valproic acid has been researched along with Complex IV Deficiency in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment." | 1.51 | ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019) |
| "Valproate-induced Fanconi syndrome is a rare adverse effect of valproate." | 1.40 | Fever of unknown origin as the initial manifestation of valproate-induced Fanconi syndrome. ( Fujii, T; Kumada, T; Kusunoki, T; Murayama, K; Nozaki, F; Ohtake, A, 2014) |
| "We report a 3 year-old girl with a myoclonic epilepsy." | 1.29 | Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency. ( Chabrol, B; Chretien, D; Mancini, J; Munnich, A; Pinsard, N; Rustin, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kwong, AK | 1 |
| Chu, VL | 1 |
| Rodenburg, RJT | 1 |
| Smeitink, J | 1 |
| Fung, CW | 1 |
| Nozaki, F | 1 |
| Kumada, T | 1 |
| Kusunoki, T | 1 |
| Fujii, T | 1 |
| Murayama, K | 1 |
| Ohtake, A | 1 |
| Ponchaut, S | 2 |
| Van Hoof, F | 2 |
| Veitch, K | 2 |
| Chabrol, B | 1 |
| Mancini, J | 1 |
| Chretien, D | 1 |
| Rustin, P | 1 |
| Munnich, A | 1 |
| Pinsard, N | 1 |
5 other studies available for valproic acid and Complex IV Deficiency
| Article | Year |
|---|---|
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps | 2019 |
Fever of unknown origin as the initial manifestation of valproate-induced Fanconi syndrome.
Topics: Adolescent; Cytochrome-c Oxidase Deficiency; Enzyme Inhibitors; Fanconi Syndrome; Fever of Unknown O | 2014 |
Valproate and cytochrome c oxidase deficiency.
Topics: Animals; Child, Preschool; Cytochrome-c Oxidase Deficiency; Female; Humans; Liver Failure; Mitochond | 1995 |
Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency.
Topics: Amino Acids; Child, Preschool; Chromatography, Gas; Cytochrome-c Oxidase Deficiency; Epilepsies, Myo | 1994 |
Cytochrome aa3 depletion is the cause of the deficient mitochondrial respiration induced by chronic valproate administration.
Topics: Animals; Citrate (si)-Synthase; Cytochrome-c Oxidase Deficiency; Electron Transport Complex IV; Glut | 1992 |