valproic acid has been researched along with Colitis in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ulcerative colitis is a chronic recurrent disease with incomplete treatment options." | 5.46 | The effect of sodium valproate on acetic acid-induced colitis in rats. ( Ghasemi-Pirbaluti, M; Hosseini, MJ; Motaghi, E; Najafi, A, 2017) |
| " The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
| " Valproic acid (VPA) and suberyolanilide hydroxamic acid (SAHA) were chosen for further studies in dextran sulfate sodium- and trinitrobenzene sulfonic acid-induced colitis in mice." | 3.73 | Histone hyperacetylation is associated with amelioration of experimental colitis in mice. ( Batra, A; Dinarello, CA; Fantuzzi, G; Fedke, I; Glauben, R; Lehr, HA; Leoni, F; Mascagni, P; Siegmund, B; Zeitz, M, 2006) |
| "Ulcerative colitis is a chronic recurrent disease with incomplete treatment options." | 1.46 | The effect of sodium valproate on acetic acid-induced colitis in rats. ( Ghasemi-Pirbaluti, M; Hosseini, MJ; Motaghi, E; Najafi, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Caro, C | 1 |
| Leo, A | 1 |
| Nesci, V | 1 |
| Ghelardini, C | 1 |
| di Cesare Mannelli, L | 1 |
| Striano, P | 1 |
| Avagliano, C | 1 |
| Calignano, A | 1 |
| Mainardi, P | 1 |
| Constanti, A | 1 |
| Citraro, R | 1 |
| De Sarro, G | 1 |
| Russo, E | 1 |
| Qu, M | 1 |
| Xiong, L | 1 |
| Lyu, Y | 1 |
| Zhang, X | 1 |
| Shen, J | 1 |
| Guan, J | 1 |
| Chai, P | 1 |
| Lin, Z | 1 |
| Nie, B | 1 |
| Li, C | 1 |
| Xu, J | 1 |
| Deng, H | 1 |
| Najafi, A | 1 |
| Motaghi, E | 1 |
| Hosseini, MJ | 1 |
| Ghasemi-Pirbaluti, M | 1 |
| Glauben, R | 1 |
| Batra, A | 1 |
| Fedke, I | 1 |
| Zeitz, M | 1 |
| Lehr, HA | 1 |
| Leoni, F | 1 |
| Mascagni, P | 1 |
| Fantuzzi, G | 1 |
| Dinarello, CA | 1 |
| Siegmund, B | 1 |
4 other studies available for valproic acid and Colitis
| Article | Year |
|---|---|
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration.
Topics: Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Colitis; Culture Media, Conditioned; Dextr | 2021 |
The effect of sodium valproate on acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Colitis; Inflammation Mediators; Male; Random Allocation; Rats; Rats, Wistar; | 2017 |
Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Topics: Acetylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Colitis; Cytokines; Diseas | 2006 |