valproic acid has been researched along with Cytomegalovirus in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA), a simple branched-chain fatty acid having anticonvulsant activity and used in the treatment of many forms of epilepsy, markedly stimulated human cytomegalovirus (HCMV) replication in human fibroblasts (MRC-5 cells)." | 3.69 | Sodium valproate, an anticonvulsant drug, stimulates human cytomegalovirus replication. ( Kuntz-Simon, G; Obert, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Albright, ER | 1 |
| Walter, RM | 1 |
| Saffert, RT | 1 |
| Kalejta, RF | 1 |
| Ornaghi, S | 1 |
| Davis, JN | 1 |
| Gorres, KL | 1 |
| Miller, G | 1 |
| Paidas, MJ | 1 |
| van den Pol, AN | 1 |
| Michaelis, M | 3 |
| Köhler, N | 1 |
| Reinisch, A | 2 |
| Eikel, D | 2 |
| Gravemann, U | 1 |
| Doerr, HW | 3 |
| Nau, H | 2 |
| Cinatl, J | 3 |
| Suhan, T | 1 |
| Reisenauer, A | 1 |
| Fleckenstein, C | 1 |
| Gümbel, H | 1 |
| Ha, TA | 1 |
| Kuntz-Simon, G | 1 |
| Obert, G | 1 |
| Jefferson, JW | 1 |
| Jennings, HR | 1 |
| Romanelli, F | 1 |
8 other studies available for valproic acid and Cytomegalovirus
| Article | Year |
|---|---|
NFκB and Cyclic AMP Response Element Sites Mediate the Valproic Acid and UL138 Responsiveness of the Human Cytomegalovirus Major Immediate Early Enhancer and Promoter.
Topics: Cyclic AMP; Cytomegalovirus; Gene Expression Regulation, Viral; Humans; NF-kappa B; Response Element | 2023 |
Mood stabilizers inhibit cytomegalovirus infection.
Topics: Amides; Animals; Cell Line; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Disease Mo | 2016 |
Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid.
Topics: Acetylation; Anticonvulsants; Cells, Cultured; Cytomegalovirus; Dose-Response Relationship, Drug; Fi | 2004 |
Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition.
Topics: Acetylation; Antigens, Viral; Blotting, Western; Cells, Cultured; Cytomegalovirus; Enzyme Inhibitors | 2005 |
Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Drug Interactions; Endothelial Cells; Enzyme Inh | 2008 |
Sodium valproate, an anticonvulsant drug, stimulates human cytomegalovirus replication.
Topics: Anticonvulsants; Antigens, Viral; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cytomegaloviru | 1995 |
Possible risks associated with valproate treatment of AIDS-related mania.
Topics: Acquired Immunodeficiency Syndrome; Bipolar Disorder; Cytomegalovirus; Drug Costs; HIV-1; Humans; In | 1998 |
Comment: potential risk of valproic acid therapy in patients who are HIV-positive.
Topics: Anticonvulsants; Cytomegalovirus; Drug Interactions; HIV Seropositivity; Humans; Nervous System Dise | 2000 |