valproic acid has been researched along with Colorectal Cancer in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study examined the combination of the histone deacetylase inhibitor (HDACi) valproic acid (VPA) with fluoropyrimidine-based chemo-radiotherapy on colorectal cancer (CRC) cells." | 7.85 | Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53. ( Avallone, A; Bruzzese, F; Budillon, A; Delrio, P; Di Gennaro, E; Imbimbo, S; Leone, A; Muto, P; Pecori, B; Roca, MS; Terranova-Barberio, M, 2017) |
| " The effects of VPA in combination with PIs on the growth of colorectal cancer cells were assessed with regard to proliferation, cell cycle, apoptosis, reactive oxygen species (ROS) generation and the expression of genes that control the cell cycle, apoptosis and pro-survival/stress-related pathways." | 5.40 | Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: underlying molecular mechanisms. ( Abaza, MS; Al-Attiyah, RJ; Bahman, AM, 2014) |
| " The present study examined the combination of the histone deacetylase inhibitor (HDACi) valproic acid (VPA) with fluoropyrimidine-based chemo-radiotherapy on colorectal cancer (CRC) cells." | 3.85 | Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53. ( Avallone, A; Bruzzese, F; Budillon, A; Delrio, P; Di Gennaro, E; Imbimbo, S; Leone, A; Muto, P; Pecori, B; Roca, MS; Terranova-Barberio, M, 2017) |
| " The aim of this study was to evaluate the effects of low, minimally cytotoxic concentrations of the HDAC inhibitor, valproic acid (VPA), on radiation response of colorectal cancer cells." | 3.75 | HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells. ( Chen, X; Radany, E; Wong, JY; Wong, P, 2009) |
| "Vorinostat was the first drug of this group used in clinical trial in combination with conventional chemotherapy and managed to stabilize advanced colorectal cancer." | 2.50 | Histone deacetylase inhibitors and colorectal cancer: what is new? ( Kouraklis, G; Nebiker, CA; Tampaki, EC; Tampakis, A, 2014) |
| " The effects of VPA in combination with PIs on the growth of colorectal cancer cells were assessed with regard to proliferation, cell cycle, apoptosis, reactive oxygen species (ROS) generation and the expression of genes that control the cell cycle, apoptosis and pro-survival/stress-related pathways." | 1.40 | Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: underlying molecular mechanisms. ( Abaza, MS; Al-Attiyah, RJ; Bahman, AM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Anirudh, BVM | 1 |
| Ezhilarasan, D | 1 |
| Ishida, R | 1 |
| Koyanagi-Aoi, M | 1 |
| Oshima, N | 1 |
| Kakeji, Y | 1 |
| Aoi, T | 1 |
| Terranova-Barberio, M | 1 |
| Pecori, B | 1 |
| Roca, MS | 1 |
| Imbimbo, S | 1 |
| Bruzzese, F | 1 |
| Leone, A | 1 |
| Muto, P | 1 |
| Delrio, P | 1 |
| Avallone, A | 1 |
| Budillon, A | 1 |
| Di Gennaro, E | 1 |
| Stypula-Cyrus, Y | 1 |
| Damania, D | 1 |
| Kunte, DP | 1 |
| Cruz, MD | 1 |
| Subramanian, H | 1 |
| Roy, HK | 1 |
| Backman, V | 1 |
| Abaza, MS | 1 |
| Bahman, AM | 1 |
| Al-Attiyah, RJ | 1 |
| Tampakis, A | 1 |
| Tampaki, EC | 1 |
| Nebiker, CA | 1 |
| Kouraklis, G | 1 |
| Feng, J | 1 |
| Cen, J | 1 |
| Li, J | 1 |
| Zhao, R | 1 |
| Zhu, C | 1 |
| Wang, Z | 1 |
| Xie, J | 1 |
| Tang, W | 1 |
| Chen, X | 1 |
| Wong, P | 1 |
| Radany, E | 1 |
| Wong, JY | 1 |
| Zhu, P | 1 |
| Martin, E | 1 |
| Mengwasser, J | 1 |
| Schlag, P | 1 |
| Janssen, KP | 1 |
| Göttlicher, M | 1 |
1 review available for valproic acid and Colorectal Cancer
| Article | Year |
|---|---|
Histone deacetylase inhibitors and colorectal cancer: what is new?
Topics: Antineoplastic Agents; Azacitidine; Colorectal Neoplasms; Combined Modality Therapy; Decitabine; His | 2014 |
8 other studies available for valproic acid and Colorectal Cancer
| Article | Year |
|---|---|
Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Triggers Sodium Valproate-Induced Cytotoxicity in Human Colorectal Adenocarcinoma Cells.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Enzyme Inhibitors; Humans; Mitoch | 2021 |
The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glycogen Synthase Ki | 2017 |
Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53.
Topics: Capecitabine; Colorectal Neoplasms; Flow Cytometry; Humans; Tumor Suppressor Protein p53; Valproic A | 2017 |
HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure.
Topics: Animals; Carcinogenesis; Cell Survival; Chromatin; Colorectal Neoplasms; Histone Deacetylase Inhibit | 2013 |
Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: underlying molecular mechanisms.
Topics: Anticonvulsants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Synergi | 2014 |
Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail.
Topics: Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expression Regulation, | 2015 |
HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells.
Topics: Animals; bcl-2-Associated X Protein; Cell Cycle; Cell Division; Cell Line, Tumor; Colorectal Neoplas | 2009 |
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Cell Cycle; Cell Tran | 2004 |