valproic acid has been researched along with Chronic Kidney Failure in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders." | 7.68 | Pancreatitis in children on chronic dialysis treated with valproic acid. ( Ford, DM; Lum, GM; Portman, RJ, 1990) |
| "Pancreatitis is a serious adverse effect of valproic acid (VPA)." | 3.70 | On the toxicity of valproic-acid. ( Alonso, R; Cuiña, L; Moreiras Plaza, M; Rodríguez Goyanes, G, 1999) |
| "Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders." | 3.68 | Pancreatitis in children on chronic dialysis treated with valproic acid. ( Ford, DM; Lum, GM; Portman, RJ, 1990) |
| "Cases of acute pancreatitis caused by sodium valproate (VPA) have been reported by many authors thus far." | 1.40 | Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report. ( Okayasu, H; Osone, A; Ozeki, Y; Shimoda, K; Shinozaki, T, 2014) |
| "We treated a 31-year-old woman with systemic lupus erythematosus, renal failure with nephrotic syndrome, and a long-standing seizure disorder, who developed severe hyperammonemia with a fatal outcome." | 1.30 | Fatal hyperammonemia in a patient with systemic lupus erythematosus. ( Amano, T; Ichikawa, H; Kawabata, K; Kushiro, M; Makino, H; Nagake, Y; Wada, J, 1998) |
| "Valproic acid was proved to be effective in reducing the number of attacks over 4 months." | 1.30 | Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. ( Fujieda, M; Kurashige, T; Machida, Y; Maeda, A; Maeda, H; Naruse, K; Okada, T; Ushida, M; Wakiguchi, H; Yokoyama, W, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okayasu, H | 1 |
| Shinozaki, T | 1 |
| Osone, A | 1 |
| Ozeki, Y | 1 |
| Shimoda, K | 1 |
| Rosenberg, SL | 1 |
| Chen, S | 1 |
| McLaughlin, N | 1 |
| El-Dahr, SS | 1 |
| Burtey, S | 1 |
| Dai, XY | 1 |
| Zhao, MM | 1 |
| Cai, Y | 1 |
| Guan, QC | 1 |
| Zhao, Y | 1 |
| Guan, Y | 1 |
| Kong, W | 1 |
| Zhu, WG | 1 |
| Xu, MJ | 1 |
| Wang, X | 1 |
| Ferrari, R | 1 |
| Merli, E | 1 |
| Cicchitelli, G | 1 |
| Mele, D | 1 |
| Fucili, A | 1 |
| Ceconi, C | 1 |
| Schneider, AL | 1 |
| Wacarda, L | 1 |
| von Klitzing, E | 1 |
| Kochen, W | 1 |
| Hellenbrecht, D | 1 |
| Bruni, J | 1 |
| Wang, LH | 1 |
| Marbury, TC | 1 |
| Lee, CS | 1 |
| Wilder, BJ | 1 |
| Elias, AN | 1 |
| Pahl, M | 1 |
| Stone, S | 1 |
| Vaziri, ND | 1 |
| Valenta, LJ | 1 |
| Jefferson, JW | 1 |
| Sen, D | 1 |
| Levin, TL | 1 |
| Berdon, WE | 1 |
| Seigle, RR | 1 |
| Nash, MA | 1 |
| Driessen, JJ | 1 |
| Robertson, EN | 1 |
| Booij, LH | 1 |
| Vree, TB | 1 |
| Ichikawa, H | 1 |
| Amano, T | 1 |
| Kawabata, K | 1 |
| Kushiro, M | 1 |
| Wada, J | 1 |
| Nagake, Y | 1 |
| Makino, H | 1 |
| Yokoyama, W | 1 |
| Fujieda, M | 1 |
| Okada, T | 1 |
| Maeda, H | 1 |
| Ushida, M | 1 |
| Machida, Y | 1 |
| Naruse, K | 1 |
| Maeda, A | 1 |
| Wakiguchi, H | 1 |
| Kurashige, T | 1 |
| Lapierre, O | 1 |
| Dubreucq, JL | 1 |
| Beauchemin, MA | 1 |
| Vinet, B | 1 |
| Moreiras Plaza, M | 1 |
| Rodríguez Goyanes, G | 1 |
| Cuiña, L | 1 |
| Alonso, R | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Ritter, G | 1 |
| Sungur, C | 1 |
| Sungur, A | 1 |
| Akpolat, T | 1 |
| Yasavul, U | 1 |
| Turgan, C | 1 |
| Caglar, S | 1 |
| Ford, DM | 1 |
| Portman, RJ | 1 |
| Lum, GM | 1 |
| Sedman, AJ | 1 |
| Molitoris, BA | 1 |
| Nakata, LM | 1 |
| Gal, J | 1 |
| Böhles, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for valproic acid and Chronic Kidney Failure
| Article | Year |
|---|---|
Regulation of kidney development by histone deacetylases.
Topics: Animals; Child; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, | 2011 |
[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Chromosomes, Human, Pair 16; Clini | 2011 |
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.
Topics: Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Humans; Kidney Failure, Chronic; Liver; Myoc | 2004 |
17 other studies available for valproic acid and Chronic Kidney Failure
| Article | Year |
|---|---|
Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report.
Topics: Abdominal Pain; Acute Disease; Anticonvulsants; Bipolar Disorder; Humans; Japan; Kidney Failure, Chr | 2014 |
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Topics: Adenine; Alkaline Phosphatase; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Autophagy; Au | 2013 |
Experimental observations on peritoneal transport in rabbits.
Topics: Animals; Biological Transport; Creatinine; Disease Models, Animal; Dopamine; Fenoterol; Inulin; Isop | 1983 |
Protein binding of valproic acid in uremic patients.
Topics: Humans; Kidney Failure, Chronic; Protein Binding; Renal Dialysis; Uremia; Valproic Acid | 1980 |
Modulatory role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin secretion in patients with chronic renal failure.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releas | 1982 |
Manic depressive disorder and lithium over the decades: the very educational case of Mrs. L.
Topics: Aged; Aged, 80 and over; Bipolar Disorder; Drug Administration Schedule; Electroconvulsive Therapy; | 1994 |
Valproic-acid-associated pancreatitis and hepatic toxicity in children with endstage renal disease.
Topics: Adolescent; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Fatal Outcome; Fatty Liv | 1997 |
Accelerated recovery and disposition from rocuronium in an end-stage renal failure patient on chronic anticonvulsant therapy with sodium valproate and primidone.
Topics: Adult; Androstanols; Anticonvulsants; Drug Interactions; Humans; Kidney Failure, Chronic; Male; Neur | 1998 |
Fatal hyperammonemia in a patient with systemic lupus erythematosus.
Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Fatal Outcome; Female; Humans; Kidney Failure, Chro | 1998 |
Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis.
Topics: Adrenocorticotropic Hormone; Child; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chr | 1998 |
Valproic acid intoxication in a patient with bipolar disorder and chronic uremia.
Topics: Antimanic Agents; Bipolar Disorder; Depression; Female; Humans; Hypokinesia; Kidney Failure, Chronic | 1999 |
On the toxicity of valproic-acid.
Topics: Acute Disease; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Kidney Failure, Chronic; Male | 1999 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Unresponsiveness to human recombinant erythropoietin in an epileptic dialysis patient secondary to valproic acid toxicity.
Topics: Adult; Electrocardiography; Epilepsy, Tonic-Clonic; Erythropoietin; Female; Humans; Kidney Failure, | 1992 |
Pancreatitis in children on chronic dialysis treated with valproic acid.
Topics: Child; Child, Preschool; Female; Humans; Infant; Kidney Failure, Chronic; Male; Pancreatitis; Renal | 1990 |
Therapeutic drug monitoring in patients with chronic renal failure: evaluation of the Abbott TDx drug assay system.
Topics: Carbamazepine; Cross Reactions; Digoxin; Gentamicins; Humans; Immunoassay; Kidney Failure, Chronic; | 1986 |
[When is parenteral carnitine administration indicated?].
Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Pr | 1986 |