valproic acid has been researched along with Convulsive Generalized Seizure Disorder in 243 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy." | 9.08 | Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997) |
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 8.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types." | 8.81 | Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001) |
| "To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy." | 7.96 | [Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020) |
| "To investigate the presence of insulin resistance in obese children with idiopathic epilepsy on valproic acid (VPA) monotherapy in comparison to obese otherwise healthy subjects." | 7.81 | Insulin resistance in patients on valproic acid: relation to adiponectin. ( Aly, RH; Amr, NH; Megahed, AA; Saad, WE, 2015) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 7.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 7.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "A 28-year-old patient with a 5-year history of bipolar disorder developed signs of encephalopathy 2 weeks after the addition of valproic acid to his treatment regimen of doxepine, risperidone, and biperidene." | 7.70 | [Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy]. ( Rottach, KG; Schmauss, M; Weiss-Brummer, J; Wieland, U, 2000) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 7.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)." | 6.82 | A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 5.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| " As adjunctive therapies, topiramate ranked best for GTCA as well as overall for IGEs, while levetiracetam ranked best for myoclonic seizures." | 5.41 | Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis. ( Chu, H; Shi, J; Yang, X; Zhang, X; Zhou, Z, 2023) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 5.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 5.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| "Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)." | 5.29 | Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993) |
| "To explore the efficacy and safety of the combined therapy of valproic acid (VPA) and lamotrigine (LTG) for various types of epilepsy." | 5.16 | [Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics]. ( Hu, Q; Kang, HC; Li, X; Liu, XY; Liu, ZG; Wang, M; Xu, F; Zeng, Z; Zhu, SQ, 2012) |
| " This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy." | 5.08 | Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997) |
| "To review the time to treatment failure, remission and first seizure of sodium valproate compared to phenytoin when used as monotherapy in people with focal onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 4.98 | Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C; Weston, J, 2018) |
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 4.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.88 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2012) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.86 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types." | 4.81 | Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001) |
| "To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy." | 3.96 | [Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020) |
| "To investigate the presence of insulin resistance in obese children with idiopathic epilepsy on valproic acid (VPA) monotherapy in comparison to obese otherwise healthy subjects." | 3.81 | Insulin resistance in patients on valproic acid: relation to adiponectin. ( Aly, RH; Amr, NH; Megahed, AA; Saad, WE, 2015) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 3.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 3.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "A child with Sturge-Weber syndrome and a left occipital leptomeningeal angioma developed focal seizures at 6 years of age that responded initially to oxcarbazepine." | 3.74 | Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome. ( Comi, AM; Ewen, JB; Kossoff, EH, 2007) |
| "Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA)." | 3.72 | Neurotoxicity following addition of intravenous valproate to lamotrigine therapy. ( Burneo, JG; Faught, E; Knowlton, RC; Kuzniecky, RI; Lawn, N; Limdi, N; Mendez, M; Prasad, A; Welty, TE, 2003) |
| "We report the case of a 4-year-old boy with long-term sodium valproate (valproic acid; VPA) therapy who suddenly developed clinically relevant thrombocytopenia and signs of hepatotoxicity." | 3.72 | Valproic-acid-induced thrombocytopenia and hepatotoxicity: discontinuation of treatment? ( Lackmann, GM, 2004) |
| "The study aimed at a comparative analysis of safety and efficacy of valproic acid (valproate) and barbiturates in the treatment of epilepsy in children." | 3.72 | [Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]. ( Petrukhin, AS; Pylaeva, OA; Voronkova, KV, 2004) |
| "A 28-year-old patient with a 5-year history of bipolar disorder developed signs of encephalopathy 2 weeks after the addition of valproic acid to his treatment regimen of doxepine, risperidone, and biperidene." | 3.70 | [Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy]. ( Rottach, KG; Schmauss, M; Weiss-Brummer, J; Wieland, U, 2000) |
| " Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE." | 3.69 | Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 3.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "Rare case reports describe genetic generalized epilepsy (GGE) starting de novo in people ≥50 years of age (older adults and the elderly)." | 3.01 | Extreme late onset of genetic generalized epilepsy in older adults and the elderly: A cohort study and literature review. ( Alzahrany, M; Punia, V, 2023) |
| "Levetiracetam was dominated by valproate in the cost-utility analysis, with a negative incremental net health benefit of -0·040 (95% central range -0·175 to 0·037) and a probability of 0·17 of being cost-effectiveness at a threshold of £20 000 per quality-adjusted life-year." | 3.01 | The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. ( Appleton, R; Baker, GA; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, A; Mohanraj, R; Plumpton, C; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, P, 2021) |
| "Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)." | 2.82 | A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022) |
| " Mean VPA dosage was of approximately 870 mg/day (approximately 22 mg/kg/day) and mean VPA concentration was of approximately 89 mg/l at 12 h post-dose and of 54 mg/l at 24 h post-dose." | 2.72 | Conventional and sustained-release valproate in children with newly diagnosed epilepsy: a randomized and crossover study comparing clinical effects, patient preference and pharmacokinetics. ( Adín, J; Armijo, JA; Arteaga, R; Herranz, JL, 2006) |
| "100 children with the first episode of febrile seizures (from 6 months to 4 years old) were investigated." | 2.71 | [Mexidol in treatment of children with generalized epilepsy and febrile seizures]. ( Kapanadze, N; Natriashvili, G; Natriashvili, S, 2005) |
| " The rate of patients discontinuing treatment due to adverse events or a lack of efficacy was 19% with CBZ compared to 9% with LTG (not statistically different)." | 2.71 | The LAM-SAFE Study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults. ( Bergmann, L; Kurlemann, G; Schmitz, B; Siemes, H; Steinhoff, BJ; Ueberall, MA, 2005) |
| "Weight gain is a common side effect of valproate treatment." | 2.69 | Weight gain associated with valproate in childhood. ( Aysun, S; Demir, E, 2000) |
| "Oxcarbazepine (OXC) has been licensed as monotherapy and add-on treatment in epilepsy patients with partial seizures with or without secondarily generalized seizures (PS) and generalized tonic-clonic seizures without partial onset (GTCS)." | 2.68 | A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy. ( Brodie, MJ; Christe, W; Krämer, G; Moore, A; Pohlmann, H; Steinhoff, BJ; Vigonius, U, 1997) |
| " Recommendations are made for a higher initial dosage regime for sodium valproate in partial seizures." | 2.67 | A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group. ( Cartlidge, NE; Davidson, DL; Easter, DJ; Richens, A, 1994) |
| "Felbamate (FBM) is a new antiepileptic drug (AED) that has been tested in open and controlled studies in patients with therapy-refractory partial-onset seizures." | 2.67 | Felbamate in the treatment of refractory partial-onset seizures. ( Jensen, PK, 1993) |
| "A prospective clinical pharmacokinetic study was carried out in 10 adult patients with primary or secondary generalized tonic-clonic seizures on the efficacy of valproic acid (VPA) administered as a single daily dose in comparison with divided doses thrice daily." | 2.67 | [A single daily dose with valproic acid. A pharmacodynamic and clinical study]. ( Mamoli, B; Pelzl, G, 1992) |
| "Ninety four patients of generalised and partial epilepsy were randomly assigned to treatment with sodium valproate (49 cases) or phenytoin (45 cases)." | 2.67 | Comparison of sodium valproate and phenytoin as single drug treatment in generalised and partial epilepsy. ( Agarwala, RK; Mehrotra, TN; Rastogi, P; Singh, VS, 1991) |
| "These patients with refractory generalized epilepsy with sleep-related fast activities do not belong to a well-established syndromic category." | 2.66 | Genetic/idiopathic generalized epilepsies: Not so good as that! ( Crespel, A; Gelisse, P; Nilo, A, 2020) |
| "VPA is widely used for the treatment of generalized epilepsy." | 2.61 | [Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy]. ( Araki, M; Mukai, T; Naka, H; Shishido, T; Tokinobu, H; Yamada, H, 2019) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Occurrence of generalized tonic-clonic seizures (GTCS) is one of the most important risk factors of seizure-related complications and comorbidities in patients with epilepsy." | 2.50 | Pharmacotherapy for tonic-clonic seizures. ( Rheims, S; Ryvlin, P, 2014) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures." | 2.45 | The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? ( Abou-Khalil, B; Montouris, G, 2009) |
| "Most idiopathic generalized epilepsy (IGE) begins in childhood." | 2.43 | Management guidelines for children with idiopathic generalized epilepsy. ( Camfield, C; Camfield, P, 2005) |
| "We related seizure control to VPA doses through uni- and multivariate statistical analyses." | 1.91 | Minimum effective sodium valproate dose in genetic generalized epilepsies. ( Bittar Guaranha, MS; Duarte, JTC; Guilhoto, LM; Hackbart, BA; Marques, VD; Peixoto-Santos, JE; Yacubian, EMT, 2023) |
| "We present two cases of arginase deficiency with genetically confirmed ARG1 mutation in one and biochemical confirmation in both." | 1.91 | Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy. ( Banerjee, M; Fasaludeen, A; Jose, M; Menon, RN; Pavuluri, H; Radhakrishnan, A; Sundaram, S, 2023) |
| "Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures is an extremely rare condition." | 1.91 | Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report. ( Jiang, Y; Zhou, X, 2023) |
| "We examined 60 patients with genetic generalized epilepsy (GGE) aged 8-17 years." | 1.72 | Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy. ( Kaplan, AT; Oskan Yalcın, S; Sager, SG, 2022) |
| "Idiopathic Generalized Epilepsy (IGE) patients may not achieve optimal seizure control with monotherapy." | 1.72 | Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy. ( Castro, LHM; Pipek, HZ; Pipek, LZ, 2022) |
| "Female patients with genetic generalized epilepsy who were followed up in our centre were included in the study." | 1.72 | Our reasons for converting to valproic acid treatment in female patients with genetic generalized epilepsy: a retrospective, single-centre study. ( Baklan, B; Mermi Dibek, D; Öztura, İ, 2022) |
| "Herein, we present a 13-year-old generalized epilepsy patient with eating-induced generalized seizures since the age of 5." | 1.62 | Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks. ( Chen, B; Jin, L; Liu, Y; Wang, X; Zhang, W, 2021) |
| "Under lamotrigine, seizure aggravation was observed in 15 patients (two patients during levetiracetam, one patient during zonisamide, none during phenobarbital and valproic acid)." | 1.62 | Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. ( Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G, 2021) |
| "Four (80%) had a referral diagnosis of focal epilepsy based on historical focal features with exacerbation of seizures on oxcarbazepine." | 1.62 | Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes! ( Er, S; Menon, RN; Radhakrishnan, A; Rudrabhatla, PK, 2021) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 1.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| "We also studied the seizure outcome in patients with IGEs." | 1.56 | Tonic-clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome. ( Asadi-Pooya, AA; Homayoun, M, 2020) |
| "Levetiracetam was preferred as an add-on therapy for both generalized and focal epilepsy." | 1.56 | Treatment of epilepsy in adults: Expert opinion in South Korea. ( Byun, JI; Cho, YW; Kang, KW; Kim, D; Kim, DW; Kim, JM; Kim, KT; Lee, ST; No, YJ; Seo, JG; Yang, KI, 2020) |
| "Idiopathic Generalized Epilepsy (IGE) management has become increasingly challenging due to the restricted use of Valproate (VPA) in females." | 1.56 | Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy. ( Albini, M; Barone, FA; Casciato, S; Cerulli Irelli, E; Cocchi, E; Di Bonaventura, C; Di Gennaro, G; Fanella, M; Fattouch, J; Fisco, G; Giallonardo, AT; Manfredi, M; Mascia, A; Morano, A; Orlando, B, 2020) |
| "The most common syndrome was juvenile myoclonic epilepsy (JME), diagnosed in 44." | 1.56 | Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center. ( Barone, FA; Cerulli Irelli, E; Di Bonaventura, C; Fanella, M; Fattouch, J; Fisco, G; Giallonardo, AT; Manfredi, M; Morano, A; Orlando, B, 2020) |
| "Topiramate was more likely prescribed for those with comorbid headache or migraine (incident: 335 of 1251 [26." | 1.51 | Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. ( Faught, E; Fishman, J; Kalilani, L; Kim, H; Thurman, DJ, 2019) |
| "Ataxia was observed in 7/34 cases." | 1.48 | Defining the phenotypic spectrum of SLC6A1 mutations. ( Abi-Warde, MT; Afenjar, A; Bird, LM; Carvill, GL; Chae, JH; Chelly, J; Choi, M; Christensen, J; Courage, C; Czapansky-Beilman, D; de Saint Martin, A; Devinsky, O; Doummar, D; Dubbs, H; Gardella, E; Gleeson, JG; Helbig, I; Helbig, KL; Hopkins, S; Johannesen, KM; Keren, B; Lehesjoki, AE; Lesca, G; Linnankivi, T; Mecarelli, O; Mefford, HC; Merritt, JL; Mignot, C; Millichap, JJ; Myers, CT; Møller, RS; Nava, C; Nespeca, M; Pal, DK; Pendziwiat, M; Pisani, L; Piton, A; Reichert, SC; Rodan, LH; Rubboli, G; Schaefer, E; Schelhaas, HJ; Shaw, JE; Specchio, N; Striano, P; Tan, WH; Tang, S; Trivisano, M; Verhoeven, JS; Weber, YG; Yoo, Y, 2018) |
| "Eslicarbazepine acetate is a recently approved antiepileptic drug that is rapidly metabolized to (S)-licarbazepine." | 1.42 | Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsy. ( Kim, TH; Petrou, S; Reid, CA, 2015) |
| "The boy is currently seizure-free under valproic acid, after twelve months of follow-up." | 1.42 | A child with ictal vocalizations and generalized epilepsy. ( Heritier Barras, AC; Korff, CM; Kurian, M, 2015) |
| "Fifty-four patients were included, with juvenile myoclonic epilepsy (JME) in 23 (42." | 1.40 | Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies. ( Aiguabella, M; Falip, M; Juvany, R; Leiva, E; Miró, J; Salas-Puig, J; Santurino, M; Veciana, M, 2014) |
| "Beckwith-Wiedemann syndrome (BWS) is etiologically connected with genetic/epigenetic growth dysregulation." | 1.40 | [Case of combination of Beckwith-Wiedemann syndrome with West syndrome]. ( Globa, OV; Kremenchugskaya, MR; Kuzenkova, LM; Podkletnova, TV, 2014) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 1.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "Among those with Idiopathic Generalized Epilepsy (46%), generalized tonic clonic seizure was encountered in 74% and absence seizure was observed in 13%." | 1.39 | Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. ( Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM, 2013) |
| "Idiopathic generalized epilepsy (IGE) resistant to treatment is common, but its neuronal correlates are not entirely understood." | 1.39 | Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy. ( DiFrancesco, MW; Gotman, J; Holland, SK; Kay, BP; Privitera, MD; Szaflarski, JP, 2013) |
| "Up to 30% of patients with idiopathic generalized epilepsy (IGE) have seizures that are refractory to medication despite appropriate therapy that commonly includes valproate (VPA)." | 1.39 | The relationship between the localization of the generalized spike and wave discharge generators and the response to valproate. ( Gotman, J; Holland, SK; Kay, B; Privitera, MD; Szaflarski, JP, 2013) |
| "We report a child with idiopathic generalized epilepsy who developed myoclonic seizures and had an abnormal electroencephalogram (EEG) when oral suspension of OXC was introduced." | 1.38 | Myoclonus precipitated by oral suspension of oxcarbazepine in idiopathic generalized epilepsy. ( Deng, S; Huang, L; Luo, R; Mao, M, 2012) |
| "Idiopathic generalized epilepsy (IGE) was diagnosed in 85 cases, cryptogenic focal epilepsy in 107 cases, symptomatic focal epilepsy in 51 cases, unclassified epilepsy in 32 cases." | 1.38 | [Idiopathic generalized epilepsy in young women: choise of treatment strategy]. ( Kotov, AS, 2012) |
| "Valproic acid (VPA) is a first-line antiepileptic drug for therapy of patients with IGE." | 1.37 | Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies. ( Boor, R; Ettle, E; Muhle, H; Siniatchkin, M; Stephani, U, 2011) |
| "Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available." | 1.36 | Valproate in children with newly diagnosed idiopathic generalized epilepsy. ( Glauser, TA; Holland, KD; Monahan, S; Morita, D; Vartzelis, G, 2010) |
| "Prednisolone was tapered to 20 mg/day for 5 months." | 1.36 | Rheumatoid leptomeningitis: radiological alteration of cerebral hypoperfusion and subarachnoid lesions. ( Ikeda, K; Ishikawa, Y; Ito, H; Iwasaki, Y; Kawabe, K; Miura, K; Takazawa, T; Yoshii, Y, 2010) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED) with efficacy against multiple seizure types." | 1.35 | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? ( Czapp, M; Hoffmann, K; Löscher, W, 2008) |
| "Epilepsy was most common among those with maternal deletions and unknown subtypes, with catastrophic epilepsies present in only these two subtypes." | 1.35 | Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. ( Braun, EK; Bruno, P; Conant, KD; Nespeca, MP; Said, RR; Thibert, RL; Thiele, EA, 2009) |
| "In this study 27 patients with focal or generalized epilepsy receiving a single dosage of prolonged-release valproate given in the evening were included." | 1.35 | Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study. ( Fraunberger, B; Graf, W; Kerling, F; Pauli, E; Stefan, H; Yang, T, 2009) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 1.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| "Visual auras are reported to be uncommon or rare in patients with idiopathic generalized epilepsy." | 1.35 | [Visual auras in idiopathic generalized epilepsy]. ( Coubes, P; Crespel, A; Gelisse, P, 2008) |
| "Primary generalized epilepsy may be the result of maldevelopment of central nervous system and each seizure may be the consequence of a neuronal maladaptation to an unknown stimulus using the paleospinothalamical tract due to an overexpression of brain-derived neurotrophic factor and neurotrophin-3." | 1.33 | The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate. ( Toth, M, 2005) |
| " The dosage schedule was: 5 mg every day or every second day for 14 days, increased by 5 mg every 14th day to 25 mg a day." | 1.33 | Lamotrigine-induced rash--worth a rechallenge. ( Dam, M; P-Codrea Tigaran, S; Sidenius, P, 2005) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| " Resting EEG with 19 channels was investigated before and during chronic administration of valproate (VPA)." | 1.33 | Distribution of spatial complexity of EEG in idiopathic generalized epilepsy and its change after chronic valproate therapy. ( Clemens, B; Czopf, J; Gyimesi, C; Kondakor, I; Toth, M; Wackermann, J, 2005) |
| "thirty patients with generalized epilepsy were studied at baseline, and re-examined 4 (S1) and 25 (S2) weeks after the administration of valproate (mean dose: 1040 +/- 284 mg)." | 1.33 | The effect of valproate on silent period and corticomotor excitability. ( Divanoglou, D; Kazis, A; Kazis, DA; Kimiskidis, VK; Mills, KR; Papagiannopoulos, S; Sotirakoglou, K; Vlaikidis, N, 2006) |
| "One hundred seventy-eight men had focal epilepsy (117 of these had temporal lobe epilepsy [TLE]) and 22 idiopathic generalized epilepsy (IGE)." | 1.32 | Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. ( Bauer, J; Blumenthal, S; Reuber, M; Stoffel-Wagner, B, 2004) |
| "Men with epilepsy have reduced fertility, and antiepileptic drugs may affect semen quality." | 1.32 | Effect of epilepsy and antiepileptic drugs on male reproductive health. ( Isojärvi, JI; Juntunen, KS; Löfgren, E; Päivänsalo, M; Pakarinen, AJ; Rautakorpi, I; Tuomivaara, L, 2004) |
| "The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)." | 1.32 | Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004) |
| "A 25-year-old girl with mild mental retardation had a 6-year history of absence seizures, with occasional head drop." | 1.31 | Mild generalized epilepsy and developmental disorder associated with large inv dup(15). ( Canevini, MP; Canger, R; Cavani, S; Chifari, R; Elia, M; Guerrini, R; Pierluigi, M; Sgrò, V, 2002) |
| "The complex relationship between migraine and epilepsy is highlighted by the occurrence of a seizure during a migraine attack without aura." | 1.31 | Migraine-associated seizure: a case of reversible MRI abnormalities and persistent nondominant hemisphere syndrome. ( Dodick, DW; Friedenberg, S, 2000) |
| "an elderly patient presented with acute confusion and was found to have nonconvulsive status epilepticus." | 1.31 | Nonconvulsive status epilepticus causing acute confusion. ( Mitchell, SC; Pollock, LM, 2000) |
| "Idiopathic generalized epilepsy presenting with hemiconvulsive seizures has not, to our knowledge, been previously described." | 1.31 | Idiopathic generalized epilepsy presenting with hemiconvulsive seizures. ( Kiley, MA; Sander, JW; Smith, SJ, 2000) |
| "Seven patients had comorbid psychiatric disorders, whereas six patients had epilepsy (three rolandic, two generalized, and one indeterminate)." | 1.31 | Pediatric migraine prophylaxis with divalproex. ( Drake, ME; Greenberg, G; Pakalnis, A; Paolichi, J, 2001) |
| "Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus." | 1.31 | [Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment]. ( Bensouda, B; Bruel, H; Chabrolle, JP; Degre, S; Ickowicz, V; Poinsot, J; Simon, A, 2001) |
| "Zonisamide was changed to sodium valproate." | 1.31 | Smoldering myeloma associated with zonisamide treatment. ( Ando, Y; Asai, S; Hotta, T; Kobayashi, H; Miyachi, H, 2002) |
| "Stomatitis is a rare but potentially serious adverse effect of divalproex sodium administration." | 1.31 | Valproate-associated stomatitis. ( Baker, C; Baumann, RJ; Miller, CS; Ryan, M, 2002) |
| " The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system." | 1.30 | Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997) |
| " Toxic damage of CNS was the most significant." | 1.30 | [Side effects of anticonvulsants in the treatment of idiopathic generalized epilepsy]. ( Mukhin, KIu; Petrukhin, AS; Rykova, EA, 1997) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| "A child with primary ciliary dyskinesia syndrome (PCDS) developed primary generalised epilepsy (PGE)." | 1.30 | Primary ciliary dyskinesia syndrome and primary generalised epilepsy. ( Shepherd, RC, 1999) |
| " Significant correlations between platelet count, aggregation, and ATP release and VPA dosage and plasma concentration were also observed." | 1.30 | Platelet count and function in children receiving sodium valproate. ( Altobelli, E; Chiarelli, F; Greco, R; Matera, V; Morgese, G; Verrotti, A, 1999) |
| "When phenytoin was discontinued, valproate levels increased, and he progressively improved." | 1.30 | Exceptionally long absence status: multifactorial etiology, drug interactions and complications. ( Andermann, F; Bastos, A; D'Agostino, MD; Dubeau, F; Fedi, M, 1999) |
| "Carbamazepine treatment resulted in prolongation of peak latencies of waves I-III-V and interpeak intervals I-III and I-V." | 1.29 | Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children. ( Cenani, A; Dirican, A; Keskin, G; Senocak, D; Sozuer, D; Yalcin, E; Yuksel, A, 1995) |
| "In all experiments, the PTZ seizure threshold was repeatedly determined in individual rats with chronically implanted catheters at daily intervals." | 1.29 | Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats. ( Hönack, D; Löscher, W, 1995) |
| "Lamotrigine was well tolerated." | 1.29 | Lamotrigine as an add-on drug in typical absence seizures. ( Ferrie, CD; Knott, C; Panayiotopoulos, CP; Robinson, RO, 1995) |
| "Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)." | 1.29 | Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993) |
| "However, the hydrocephalus remained stable even when the shunt was removed due to infection." | 1.28 | [A case of Klippel-Trenaunay-Weber syndrome accompanied by congenital hydrocephalus and micropolygyria]. ( Araki, R; Koide, H; Miyaji, T; Shime, H; Shioda, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 56 (23.05) | 18.2507 |
| 2000's | 76 (31.28) | 29.6817 |
| 2010's | 68 (27.98) | 24.3611 |
| 2020's | 43 (17.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kaplan, AT | 1 |
| Oskan Yalcın, S | 1 |
| Sager, SG | 1 |
| Kiiski, R | 1 |
| Basnyat, P | 1 |
| Raitanen, J | 1 |
| Rainesalo, S | 1 |
| Peltola, J | 1 |
| Mäkinen, J | 1 |
| Ozyurek, H | 1 |
| Bayrak, I | 1 |
| Yayici Koken, O | 1 |
| Ince, H | 1 |
| Tasdemir, HA | 1 |
| Aydin, OF | 1 |
| Hochbaum, M | 1 |
| Kienitz, R | 1 |
| Rosenow, F | 1 |
| Schulz, J | 1 |
| Habermehl, L | 1 |
| Langenbruch, L | 1 |
| Kovac, S | 1 |
| Knake, S | 1 |
| von Podewils, F | 1 |
| von Brauchitsch, S | 1 |
| Hamacher, M | 1 |
| Strzelczyk, A | 1 |
| Willems, LM | 1 |
| Yang, H | 1 |
| Liao, H | 1 |
| Gan, S | 1 |
| Xiao, T | 1 |
| Wu, L | 1 |
| Mir, A | 1 |
| Alghamdi, A | 1 |
| Alotaibi, W | 1 |
| Samreen, D | 1 |
| Alotaibi, M | 1 |
| Albaradie, R | 1 |
| Bashir, S | 1 |
| Pipek, LZ | 1 |
| Pipek, HZ | 1 |
| Castro, LHM | 1 |
| Ascoli, M | 1 |
| Elia, M | 2 |
| Gasparini, S | 1 |
| Bonanni, P | 1 |
| Mastroianni, G | 1 |
| Cianci, V | 1 |
| Neri, S | 1 |
| Pascarella, A | 1 |
| Santangelo, D | 1 |
| Aguglia, U | 2 |
| Ferlazzo, E | 2 |
| Hamed, SA | 1 |
| Osiely, AM | 1 |
| Bleakley, LE | 1 |
| McKenzie, CE | 1 |
| Reid, CA | 2 |
| Alzahrany, M | 1 |
| Punia, V | 1 |
| van der Meer, PB | 1 |
| Dirven, L | 1 |
| Fiocco, M | 1 |
| Vos, MJ | 1 |
| Kouwenhoven, MCM | 1 |
| van den Bent, MJ | 1 |
| Taphoorn, MJB | 1 |
| Koekkoek, JAF | 1 |
| Marques, VD | 1 |
| Hackbart, BA | 1 |
| Guilhoto, LM | 1 |
| Duarte, JTC | 1 |
| Peixoto-Santos, JE | 1 |
| Yacubian, EMT | 1 |
| Bittar Guaranha, MS | 1 |
| Pavuluri, H | 1 |
| Jose, M | 1 |
| Fasaludeen, A | 1 |
| Sundaram, S | 1 |
| Radhakrishnan, A | 3 |
| Banerjee, M | 1 |
| Menon, RN | 3 |
| Chu, H | 1 |
| Zhang, X | 1 |
| Shi, J | 1 |
| Zhou, Z | 1 |
| Yang, X | 2 |
| Fantaneanu, TA | 1 |
| Thornton, HF | 1 |
| Zhang, T | 1 |
| Bercovici, E | 1 |
| Hrazdil, C | 1 |
| Ikeda, KM | 1 |
| Kassiri, J | 1 |
| Suller Marti, A | 1 |
| Pana, R | 1 |
| Rezazadeh, A | 1 |
| Kobayashi, E | 1 |
| Bui, E | 1 |
| Jiang, Y | 1 |
| Zhou, X | 1 |
| Brigo, F | 1 |
| Striano, P | 4 |
| Belcastro, V | 1 |
| Tabrizi, N | 1 |
| Zarvani, A | 1 |
| Rezaei, P | 1 |
| Cheraghmakani, H | 1 |
| Alizadeh-Navaei, R | 1 |
| Cerulli Irelli, E | 3 |
| Morano, A | 3 |
| Cocchi, E | 2 |
| Casciato, S | 2 |
| Fanella, M | 3 |
| Albini, M | 2 |
| Avorio, F | 1 |
| Basili, LM | 1 |
| Fisco, G | 3 |
| Barone, FA | 3 |
| Mascia, A | 2 |
| D'Aniello, A | 2 |
| Manfredi, M | 3 |
| Fattouch, J | 3 |
| Quarato, P | 1 |
| Giallonardo, AT | 3 |
| Di Gennaro, G | 2 |
| Di Bonaventura, C | 3 |
| Asadi-Pooya, AA | 1 |
| Homayoun, M | 1 |
| Andreasson, AC | 1 |
| Sigurdsson, GV | 1 |
| Pegenius, G | 1 |
| Thordstein, M | 1 |
| Hallböök, T | 1 |
| Byun, JI | 1 |
| Kim, DW | 1 |
| Kim, KT | 1 |
| Yang, KI | 1 |
| Lee, ST | 1 |
| Seo, JG | 1 |
| No, YJ | 1 |
| Kang, KW | 1 |
| Kim, D | 1 |
| Kim, JM | 1 |
| Cho, YW | 1 |
| Toledo, M | 3 |
| Mostacci, B | 2 |
| Bosak, M | 1 |
| Jedrzejzak, J | 1 |
| Thomas, RH | 1 |
| Salas-Puig, J | 5 |
| Biraben, A | 1 |
| Schmitz, B | 3 |
| Wolking, S | 1 |
| Schulz, H | 1 |
| Nies, AT | 1 |
| McCormack, M | 1 |
| Schaeffeler, E | 1 |
| Auce, P | 1 |
| Avbersek, A | 1 |
| Becker, F | 1 |
| Klein, KM | 1 |
| Krenn, M | 1 |
| Møller, RS | 3 |
| Nikanorova, M | 1 |
| Weckhuysen, S | 1 |
| Consortium, E | 1 |
| Cavalleri, GL | 1 |
| Delanty, N | 2 |
| Depondt, C | 1 |
| Johnson, MR | 1 |
| Koeleman, BP | 1 |
| Kunz, WS | 2 |
| Marson, AG | 14 |
| Sander, JW | 2 |
| Sills, GJ | 1 |
| Zara, F | 2 |
| Zimprich, F | 1 |
| Weber, YG | 3 |
| Krause, R | 1 |
| Sisodiya, S | 1 |
| Schwab, M | 1 |
| Sander, T | 2 |
| Lerche, H | 2 |
| Hamdy, MM | 1 |
| Elfatatry, AM | 1 |
| Mekky, JF | 1 |
| Hamdy, E | 1 |
| Nilo, A | 1 |
| Gelisse, P | 2 |
| Crespel, A | 2 |
| Orlando, B | 2 |
| Gesche, J | 4 |
| Hjalgrim, H | 4 |
| Rubboli, G | 4 |
| Beier, CP | 4 |
| Wu, K | 1 |
| Hirsch, LJ | 1 |
| Babl, FE | 1 |
| Josephson, SA | 1 |
| Karlov, VA | 3 |
| Kozhokaru, AB | 1 |
| Vlasov, PN | 2 |
| Pushkar, TN | 1 |
| Orlova, AS | 1 |
| Wang, X | 3 |
| Chen, B | 1 |
| Jin, L | 1 |
| Zhang, W | 1 |
| Liu, Y | 1 |
| Ranzato, F | 1 |
| Giuliano, L | 1 |
| La Neve, A | 1 |
| Bilo, L | 1 |
| Durante, V | 1 |
| Ermio, C | 1 |
| Monti, G | 1 |
| Zambrelli, E | 1 |
| Lodi, MAM | 1 |
| Galimberti, CA | 1 |
| Ballvé, A | 1 |
| Quintana, M | 1 |
| Campos, D | 1 |
| Llauradó, A | 1 |
| Raspall, M | 1 |
| Fonseca, E | 1 |
| Abraira, L | 1 |
| Santamarina, E | 1 |
| Marson, A | 2 |
| Burnside, G | 1 |
| Appleton, R | 3 |
| Smith, D | 2 |
| Leach, JP | 2 |
| Sills, G | 1 |
| Tudur-Smith, C | 1 |
| Plumpton, C | 1 |
| Hughes, DA | 1 |
| Williamson, P | 1 |
| Baker, GA | 2 |
| Balabanova, S | 1 |
| Taylor, C | 1 |
| Brown, R | 1 |
| Hindley, D | 1 |
| Howell, S | 1 |
| Maguire, M | 3 |
| Mohanraj, R | 1 |
| Smith, PE | 3 |
| Rudrabhatla, PK | 1 |
| Er, S | 1 |
| Mermi Dibek, D | 1 |
| Öztura, İ | 1 |
| Baklan, B | 1 |
| Atalar, AÇ | 1 |
| Şirin, NG | 1 |
| Bebek, N | 1 |
| Baykan, B | 1 |
| Steinbart, D | 1 |
| Gaus, V | 1 |
| Kowski, AB | 1 |
| Holtkamp, M | 1 |
| Pellegrino, F | 1 |
| Tardivo, I | 1 |
| Abdelmesih, SK | 1 |
| Elkhateeb, N | 1 |
| Zakaria, M | 1 |
| Girgis, MY | 1 |
| Hakami, T | 1 |
| Coppola, G | 2 |
| Piccorossi, A | 1 |
| Operto, FF | 1 |
| Verrotti, A | 4 |
| Nevitt, SJ | 3 |
| Sudell, M | 2 |
| Weston, J | 4 |
| Tudur Smith, C | 7 |
| Salinas, FS | 1 |
| Szabó, CÁ | 1 |
| Tang, L | 1 |
| Ge, L | 1 |
| Wu, W | 1 |
| Rui, P | 1 |
| Wu, Y | 1 |
| Yu, W | 1 |
| Johannesen, KM | 1 |
| Gardella, E | 1 |
| Linnankivi, T | 1 |
| Courage, C | 1 |
| de Saint Martin, A | 1 |
| Lehesjoki, AE | 1 |
| Mignot, C | 1 |
| Afenjar, A | 1 |
| Lesca, G | 1 |
| Abi-Warde, MT | 1 |
| Chelly, J | 1 |
| Piton, A | 1 |
| Merritt, JL | 1 |
| Rodan, LH | 1 |
| Tan, WH | 1 |
| Bird, LM | 1 |
| Nespeca, M | 1 |
| Gleeson, JG | 1 |
| Yoo, Y | 1 |
| Choi, M | 1 |
| Chae, JH | 1 |
| Czapansky-Beilman, D | 1 |
| Reichert, SC | 1 |
| Pendziwiat, M | 1 |
| Verhoeven, JS | 1 |
| Schelhaas, HJ | 1 |
| Devinsky, O | 1 |
| Christensen, J | 1 |
| Specchio, N | 1 |
| Trivisano, M | 1 |
| Nava, C | 1 |
| Keren, B | 1 |
| Doummar, D | 1 |
| Schaefer, E | 1 |
| Hopkins, S | 1 |
| Dubbs, H | 1 |
| Shaw, JE | 2 |
| Pisani, L | 1 |
| Myers, CT | 1 |
| Tang, S | 2 |
| Pal, DK | 1 |
| Millichap, JJ | 1 |
| Carvill, GL | 1 |
| Helbig, KL | 1 |
| Mecarelli, O | 1 |
| Helbig, I | 2 |
| Mefford, HC | 2 |
| Campos, MSA | 1 |
| Ayres, LR | 1 |
| Morelo, MRS | 1 |
| Carizio, FAM | 1 |
| Pereira, LRL | 1 |
| Kim, H | 1 |
| Faught, E | 2 |
| Thurman, DJ | 1 |
| Fishman, J | 1 |
| Kalilani, L | 1 |
| Olsen, D | 1 |
| Baftiu, A | 1 |
| Alvestad, S | 1 |
| Bjørnvold, M | 1 |
| Molteberg, E | 1 |
| Lossius, M | 1 |
| Landmark, CJ | 1 |
| Yamada, H | 1 |
| Shishido, T | 1 |
| Mukai, T | 1 |
| Araki, M | 1 |
| Naka, H | 1 |
| Tokinobu, H | 1 |
| Sonmez, FM | 1 |
| Serin, HM | 1 |
| Alver, A | 1 |
| Aliyazicioglu, R | 1 |
| Cansu, A | 1 |
| Can, G | 1 |
| Zaman, D | 1 |
| Mareš, P | 1 |
| Kubová, H | 1 |
| Hen, N | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Nolan, SJ | 2 |
| Pulman, J | 1 |
| Habib, M | 1 |
| Khan, SU | 1 |
| Hoque, A | 1 |
| Mondal, BA | 1 |
| Hasan, AT | 1 |
| Chowdhury, RN | 1 |
| Haque, B | 1 |
| Rahman, KM | 1 |
| Chowdhury, AH | 1 |
| Ghose, SK | 1 |
| Mohammad, QD | 1 |
| Bonnett, LJ | 1 |
| Williamson, PR | 4 |
| Chadwick, D | 3 |
| Miró, J | 1 |
| Aiguabella, M | 1 |
| Veciana, M | 1 |
| Juvany, R | 1 |
| Santurino, M | 1 |
| Leiva, E | 1 |
| Falip, M | 1 |
| Rheims, S | 1 |
| Ryvlin, P | 1 |
| Cheuk, DK | 1 |
| Wong, V | 1 |
| Guo, J | 1 |
| Wang, D | 1 |
| Ren, M | 1 |
| Xiong, B | 1 |
| Li, Z | 1 |
| Zeng, K | 1 |
| Perry, G | 1 |
| Brindley, LM | 1 |
| Muthukumaraswamy, SD | 1 |
| Singh, KD | 1 |
| Hamandi, K | 1 |
| Taskin, E | 1 |
| Atli, B | 1 |
| Kiliç, M | 1 |
| Sari, Y | 1 |
| Aydin, S | 1 |
| Mole, TB | 1 |
| Aly, RH | 1 |
| Amr, NH | 1 |
| Saad, WE | 1 |
| Megahed, AA | 1 |
| El-Farahaty, RM | 1 |
| El-Mitwalli, A | 1 |
| Azzam, H | 1 |
| Wasel, Y | 1 |
| Elrakhawy, MM | 1 |
| Hasaneen, BM | 1 |
| Steinborn, B | 1 |
| Zarowski, M | 1 |
| Winczewska-Wiktor, A | 1 |
| Wójcicka, M | 1 |
| Młodzikowska-Albrecht, J | 1 |
| Losy, J | 1 |
| Clemens, B | 3 |
| Puskás, S | 1 |
| Besenyei, M | 1 |
| Kovács, NZ | 1 |
| Spisák, T | 1 |
| Kis, SA | 1 |
| Emri, M | 1 |
| Hollódy, K | 1 |
| Fogarasi, A | 1 |
| Kondákor, I | 2 |
| Fekete, I | 1 |
| Schmidt, D | 1 |
| Kim, TH | 1 |
| Petrou, S | 1 |
| Kurian, M | 1 |
| Heritier Barras, AC | 1 |
| Korff, CM | 1 |
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| Kremenchugskaya, MR | 1 |
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| Mundlamuri, RC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness and Safety of Thread Embedding Acupuncture for Drug Resistant Epilepsy: a Randomized Clinical Trial[NCT04673071] | 60 participants (Anticipated) | Interventional | 2020-11-17 | Recruiting | |||
| A Therapeutic Confirmatory, Open-label, Multi-center, Randomized 2 Parallel Groups, Community-based Trial Studying the Efficacy and Safety of Levetiracetam (1000 to 3000 mg/Day Oral Tablets 250-500 mg b.i.d.) Compared to Sodium Valproate (1000 to 2000 mg/[NCT00175903] | Phase 3 | 1,701 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
36 reviews available for valproic acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Generalized; Humans; Immunoglobulin E; Levetiracet | 2022 |
Therapeutic approach to neurological manifestations of Angelman syndrome.
Topics: Angelman Syndrome; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Humans; Valproic Acid | 2022 |
Extreme late onset of genetic generalized epilepsy in older adults and the elderly: A cohort study and literature review.
Topics: Aged; Anticonvulsants; Cohort Studies; Epilepsy, Absence; Epilepsy, Generalized; Female; Humans; Mal | 2023 |
Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Child; Epilepsy, Generalized; Ethosuximide; Humans; Levetiracetam; Network Meta-Ana | 2023 |
A reappraisal of atypical absence seizures in children and adults: therapeutic implications.
Topics: Anticonvulsants; Epilepsy, Generalized; Ethosuximide; Humans; Lamotrigine; Lennox Gastaut Syndrome; | 2019 |
Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.
Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnancy Compli | 2021 |
Genetic/idiopathic generalized epilepsies: Not so good as that!
Topics: Abnormalities, Drug-Induced; Adult; Comorbidity; Contraindications, Drug; Death, Sudden; Epilepsy, G | 2020 |
Alternatives to valproate in girls and women of childbearing potential with Idiopathic Generalized Epilepsies: state of the art and guidance for the clinician proposed by the Epilepsy and Gender Commission of the Italian League Against Epilepsy (LICE).
Topics: Animals; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Italy; Phthiraptera; Pregnan | 2021 |
Neuropharmacology of Antiseizure Drugs.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Neuropharmacology; Ph | 2021 |
Anticonvulsant drugs for generalized tonic-clonic epilepsy.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Fructose; Humans | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies.
Topics: Anticonvulsants; Epilepsy, Generalized; Female; Humans; Lamotrigine; Male; Triazines; Valproic Acid | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Comparative efficacy of antiepileptic drugs for patients with generalized epileptic seizures: systematic review and network meta-analyses.
Topics: Anticonvulsants; Bayes Theorem; Epilepsy, Generalized; Humans; Network Meta-Analysis; Randomized Con | 2018 |
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle | 2018 |
[Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy].
Topics: Aged; Ammonia; Anticonvulsants; Biomarkers; Cardiomyopathies; Carnitine; Consciousness Disorders; Ep | 2019 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2013 |
Pharmacotherapy for tonic-clonic seizures.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fructose; Humans; Lacosa | 2014 |
Acupuncture for epilepsy.
Topics: Acupuncture Therapy; Anticonvulsants; Child; Combined Modality Therapy; Drugs, Chinese Herbal; Epile | 2014 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2016 |
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Gener | 2009 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2010 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2012 |
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile | 2012 |
Statistical issues in the assessment of the evidence for an interaction between factors in epilepsy trials.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; | 2002 |
[Other generalized epilepsies not defined above].
Topics: Diagnosis, Differential; Epilepsy, Generalized; Humans; Phenobarbital; Prognosis; Syndrome; Valproic | 2002 |
Chronic management of seizures in the syndromes of idiopathic generalized epilepsy.
Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy, Generalized; Fructose; Humans; La | 2003 |
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
Management guidelines for children with idiopathic generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized | 2005 |
Practical management issues for idiopathic generalized epilepsies.
Topics: Age Factors; Age of Onset; Anticonvulsants; Electric Stimulation Therapy; Epilepsy, Generalized; Hum | 2005 |
New statistical method for analyzing time to first seizure: example using data comparing carbamazepine and valproate monotherapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Data Interpretation, Statistical; Epileps | 2007 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; | 1993 |
[Clinical results with sodium valproate in childhood and in adolescence].
Topics: Adolescent; Child; Child, Preschool; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; | 1994 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
The management of refractory idiopathic epilepsies.
Topics: Adolescent; Anticonvulsants; Child; Clinical Protocols; Drug Administration Schedule; Drug Therapy, | 2001 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle | 2001 |
32 trials available for valproic acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Levetiracetam in genetic generalized epilepsy: A prospective unblinded active-controlled trial.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Humans; Levetiracetam; Male; Myoc | 2019 |
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Cost-Benefit A | 2021 |
Time to 12-month remission and treatment failure for generalised and unclassified epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy, Generalized; Female; Fr | 2014 |
Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam--Pilot study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epileps | 2015 |
Monotherapy of epilepsy in women: psychiatric and neuroendocrine aspects.
Topics: Adult; Anticonvulsants; Barbiturates; Carbamazepine; Epilepsies, Partial; Epilepsy, Generalized; Est | 2010 |
[Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics].
Topics: Child; Child, Preschool; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence | 2012 |
KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Dose-Response Relationship, Drug | 2013 |
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile | 2012 |
Divalproex extended-release versus the original divalproex tablet: results of a randomized, crossover study of well-controlled epileptic patients with primary generalized seizures.
Topics: Adolescent; Adult; Analysis of Variance; Asthenia; Child; Cross-Over Studies; Delayed-Action Prepara | 2002 |
Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Pr | 2002 |
[Clinical efficacy and tolerability of topamax in combined therapy of epilepsy].
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Therapy, Combination; Drug | 2003 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal | 2003 |
Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Epilepsies | 2005 |
[Mexidol in treatment of children with generalized epilepsy and febrile seizures].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalogra | 2005 |
[Efficacy of keppra in combined therapy in pharmacoresistant adult epilepsy patients].
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Ep | 2005 |
The LAM-SAFE Study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Demography; Epilepsies, Partial; Epilepsy, Genera | 2005 |
Conventional and sustained-release valproate in children with newly diagnosed epilepsy: a randomized and crossover study comparing clinical effects, patient preference and pharmacokinetics.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Chronic Disease; Cross-Over Studies; Data Inte | 2006 |
Evaluation of renal tubular function in children taking anti-epileptic treatment.
Topics: Acetylglucosaminidase; Anticonvulsants; Biomarkers; Blood Urea Nitrogen; Carbamazepine; Child; Child | 2006 |
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Epilepsy, Genera | 2007 |
Sodium valproate and mental processes in newly referred epileptic patients. A computerized EEG study.
Topics: Adolescent; Adult; Child; Cognition; Electroencephalography; Epilepsy, Generalized; Female; Fixation | 1995 |
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; | 1995 |
A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group.
Topics: Administration, Oral; Adolescent; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; | 1995 |
A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group.
Topics: Administration, Oral; Adult; Ambulatory Care Facilities; Carbamazepine; Clinical Protocols; Drug Eru | 1994 |
Felbamate in the treatment of refractory partial-onset seizures.
Topics: Adult; Anticonvulsants; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial; | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Complex Partial; Epile | 1993 |
A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Double-Bl | 1997 |
Weight gain with valproate or carbamazepine--a reappraisal.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies; Dose-Respon | 1997 |
Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Drug Therapy, Combination; Ep | 1997 |
Weight gain associated with valproate in childhood.
Topics: Adolescent; Anticonvulsants; Blood Glucose; Carnitine; Child; Child, Preschool; Drug Therapy, Combin | 2000 |
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi | 2000 |
[A single daily dose with valproic acid. A pharmacodynamic and clinical study].
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Com | 1992 |
Comparison of sodium valproate and phenytoin as single drug treatment in generalised and partial epilepsy.
Topics: Adolescent; Adult; Child; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Male; Middle A | 1991 |
176 other studies available for valproic acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy.
Topics: Adolescent; Epilepsy; Epilepsy, Generalized; Humans; Retina; Tomography, Optical Coherence; Valproic | 2022 |
Treatment outcomes in women with idiopathic generalized epilepsy.
Topics: Adult; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Male; Retrospective Studies; T | 2022 |
Effect of Chronic Valproic Acid Use on Anterior Cerebral Blood Flow of Children with Idiopathic Generalized Epilepsy.
Topics: Anticonvulsants; Blood Flow Velocity; Cerebrovascular Circulation; Child; Child, Preschool; Epilepsy | 2022 |
Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020.
Topics: Aged; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Prescriptions; Epilepsy; Epilepsy, Gener | 2022 |
ARHGEF9 gene variant leads to developmental and epileptic encephalopathy: Genotypic phenotype analysis and treatment exploration.
Topics: Epilepsy; Epilepsy, Generalized; Humans; Levetiracetam; Phenotype; Retrospective Studies; Rho Guanin | 2022 |
Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy.
Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Generalized; Female; Humans; Immun | 2022 |
Vestibular function in children with generalized epilepsy and treated with valproate.
Topics: Child; Cross-Sectional Studies; Epilepsy, Generalized; Female; Humans; Male; Valproic Acid; Vestibul | 2022 |
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleo | 2023 |
Effectiveness of Antiseizure Medication Triple Therapy in Patients With Glioma With Refractory Epilepsy: An Observational Cohort Study.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Epilepsy, Generalized; Glioma; Humans; Retrospective Studi | 2023 |
Minimum effective sodium valproate dose in genetic generalized epilepsies.
Topics: Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy, Generalized; Humans; Ret | 2023 |
Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy.
Topics: Child; Epilepsy; Epilepsy, Generalized; Humans; Hyperammonemia; Hyperargininemia; Valproic Acid | 2023 |
Real-world practices for the care of women with epilepsy during pregnancy: A Canadian perspective.
Topics: Adult; Anticonvulsants; Canada; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnanc | 2023 |
Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report.
Topics: Adult; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fem | 2023 |
Doing without valproate in women of childbearing potential with idiopathic generalized epilepsy: Implications on seizure outcome.
Topics: Adolescent; Adult; Anticonvulsants; Drug Substitution; Epilepsy, Generalized; Female; Humans; Retros | 2020 |
Tonic-clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Generalized; | 2020 |
Cortical excitability measured with transcranial magnetic stimulation in children with epilepsy before and after antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cortical Excitability; Electroencephalography; | 2020 |
Treatment of epilepsy in adults: Expert opinion in South Korea.
Topics: Adult; Aged; Anticonvulsants; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; Expert | 2020 |
Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study.
Topics: Adolescent; Anticonvulsants; Case-Control Studies; Child; Cohort Studies; Epilepsy, Generalized; Eur | 2020 |
Rapid eye movement (REM) sleep and seizure control in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cohort Studies; Egypt; Epilepsy, Generalized; Female; Fol | 2020 |
Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Humans; Male; Middle Aged; Retros | 2020 |
The clinical spectrum of familial and sporadic idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Genetic Predisposition to Disease | 2020 |
Choosing Anticonvulsant Medications to Manage Status Epilepticus.
Topics: Adult; Anticonvulsants; Disease Management; Drug Therapy, Combination; Epilepsy, Generalized; Female | 2020 |
[Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, | 2020 |
Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks.
Topics: Adolescent; China; Clonazepam; Eating; Epilepsy, Generalized; Follow-Up Studies; Humans; Male; Myocl | 2021 |
Patterns and prognostic markers for treatment response in generalized epilepsies.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Drug Resistance; Epilepsy, Generalized; Humans; Lamo | 2020 |
Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center.
Topics: Adult; Anticonvulsants; Cohort Studies; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, G | 2020 |
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps | 2021 |
Levetiracetam as first-line monotherapy for Idiopathic Generalized Epilepsy in women.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Leveti | 2021 |
Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes!
Topics: Adolescent; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Abs | 2021 |
Our reasons for converting to valproic acid treatment in female patients with genetic generalized epilepsy: a retrospective, single-centre study.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Generalized; Female; Humans; R | 2022 |
Predictors of successful valproate withdrawal in women with epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Levetiracetam; Valproic Acid | 2021 |
Valproic acid use in fertile women with genetic generalized epilepsies.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Infant, Newborn; Male; Retrospecti | 2021 |
SLC13A5-related epileptic encephalopathy successfully treated with valproate and acetazolamide.
Topics: Acetazolamide; Brain Diseases; Epilepsy, Generalized; Humans; Symporters; Valproic Acid | 2021 |
Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures.
Topics: Anticonvulsants; Child; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Infant; Levetiracetam | 2021 |
Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Epilepsy, Generalized; Female; Magnetic Reson | 2017 |
Defining the phenotypic spectrum of SLC6A1 mutations.
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Child; Child, Preschool; Cohort Studies; Electroencephal | 2018 |
Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dissociative Disorders; Epilepsi | 2019 |
D. Olsen and A. Baftiu respond.
Topics: Epilepsy, Generalized; Female; Humans; Valproic Acid | 2019 |
Continued importance of valproate for women with generalised epilepsy.
Topics: Anticonvulsants; Epilepsy, Generalized; Female; Humans; Pregnancy; Valproic Acid | 2019 |
Blood levels of cytokines in children with idiopathic partial and generalized epilepsy.
Topics: Anticonvulsants; Chi-Square Distribution; Child; Cytokines; Disease Progression; Electroencephalogra | 2013 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized | 2013 |
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.
Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies, | 2013 |
Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; | 2014 |
QPEEG analysis of the effects of sodium valproate on adult Chinese patients with generalized tonic-clonic seizures.
Topics: Adolescent; Adult; Brain; China; Electroencephalography; Epilepsy, Generalized; Female; Humans; Male | 2014 |
Evidence for increased visual gamma responses in photosensitive epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Child; Epilepsy, Generalized; Epilepsy, Reflex; Evoked Po | 2014 |
Serum, urine, and saliva levels of ghrelin and obestatin pre- and post-treatment in pediatric epilepsy.
Topics: Anticonvulsants; Blood Chemical Analysis; Child; Child, Preschool; Epilepsy, Generalized; Female; Gh | 2014 |
Withholding the choice of sodium valproate to young women with generalised epilepsy: Are we causing more harm than good?
Topics: Adolescent; Anticonvulsants; Epilepsy, Generalized; Female; Humans; Treatment Outcome; Valproic Acid | 2015 |
Insulin resistance in patients on valproic acid: relation to adiponectin.
Topics: Adiponectin; Adolescent; Anticonvulsants; Blood Glucose; Child; Epilepsy, Generalized; Female; Human | 2015 |
Atherosclerotic effects of long-term old and new antiepileptic drugs monotherapy: a cross-sectional comparative study.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carotid Arteries; Carotid Intima-Media Thickness; Cross- | 2015 |
Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Epilepsy, Generalized; | 2014 |
Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients.
Topics: Adolescent; Adult; Alpha Rhythm; Anticonvulsants; Brain; Brain Mapping; Child; Delta Rhythm; Electro | 2014 |
The dilemma of treating young women with generalized epilepsy with sodium valproate and how to get out of it.
Topics: Anticonvulsants; Epilepsy, Generalized; Female; Humans; Valproic Acid; Young Adult | 2015 |
Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsy.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Carbamazepine; Dibenzazepines; Disease Models, Animal; | 2015 |
A child with ictal vocalizations and generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Electroencephalography; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; | 2015 |
[Case of combination of Beckwith-Wiedemann syndrome with West syndrome].
Topics: Anticonvulsants; Beckwith-Wiedemann Syndrome; Child; Clonazepam; Electroencephalography; Epilepsy, G | 2014 |
1-Triacontanol cerotate; isolated from Marsilea quadrifolia Linn. ameliorates reactive oxidative damage in the frontal cortex and hippocampus of chronic epileptic rats.
Topics: Animals; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy, Generalized; Fatty Alcohols; F | 2015 |
[Hyperekplexia associated to precocious puberty].
Topics: Anticonvulsants; Benzodiazepines; Cerebral Palsy; Child; Clobazam; Drug Therapy, Combination; Electr | 2015 |
Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies.
Topics: Adult; Anticonvulsants; Cohort Studies; Delta Rhythm; Demography; Drug Resistant Epilepsy; Electroen | 2017 |
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Genera | 2008 |
Lamotrigine-valproic acid combination therapy for medically refractory epilepsy.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationshi | 2009 |
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options.
Topics: Adolescent; Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbid | 2009 |
Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Chronobiology Phenomena; Delayed-Action Prepa | 2009 |
Chitosan may decrease serum valproate and increase the risk of seizure reappearance.
Topics: Adult; Anti-Obesity Agents; Anticonvulsants; Chitosan; Dietary Supplements; Drug Interactions; Epile | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Valproate in children with newly diagnosed idiopathic generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencep | 2010 |
Reversible rapidly progressive dementia with parkinsonism induced by valproate in a patient with systemic lupus erythematosus.
Topics: Aged; Anticonvulsants; Dementia; Diagnosis, Differential; Disease Progression; Epilepsy, Generalized | 2010 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Gen | 2010 |
[Valproate for treatment of women with epilepsy: recommendations of the German Society for Epileptology].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combin | 2010 |
[Seizure aggravation by valproate in primary generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Epilepsy, Generalized; Humans; Male; Seizures; Valproic Acid | 2011 |
Rheumatoid leptomeningitis: radiological alteration of cerebral hypoperfusion and subarachnoid lesions.
Topics: Affective Symptoms; Anticonvulsants; Arthritis, Rheumatoid; Cerebrovascular Circulation; Diffusion M | 2010 |
Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Epilepsy, Generalized; Female; Frontal Lob | 2011 |
Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies.
Topics: Adolescent; Anticonvulsants; Brain; Child; Electroencephalography; Epilepsy, Generalized; Female; Hu | 2011 |
Association of genetic variants in six candidate genes with valproic acid therapy optimization.
Topics: Adult; Alleles; Anticonvulsants; DNA; Epilepsy; Epilepsy, Generalized; Female; Gene Frequency; Genet | 2011 |
Thyroid hormone levels in children receiving carbamazepine or valproate.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Dose-Response Rela | 2011 |
Atonic variant of benign childhood epilepsy with centrotemporal spikes (atonic-BECTS): a distinct electro-clinical syndrome.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Generalized; Epil | 2012 |
Myoclonus precipitated by oral suspension of oxcarbazepine in idiopathic generalized epilepsy.
Topics: Administration, Oral; Anticonvulsants; Carbamazepine; Drug Substitution; Electroencephalography; Epi | 2012 |
Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Audiometry, Pure-Tone; Central Nervo | 2013 |
[Complex therapy of idiopathic forms of epilepsy with small doses of valproates and levetiracetam].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy, Absence; | 2012 |
[Idiopathic generalized epilepsy in young women: choise of treatment strategy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Generalized; Fe | 2012 |
Comparison of triphasic waves and epileptic discharges in one patient with genetic epilepsy.
Topics: Anticonvulsants; Brain; Brain Mapping; Brain Waves; Diagnosis, Differential; Electroencephalography; | 2012 |
The problem of non-superiority: what do we know after KOMET?
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Levetira | 2013 |
[Reversible encephalopathy caused by valproic acid in an adolescent with idiopathic generalised epilepsy].
Topics: Adolescent; Anticonvulsants; Brain Diseases; Epilepsy, Generalized; Humans; Male; Valproic Acid | 2012 |
Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Down-Regulation; Epilepsy, Generalized; Female; Humans; Male; Middle Aged; Nerve | 2013 |
The relationship between the localization of the generalized spike and wave discharge generators and the response to valproate.
Topics: Action Potentials; Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsy, Generalized | 2013 |
Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy.
Topics: Adult; Age of Onset; Anticonvulsants; Calcium-Binding Proteins; Case-Control Studies; Cell Adhesion | 2013 |
Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Generalize | 2013 |
Mild generalized epilepsy and developmental disorder associated with large inv dup(15).
Topics: Adult; Age of Onset; Angelman Syndrome; Anticonvulsants; Chromosome Aberrations; Chromosome Inversio | 2002 |
Pro- and anticoagulatory factors under sodium valproate-therapy in children.
Topics: Adolescent; Adult; Blood Coagulation Disorders; Child; Child, Preschool; Epilepsies, Partial; Epilep | 2002 |
[Use of convulex in patients with epilepsy with and without affective disorders].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Gen | 2002 |
Non convulsive status epilepticus after replacement of valproate with lamotrigine.
Topics: Adult; Aged; Anticoagulants; Benzodiazepines; Electroencephalography; Epilepsy, Generalized; Female; | 2002 |
Near reflex accommodation spasm: unusual presentation of generalized photosensitive epilepsy.
Topics: Accommodation, Ocular; Anticonvulsants; Child; Electroencephalography; Epilepsy, Generalized; Female | 2002 |
[GEFS + syndrome: phenotypic variations from the newborn to the adult in a large French pedigree].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Gener | 2003 |
Favorable outcome of epileptic blindness in children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Blindness, Cortical; Carbamazepine; Child; Electroenceph | 2003 |
Neurotoxicity following addition of intravenous valproate to lamotrigine therapy.
Topics: Administration, Oral; Adult; Ammonia; Anticonvulsants; Confusion; Drug Interactions; Drug Therapy, C | 2003 |
Rapid infusion of sodium valproate in acutely ill children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru | 2003 |
[The use of depakene and depakene-chrono in idiopathic generalized epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy, G | 2003 |
Valproic-acid-induced thrombocytopenia and hepatotoxicity: discontinuation of treatment?
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child, Preschool; Epilepsy, Generalized; Hu | 2004 |
Factor XIII deficiency associated with valproate treatment.
Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Epistaxis; | 2004 |
Epilepsy versus antiepileptic drugs and gonadal function in men.
Topics: Androstenedione; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy, Generalized; Humans; | 2004 |
Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epileps | 2004 |
Effect of epilepsy and antiepileptic drugs on male reproductive health.
Topics: Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; Epilepsies, | 2004 |
Primary generalized epilepsy during infancy and early childhood.
Topics: Anticonvulsants; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsy, Gene | 2004 |
Non-equivalence of bioavailability between generic and branded form of sodium valproate.
Topics: Adult; Anticonvulsants; Biological Availability; Drugs, Generic; Epilepsy, Generalized; Humans; Inte | 2004 |
[Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)].
Topics: Adolescent; Age Factors; Anticonvulsants; Barbiturates; Child; Child, Preschool; Electroencephalogra | 2004 |
The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate.
Topics: Calcium; Central Nervous System; Epilepsy, Generalized; Humans; Nerve Growth Factors; Protein Kinase | 2005 |
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 2004 |
Influence of ethanol on the threshold for electroshock-induced seizures and electrically-evoked hippocampal afterdischarges.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Synergism; Electric Stimulatio | 2005 |
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug | 2004 |
Lamotrigine-induced rash--worth a rechallenge.
Topics: Anticonvulsants; Epilepsy, Generalized; Exanthema; Humans; Lamotrigine; Retrospective Studies; Risk | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 2005 |
Distribution of spatial complexity of EEG in idiopathic generalized epilepsy and its change after chronic valproate therapy.
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Data Interpretation, Statistical; Dose-Response | 2005 |
The effect of valproate on silent period and corticomotor excitability.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Generalized; Evoked | 2006 |
Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Pa | 2007 |
Valproate selectively reduces EEG activity in anterior parts of the cortex in patients with idiopathic generalized epilepsy. A low resolution electromagnetic tomography (LORETA) study.
Topics: Adolescent; Adult; Anticonvulsants; Cerebral Cortex; Child; Data Interpretation, Statistical; Delta | 2007 |
Valproate decreases EEG synchronization in a use-dependent manner in idiopathic generalized epilepsy.
Topics: Anticonvulsants; Cortical Synchronization; Electroencephalography; Epilepsy, Generalized; Humans; Va | 2008 |
Acute hemorrhagic pancreatitis due to the use of valproic acid in a child.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy, Generalized; Hemorrhage; Humans; Intellectual Disab | 2008 |
Absence status epilepsy: delineation of a distinct idiopathic generalized epilepsy syndrome.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Anticonvulsants; Benzodiazepines; Child; Comorbi | 2008 |
Increased oxidative stress in epileptic children treated with valproic acid.
Topics: Anthropometry; Anticonvulsants; Antioxidants; Blood Chemical Analysis; Blood Glucose; Child; Epileps | 2008 |
Congenital gingival hyperplasia in a neonate with foetal valproate syndrome.
Topics: Adult; Anticonvulsants; Apgar Score; Craniofacial Abnormalities; Dose-Response Relationship, Drug; E | 2007 |
[Visual auras in idiopathic generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Behavior; Electroencephalography; Epilepsy; Epilepsy, Generalized; Epil | 2008 |
[The effect of valproic acid monotherapy on behavior and cognitive performance of children with idiopathic generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Dose-Response Relationship, Drug; Elec | 1995 |
Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children.
Topics: Anticonvulsants; Auditory Pathways; Brain Stem; Carbamazepine; Child; Child, Preschool; Epilepsies, | 1995 |
Valproic toxicity with fluoxetine therapy.
Topics: Adolescent; Age of Onset; Depressive Disorder; Dose-Response Relationship, Drug; Epilepsy, Generaliz | 1995 |
Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats.
Topics: Animals; Delayed-Action Preparations; Epilepsy, Generalized; Female; Infusions, Intravenous; Pentyle | 1995 |
Carbamazepine-induced Stevens-Johnson syndrome in a child.
Topics: Anti-Bacterial Agents; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy, Generalized; Human | 1995 |
[The pharmacokinetic optimization of depakin in children with epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Ep | 1994 |
Lamotrigine versus carbamazepine in epilepsy.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1995 |
Effects of antiepileptic drugs on EEG background activity in children with epilepsy: initial phase of therapy.
Topics: Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Delta Rhythm; Electroencephalography; Epilepsie | 1995 |
Lamotrigine as an add-on drug in typical absence seizures.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy, Ge | 1995 |
Discontinuation of antiepileptic drug in childhood epilepsy: evaluation of the differences between epileptic syndromes.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; E | 1994 |
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a | 1994 |
Neurological side effects related to valproate after neurosurgery.
Topics: Acidosis; Adult; Aged; Akathisia, Drug-Induced; Anesthesia Recovery Period; Craniotomy; Epilepsy, Ge | 1994 |
Disabling tremor after lamotrigine with sodium valproate.
Topics: Anticonvulsants; Drug Interactions; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1993 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Ther | 1993 |
[Absence seizures in adulthood: four cases].
Topics: Adult; Age Factors; Age of Onset; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absen | 1994 |
Differential effects of first antiepileptic drug application on cognition in lesional and non-lesional patients with epilepsy.
Topics: Attention; Brain Damage, Chronic; Carbamazepine; Cognition Disorders; Electroencephalography; Epilep | 1993 |
A new chronic model of spontaneous nonconvulsive generalized seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Corpus Callosum; Electroencephalography; Epilepsy, Absenc | 1993 |
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.
Topics: Aged; Electroencephalography; Electromyography; Epilepsies, Myoclonic; Epilepsy, Generalized; Evoked | 1993 |
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Cross-Sectional Studies; Epilepsies, Partial | 1993 |
Serum carnitine levels in ambulatory epilepsy outpatients.
Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Carnitine; Drug Therapy, Combination; Epilepsie | 1996 |
[Epileptic seizures during sleep].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Ge | 1996 |
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1996 |
Nonconvulsive status epilepticus with generalized 'fast activity'.
Topics: Alpha Rhythm; Anticonvulsants; Cerebral Cortex; Diagnosis, Differential; Drug Therapy, Combination; | 1997 |
Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid.
Topics: Anti-Dyskinesia Agents; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autistic Dis | 1997 |
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate; | 1997 |
[The efficacy of the valproic acid-ethosuximide combination in the continuous slow point wave syndrome during sleep].
Topics: Anticonvulsants; Brain; Child; Electroencephalography; Epilepsy, Generalized; Ethosuximide; Female; | 1997 |
[Lamotrigine (Lamictal)].
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Drug Combinations; Drug Eruptions; Epilepsies, Part | 1997 |
[Side effects of anticonvulsants in the treatment of idiopathic generalized epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Central Nervous System; Child; Child, Preschool; D | 1997 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study.
Topics: Adult; Analysis of Variance; Brain; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Epilepsy, Gen | 1997 |
Idiopathic generalised epilepsy in adults manifested by phantom absences, generalised tonic-clonic seizures, and frequent absence status.
Topics: Adult; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Evo | 1998 |
Worsening seizures after surgery for focal epilepsy due to emergence of primary generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Disease Progression; Electroencephalography; Epilepsies, Partial; Epile | 1998 |
Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Folic Acid; Huma | 1999 |
Primary ciliary dyskinesia syndrome and primary generalised epilepsy.
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Ciliary Motility Disorders; Electroencephalography; | 1999 |
Platelet count and function in children receiving sodium valproate.
Topics: Adenosine Triphosphate; Anticonvulsants; Blood Platelets; Case-Control Studies; Child; Child, Presch | 1999 |
Clozapine-induced stuttering: epileptic brain activity?
Topics: Anticonvulsants; Antipsychotic Agents; Brain; Clozapine; Dose-Response Relationship, Drug; Electroen | 1999 |
Fatal pulmonary hemorrhage during high-dose valproate monotherapy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Fatal Outcome; Female; Hemorrhage; Humans; Lung Disea | 2000 |
[Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy].
Topics: Adult; Antimanic Agents; Ataxia; Bipolar Disorder; Brain Diseases, Metabolic; Dyskinesias; Epilepsy, | 2000 |
Migraine-associated seizure: a case of reversible MRI abnormalities and persistent nondominant hemisphere syndrome.
Topics: Anticonvulsants; Brain; Epilepsy, Generalized; Female; Humans; Magnetic Resonance Imaging; Middle Ag | 2000 |
Exceptionally long absence status: multifactorial etiology, drug interactions and complications.
Topics: Aged; Anticonvulsants; Brain Ischemia; Dementia, Vascular; Drug Interactions; Epilepsy, Generalized; | 1999 |
Nonconvulsive status epilepticus causing acute confusion.
Topics: Acute Disease; Aged; Anticonvulsants; Confusion; Diazepam; Epilepsy, Generalized; Fatal Outcome; Fem | 2000 |
Idiopathic generalized epilepsy presenting with hemiconvulsive seizures.
Topics: Adolescent; Anticonvulsants; Child; Comorbidity; Electroencephalography; Epilepsy, Frontal Lobe; Epi | 2000 |
A case of pharmacokinetic interference in comedication of clozapine and valproic acid.
Topics: Adult; Anticonvulsants; Clozapine; Drug Interactions; Drug Therapy, Combination; Epilepsy, Generaliz | 2000 |
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.
Topics: Adolescent; Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; | 2001 |
Absence epilepsy with fast rhythmic discharges during sleep: an intermediary form of generalized epilepsy?
Topics: Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Diagnosis, Different | 2001 |
Pediatric migraine prophylaxis with divalproex.
Topics: Adolescent; Child; Epilepsy, Generalized; Epilepsy, Rolandic; Female; Humans; Male; Mental Disorders | 2001 |
'Foetal valproate syndrome and autism: additional evidence of an association'.
Topics: Abnormalities, Drug-Induced; Autistic Disorder; Child; Epilepsy, Generalized; Female; Humans; Male; | 2001 |
[Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment].
Topics: Abnormalities, Drug-Induced; Craniosynostoses; Diseases in Twins; Epilepsy, Generalized; Female; Hum | 2001 |
Smoldering myeloma associated with zonisamide treatment.
Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy, Generalized; Humans; Immunoglobulin lambda-Cha | 2002 |
Valproate-associated stomatitis.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Generalized; Female; Humans; St | 2002 |
[The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of generalized korazol-induced epileptic activity].
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Ev | 1992 |
[A case of Klippel-Trenaunay-Weber syndrome accompanied by congenital hydrocephalus and micropolygyria].
Topics: Brain; Electroencephalography; Epilepsy, Generalized; Humans; Hydrocephalus; Infant, Newborn; Klippe | 1992 |
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog | 1992 |
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia | 1992 |
Effects of long-term anticonvulsant therapy on copper, zinc, and magnesium in hair and serum of epileptics.
Topics: Adult; Anticonvulsants; Carbamazepine; Copper; Drug Therapy, Combination; Epilepsy, Generalized; Fem | 1992 |