valproic acid has been researched along with Cocaine-Related Disorders in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of valproate as a treatment for cocaine dependence is not supported." | 2.74 | Valproate treatment and cocaine cue reactivity in cocaine dependent individuals. ( Reid, MS; Thakkar, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, JS | 1 |
| Tallarida, RJ | 1 |
| Unterwald, EM | 1 |
| Reid, MS | 2 |
| Thakkar, V | 1 |
| Casadonte, P | 1 |
| Baker, S | 1 |
| Sanfilipo, M | 1 |
| Braunstein, D | 1 |
| Hitzemann, R | 1 |
| Montgomery, A | 1 |
| Majewska, D | 1 |
| Robinson, J | 1 |
| Rotrosen, J | 1 |
| Salloum, IM | 1 |
| Douaihy, A | 1 |
| Cornelius, JR | 1 |
| Kirisci, L | 1 |
| Kelly, TM | 1 |
| Hayes, J | 1 |
| Pabello, NG | 1 |
| Hubbell, CL | 1 |
| Cavallaro, CA | 1 |
| Barringer, TM | 1 |
| Mendez, JJ | 1 |
| Reid, LD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Valproate Efficacy in Cocaine-Bipolar Comorbidity[NCT00240110] | Phase 1/Phase 2 | 152 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change from baseline in percentage of self-report cocaine-abstinent (non-use) days (difference in base percent values) (NCT00240110)
Timeframe: Week 12
| Intervention | percentage of days cocaine abstinent (Mean) |
|---|---|
| Lithium Carbonate Add on Placebo | 16.4 |
| Lithium Carbonate Add on Valproate | 14.5 |
Change from baseline in percentage of the amount of money spent on cocaine (NCT00240110)
Timeframe: week 12
| Intervention | Percentage of Money Spent on Cocaine (Mean) |
|---|---|
| Lithium Carbonate Add on Placebo | -43.6 |
| Lithium Carbonate Add on Valproate | -34.9 |
3 trials available for valproic acid and Cocaine-Related Disorders
| Article | Year |
|---|---|
Valproate treatment and cocaine cue reactivity in cocaine dependent individuals.
Topics: Adult; Affect; Antimanic Agents; Cocaine-Related Disorders; Crack Cocaine; Cross-Over Studies; Cues; | 2009 |
A placebo-controlled screening trial of olanzapine, valproate, and coenzyme Q10/L-carnitine for the treatment of cocaine dependence.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carnitine; Cocaine-Related Disorders; Coenzymes | 2005 |
Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study.
Topics: Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Cocaine-Related Disorders; Counseling; | 2007 |
2 other studies available for valproic acid and Cocaine-Related Disorders
| Article | Year |
|---|---|
Cocaine-induced hyperactivity and sensitization are dependent on GSK3.
Topics: Animals; Caudate Nucleus; Cocaine; Cocaine-Related Disorders; Enzyme Activation; Glycogen Synthase K | 2009 |
Responding for rewarding brain stimulation: cocaine and isradipine plus naltrexone.
Topics: Analysis of Variance; Animals; Brain; Calcium Channel Blockers; Cocaine-Related Disorders; Drug Ther | 1998 |