valproic acid has been researched along with Concussive Convulsion in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a first-line antiepileptic drug, though its metabolism is affected by genetic polymorphisms and varies between individuals." | 1.46 | Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury. ( Hu, J; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2017) |
| "Some authors suggest that most impact seizures are non-epileptic in origin and hence coined the term "concussive convulsions" for benign impact seizures." | 1.37 | [Concussive convulsions: seizure or no seizure?]. ( Burghaus, L; Elger, CE; Fink, GR; Nass, RD, 2011) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, SJ | 1 |
| Park, E | 1 |
| Baker, A | 1 |
| Reid, AY | 1 |
| Sun, Y | 1 |
| Yu, J | 1 |
| Yuan, Q | 1 |
| Wu, X | 2 |
| Hu, J | 1 |
| Boussaadani Soubai, R | 1 |
| Lahlou, M | 1 |
| Tahiri, L | 1 |
| Rabhi, S | 1 |
| Harzy, T | 1 |
| Bono, W | 1 |
| Seidahmed, MZ | 1 |
| Miqdad, AM | 1 |
| Al-Dohami, HS | 1 |
| Shareefi, OM | 1 |
| Ma, CY | 1 |
| Xue, YJ | 1 |
| Li, M | 1 |
| Zhang, Y | 1 |
| Li, GZ | 1 |
| Nass, RD | 1 |
| Elger, CE | 1 |
| Fink, GR | 1 |
| Burghaus, L | 1 |
| Brownstone, E | 1 |
| Voigtländer, T | 1 |
| Baumhackl, U | 1 |
| Finsterer, J | 1 |
| Benardo, LS | 1 |
| McCall, M | 1 |
| Bourgeois, JA | 1 |
| Mauz, PS | 1 |
| Mörike, K | 1 |
| Kaiserling, E | 1 |
| Brosch, S | 1 |
| Schmidt, D | 1 |
| Lancman, ME | 1 |
| Asconapé, JJ | 1 |
| Walker, F | 1 |
| Guieu, R | 1 |
| Mesdjian, E | 1 |
| Rochat, H | 1 |
| Roger, J | 1 |
| Kudoh, A | 1 |
| Matsuki, A | 1 |
1 review available for valproic acid and Concussive Convulsion
| Article | Year |
|---|---|
Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Epi | 2003 |
13 other studies available for valproic acid and Concussive Convulsion
| Article | Year |
|---|---|
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista | 2021 |
Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries, Traumatic; Case-Control Studies; Cytochrome P-450 CYP2 | 2017 |
Valproate-induced systemic lupus erythematous: A case report.
Topics: Anticonvulsants; Epilepsy, Post-Traumatic; Female; Humans; Lupus Erythematosus, Systemic; Middle Age | 2013 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy, Post-Traumatic; Female; Fetus; Humans; Infant; P | 2009 |
Sodium valproate for prevention of early posttraumatic seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Injuries; Epilepsy, Post-Traumatic; Female; Humans; | 2010 |
[Concussive convulsions: seizure or no seizure?].
Topics: Adult; Anticonvulsants; Brain; Brain Concussion; Electroencephalography; Epilepsy, Post-Traumatic; E | 2011 |
Epilepsy in adult X-linked adrenoleucodystrophy due to the deletion c.1415-1416delAG in exon 5 of the ABCD1-gene.
Topics: Adrenoleukodystrophy; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP- | 2013 |
Valproic acid-induced hyperammonemia: a case report.
Topics: Ammonia; Anticonvulsants; Blood Urea Nitrogen; Consciousness Disorders; Diagnosis, Differential; Dru | 2004 |
Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects.
Topics: Adult; Anticonvulsants; Biopsy; Chronic Disease; Diagnosis, Differential; Epilepsy, Post-Traumatic; | 2005 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Acetazolamide appears effective in the management of valproate-induced tremor.
Topics: Acetazolamide; Drug Therapy, Combination; Epilepsy, Post-Traumatic; Humans; Male; Middle Aged; Motor | 1994 |
Central analgesic effect of valproate in patients with epilepsy.
Topics: Adolescent; Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Electric Stimulati | 1993 |
Current perception thresholds of epileptic patients treated with valproate.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Epilepsy, Post-Traumatic; Humans | 2000 |