valproic acid has been researched along with Conduct Disorder in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Conduct Disorder: A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Children whose aggressive behavior persisted at the conclusion of the lead-in phase were randomly assigned to receive double-blind, flexibly dosed divalproex or a placebo adjunctive to stimulant for 8 weeks." | 2.74 | Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. ( Blader, JC; Jensen, PS; Kafantaris, V; Pliszka, SR; Schooler, NR, 2009) |
| "Twelve had PTSD." | 2.73 | Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial. ( Carrion, V; Chang, K; Khanzode, LA; Saxena, KS; Silverman, M; Steiner, H, 2007) |
| "New treatments for conduct disorder are sorely needed." | 2.71 | Divalproex sodium for the treatment of conduct disorder: a randomized controlled clinical trial. ( Ford, S; Matthews, Z; Petersen, ML; Saxena, K; Steiner, H, 2003) |
| "Successful treatment of conduct disorder remains difficult." | 2.71 | Baseline predictors of response to divalproex in conduct disorder. ( Chang, K; Khanzode, L; Saxena, K; Silverman, MA; Steiner, H, 2005) |
| "All patients met DSM-IV criteria for a disruptive behavior disorder (oppositional defiant disorder of conduct disorder) in addition to research criteria." | 1.32 | "Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder? ( Donovan, SJ; Jensen, PS; Klein, DF; Nunes, EV; Quitkin, FM; Ross, D; Stewart, JW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blader, JC | 1 |
| Schooler, NR | 1 |
| Jensen, PS | 2 |
| Pliszka, SR | 1 |
| Kafantaris, V | 1 |
| Steiner, H | 6 |
| Karnik, NS | 1 |
| Padhy, R | 1 |
| Saxena, K | 4 |
| Remsing, L | 1 |
| Huemer, J | 1 |
| Plattner, B | 1 |
| Levy, T | 1 |
| Bloch, Y | 1 |
| Gérardin, P | 1 |
| Cohen, D | 1 |
| Mazet, P | 1 |
| Flament, MF | 1 |
| Donovan, SJ | 1 |
| Nunes, EV | 1 |
| Stewart, JW | 1 |
| Ross, D | 1 |
| Quitkin, FM | 1 |
| Klein, DF | 1 |
| Petersen, ML | 1 |
| Ford, S | 1 |
| Matthews, Z | 1 |
| Silverman, MA | 1 |
| Chang, K | 3 |
| Khanzode, L | 1 |
| Sugden, SG | 1 |
| Kile, SJ | 1 |
| Farrimond, DD | 1 |
| Hilty, DM | 1 |
| Bourgeois, JA | 1 |
| Khanzode, LA | 2 |
| Kraemer, H | 1 |
| Saxena, KS | 1 |
| Carrion, V | 1 |
| Silverman, M | 1 |
| Barinaga, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind, Placebo-Controlled Trial of Flexible Dose Divalproex Sodium Adjunctive to Stimulant Treatment for Aggressive Children With Attention-Deficit Hyperactivity Disorder[NCT00228046] | Phase 4 | 40 participants (Anticipated) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Conduct Disorder
| Article | Year |
|---|---|
[Pharmacotherapy for conduct disorder in children and adolescents].
Topics: Adolescent; Aggression; Anticoagulants; Antimanic Agents; Antipsychotic Agents; Attention Deficit Di | 2012 |
6 trials available for valproic acid and Conduct Disorder
| Article | Year |
|---|---|
Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy.
Topics: Adolescent; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Atten | 2009 |
Symptomatic response to divalproex in subtypes of conduct disorder.
Topics: Adolescent; Aggression; Antimanic Agents; Conduct Disorder; Double-Blind Method; Humans; Male; Self | 2011 |
Divalproex sodium for the treatment of conduct disorder: a randomized controlled clinical trial.
Topics: Adolescent; Aggression; Anger; Anticonvulsants; Arousal; Conduct Disorder; Crime; Dose-Response Rela | 2003 |
Baseline predictors of response to divalproex in conduct disorder.
Topics: Adaptation, Psychological; Adolescent; Anticonvulsants; Comorbidity; Conduct Disorder; Defense Mecha | 2005 |
Efficacy profiles of psychopharmacology: divalproex sodium in conduct disorder.
Topics: Adolescent; Antidepressive Agents; Conduct Disorder; Double-Blind Method; Female; Humans; Male; Soci | 2006 |
Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial.
Topics: Adolescent; Anticonvulsants; Comorbidity; Conduct Disorder; Dose-Response Relationship, Drug; Double | 2007 |
5 other studies available for valproic acid and Conduct Disorder
| Article | Year |
|---|---|
Integrated treatment of aggression in the context of ADHD in children refractory to stimulant monotherapy: a window into the future of child psychopharmacology.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimul | 2009 |
Drug treatment of conduct disorder in young people.
Topics: Adolescent; Adrenergic alpha-Agonists; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Central | 2002 |
"Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder?
Topics: Adolescent; Adult; Age Factors; Aggression; Anticonvulsants; Attention Deficit and Disruptive Behavi | 2003 |
Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury.
Topics: Adult; Aggression; Amantadine; Cognition Disorders; Conduct Disorder; Donepezil; Frontal Lobe; Human | 2006 |
Research risks. California probes prison teens study.
Topics: Adolescent; California; Clinical Trials as Topic; Conduct Disorder; Ethics Committees, Research; Gov | 1999 |