valproic acid has been researched along with Congenital Limb Deformities in 13 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or valproic acid [VA]) were given to pregnant mice to induce cleft palate (TCDD, urethane), digital defects (urethane, MNU), or exencephaly (VA)." | 3.70 | Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. ( Blaylock, BL; Gogal, RM; Holladay, SD; Sharova, L; Smith, BJ; Ward, DL, 2000) |
| "Neural tube defects were seen in 3% of the sample." | 2.41 | Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. ( Kozma, C, 2001) |
| "Valproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders." | 1.37 | Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( Cetinkaya, M; Köksal, N; Ozkan, H; Yapici, S, 2011) |
| "Women with epilepsy have a higher risk of having dysmorphic child." | 1.33 | A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. ( Batukan, C; Ceylaner, G; Ceylaner, S; Guven, MA; Uzel, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gandhi, M | 1 |
| Rac, MWF | 1 |
| McKinney, J | 1 |
| Alessandri, JL | 1 |
| Isidor, B | 1 |
| David, A | 1 |
| Martin-Coignard, D | 1 |
| Ghazouani, J | 1 |
| Ramful, D | 1 |
| Laville, JM | 1 |
| Le Caignec, C | 1 |
| Ozkan, H | 1 |
| Cetinkaya, M | 1 |
| Köksal, N | 1 |
| Yapici, S | 1 |
| Paradis, FH | 1 |
| Hales, BF | 1 |
| Holmes, LB | 1 |
| Guven, MA | 1 |
| Batukan, C | 1 |
| Ceylaner, S | 1 |
| Ceylaner, G | 1 |
| Uzel, M | 1 |
| Aulthouse, AL | 1 |
| Hitt, DC | 1 |
| Sharony, R | 1 |
| Garber, A | 1 |
| Viskochil, D | 1 |
| Schreck, R | 1 |
| Platt, LD | 1 |
| Ward, R | 1 |
| Buehler, BA | 1 |
| Graham, JM | 1 |
| Clayton-Smith, J | 1 |
| Donnai, D | 1 |
| Rodríguez-Pinilla, E | 1 |
| Arroyo, I | 1 |
| Fondevilla, J | 1 |
| García, MJ | 1 |
| Martínez-Frías, ML | 1 |
| Pandya, NA | 1 |
| Jani, BR | 1 |
| Holladay, SD | 1 |
| Sharova, L | 1 |
| Smith, BJ | 1 |
| Gogal, RM | 1 |
| Ward, DL | 1 |
| Blaylock, BL | 1 |
| Kozma, C | 1 |
3 reviews available for valproic acid and Congenital Limb Deformities
| Article | Year |
|---|---|
Teratogen-induced limb defects.
Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin | 2002 |
The teratogenic effects of valproic acid in human chondrogenesis in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Cartilage; Cell Aggregation; Cell Differentiation; Cells, Cult | 1994 |
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Face; Female | 2001 |
10 other studies available for valproic acid and Congenital Limb Deformities
| Article | Year |
|---|---|
Radial Ray Malformation.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Amniocentesis; Amniotic Band Syndrome; Anal Ca | 2019 |
Tibial developmental field defect in valproic acid embryopathy: Report on three cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Comparative Genomic Hybridization; Female; Fetal Disease | 2010 |
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniosynostoses; Fatal Outcome; Female; Heart | 2011 |
Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs.
Topics: Animals; Blotting, Western; Cells, Cultured; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; Do | 2013 |
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases | 2006 |
Preaxial ray reduction defects as part of valproic acid embryofetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Therapeutic; Adolescent; Adult; Extr | 1993 |
Fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Human | 1995 |
Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study.
Topics: Anticonvulsants; Case-Control Studies; Female; Humans; Infant; Infant, Newborn; Limb Deformities, Co | 2000 |
Post-axial limb defects with maternal sodium valproate exposure.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Infant; Limb Deformities, Congenital; | 2000 |
Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; BCG Vaccine; | 2000 |