valproic acid has been researched along with Crohn Disease in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study underscores the importance of considering drugs as a cause and a contributor to pancreatitis in children, particularly valproic acid in young children." | 3.77 | Novel characterization of drug-associated pancreatitis in children. ( Bai, HX; Bhandari, V; Husain, SZ; Latif, SU; Ma, MH; Orabi, AI; Park, A, 2011) |
| "Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate." | 1.36 | Incidence, severity, and etiology of drug-induced acute pancreatitis. ( Procházka, M; Procházka, V; Urbánek, K; Vinklerová, I, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Felice, C | 1 |
| Lewis, A | 1 |
| Iqbal, S | 1 |
| Gordon, H | 1 |
| Rigoni, A | 1 |
| Colombo, MP | 1 |
| Armuzzi, A | 1 |
| Feakins, R | 1 |
| Lindsay, JO | 1 |
| Silver, A | 1 |
| Vinklerová, I | 1 |
| Procházka, M | 1 |
| Procházka, V | 1 |
| Urbánek, K | 1 |
| Bai, HX | 1 |
| Ma, MH | 1 |
| Orabi, AI | 1 |
| Park, A | 1 |
| Latif, SU | 1 |
| Bhandari, V | 1 |
| Husain, SZ | 1 |
3 other studies available for valproic acid and Crohn Disease
| Article | Year |
|---|---|
Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients.
Topics: Acetylation; Adolescent; Adult; Aged; Animals; Biopsy; Cohort Studies; Colitis, Ulcerative; Colon; C | 2021 |
Incidence, severity, and etiology of drug-induced acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Child, Preschool; Cr | 2010 |
Novel characterization of drug-associated pancreatitis in children.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Child; Child, Preschool; Comorbidity; Crohn Dise | 2011 |