valproic acid has been researched along with Cleft Palate in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "Orofacial clefting (OFC) has been described in infants exposed to valproic acid (VPA) prenatally, but often no distinction is made between cleft lip and palate (CLP) and isolated cleft palate (ICP)." | 4.93 | In utero exposure to valproate increases the risk of isolated cleft palate. ( Bromley, R; Clayton-Smith, J; Irwin, B; Jackson, A; Morrow, J, 2016) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| " To assess the impact of influencing AED prescribing practices on spina bifida and cleft palate we searched the literature for estimates of the association between valproic acid or carbamazepine use during pregnancy and these defects and summarized the associations using meta-analyses." | 3.77 | Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. ( Boulet, SL; Broussard, CS; Devine, OJ; Duwe, KN; Flak, AL; Gilboa, SM; Honein, MA; Moore, CA; Werler, MM, 2011) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or valproic acid [VA]) were given to pregnant mice to induce cleft palate (TCDD, urethane), digital defects (urethane, MNU), or exencephaly (VA)." | 3.70 | Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. ( Blaylock, BL; Gogal, RM; Holladay, SD; Sharova, L; Smith, BJ; Ward, DL, 2000) |
| "Valproic acid is an anticonvulsant that has been associated with open neural tube defects." | 2.38 | Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989) |
| " We investigated potential transgenerational adverse effects of valproate." | 1.72 | Transgenerational adverse effects of valproate? A patient report from 90 affected families. ( Bewley, S; Braillon, A; Hill, C; MacLennan, AH; Martin, M, 2022) |
| "Valproic acid (VPA) is an anti-epileptic drug known to cause congenital craniofacial abnormalities, including orofacial clefts (OFC)." | 1.56 | The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae. ( Carels, CEL; Gebuijs, IGE; Metz, JR; Von den Hoff, JW; Wagener, FADTG; Zethof, J, 2020) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| "The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice." | 1.26 | Teratogenic effects of anticonvulsants. ( Paulson, GW; Paulson, RB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, M | 1 |
| Hill, C | 1 |
| Bewley, S | 1 |
| MacLennan, AH | 1 |
| Braillon, A | 1 |
| Gebuijs, IGE | 1 |
| Metz, JR | 1 |
| Zethof, J | 1 |
| Carels, CEL | 1 |
| Wagener, FADTG | 1 |
| Von den Hoff, JW | 1 |
| Jackson, A | 1 |
| Bromley, R | 1 |
| Morrow, J | 1 |
| Irwin, B | 1 |
| Clayton-Smith, J | 1 |
| Gilboa, SM | 1 |
| Broussard, CS | 1 |
| Devine, OJ | 1 |
| Duwe, KN | 1 |
| Flak, AL | 1 |
| Boulet, SL | 1 |
| Moore, CA | 1 |
| Werler, MM | 1 |
| Honein, MA | 1 |
| Ozkinay, F | 1 |
| Cogulu, O | 1 |
| Gunduz, C | 1 |
| Yilmaz, D | 1 |
| Kultursay, N | 1 |
| Yerby, MS | 1 |
| Alsdorf, R | 1 |
| Wyszynski, DF | 1 |
| Artama, M | 1 |
| Auvinen, A | 1 |
| Raudaskoski, T | 1 |
| Isojärvi, I | 1 |
| Isojärvi, J | 1 |
| Paulson, GW | 1 |
| Paulson, RB | 1 |
| Holladay, SD | 1 |
| Sharova, L | 1 |
| Smith, BJ | 1 |
| Gogal, RM | 1 |
| Ward, DL | 1 |
| Blaylock, BL | 1 |
| Carter, BS | 1 |
| Stewart, JM | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
4 reviews available for valproic acid and Cleft Palate
| Article | Year |
|---|---|
In utero exposure to valproate increases the risk of isolated cleft palate.
Topics: Anticonvulsants; Cleft Palate; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregn | 2016 |
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip; | 2005 |
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female; | 1989 |
8 other studies available for valproic acid and Cleft Palate
| Article | Year |
|---|---|
Transgenerational adverse effects of valproate? A patient report from 90 affected families.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Drug-Related Side Ef | 2022 |
The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae.
Topics: Animals; Cartilage; Cell Differentiation; Chondrogenesis; Cleft Lip; Cleft Palate; Embryo, Nonmammal | 2020 |
Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States.
Topics: Anticonvulsants; Carbamazepine; Cleft Palate; Female; Humans; Pregnancy; Pregnancy Complications; Pr | 2011 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Antiepileptic drug use of women with epilepsy and congenital malformations in offspring.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cardiovascular Abnormalities; Cleft Palate; Coh | 2005 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cleft Palate; Eyelid Diseases; | 1981 |
Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; BCG Vaccine; | 2000 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |