valproic acid has been researched along with Coma in 54 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report the case of a patient who developed hyperammonemia and coma during therapy with valproic acid for affective disorder." | 7.70 | Hyperammonemia and coma developed by a woman treated with valproic acid for affective disorder. ( Donley, B; Eze, E; Workman, M, 1998) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 7.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 7.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "We present a case of hyperammonaemic coma precipitated by sodium valproate use for symptomatic epilepsy in a patient with unrecognised portosystemic shunt, secondary to earlier alcoholism." | 5.39 | Valproic acid-induced hyperammonaemic coma and unrecognised portosystemic shunt. ( Basilio, C; Carrapatoso, L; Ferreira, F; Nzwalo, H, 2013) |
| "A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase." | 5.33 | Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005) |
| "He presented coma requiring tracheal intubation and mechanical ventilation at 11 hours and central diabetes insipidus." | 5.33 | [Transient central diabetes insipidus during a valproic acid poisoning]. ( Corne, P; Jonquet, O; Lemaire, X, 2006) |
| "Both patients had ketosis and adipic aciduria." | 5.28 | Valproate-induced coma with ketosis and carnitine insufficiency. ( Bohan, TP; Lin, SN; Triggs, WJ; Willmore, LJ, 1990) |
| "To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma." | 4.78 | Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993) |
| ", drowsiness, coma) were selected for treatment with l-arginine." | 3.85 | L-Arginine in the treatment of valproate overdose - five clinical cases. ( Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V, 2017) |
| "Magnetic resonance (MR) multimodality evoked potentials (MEPs) and clinical findings were correlated in a 47-year-old epileptic man in whom parenteral valproic acid (VPA) therapy induced severe comatose hyperammonemic encephalopathy without biological signs of hepatotoxicity (or hepatocytic dysfunction)." | 3.73 | Comparison of clinical, magnetic resonance and evoked potentials data in a case of valproic-acid-related hyperammonemic coma. ( Duprez, T; Grandin, C; Guérit, JM; Hantson, P; Nassogne, MC, 2005) |
| "The authors report the case of a patient who developed hyperammonemia and coma during therapy with valproic acid for affective disorder." | 3.70 | Hyperammonemia and coma developed by a woman treated with valproic acid for affective disorder. ( Donley, B; Eze, E; Workman, M, 1998) |
| "A 31-y-old epileptic man developed coma and shock after suicidally ingesting large amounts of valproic acid and gabapentin." | 3.69 | Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning. ( Brady, LA; Do, SM; Fernandez, MC; Kloster, JC; Prosnitz, EH; Ruffenach, SJ; Salmon, JV; Villarin, A; Walter, FG, 1996) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 3.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "A case of severe valproic acid poisoning with coma and insufficient respiration is reported." | 3.67 | Electroencephalographic alterations during intoxication with sodium valproate: a case report. ( Juul-Jensen, P; Pedersen, B, 1984) |
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 3.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "A case of valproic acid poisoning with coma and neurological sequelae is presented." | 3.67 | Neurological sequelae after intoxication with sodium valproate. ( Bigler, D, 1985) |
| "The diagnoses of hepatic encephalopathy was confirmed." | 2.55 | Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review. ( Gao, L; Guo, X; Wei, J; Xing, B; Xu, Z, 2017) |
| "After cardiac arrest, the impact of AEDs may depend on the presence of continuous cortical background activity." | 1.51 | Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest. ( Baldwin, MA; Callaway, CW; Coppler, PJ; Elmer, J; Kvaløy, JT; Solanki, P, 2019) |
| "We present a case of hyperammonaemic coma precipitated by sodium valproate use for symptomatic epilepsy in a patient with unrecognised portosystemic shunt, secondary to earlier alcoholism." | 1.39 | Valproic acid-induced hyperammonaemic coma and unrecognised portosystemic shunt. ( Basilio, C; Carrapatoso, L; Ferreira, F; Nzwalo, H, 2013) |
| "Impaired consciousness or coma can occur in such patients." | 1.37 | Basilar-type migraine with coma: case reports and literature review. ( Li, Q; Tan, G; Zhou, J, 2011) |
| "A 32-year-old comatose woman was admitted to the ICU at our hospital; she suffered from hypotension, respiratory depression, hypoglycaemia, sinus bradycardia, hyperammonaemia, metabolic acidosis, and her core body temperature was 33." | 1.35 | Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination. ( Meulenbelt, J; Sikma, MA; van den Broek, MP; Ververs, TF, 2009) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase." | 1.33 | Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005) |
| "He presented coma requiring tracheal intubation and mechanical ventilation at 11 hours and central diabetes insipidus." | 1.33 | [Transient central diabetes insipidus during a valproic acid poisoning]. ( Corne, P; Jonquet, O; Lemaire, X, 2006) |
| "Valproic acid induced coma was likely related to a urea cycle enzymopathy." | 1.32 | Ammonia induced encephalopathy from valproic acid in a bipolar patient: case report. ( Elgudin, L; Hall, Y; Schubert, D, 2003) |
| " At the time of deterioration, serum valproate was at toxic level in the three reported cases." | 1.32 | Delayed toxicity following acute ingestion of valpromide. ( Descotes, J; Frantz, P; Martin, O; Moulsma, M; Parant, F; Payen, C; Pulce, C, 2004) |
| "The onset of coma may have been related to inhibition of beta-oxidation in the mitochondria, which was reversible by elimination of plasma VPA by DHP." | 1.30 | Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication. ( Kuhara, T; Maeyama, R; Matsumoto, I; Matsumoto, J; Ogawa, H; Okudaira, K; Shinka, T, 1997) |
| "The patients were comatose for 6 and 7 days and required mechanical ventilation for 7 and 10 days." | 1.29 | Life threatening intoxication with sodium valproate. ( Andersen, GO; Ritland, S, 1995) |
| " All these patients were receiving the usual dosage (1000 to 1500 mg per day) of Valproic acid (VPA)." | 1.29 | Impairment of consciousness induced by valproate treatment following neurosurgical operation. ( Baulac, M; de Billy, A; Durand, G; Landau, J; Philippon, J, 1993) |
| "Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level." | 1.28 | Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin. ( Hanson, SK; Lin, SN; Rhead, WJ; Roe, CR; Triggs, WJ; Willmore, LJ, 1992) |
| "Both patients had ketosis and adipic aciduria." | 1.28 | Valproate-induced coma with ketosis and carnitine insufficiency. ( Bohan, TP; Lin, SN; Triggs, WJ; Willmore, LJ, 1990) |
| "Stupor and coma were produced in mice by the intraperitoneal injection of sodium valproate at a dose of 600 mg/kg." | 1.27 | Sodium valproate and brainstem energetics. ( Looney, G; McCandless, DW, 1985) |
| "Cerebral coma, which lasted for twenty hrs, was followed by an undisturbed period of approximately sixteen hrs." | 1.27 | Acute valproate intoxication with fatal outcome in an infant. ( Janssen, F; Rambeck, B; Schnabel, R, 1985) |
| "7 cases of stuporous states or coma induced in epileptic subjects by the rapid administration of high doses of sodium valproate are described." | 1.26 | Stuporous states or coma induced by the rapid administration of high doses of sodium valproate. ( Gastaut, H; Iemolo, F, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (20.37) | 18.7374 |
| 1990's | 16 (29.63) | 18.2507 |
| 2000's | 16 (29.63) | 29.6817 |
| 2010's | 10 (18.52) | 24.3611 |
| 2020's | 1 (1.85) | 2.80 |
| Authors | Studies |
|---|---|
| Boels, D | 1 |
| Mégarbane, B | 1 |
| Bouquié, R | 1 |
| Guo, X | 1 |
| Wei, J | 1 |
| Gao, L | 1 |
| Xing, B | 1 |
| Xu, Z | 1 |
| Ge, Y | 1 |
| Xu, B | 1 |
| Zhu, S | 1 |
| Li, C | 1 |
| He, Q | 1 |
| Zhu, T | 1 |
| Fan, R | 1 |
| Gong, D | 1 |
| Diaz-Rangel, M | 1 |
| Grande-Martin, A | 1 |
| Monsalve-Naharro, JA | 1 |
| Domingo-Chiva, E | 1 |
| Cuesta-Montero, P | 1 |
| Lopez-Perez, A | 1 |
| Solanki, P | 1 |
| Coppler, PJ | 1 |
| Kvaløy, JT | 1 |
| Baldwin, MA | 1 |
| Callaway, CW | 1 |
| Elmer, J | 1 |
| Nzwalo, H | 1 |
| Carrapatoso, L | 1 |
| Ferreira, F | 1 |
| Basilio, C | 1 |
| Schrettl, V | 1 |
| Felgenhauer, N | 1 |
| Rabe, C | 1 |
| Fernando, M | 1 |
| Eyer, F | 1 |
| van den Broek, MP | 1 |
| Sikma, MA | 2 |
| Ververs, TF | 1 |
| Meulenbelt, J | 2 |
| Rupasinghe, J | 1 |
| Jasinarachchi, M | 1 |
| Li, Q | 1 |
| Tan, G | 1 |
| Zhou, J | 1 |
| Ray, S | 1 |
| Skellett, S | 1 |
| Kesav, P | 1 |
| V Y, V | 1 |
| Khurana, D | 1 |
| LoVecchio, F | 1 |
| Thole, D | 1 |
| Bagnasco, T | 1 |
| Elgudin, L | 1 |
| Hall, Y | 1 |
| Schubert, D | 1 |
| Payen, C | 1 |
| Frantz, P | 1 |
| Martin, O | 1 |
| Parant, F | 1 |
| Moulsma, M | 1 |
| Pulce, C | 1 |
| Descotes, J | 1 |
| Hantson, P | 1 |
| Grandin, C | 1 |
| Duprez, T | 1 |
| Nassogne, MC | 1 |
| Guérit, JM | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Cuturic, M | 1 |
| Abramson, RK | 1 |
| Lemaire, X | 1 |
| Corne, P | 1 |
| Jonquet, O | 1 |
| Wilimowska, J | 1 |
| Florek, E | 1 |
| Piekoszewski, W | 1 |
| Mier, JC | 1 |
| Pedersen, B | 1 |
| Juul-Jensen, P | 1 |
| Diehl, LW | 1 |
| Gastaut, H | 1 |
| Iemolo, F | 1 |
| Seghieri, G | 1 |
| De Giorgio, LA | 1 |
| Innocenti, F | 1 |
| Pettiná, G | 1 |
| Zolfanelli, F | 1 |
| Apicella, P | 1 |
| Settle, EC | 1 |
| Andersen, GO | 1 |
| Ritland, S | 1 |
| Landau, J | 1 |
| Baulac, M | 1 |
| Durand, G | 1 |
| de Billy, A | 1 |
| Philippon, J | 1 |
| Kerleau, JM | 1 |
| Bohu, PA | 1 |
| Héron, F | 1 |
| Manchon, ND | 1 |
| Bourreille, J | 1 |
| Visticot, F | 1 |
| Montreuil, G | 1 |
| Duarte, J | 1 |
| Macias, S | 1 |
| Coria, F | 1 |
| Fernandez, E | 1 |
| Clavería, LE | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Woo, M | 1 |
| Nishida, N | 1 |
| Muro, H | 1 |
| Fernandez, MC | 1 |
| Walter, FG | 1 |
| Kloster, JC | 1 |
| Do, SM | 1 |
| Brady, LA | 1 |
| Villarin, A | 1 |
| Ruffenach, SJ | 1 |
| Prosnitz, EH | 1 |
| Salmon, JV | 1 |
| Matsumoto, J | 1 |
| Ogawa, H | 1 |
| Maeyama, R | 1 |
| Okudaira, K | 1 |
| Shinka, T | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Eze, E | 1 |
| Workman, M | 1 |
| Donley, B | 1 |
| Montero, FJ | 1 |
| Ellaway, CJ | 1 |
| Bennetts, B | 1 |
| Tuck, RR | 1 |
| Wilcken, B | 1 |
| Nicolai, J | 1 |
| Smith, SJ | 1 |
| Keunen, RW | 1 |
| Sbei, M | 1 |
| Campellone, JV | 1 |
| Barrueto, F | 1 |
| Hack, JB | 1 |
| Padilla, Mde L | 1 |
| Miguélez, M | 1 |
| Riverola, A | 1 |
| Bueno, J | 1 |
| Lee, SA | 1 |
| Lee, JK | 1 |
| Heo, K | 1 |
| Vainstein, G | 1 |
| Korzets, Z | 1 |
| Pomeranz, A | 1 |
| Gadot, N | 1 |
| Koskiniemi, M | 1 |
| Hakamies, L | 1 |
| Verbiest, HB | 1 |
| Straver, JS | 1 |
| Colombo, JP | 1 |
| van der Vijver, JC | 1 |
| van Woerkom, TC | 1 |
| Triggs, WJ | 2 |
| Roe, CR | 1 |
| Rhead, WJ | 1 |
| Hanson, SK | 1 |
| Lin, SN | 2 |
| Willmore, LJ | 2 |
| Tokatli, A | 1 |
| Coşkun, T | 1 |
| Cataltepe, S | 1 |
| Ozalp, I | 1 |
| Bohan, TP | 1 |
| Zieve, L | 1 |
| Lyftogt, C | 1 |
| Gram, L | 1 |
| Bentsen, KD | 1 |
| Fahn, S | 1 |
| Bigler, D | 1 |
| McCandless, DW | 1 |
| Looney, G | 1 |
| Janssen, F | 1 |
| Rambeck, B | 1 |
| Schnabel, R | 1 |
4 reviews available for valproic acid and Coma
| Article | Year |
|---|---|
Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review.
Topics: Anticonvulsants; Coma; Craniotomy; Diagnosis, Differential; Female; Gastrointestinal Hemorrhage; Hep | 2017 |
Valproate-induced coma: case report and literature review.
Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val | 1993 |
Valproate: an updated review.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi | 1985 |
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
50 other studies available for valproic acid and Coma
| Article | Year |
|---|---|
Delayed and prolonged coma following valpromide poisoning in a 4-year-old girl.
Topics: Anticonvulsants; Child, Preschool; Coma; Drug Overdose; Female; Humans; Intubation; Valproic Acid | 2021 |
Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy.
Topics: Adult; Anticonvulsants; Coma; Drug Overdose; Female; Hemofiltration; Humans; Hypotension; Severity o | 2017 |
[Valproate-induced hyperammonemic encephalopathy].
Topics: Acetamides; Anticonvulsants; Brain Diseases, Metabolic; Carnitine; Coma; Drug Therapy, Combination; | 2017 |
Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest.
Topics: Anticonvulsants; Cohort Studies; Coma; Combined Modality Therapy; Electroencephalography; Female; He | 2019 |
Valproic acid-induced hyperammonaemic coma and unrecognised portosystemic shunt.
Topics: Anticonvulsants; Coma; Humans; Hyperammonemia; Hypertension, Portal; Liver Diseases, Alcoholic; Male | 2013 |
L-Arginine in the treatment of valproate overdose - five clinical cases.
Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Ove | 2017 |
Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination.
Topics: Adult; Anticonvulsants; Charcoal; Coma; Drug-Related Side Effects and Adverse Reactions; Female; Gla | 2009 |
Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.
Topics: Adult; Antimanic Agents; Brain Edema; Brain Infarction; Chemical and Drug Induced Liver Injury; Coma | 2011 |
Basilar-type migraine with coma: case reports and literature review.
Topics: Adolescent; Anticonvulsants; Antihypertensive Agents; Asian People; Coma; Female; Humans; Male; Migr | 2011 |
Valproate toxicity in a child: two novel observations.
Topics: Anticonvulsants; Child, Preschool; Coma; Drug Overdose; Female; Half-Life; Hemofiltration; Humans; M | 2013 |
A reversible cause of coma in epilepsy.
Topics: Adolescent; Anticonvulsants; Coma; Epilepsy; Female; Humans; Hyperammonemia; Valproic Acid | 2012 |
Delayed absorption of valproic acid, resulting in coma.
Topics: Adult; Ammonia; Coma; Humans; Male; Time Factors; Valproic Acid | 2002 |
Ammonia induced encephalopathy from valproic acid in a bipolar patient: case report.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Coma; Diagnosis, Dual (Psychiatry); Electroencephalograph | 2003 |
Delayed toxicity following acute ingestion of valpromide.
Topics: Adult; Anticonvulsants; Coma; Dyspnea; Female; Hepatic Encephalopathy; Humans; Male; Prodrugs; Time | 2004 |
Comparison of clinical, magnetic resonance and evoked potentials data in a case of valproic-acid-related hyperammonemic coma.
Topics: Atrophy; Coma; Evoked Potentials; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Rett Syndro | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Acute hyperammonemic coma with chronic valproic acid therapy.
Topics: Anticonvulsants; Coma; Electroencephalography; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged | 2005 |
[Transient central diabetes insipidus during a valproic acid poisoning].
Topics: Adult; Bipolar Disorder; Coma; Diabetes Insipidus; Fluid Therapy; Humans; Intubation, Intratracheal; | 2006 |
Disposition of valproic acid in self-poisoned adults.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Coma; Drug Interactions; Female; Fluorescence Po | 2006 |
Massive valproic acid overdose, a misleading case.
Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; P | 2008 |
Electroencephalographic alterations during intoxication with sodium valproate: a case report.
Topics: Adult; Coma; Electroencephalography; Female; Humans; Renal Dialysis; Respiration Disorders; Substanc | 1984 |
[Complications of valproic acid therapy: an overview (author's transl)].
Topics: Adult; Alcohol Withdrawal Delirium; Chemical and Drug Induced Liver Injury; Child; Coma; Electroence | 1981 |
Stuporous states or coma induced by the rapid administration of high doses of sodium valproate.
Topics: Adult; Anticonvulsants; Barbiturates; Coma; Drug Therapy, Combination; Electroencephalography; Epile | 1982 |
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb | 1982 |
Valproic acid-associated encephalopathy with coma.
Topics: Ammonia; Coma; Female; Humans; Middle Aged; Paralysis; Valproic Acid | 1995 |
Life threatening intoxication with sodium valproate.
Topics: Adult; Clonazepam; Coma; Female; Humans; Pancreatitis; Valproic Acid | 1995 |
Impairment of consciousness induced by valproate treatment following neurosurgical operation.
Topics: Adolescent; Adult; Arousal; Brain Neoplasms; Cerebral Hemorrhage; Coma; Consciousness Disorders; Del | 1993 |
[Hyperammonemic encephalopathy caused by sodium valproate].
Topics: Aged; Ammonia; Coma; Female; Humans; Valproic Acid | 1994 |
[Stupor encephalopathy caused by sodium valproate].
Topics: Coma; Confusion; Female; Humans; Middle Aged; Valproic Acid | 1994 |
Effect of L-carnitine supplementation on acute valproate intoxication.
Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro | 1996 |
Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning.
Topics: Acetates; Adult; Amines; Anticonvulsants; Biomarkers; Blood Chemical Analysis; Chromatography, Thin | 1996 |
Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication.
Topics: Acute Disease; Adult; Carnitine; Charcoal; Coma; Drug Overdose; Female; Glasgow Coma Scale; Hemoperf | 1997 |
Hyperammonemia and coma developed by a woman treated with valproic acid for affective disorder.
Topics: Aged; Ammonia; Anticonvulsants; Coma; Female; Humans; Mood Disorders; Valproic Acid | 1998 |
Naloxone in the reversal of coma induced by sodium valproate.
Topics: Adult; Anticonvulsants; Coma; Drug Overdose; Female; Glasgow Coma Scale; Humans; Naloxone; Narcotic | 1999 |
Clumsiness, confusion, coma, and valproate.
Topics: Adult; Coma; Confusion; Fatal Outcome; GABA Agents; Humans; Machado-Joseph Disease; Male; Valproic A | 1999 |
Simultaneous side effects of both clozapine and valproate.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Carnitine; Clozapine; Coma; Diabetic Ketoacidosis; Dru | 2001 |
Stupor from lamotrigine toxicity.
Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle | 2001 |
Hyperammonemia and coma without hepatic dysfunction induced by valproate therapy.
Topics: Adult; Anticonvulsants; Coma; Humans; Hyperammonemia; Liver; Liver Failure; Male; Valproic Acid | 2001 |
[Hyperammonaemic coma after valproate therapy as adult onset of ornithine transcarbamylase deficiency].
Topics: Coma; Female; Humans; Hyperammonemia; Middle Aged; Ornithine Carbamoyltransferase Deficiency Disease | 2002 |
Coma probably induced by lorazepam-valproate interaction.
Topics: Adult; Anticonvulsants; Coma; Drug Interactions; Epilepsy; Female; Humans; Lorazepam; Valproic Acid | 2002 |
Deepening coma in an epileptic patient: the missing link to the urea cycle. Hyperammonaemic metabolic encephalopathy.
Topics: Anticonvulsants; Atrophy; Cerebellum; Coma; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; T | 2002 |
Valporic acid and coma.
Topics: Adult; Coma; Humans; Male; Valproic Acid | 1979 |
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia | 1992 |
Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin.
Topics: Acids; Adult; Coma; Electron-Transferring Flavoproteins; Epilepsy, Complex Partial; Fatty Acid Desat | 1992 |
Valproate-induced lethal hyperammonaemic coma in a carrier of ornithine carbamoyltransferase deficiency.
Topics: Ammonia; Child, Preschool; Coma; Epilepsy; Female; Heterozygote; Humans; Ornithine Carbamoyltransfer | 1991 |
Valproate-induced coma with ketosis and carnitine insufficiency.
Topics: Acids; Adult; Carnitine; Coma; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; Ketosis | 1990 |
Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital.
Topics: Ammonium Chloride; Animals; Anticonvulsants; Caprylates; Coma; Dose-Response Relationship, Drug; Dru | 1989 |
Neurological sequelae after intoxication with sodium valproate.
Topics: Adult; Central Nervous System Diseases; Coma; Humans; Male; Valproic Acid | 1985 |
Sodium valproate and brainstem energetics.
Topics: Adenosine Triphosphate; Animals; Brain Stem; Coma; Energy Metabolism; Female; Glucose; Glycogen; Mic | 1985 |
Acute valproate intoxication with fatal outcome in an infant.
Topics: Brain; Coma; Heart Arrest; Humans; Infant; Male; Neurons; Respiratory Paralysis; Valproic Acid | 1985 |