valproic acid has been researched along with Craniocerebral Trauma in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy." | 4.91 | Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015) |
| "A relation between head trauma and cluster headache is frequently described in the literature." | 2.38 | Cluster headache following head injury: a case report and review of the literature. ( Casaly, JS; Dawson, GA; Turkewitz, LJ; Wirth, O, 1992) |
| "Our case supports the notion of adult myoclonic epilepsy with possible occurrence of praxis-activation of seizures, as has been noted with the other idiopathic generalised epilepsies." | 1.38 | Late-onset, praxis-induced myoclonic epilepsy. ( Carrazana, EJ; Glenn, M; Lopez, MR; Wallace, DM, 2012) |
| "In our study, we report a patient having head trauma history with partial and secondary generalized seizures taking 1500 mg/day valproate." | 1.31 | Reversible valproate-induced choreiform movements. ( Bingol, CA; Guleryuz, M; Gunal, DI, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belze, O | 1 |
| Remérand, F | 1 |
| Pujol, A | 1 |
| Fusciardi, J | 1 |
| Thompson, K | 1 |
| Pohlmann-Eden, B | 1 |
| Campbell, LA | 1 |
| Abel, H | 1 |
| Alisky, JM | 1 |
| Chen, P | 1 |
| Zhou, Y | 1 |
| Xiong, N | 1 |
| Yang, L | 1 |
| Zhu, L | 1 |
| Glenn, M | 1 |
| Carrazana, EJ | 1 |
| Lopez, MR | 1 |
| Wallace, DM | 1 |
| Anderson, GD | 1 |
| Gidal, BE | 1 |
| Hendryx, RJ | 1 |
| Awan, AB | 1 |
| Temkin, NR | 1 |
| Wilensky, AJ | 1 |
| Winn, HR | 1 |
| Park-Matsumoto, YC | 1 |
| Tazawa, T | 1 |
| Kehne, JH | 1 |
| Kane, JM | 1 |
| Chaney, SF | 1 |
| Hurst, G | 1 |
| McCloskey, TC | 1 |
| Petty, MA | 1 |
| Senyah, Y | 1 |
| Wolf, HH | 1 |
| Zobrist, R | 1 |
| White, HS | 1 |
| Packard, RC | 1 |
| Gunal, DI | 1 |
| Guleryuz, M | 1 |
| Bingol, CA | 1 |
| Turkewitz, LJ | 1 |
| Wirth, O | 1 |
| Dawson, GA | 1 |
| Casaly, JS | 1 |
| Matsumura, S | 1 |
| Shima, T | 1 |
| Okada, Y | 1 |
| Nishida, M | 1 |
| Yamada, T | 1 |
| Okita, S | 1 |
| Kitayama, K | 1 |
| Funaoka, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire (Non-Invasive Vagus Nerve Stimulator) for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)[NCT04071743] | 0 participants (Actual) | Interventional | 2020-01-01 | Withdrawn (stopped due to Primary Investigator left UT Southwestern and was not replaced.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for valproic acid and Craniocerebral Trauma
| Article | Year |
|---|---|
Pharmacological treatments for preventing epilepsy following traumatic head injury.
Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human | 2015 |
Penetrating cranionasal injury in a child caused by a bicycle spoke.
Topics: Anti-Bacterial Agents; Bed Rest; Bicycling; Ceftriaxone; Child, Preschool; Craniocerebral Trauma; Fe | 2010 |
Cluster headache following head injury: a case report and review of the literature.
Topics: Adult; Cluster Headache; Craniocerebral Trauma; Female; Humans; Valproic Acid | 1992 |
9 other studies available for valproic acid and Craniocerebral Trauma
| Article | Year |
|---|---|
Hyperammonaemic encephalopathy and a flat electroencephalogram caused by valproic acid.
Topics: Adult; Anesthesia, General; Anticonvulsants; Brain Diseases; Craniocerebral Trauma; Electroencephalo | 2013 |
Minimally-responsive head injury survivors may have chronic catatonia reversed years after an accident.
Topics: Accidents; Benzodiazepines; Brain Injuries; Craniocerebral Trauma; Electroconvulsive Therapy; Fructo | 2009 |
Late-onset, praxis-induced myoclonic epilepsy.
Topics: Age of Onset; Anticonvulsants; Brain; Craniocerebral Trauma; Electroencephalography; Epilepsies, Myo | 2012 |
Decreased plasma protein binding of valproate in patients with acute head trauma.
Topics: Acute Disease; Adult; Craniocerebral Trauma; Female; Humans; Male; Middle Aged; Protein Binding; Ser | 1994 |
Valproate induced lupus-like syndrome.
Topics: Adolescent; Anticonvulsants; Craniocerebral Trauma; HLA-DR4 Antigen; Humans; Lupus Erythematosus, Sy | 1996 |
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.
Topics: Animals; Anticonvulsants; Cerebral Infarction; Craniocerebral Trauma; Electroshock; Injections, Intr | 1997 |
Treatment of chronic daily posttraumatic headache with divalproex sodium.
Topics: Chronic Disease; Craniocerebral Trauma; Follow-Up Studies; GABA Agents; Headache; Humans; Recurrence | 2000 |
Reversible valproate-induced choreiform movements.
Topics: Adult; Anticonvulsants; Chorea; Craniocerebral Trauma; Epilepsy; Humans; Male; Time Factors; Valproi | 2002 |
[Serum concentration of valproic acid after rectal administration].
Topics: Administration, Rectal; Adolescent; Adult; Aged; Craniocerebral Trauma; Female; Humans; Male; Middle | 1988 |