valproic acid has been researched along with Complex Partial Epilepsy in 49 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 7.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| "A 42-year-old man with human immunodeficiency virus (HIV) infection and a history of complex partial seizures developed severe anemia after the addition of valproic acid to his stable antiretroviral regimen of zidovudine, lamivudine, and abacavir." | 7.72 | Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid. ( Antoniou, T; Arbess, G; Gough, K; Yoong, D, 2004) |
| "Three weeks after diagnosis of nonconvulsive status epilepticus, general anesthesia was induced with propofol and titrated to burst suppression on the electroencephalogram (EEG)." | 7.70 | Treatment of refractory complex-partial status epilepticus with propofol: case report. ( Begemann, M; Rowan, AJ; Tuhrim, S, 2000) |
| "To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma." | 4.78 | Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993) |
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 3.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| "A 42-year-old man with human immunodeficiency virus (HIV) infection and a history of complex partial seizures developed severe anemia after the addition of valproic acid to his stable antiretroviral regimen of zidovudine, lamivudine, and abacavir." | 3.72 | Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid. ( Antoniou, T; Arbess, G; Gough, K; Yoong, D, 2004) |
| "Three weeks after diagnosis of nonconvulsive status epilepticus, general anesthesia was induced with propofol and titrated to burst suppression on the electroencephalogram (EEG)." | 3.70 | Treatment of refractory complex-partial status epilepticus with propofol: case report. ( Begemann, M; Rowan, AJ; Tuhrim, S, 2000) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "A 32-year-old man with mental retardation and uncontrolled complex partial epilepsy receiving carbamazepine (CBZ) and divalproex sodium (VPA), developed frequent episodes of forced upward gaze after increase in the daily VPA dosage." | 3.69 | Oculogyric crisis induced by carbamazepine. ( Barkley, GL; Gorman, M, 1995) |
| "Lamotrigine or placebo was added to the patients' existing antiepileptic drugs (AEDs)." | 2.68 | Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures. ( Boas, J; Dam, M; Friis, ML; Gallagher, J; Kristensen, O; Pedersen, B, 1996) |
| "Tiagabine was well tolerated." | 2.68 | A single-dose study to define tiagabine pharmacokinetics in pediatric patients with complex partial seizures. ( Boellner, SW; el-Shourbagy, T; Granneman, GR; Guenther, HJ; Gustavson, LE; Qian, JX; Sommerville, KW, 1997) |
| "Carbamazepine was also superior according to a composite score that combined scores for the control of seizures and for adverse effects (P less than 0." | 2.67 | A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. ( Collins, JF; Cramer, JA; Mattson, RH, 1992) |
| "The 6-Hz psychomotor seizure induced ultra-structural changes in both cortex and hippocampus in mice treated with PCPA." | 1.51 | Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice. ( Jahan, K; Pillai, KK; Vohora, D, 2019) |
| "There are several reports describing population pharmacokinetic (PPK) models of valproic acid (VPA)." | 1.42 | Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen. ( Guo, XZ; Huang, PF; Jiao, Z; Lin, WW; Liu, YW; Ma, CL; Wang, CL; Wang, HY, 2015) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED); however, its use is limited by two life-threatening side effects: teratogenicity and hepatotoxicity." | 1.34 | Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. ( Bialer, M; Finnell, RH; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2007) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "Carbamazepine was the most commonly used AED in 71." | 1.31 | Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring. ( Chen, C; Guo, YC; Kwan, SY; Liu, LT; Shih, YH; Yen, DJ; Yiu, CH; Yu, HY, 2001) |
| "We describe a 27-year-old woman who developed encephalopathy and cerebral edema during treatment of refractory complex partial seizures that included acute administration of valproate (VPA) at a dosage of 35 mg/kg per day." | 1.30 | Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. ( Bunch, TS; Cibula, J; Gilmore, RL; Harman, E; Millington, DS; Triggs, WJ, 1997) |
| "Ornithine transcarbamylase deficiency is an X linked disorder and the most common inherited cause of hyperammonaemia." | 1.30 | Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. ( Kohlschütter, A; Oechsner, M; Steen, C; Stürenburg, HJ, 1998) |
| " Despite methodologic limitations in the nonrandomized treatment sequence, these findings suggest that VPA and LTG exhibit a favorable pharmacodynamic interaction in patients with refractory partial epilepsy." | 1.30 | The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. ( Di Perri, R; Oteri, G; Perucca, E; Pisani, F; Richens, A; Russo, MF, 1999) |
| "Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level." | 1.28 | Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin. ( Hanson, SK; Lin, SN; Rhead, WJ; Roe, CR; Triggs, WJ; Willmore, LJ, 1992) |
| "Carbamazepine was the antiepileptic drug prescribed most frequently followed by valproic acid." | 1.28 | [The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (51.02) | 18.2507 |
| 2000's | 16 (32.65) | 29.6817 |
| 2010's | 8 (16.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimshoni, JA | 1 |
| Bialer, M | 1 |
| Wlodarczyk, B | 1 |
| Finnell, RH | 1 |
| Yagen, B | 1 |
| Luszczki, JJ | 1 |
| Patrzylas, P | 1 |
| Zagaja, M | 1 |
| Andres-Mach, M | 1 |
| Zaluska, K | 1 |
| Kondrat-Wrobel, MW | 1 |
| Szpringer, M | 1 |
| Chmielewski, J | 1 |
| Florek-Luszczki, M | 1 |
| Recena Pérez, P | 1 |
| Leizaola Irigoyen, O | 1 |
| Antuña Braña, MT | 1 |
| Jahan, K | 1 |
| Pillai, KK | 1 |
| Vohora, D | 1 |
| Tanaka, S | 1 |
| Tanaka, T | 1 |
| Lin, WW | 1 |
| Jiao, Z | 1 |
| Wang, CL | 1 |
| Wang, HY | 1 |
| Ma, CL | 1 |
| Huang, PF | 1 |
| Guo, XZ | 1 |
| Liu, YW | 1 |
| Fujiwara, A | 1 |
| Watanabe, Y | 1 |
| Takechi, K | 1 |
| Ishikawa, T | 1 |
| Kaida, Y | 1 |
| Akagi, M | 1 |
| Kamei, C | 1 |
| Rosenzweig, I | 1 |
| Valentin, A | 1 |
| Brex, PA | 1 |
| Elwes, RD | 1 |
| Alarcon, G | 1 |
| Kim, SE | 1 |
| Park, KM | 1 |
| Kim, SH | 1 |
| Kwon, OY | 1 |
| No, SK | 1 |
| Calabrò, RS | 1 |
| Italiano, D | 1 |
| Militi, D | 1 |
| Bramanti, P | 1 |
| Birnbaum, AK | 1 |
| Kriel, RL | 1 |
| Norberg, SK | 1 |
| Wical, BS | 1 |
| Le, DN | 1 |
| Leppik, IE | 1 |
| Cloyd, JC | 1 |
| Antoniou, T | 1 |
| Gough, K | 1 |
| Yoong, D | 1 |
| Arbess, G | 1 |
| Hashim, N | 1 |
| Bandara, D | 1 |
| Tan, E | 1 |
| Ilchyshyn, A | 1 |
| Verrotti, A | 1 |
| Latini, G | 1 |
| Giannuzzi, R | 1 |
| Cutarella, R | 1 |
| Trotta, D | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Sheen, VL | 1 |
| Basel-Vanagaite, L | 1 |
| Goodman, JR | 1 |
| Scheffer, IE | 1 |
| Bodell, A | 1 |
| Ganesh, VS | 1 |
| Ravenscroft, R | 1 |
| Hill, RS | 1 |
| Cherry, TJ | 1 |
| Shugart, YY | 1 |
| Barkovich, J | 1 |
| Straussberg, R | 1 |
| Walsh, CA | 1 |
| Mueller, TH | 1 |
| Beeber, AR | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Gerstner, T | 1 |
| Lipinski, C | 1 |
| Longin, E | 1 |
| König, S | 1 |
| Gorman, M | 1 |
| Barkley, GL | 1 |
| Helmstaedter, C | 1 |
| Wagner, G | 1 |
| Elger, CE | 1 |
| de Romanis, F | 1 |
| Sopranzi, N | 1 |
| Kulick, SK | 1 |
| Kramer, DA | 1 |
| Pierce, MW | 1 |
| Shu, VS | 1 |
| Duarte, J | 1 |
| Macias, S | 1 |
| Coria, F | 1 |
| Fernandez, E | 1 |
| Clavería, LE | 1 |
| Reynolds, EH | 1 |
| Heller, AJ | 1 |
| Chadwick, D | 1 |
| Johnson, T | 1 |
| Monfort, JC | 1 |
| Willmore, LJ | 2 |
| Shu, V | 1 |
| Wallin, B | 1 |
| Mackenzie, RA | 1 |
| Boas, J | 1 |
| Dam, M | 1 |
| Friis, ML | 1 |
| Kristensen, O | 1 |
| Pedersen, B | 1 |
| Gallagher, J | 1 |
| Gustavson, LE | 1 |
| Boellner, SW | 1 |
| Granneman, GR | 1 |
| Qian, JX | 1 |
| Guenther, HJ | 1 |
| el-Shourbagy, T | 1 |
| Sommerville, KW | 1 |
| Triggs, WJ | 2 |
| Gilmore, RL | 1 |
| Millington, DS | 1 |
| Cibula, J | 1 |
| Bunch, TS | 1 |
| Harman, E | 1 |
| Oechsner, M | 1 |
| Steen, C | 1 |
| Stürenburg, HJ | 1 |
| Kohlschütter, A | 1 |
| Vaquerizo, J | 1 |
| Romero-Rodríguez, JC | 1 |
| González-Roncero, A | 1 |
| Gómez-Marcos, A | 1 |
| Petroff, OA | 1 |
| Rothman, DL | 1 |
| Behar, KL | 1 |
| Hyder, F | 1 |
| Mattson, RH | 2 |
| López, L | 1 |
| Thomson, A | 1 |
| Rabinowicz, AL | 1 |
| Gatzonis, S | 1 |
| Laiaki, A | 1 |
| Chioni, A | 1 |
| Siafakas, A | 1 |
| Zournas, C | 1 |
| Mantouvalos, V | 1 |
| Hamer, HM | 1 |
| Morris, HH | 1 |
| Pisani, F | 1 |
| Oteri, G | 1 |
| Russo, MF | 1 |
| Di Perri, R | 1 |
| Perucca, E | 1 |
| Richens, A | 1 |
| Begemann, M | 1 |
| Rowan, AJ | 1 |
| Tuhrim, S | 1 |
| Fayad, M | 1 |
| Choueiri, R | 1 |
| Mikati, M | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| Voigtländer, A | 1 |
| Gmünd, S | 1 |
| Yen, DJ | 1 |
| Chen, C | 1 |
| Shih, YH | 1 |
| Guo, YC | 1 |
| Liu, LT | 1 |
| Yu, HY | 1 |
| Kwan, SY | 1 |
| Yiu, CH | 1 |
| Sbei, M | 1 |
| Campellone, JV | 1 |
| Cramer, JA | 1 |
| Collins, JF | 1 |
| Shirasaka, Y | 1 |
| Ito, M | 1 |
| Okuno, T | 1 |
| Fujii, T | 1 |
| Nozaki, K | 1 |
| Mikawa, H | 1 |
| Roe, CR | 1 |
| Rhead, WJ | 1 |
| Hanson, SK | 1 |
| Lin, SN | 1 |
| Fröscher, W | 1 |
| Herrmann, R | 1 |
| Niesen, M | 1 |
| Bülau, P | 1 |
| Penin, H | 1 |
| Hildenbrand, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
3 reviews available for valproic acid and Complex Partial Epilepsy
| Article | Year |
|---|---|
Complete heart block by lacosamide.
Topics: Aged; Anticonvulsants; Atrioventricular Block; Bacterial Infections; Clonazepam; Epilepsy, Complex P | 2018 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combinati | 1993 |
Valproate-induced coma: case report and literature review.
Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val | 1993 |
8 trials available for valproic acid and Complex Partial Epilepsy
| Article | Year |
|---|---|
Factors associated with poor control in partial complex epilepsy.
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp | 2004 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; | 1994 |
Valproate versus carbamazepine for seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Complex Partial; Epile | 1993 |
Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures. The M88-194 Study Group.
Topics: Anticonvulsants; Double-Blind Method; Electroencephalography; Epilepsy, Complex Partial; Humans; Mul | 1996 |
Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Epilepsy, Complex Parti | 1996 |
A single-dose study to define tiagabine pharmacokinetics in pediatric patients with complex partial seizures.
Topics: Anticonvulsants; Body Constitution; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy, Co | 1997 |
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.
Topics: Adult; Ammonia; Anticonvulsants; Astrocytes; Epilepsy, Complex Partial; Female; gamma-Aminobutyric A | 1999 |
A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.
Topics: Adolescent; Adult; Aged; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Epilepsy, To | 1992 |
38 other studies available for valproic acid and Complex Partial Epilepsy
| Article | Year |
|---|---|
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy, Complex Partial; Mice; Rats; Stereo | 2007 |
Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Benzodiazepines; Clobaz | 2017 |
Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Epilepsy, | 2019 |
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epilepsies, Partial; E | 2013 |
Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Asian People; Chemistry, Pharmaceutical; Delay | 2015 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Face-related ictal hallucinations and illusions and reflex-type phenomena.
Topics: Adult; Anticonvulsants; Cerebral Cortex; Electroencephalography; Epilepsy, Complex Partial; Face; Fe | 2009 |
Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Complex | 2010 |
Levetiracetam-associated loss of libido and anhedonia.
Topics: Adult; Anhedonia; Anticonvulsants; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, C | 2012 |
Rapid infusion of sodium valproate in acutely ill children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru | 2003 |
Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid.
Topics: Anemia; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Interaction | 2004 |
Early cyclosporine treatment of incipient toxic epidermal necrolysis induced by concomitant use of lamotrigine and sodium valproate.
Topics: Adult; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Epilepsy, Comp | 2004 |
Etiological heterogeneity of familial periventricular heterotopia and hydrocephalus.
Topics: Adult; Anticonvulsants; Blotting, Western; Brain; Child; Child, Preschool; Choristoma; Contractile P | 2004 |
Delirium from valproic acid with lamotrigine.
Topics: Anticonvulsants; Delirium; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; | 2004 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Valproate-induced change in hair color.
Topics: Child; Epilepsy, Complex Partial; Hair Color; Humans; Male; Valproic Acid | 2008 |
Oculogyric crisis induced by carbamazepine.
Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy, Complex Partial; Fixation, Ocular; Humans | 1995 |
Differential effects of first antiepileptic drug application on cognition in lesional and non-lesional patients with epilepsy.
Topics: Attention; Brain Damage, Chronic; Carbamazepine; Cognition Disorders; Electroencephalography; Epilep | 1993 |
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.
Topics: Adult; Ammonia; Epilepsy, Complex Partial; Humans; Male; Metabolic Diseases; Valproic Acid | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Carbamazepine; Data Interpretation, Statistical; Epilepsies, Partial; Epilepsy, Complex Partial; Hum | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Carbamazepine; Epilepsy, Complex Partial; Humans; Valproic Acid | 1993 |
Examining the role of vigabatrin.
Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Complex Partial; gamma-Aminobutyri | 1996 |
Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.
Topics: Adult; Anticonvulsants; Brain Edema; Carnitine; Epilepsy, Complex Partial; Fatal Outcome; Female; Hu | 1997 |
Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Diseases, Metaboli | 1998 |
[Partial complex status epilepticus: diagnostic difficulties].
Topics: Anticonvulsants; Child; Crime; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog | 1998 |
Assessment of colour vision in epileptic patients exposed to single-drug therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Color Perception; Color Vision Defects; Dip | 1999 |
A case of fever following antiepileptic treatment.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epile | 1999 |
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens | 1999 |
The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; Fem | 1999 |
Treatment of refractory complex-partial status epilepticus with propofol: case report.
Topics: Aged; Anticonvulsants; Drug Interactions; Drug Resistance, Multiple; Electroencephalography; Epileps | 2000 |
Fatality from hepatitis A in a child taking valproate.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy, Complex Partial; Fatal Outcome; Hepatitis A; Hepati | 2000 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
[Undiagnosed complex focal epilepsy as the cause of a depressive syndrome].
Topics: Abdominal Pain; Aged; Anticonvulsants; Depressive Disorder, Major; Diagnosis, Differential; Epilepsy | 2000 |
Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial | 2001 |
Stupor from lamotrigine toxicity.
Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle | 2001 |
Ring 14 chromosome with complex partial seizures: a case report.
Topics: Child; Chromosomes, Human, Pair 14; Electroencephalography; Epilepsy, Complex Partial; Female; Human | 1992 |
Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin.
Topics: Acids; Adult; Coma; Electron-Transferring Flavoproteins; Epilepsy, Complex Partial; Fatty Acid Desat | 1992 |
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin | 1991 |