valproic acid has been researched along with Craniofacial Abnormalities in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy." | 3.85 | Fetal Valproate Syndrome. ( Bulut, C; Çaksen, H; Mutlu-Albayrak, H, 2017) |
| "Non-treated homozygous polydactyly/arhinencephaly (Pdn/Pdn) mouse fetuses exhibited exencephaly in 16." | 1.33 | Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. ( Katagiri, R; Maekawa, M; Naruse, I; Ohta, K; Ueta, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Metruccio, F | 1 |
| Palazzolo, L | 1 |
| Di Renzo, F | 1 |
| Battistoni, M | 1 |
| Menegola, E | 1 |
| Eberini, I | 1 |
| Moretto, A | 1 |
| Koch, BEV | 1 |
| Spaink, HP | 1 |
| Meijer, AH | 1 |
| Stadelmaier, R | 1 |
| Nasri, H | 1 |
| Deutsch, CK | 1 |
| Bauman, M | 1 |
| Hunt, A | 1 |
| Stodgell, CJ | 1 |
| Adams, J | 1 |
| Holmes, LB | 1 |
| Arora, V | 1 |
| Joshi, A | 1 |
| Lall, M | 1 |
| Agarwal, S | 1 |
| Bijarnia Mahay, S | 1 |
| Dua Puri, R | 1 |
| Chander Verma, I | 1 |
| Mutlu-Albayrak, H | 1 |
| Bulut, C | 1 |
| Çaksen, H | 1 |
| Toomes, M | 1 |
| Maleck, WH | 1 |
| Koetter, KP | 1 |
| Petroianu, GA | 1 |
| Maekawa, M | 1 |
| Ohta, K | 1 |
| Katagiri, R | 1 |
| Ueta, E | 1 |
| Naruse, I | 1 |
| Carrim, ZI | 1 |
| McKay, L | 1 |
| Sidiki, SS | 1 |
| Lavy, TE | 1 |
| Rodríguez-Vázquez, M | 1 |
| Carrascosa-Romero, MC | 1 |
| Pardal-Fernández, JM | 1 |
| Iniesta, I | 1 |
9 other studies available for valproic acid and Craniofacial Abnormalities
| Article | Year |
|---|---|
Development of an adverse outcome pathway for cranio-facial malformations: A contribution from in silico simulations and in vitro data.
Topics: Adverse Outcome Pathways; Animals; Anticonvulsants; Computer Simulation; Craniofacial Abnormalities; | 2020 |
A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases.
Topics: Animals; Animals, Genetically Modified; Antibiotics, Antineoplastic; Anticonvulsants; Antifungal Age | 2021 |
Exposure to Sodium Valproate during Pregnancy: Facial Features and Signs of Autism.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Autism Spectrum Disorder; Autistic | 2017 |
Fetal valproate syndrome as a phenocopy of Kleefstra syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Chromosome Deletion; Chromosomes, Human, Pair | 2018 |
Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Craniofacial Abnormalities; Cryptorc | 2017 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn.
Topics: Abnormalities, Multiple; Animals; Craniofacial Abnormalities; Down-Regulation; Fibroblast Growth Fac | 2005 |
Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Amblyopia; Anticonvulsants; Autistic Disorder; Child, Preschool; Cranio | 2007 |
Congenital gingival hyperplasia in a neonate with foetal valproate syndrome.
Topics: Adult; Anticonvulsants; Apgar Score; Craniofacial Abnormalities; Dose-Response Relationship, Drug; E | 2007 |