A | 1 |
| Poo, P | 1 |
| Perez-Duenas, B | 1 |
| Campistol, J | 1 |
| Chifari, R | 1 |
| Guerrini, R | 2 |
| Pierluigi, M | 1 |
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| Olson, DA | 1 |
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| Valente, KD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863] | 260 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for valproic acid and Deficiency, Mental
| Article | Year |
|---|---|
[Autosomal dominant mental retardation type 5 caused by
Topics: Child; Codon, Nonsense; Humans; Intellectual Disability; Mutation; ras GTPase-Activating Proteins; R | 2023 |
Recent advances in trigonocephaly.
Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Humans; Infant; Infant, Newborn; Intelle | 2019 |
A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report.
Topics: Brain Diseases; Carbamazepine; China; Chronic Disease; Female; Humans; Intellectual Disability; Magn | 2019 |
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di | 2014 |
Treating epilepsy in pregnant women.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern | 2014 |
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders.
Topics: Angelman Syndrome; Anticonvulsants; Child; Chromosome Deletion; Chromosome Disorders; Chromosomes, H | 2003 |
[Neuropsychological outcome following intrauterine exposure to valproate].
Topics: Female; Germany; Humans; Intellectual Disability; Mental Disorders; Practice Guidelines as Topic; Pr | 2006 |
Teratogenesis of sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; Infant, Newborn; Intellectual | 2007 |
Ring chromosome 22 and mood disorders.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Child; Chromosomes, Human, Pair 22; Drug Therapy, Com | 1996 |
Valproate in the treatment of epilepsy in people with intellectual disability.
Topics: Anticonvulsants; Epilepsy; Humans; Intellectual Disability; Treatment Outcome; Valproic Acid | 1998 |
Rapid cycling bipolar affective disorder in people with intellectual disability: a systematic review.
Topics: Antimanic Agents; Bipolar Disorder; Carbamazepine; Down Syndrome; Humans; Intellectual Disability; L | 1999 |
5 trials available for valproic acid and Deficiency, Mental
| Article | Year |
|---|---|
Overnight versus progressive conversion of multiple daily-dose divalproex to once-daily divalproex extended release: which strategy is better tolerated by adults with intellectual disabilities?
Topics: Adult; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Intellectual Disab | 2009 |
Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Huma | 2010 |
Long-term administration of valproic acid in the treatment of affective symptoms in people with mental retardation.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Intellectual Disability; Male; Mood Disorders; P | 1993 |
Effects of switching from Depakene to generic valproic acid on individuals with mental retardation.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cross-Over Studies; Drugs, Generic; Humans; Intellectual D | 1997 |
Effect of divalproex sodium on aggression and self-injurious behaviour in adults with intellectual disability: a retrospective review.
Topics: Adult; Aggression; Female; GABA Agents; Humans; Intellectual Disability; Male; Middle Aged; Retrospe | 1999 |
68 other studies available for valproic acid and Deficiency, Mental
| Article | Year |
|---|---|
Valproate-Induced Pancytopenia and Phenytoin Toxicity in a Young Adult With Intellectual Disability and Mesial Temporal Lobe Sclerosis.
Topics: Humans; Intellectual Disability; Pancytopenia; Phenytoin; Sclerosis; Temporal Lobe; Valproic Acid; Y | 2021 |
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies; | 2022 |
[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].
Topics: Child; Electroencephalography; Epilepsy; Facies; Female; Hirschsprung Disease; Humans; Intellectual | 2022 |
Genotype-phenotype correlations of STXBP1 pathogenic variants and the treatment choices for STXBP1-related disorders in China.
Topics: Adrenocorticotropic Hormone; China; Female; Genetic Association Studies; Humans; Intellectual Disabi | 2023 |
Cooccurrence of Two Different Genetic Diseases: A Case of Valproic Acid Hepatotoxicity in Nicolaides-Baraitser Syndrome (SMARCA2 Mutation)-Due to a POLG1-Related Effect?
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; DNA Polymerase gamma; Facies; Female | 2020 |
Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome.
Topics: Adolescent; Anticonvulsants; Epilepsy; Facies; Female; Hair; Humans; Hyperventilation; Intellectual | 2019 |
Overlapping Phenotype from Double Trouble SMARCA2 and POLG1 Variants c.2556A > C and c.3708G > T, Respectively.
Topics: Chemical and Drug Induced Liver Injury; Facies; Foot Deformities, Congenital; Humans; Hypotrichosis; | 2020 |
Response To: Overlapping Phenotype from Double Trouble SMARCA2 and POLG1 Variants c.2556A > C and c.3708G > T, Respectively.
Topics: Chemical and Drug Induced Liver Injury; Facies; Foot Deformities, Congenital; Humans; Hypotrichosis; | 2020 |
SLC6A1 G443D associated with developmental delay and epilepsy.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; GABA Plasma Membrane Transport Prote | 2020 |
Valproate prescribing practices for women with intellectual disability across Europe.
Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Europe; Female; Humans; Intellectu | 2021 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
CNKSR2 gene mutation leads to Houge type of X-linked syndromic mental retardation: A case report and review of literature.
Topics: Adaptor Proteins, Signal Transducing; Anticonvulsants; Child; Codon, Nonsense; Epilepsy; Humans; Int | 2021 |
Defining the phenotypic spectrum of SLC6A1 mutations.
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Child; Child, Preschool; Cohort Studies; Electroencephal | 2018 |
Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation.
Topics: Adult; Anticonvulsants; Carnitine; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Int | 2019 |
Fetal valproate syndrome as a phenocopy of Kleefstra syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Chromosome Deletion; Chromosomes, Human, Pair | 2018 |
Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual Disability.
Topics: Anticonvulsants; Consensus; Female; Humans; Intellectual Disability; Pregnancy; Pregnancy Complicati | 2019 |
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
[Lennox-Gastaut syndrome: Experience of Marrakech University Hospital].
Topics: Accidental Falls; Anticonvulsants; Asphyxia Neonatorum; Atrophy; Cerebral Cortex; Child; Child, Pres | 2013 |
[Valproic acid during pregnancy lowers IQ in children].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Nervous | 2013 |
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr | 2014 |
LAMA2-related congenital muscular dystrophy complicated by West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Electroencephalography; Human | 2015 |
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni | 2015 |
Independent predictors of delay in emergence from general anesthesia.
Topics: Adult; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthetic | 2015 |
Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities.
Topics: Adult; Anticonvulsants; Autism Spectrum Disorder; Blood Glucose; Body Mass Index; Carbamazepine; Cho | 2015 |
Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children.
Topics: Adult; Age of Onset; Anticonvulsants; Child; Chromosomes, Human, Pair 20; Cognition Disorders; Comor | 2009 |
[Characteristics of the children with epilepsy followed in the Marrakech University Hospital].
Topics: Adolescent; Age of Onset; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Consanguinity; E | 2010 |
The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells.
Topics: Animals; Antibodies; Antibody Specificity; Cell Differentiation; Cell Line, Tumor; Gene Knockdown Te | 2011 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response | 2011 |
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, | 2011 |
The influence of oral VPA on the required dose of propofol for sedation during dental treatment in patients with mental retardation: a prospective observer-blinded cohort study.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Dental Care; Dose-Response Relationship, D | 2012 |
Epilepsy in adult X-linked adrenoleucodystrophy due to the deletion c.1415-1416delAG in exon 5 of the ABCD1-gene.
Topics: Adrenoleukodystrophy; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP- | 2013 |
Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; DNA Mutational Analysis; Electroencephalograph | 2013 |
Mild generalized epilepsy and developmental disorder associated with large inv dup(15).
Topics: Adult; Age of Onset; Angelman Syndrome; Anticonvulsants; Chromosome Aberrations; Chromosome Inversio | 2002 |
Combination of olanzapine and divalproex for agitation in individuals with profound mental retardation.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Female; H | 2002 |
[GEFS + syndrome: phenotypic variations from the newborn to the adult in a large French pedigree].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Gener | 2003 |
[A case of infantile epileptic apnea with congenital brain anomaly].
Topics: Apnea; Brain; Electroencephalography; Epilepsy; Female; Humans; Infant; Intellectual Disability; Val | 2003 |
Normal intelligence in children with prenatal exposure to carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
The difficulties of diagnosing VPA-induced pancreatitis in children with severe motor and intellectual disabilities.
Topics: Acute Disease; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Intellectual Disability; | 2004 |
Non-equivalence of bioavailability between generic and branded form of sodium valproate.
Topics: Adult; Anticonvulsants; Biological Availability; Drugs, Generic; Epilepsy, Generalized; Humans; Inte | 2004 |
Neuropsychological effects of exposure to anticonvulsant medication in utero.
Topics: Adolescent; Anticonvulsants; Brain; Child; Cognition Disorders; Cohort Studies; Epilepsy; Female; Hu | 2005 |
A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate.
Topics: Animals; Animals, Newborn; Anticonvulsants; Attention; Autistic Disorder; Disease Models, Animal; Do | 2006 |
Immunogold study of effects of prenatal exposure to lipopolysaccharide and/or valproic acid on the rat blood-brain barrier vessels.
Topics: Albumins; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane; Cerebral Arteries; Child; Dev | 2005 |
Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature.
Topics: Adult; Anticonvulsants; Brain; Female; Genetic Counseling; Heart Neoplasms; Humans; Infant, Newborn; | 2008 |
Acute hemorrhagic pancreatitis due to the use of valproic acid in a child.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy, Generalized; Hemorrhage; Humans; Intellectual Disab | 2008 |
Childhood absence epilepsy with clinically apparent genetic and acquired burdens: a diagnostic consideration.
Topics: Action Potentials; Anticonvulsants; Birth Injuries; Brain; Causality; Child; Child, Preschool; Comor | 2008 |
Valproic acid-induced hyperammonemia in mentally retarded adults.
Topics: Adolescent; Adult; Aged; Ammonia; Female; Humans; Intellectual Disability; Male; Middle Aged; Valpro | 1984 |
Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Cholecystitis; Comorbidity; Epilepsy; Humans; Intellectual | 1995 |
Update on the costs of Depakote and Depakene.
Topics: Cost Savings; Humans; Intellectual Disability; Seizures; Valproic Acid | 1995 |
Valproic acid for dysphoric mania in a mentally retarded adolescent.
Topics: Adolescent; Bipolar Disorder; Drug Administration Schedule; Female; Humans; Intellectual Disability; | 1995 |
Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy.
Topics: Adult; Chromosomes, Human, Pair 9; Comorbidity; Epilepsy; Female; HLA-DR4 Antigen; Humans; Intellect | 1996 |
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1996 |
Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid.
Topics: Anti-Dyskinesia Agents; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autistic Dis | 1997 |
Clinical and economic impact of replacing divalproex sodium with valproic acid.
Topics: Adult; Anticonvulsants; Costs and Cost Analysis; Epilepsy; Female; Hospitals, Psychiatric; Humans; I | 1997 |
Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment.
Topics: Atrophy; Brain; Brain Diseases; Child; Cognition Disorders; Diagnosis, Differential; Electroencephal | 1998 |
Comment on Vadney and Kraushaar's "Effect of switching from Depakene to generic valproic acid on individuals with mental retardation".
Topics: Anticonvulsants; Bipolar Disorder; Humans; Intellectual Disability; Valproic Acid | 1998 |
Epilepsy with myoclonic absences with early onset: a follow-up study.
Topics: Anticonvulsants; Child, Preschool; Developmental Disabilities; Drug Therapy, Combination; Epilepsies | 1999 |
Valproic acid for nonaffective aggression in the mentally retarded.
Topics: Adult; Affect; Aggression; Animals; Female; gamma-Aminobutyric Acid; Humans; Intellectual Disability | 1992 |
Verapamil and valproic acid treatment of prolonged mania.
Topics: Adolescent; Arousal; Bipolar Disorder; Drug Therapy, Combination; Humans; Intellectual Disability; M | 1992 |
[A prognostic study of cryptogenic infantile spasms].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Cosyntropin; Developmental Disabilities; Electroencep | 1991 |
A potential drug interaction between fluoxetine and valproic acid.
Topics: Bipolar Disorder; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Intellec | 1991 |
Divalproex-responsive rapid cycling bipolar disorder in a patient with Down's syndrome: implications for the Down's syndrome-mania hypothesis.
Topics: Adult; Affect; Bipolar Disorder; Diarrhea; Humans; Intellectual Disability; Male; Valproic Acid | 1991 |
[Pellagra in anticonvulsive therapy].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Intellect | 1990 |
Valproic acid for the treatment of children with mental retardation and mood symptomatology.
Topics: Adolescent; Adolescent Behavior; Affective Disorders, Psychotic; Child; Child Behavior; Drug Evaluat | 1990 |
The use of valproate in the treatment of mentally retarded persons with typical and atypical bipolar disorders.
Topics: Adult; Autistic Disorder; Bipolar Disorder; Chronic Disease; Female; Follow-Up Studies; Fragile X Sy | 1989 |
Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy.
Topics: Ammonia; Carnitine; Epilepsy; Humans; Infant; Intellectual Disability; Kidney; Metabolic Clearance R | 1986 |
Anticonvulsant medication in a mental handicap hospital: 1972-1982.
Topics: Anticonvulsants; Carbamazepine; Female; Hospitals, Psychiatric; Humans; Intellectual Disability; Mal | 1987 |