valproic acid has been researched along with Cochlear Hearing Loss in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is an important and commonly used histone deacetylase (HDAC) inhibitor for class I (HDAC1, 2, 3, and 8) and class IIa (HDAC4, 5, 7, and 9)." | 5.91 | Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression. ( Cho, HH; Choi, YM; Lee, S; Nam, YS, 2023) |
| "Carbamazepine (CBZ) was found to be effective in most cases." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "Susac syndrome is an occlusive arteriolar disease that provokes infarcts in the cochlea, retina, and brain of young subjects, mostly women." | 2.40 | Susac syndrome. ( Aumaitre, O; Biousse, V; Bousser, MG; Fardeau, C; Godeau, P; Huong, DL; Lehoang, P; N'Guyen, N; Papo, T; Piette, JC, 1998) |
| "Valproic acid (VPA) is an important and commonly used histone deacetylase (HDAC) inhibitor for class I (HDAC1, 2, 3, and 8) and class IIa (HDAC4, 5, 7, and 9)." | 1.91 | Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression. ( Cho, HH; Choi, YM; Lee, S; Nam, YS, 2023) |
| "Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment." | 1.56 | ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020) |
| " However, this is the first case of VPA-induced hearing loss that was tested and confirmed with a VPA rechallenge, supported by serial audiometry and pharmacokinetic modelling." | 1.40 | Valproate-induced reversible sensorineural hearing loss: a case report with serial audiometry and pharmacokinetic modelling during a valproate rechallenge. ( Bakar, MZ; Lim, KS; Lo, YL; Tan, CT; Yeap, LL, 2014) |
| "These findings represent VPA-induced sensorineural hearing loss, possibly in preexisting presbycusis." | 1.28 | Sensorineural hearing loss: a reversible effect of valproic acid. ( Armon, C; Brown, E; Carwile, S; Miller, P; Shin, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nam, YS | 1 |
| Choi, YM | 1 |
| Lee, S | 1 |
| Cho, HH | 1 |
| Gasser, M | 1 |
| Boonsimma, P | 1 |
| Netbaramee, W | 1 |
| Wechapinan, T | 1 |
| Srichomthomg, C | 1 |
| Ittiwut, C | 1 |
| Krenn, M | 1 |
| Zimprich, F | 1 |
| Milenkovic, I | 1 |
| Abicht, A | 1 |
| Biskup, S | 1 |
| Roser, T | 1 |
| Shotelersuk, V | 1 |
| Tacke, M | 1 |
| Kuersten, M | 1 |
| Wagner, M | 1 |
| Borggraefe, I | 1 |
| Suphapeetiporn, K | 1 |
| von Stülpnagel, C | 1 |
| Mir, A | 1 |
| Chaudhary, M | 1 |
| Alkhaldi, H | 1 |
| Alhazmi, R | 1 |
| Albaradie, R | 1 |
| Housawi, Y | 1 |
| Chauhan, S | 1 |
| Tripathi, P | 1 |
| Goyal, P | 1 |
| Kumar, D | 1 |
| Yeap, LL | 1 |
| Lim, KS | 1 |
| Lo, YL | 1 |
| Bakar, MZ | 1 |
| Tan, CT | 1 |
| Lance, EI | 1 |
| Shapiro, BK | 1 |
| Papo, T | 1 |
| Biousse, V | 1 |
| Lehoang, P | 1 |
| Fardeau, C | 1 |
| N'Guyen, N | 1 |
| Huong, DL | 1 |
| Aumaitre, O | 1 |
| Bousser, MG | 1 |
| Godeau, P | 1 |
| Piette, JC | 1 |
| Armon, C | 1 |
| Brown, E | 1 |
| Carwile, S | 1 |
| Miller, P | 1 |
| Shin, C | 1 |
2 reviews available for valproic acid and Cochlear Hearing Loss
| Article | Year |
|---|---|
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Susac syndrome.
Topics: Adult; Anti-Inflammatory Agents; Audiometry, Pure-Tone; Brain Diseases; Cyclophosphamide; Diagnosis, | 1998 |
6 other studies available for valproic acid and Cochlear Hearing Loss
| Article | Year |
|---|---|
Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression.
Topics: Animals; Deafness; Hair Cells, Auditory; Hearing Loss; Hearing Loss, Sensorineural; Histone Deacetyl | 2023 |
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss | 2020 |
Bipolar disorder in Pendred syndrome: a case report of two siblings.
Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Female; Goiter, Nodular; Hearing Loss, Sens | 2014 |
Valproate-induced reversible sensorineural hearing loss: a case report with serial audiometry and pharmacokinetic modelling during a valproate rechallenge.
Topics: Adult; Anticonvulsants; Audiometry; Epilepsy, Temporal Lobe; Evoked Potentials, Auditory, Brain Stem | 2014 |
Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Audiometry, Pure-Tone; Central Nervo | 2013 |
Sensorineural hearing loss: a reversible effect of valproic acid.
Topics: Aged; Audiometry; Epilepsy, Temporal Lobe; Hearing Loss, Sensorineural; Humans; Male; Phenobarbital; | 1990 |