valproic acid has been researched along with Chronic Disease in 83 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of valproic acid in the treatment of intractable chronic daily headache, unresponsive to traditional prophylactic medications, was examined prospectively in 16 patients." | 9.08 | Valproic acid treatment of chronic daily headache. ( Spillane, T; Vijayan, N, 1995) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1." | 7.74 | Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride. ( Ishizaki, J; Khemawoot, P; Maruyama, C; Miyamoto, K; Noda, H; Tsukada, H; Yokogawa, K, 2007) |
| "A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis." | 7.71 | A case of chronic pancreatic insufficiency due to valproic acid in a child. ( Cooper, MA; Groll, A, 2001) |
| "Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone." | 5.09 | Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999) |
| "The efficacy of valproic acid in the treatment of intractable chronic daily headache, unresponsive to traditional prophylactic medications, was examined prospectively in 16 patients." | 5.08 | Valproic acid treatment of chronic daily headache. ( Spillane, T; Vijayan, N, 1995) |
| "The hypothesis of a gamma-aminobutyric acid (GABA) involvement in the pathophysiology of schizophrenia has been recently proposed but not confirmed." | 5.06 | Growth hormone response to sodium valproate in chronic schizophrenia. ( Iovino, M; Maj, M; Monteleone, P; Steardo, L, 1986) |
| "Under the medicine treatment of magnesium valproate with carbamazepine, the patient experienced partial seizures approximately once per month that lasted 30 to 60 seconds each without any complications observed during a follow-up period of 24 months." | 5.01 | A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report. ( Jiang, Z; Li, B; Li, J; Li, Y; Wang, L; Zhang, T, 2019) |
| "The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical therapies for chronic allergic airways diseases, such as asthma." | 3.96 | Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy. ( Bambery, KR; Karagiannis, TC; Licciardi, PV; Mazarakis, N; Royce, SG; Samuel, CS; Snibson, KJ; Tobin, MJ; Ververis, K; Vongsvivut, J, 2020) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "Many investigators agree that appropriate rational utilization of therapeutic drug monitoring (TDM) with Bayesian feedback dosage adjustment facilitates epilepsy treatment with carbamazepine (CBZ) and/or valproate (VPA) by increasing the seizure control and safety, as well as by reducing treatment costs." | 3.77 | Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy. ( Andreeva, OV; Bondareva, IB; Bondareva, KI; Jelliffe, RW, 2011) |
| "Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients." | 3.76 | Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010) |
| "The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1." | 3.74 | Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride. ( Ishizaki, J; Khemawoot, P; Maruyama, C; Miyamoto, K; Noda, H; Tsukada, H; Yokogawa, K, 2007) |
| "A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis." | 3.71 | A case of chronic pancreatic insufficiency due to valproic acid in a child. ( Cooper, MA; Groll, A, 2001) |
| "Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action." | 3.70 | Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. ( Alves, ND; de Carvalho, AM; de Castro-Costa, CM; Santos, FJ; Silveira, DG, 1999) |
| "We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin." | 3.68 | Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992) |
| "Migraine is not curable, but preventive treatments are usually used to decrease the intensity and frequency of headache attacks." | 2.84 | Levetiracetam in Compare to Sodium Valproate for Prophylaxis in Chronic Migraine Headache: A Randomized Double-Blind Clinical Trial. ( Ghadikolaei, HS; Kashipazha, D; Siavashi, M, 2017) |
| "Posttraumatic stress disorder (PTSD) is one of the chronic and disabling psychiatric disorders, particularly in combat veterans." | 2.84 | Effect of Rivastigmine Augmentation in Treatment of Male Patients With Combat-Related Chronic Posttraumatic Stress Disorder: A Randomized Controlled Trial. ( Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A; Talaei, A, 2017) |
| " Mean VPA dosage was of approximately 870 mg/day (approximately 22 mg/kg/day) and mean VPA concentration was of approximately 89 mg/l at 12 h post-dose and of 54 mg/l at 24 h post-dose." | 2.72 | Conventional and sustained-release valproate in children with newly diagnosed epilepsy: a randomized and crossover study comparing clinical effects, patient preference and pharmacokinetics. ( Adín, J; Armijo, JA; Arteaga, R; Herranz, JL, 2006) |
| "Treatment of chronic daily headache/transformed migraine is challenging, especially when it is complicated by overuse of analgesics, triptans, or both." | 2.70 | Intravenous valproate sodium in the treatment of daily headache. ( Karpitskiy, VV; Schwartz, TH; Sohn, RS, 2002) |
| "Chronic central pain is a frequent complication after spinal cord injury." | 2.67 | Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study. ( Andreasen, A; Drewes, AM; Poulsen, LH, 1994) |
| "Migraine is a common neurological disease affecting about 12% of the population in Western Europe and North America, and causing a considerable burden both to migraineurs and to society." | 2.46 | Role of antiepileptic drugs as preventive agents for migraine. ( Rapoport, AM; Vikelis, M, 2010) |
| "Bipolar disorder (BPD) is a severe and chronic illness, with a lifetime prevalence of approximately 1." | 2.44 | Anticonvulsant efficacy of valproate-like carboxylic acids: a potential target for anti-bipolar therapy. ( Azab, AN; Greenberg, ML, 2007) |
| "Lamotrigine has demonstrated efficacy in delaying time to depressive relapse." | 2.42 | Rethinking the treatment paradigm for bipolar depression: the importance of long-term management. ( Baldassano, CF; Ballas, CA; O'Reardon, JP, 2004) |
| "Headaches are a common entity in the ambulatory population." | 2.40 | Diagnosis, prophylaxis, and treatment of headaches in the athlete. ( Kaplan, B; Swain, RA, 1997) |
| "There was a reduction in the number of migraine attacks, and migraine duration and intensity were also reduced in some instances." | 2.39 | Divalproex sodium in headache: literature review and clinical guidelines. ( Silberstein, SD, 1996) |
| " There were no serious adverse events." | 1.72 | Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review. ( Allen, I; Gelfand, AA; Pavitt, S; Riggins, N; Zorrilla, N, 2022) |
| "In vehicle-treated animals, ocular hypertension resulted in a 29." | 1.40 | Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension. ( Alsarraf, O; Chou, CJ; Crosson, CE; Dahrouj, M; Fan, J; Yates, PW, 2014) |
| "We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy." | 1.36 | Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. ( Antoniou, A; Armeni, E; Boufidou, F; Evangelopoulos, EM; Lambrinoudaki, I; Triantafyllou, N; Tsivgoulis, G, 2010) |
| "Chronic migraine is an important public health problem." | 1.36 | Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials. ( D'Amico, D, 2010) |
| "In the present study we have investigated the effects of a chronic administration of olanzapine (Ola) on visual and spatial memory in normal and anhedonic rats." | 1.34 | Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats. ( Canonico, PL; Colella, L; Dellarole, A; Ghi, P; Orsetti, M, 2007) |
| "15 idiopathic generalized epilepsy (IGE) patients were examined and compared to 16 normal controls." | 1.33 | Distribution of spatial complexity of EEG in idiopathic generalized epilepsy and its change after chronic valproate therapy. ( Clemens, B; Czopf, J; Gyimesi, C; Kondakor, I; Toth, M; Wackermann, J, 2005) |
| "We have observed acute dystonias in the absence of antipsychotic treatment and in the context of seizure activity (or paroxysmal dyskinetic activity)." | 1.33 | High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. ( Botts, SR; Coffey, GL; de Leon, J, 2005) |
| "In all the patients with cerebral infarction, the current arrows exhibited the similar pattern as the normal subjects." | 1.31 | Cortical functional abnormality assessed by auditory-evoked magnetic fields and therapeutic approach in patients with chronic dizziness. ( Kandori, A; Miyashita, K; Murakami, M; Naritomi, H; Oe, H; Tsukada, K, 2002) |
| "The therapeutic dose needed to prevent migraine headaches has been examined in several studies, yet the optimum dose has not been found." | 1.29 | High-dose versus low-dose valproic acid as a prophylactic medication. ( Goldstein, J; Taylor, K, 1996) |
| "Valproic acid is a reliable and comparatively safe drug in the treatment of special forms of absence seizures." | 1.27 | [Unapparent course of pancreatitis with pseudocyst development and cholestatic jaundice in anticonvulsive therapy with valproate]. ( Braun, E; Bundschu, HD; Spannagel, B, 1987) |
| "Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children's Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate)." | 1.26 | Sodium valproate in the treatment of the intractable childhood epileptic. ( Keene, DL; Metrakos, K; Sherwin, A; Watters, GV, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (18.07) | 18.7374 |
| 1990's | 21 (25.30) | 18.2507 |
| 2000's | 25 (30.12) | 29.6817 |
| 2010's | 19 (22.89) | 24.3611 |
| 2020's | 3 (3.61) | 2.80 |
| Authors | Studies |
|---|---|
| Pavitt, S | 1 |
| Gelfand, AA | 1 |
| Zorrilla, N | 1 |
| Allen, I | 1 |
| Riggins, N | 1 |
| Ferrari, MD | 1 |
| Zuurbier, KWM | 1 |
| Barash, S | 1 |
| Ning, X | 1 |
| Cohen, JM | 1 |
| Li, Y | 1 |
| Zhang, T | 1 |
| Li, B | 1 |
| Li, J | 1 |
| Wang, L | 1 |
| Jiang, Z | 1 |
| Mazarakis, N | 1 |
| Vongsvivut, J | 1 |
| Bambery, KR | 1 |
| Ververis, K | 1 |
| Tobin, MJ | 1 |
| Royce, SG | 1 |
| Samuel, CS | 1 |
| Snibson, KJ | 1 |
| Licciardi, PV | 1 |
| Karagiannis, TC | 1 |
| Kashipazha, D | 1 |
| Ghadikolaei, HS | 1 |
| Siavashi, M | 1 |
| Quan, W | 1 |
| Shao, Q | 1 |
| Zhang, H | 1 |
| Liu, FH | 1 |
| Zhang, XH | 1 |
| Weiner, D | 1 |
| Nir, V | 1 |
| Klein-Kremer, A | 1 |
| Kassem, E | 1 |
| Wei, D | 1 |
| Yang, F | 2 |
| Wang, Y | 1 |
| Wu, C | 1 |
| Wu, SX | 1 |
| Jiang, W | 1 |
| Qiu, HM | 1 |
| Yang, JX | 1 |
| Jiang, XH | 1 |
| Fei, HZ | 1 |
| Liu, D | 1 |
| Hu, XY | 1 |
| Zhou, QX | 1 |
| Alsarraf, O | 1 |
| Fan, J | 1 |
| Dahrouj, M | 1 |
| Chou, CJ | 1 |
| Yates, PW | 1 |
| Crosson, CE | 1 |
| Snehunsu, A | 1 |
| Ghosal, C | 1 |
| Kandwal, M | 1 |
| Yadav, PK | 1 |
| Nayak, BS | 1 |
| Rao, KR | 1 |
| Kamath, SU | 1 |
| Sahoo, P | 1 |
| Srinivasan, KK | 1 |
| Naduvil Narayanan, S | 1 |
| Kumar, S | 1 |
| Joseph, A | 1 |
| Pontes, JC | 1 |
| Lima, TZ | 1 |
| Queiroz, CM | 1 |
| Cinini, SM | 1 |
| Blanco, MM | 1 |
| Mello, LE | 1 |
| Rezaei Ardani, A | 1 |
| Hosseini, G | 1 |
| Fayyazi Bordbar, MR | 1 |
| Talaei, A | 1 |
| Mostafavi Toroghi, H | 1 |
| Ding, D | 1 |
| Shi, Y | 1 |
| Shaltiel, G | 1 |
| Azab, AN | 2 |
| Pullumbi, E | 1 |
| Campbell, A | 1 |
| Mehta, DV | 1 |
| Agam, G | 1 |
| Greenberg, ML | 2 |
| Vikelis, M | 1 |
| Rapoport, AM | 1 |
| Triantafyllou, N | 1 |
| Lambrinoudaki, I | 1 |
| Armeni, E | 1 |
| Evangelopoulos, EM | 1 |
| Boufidou, F | 1 |
| Antoniou, A | 1 |
| Tsivgoulis, G | 1 |
| Kim, JE | 1 |
| Choi, HC | 1 |
| Song, HK | 1 |
| Jo, SM | 1 |
| Kim, DS | 1 |
| Choi, SY | 1 |
| Kim, YI | 1 |
| Kang, TC | 1 |
| D'Amico, D | 1 |
| Xie, W | 1 |
| Yu, Y | 1 |
| Zhao, Y | 1 |
| Bondareva, IB | 1 |
| Jelliffe, RW | 1 |
| Andreeva, OV | 1 |
| Bondareva, KI | 1 |
| Bezinover, D | 1 |
| Postula, M | 1 |
| Donahue, K | 1 |
| Bentzen, B | 1 |
| McInerney, J | 1 |
| Janicki, PK | 1 |
| Straube, A | 1 |
| Gaul, C | 1 |
| Chabwine, JN | 1 |
| Rossetti, AR | 1 |
| Hirt, L | 1 |
| Kuntzer, T | 1 |
| Schluep, M | 1 |
| Michel, P | 1 |
| Démonet, JF | 1 |
| du Pasquier, RA | 1 |
| Vingerhoets, FG | 1 |
| Schwartz, TH | 1 |
| Karpitskiy, VV | 1 |
| Sohn, RS | 1 |
| Madeb, R | 1 |
| Hirschmann, S | 1 |
| Kurs, R | 1 |
| Turkie, A | 1 |
| Modai, I | 1 |
| Oe, H | 1 |
| Kandori, A | 1 |
| Murakami, M | 1 |
| Miyashita, K | 1 |
| Tsukada, K | 1 |
| Naritomi, H | 1 |
| Maguire, GA | 1 |
| Phillips, G | 1 |
| Baldassano, CF | 1 |
| Ballas, CA | 1 |
| O'Reardon, JP | 1 |
| Mauz, PS | 1 |
| Mörike, K | 1 |
| Kaiserling, E | 1 |
| Brosch, S | 1 |
| Coffey, GL | 1 |
| Botts, SR | 1 |
| de Leon, J | 1 |
| Yatham, LN | 1 |
| Kennedy, SH | 1 |
| O'Donovan, C | 1 |
| Parikh, S | 1 |
| MacQueen, G | 1 |
| McIntyre, R | 1 |
| Sharma, V | 1 |
| Silverstone, P | 1 |
| Alda, M | 1 |
| Baruch, P | 1 |
| Beaulieu, S | 1 |
| Daigneault, A | 1 |
| Milev, R | 1 |
| Young, LT | 1 |
| Ravindran, A | 1 |
| Schaffer, A | 1 |
| Connolly, M | 1 |
| Gorman, CP | 1 |
| Kondakor, I | 1 |
| Toth, M | 1 |
| Wackermann, J | 1 |
| Gyimesi, C | 1 |
| Czopf, J | 1 |
| Clemens, B | 1 |
| Coskun, O | 1 |
| Ucler, S | 1 |
| Cavdar, L | 1 |
| Inan, LE | 1 |
| Orsetti, M | 1 |
| Colella, L | 1 |
| Dellarole, A | 1 |
| Canonico, PL | 1 |
| Ghi, P | 1 |
| Herranz, JL | 1 |
| Arteaga, R | 1 |
| Adín, J | 1 |
| Armijo, JA | 1 |
| Khemawoot, P | 1 |
| Maruyama, C | 1 |
| Tsukada, H | 1 |
| Noda, H | 1 |
| Ishizaki, J | 1 |
| Yokogawa, K | 1 |
| Miyamoto, K | 1 |
| Blumenfeld, AM | 1 |
| Schim, JD | 1 |
| Chippendale, TJ | 1 |
| Davis, LL | 2 |
| Davidson, JR | 1 |
| Ward, LC | 1 |
| Bartolucci, A | 1 |
| Bowden, CL | 1 |
| Petty, F | 2 |
| Yurekli, VA | 1 |
| Akhan, G | 1 |
| Kutluhan, S | 1 |
| Uzar, E | 1 |
| Koyuncuoglu, HR | 1 |
| Gultekin, F | 1 |
| Kausen, J | 1 |
| Zimmermann, P | 1 |
| Fünfgeld, EW | 1 |
| Klenke, D | 1 |
| Henkel, H | 1 |
| Puca, FM | 1 |
| Genco, S | 1 |
| Minervini, MG | 1 |
| Specchio, LM | 1 |
| Napoletano, V | 1 |
| Brancasi, B | 1 |
| Reggio, F | 1 |
| Werdan, K | 1 |
| Hannig, C | 1 |
| Bolte, HD | 1 |
| Nair, NP | 1 |
| Lal, S | 1 |
| Schwartz, G | 1 |
| Thavundayil, JX | 1 |
| Swerdlow, M | 1 |
| Cundill, JG | 1 |
| Keene, DL | 1 |
| Metrakos, K | 1 |
| Watters, GV | 1 |
| Sherwin, A | 1 |
| Mathew, NT | 2 |
| Drewes, AM | 1 |
| Andreasen, A | 1 |
| Poulsen, LH | 1 |
| Karlov, VA | 2 |
| Vijayan, N | 1 |
| Spillane, T | 1 |
| Taylor, K | 1 |
| Goldstein, J | 1 |
| Silberstein, SD | 1 |
| Maksumova, EL | 1 |
| Muzychenko, AP | 1 |
| Sokolova, LV | 1 |
| Zheleznova, EV | 1 |
| Swain, RA | 1 |
| Kaplan, B | 1 |
| Zed, PJ | 1 |
| Loewen, PS | 1 |
| Robinson, G | 1 |
| Vlasov, PN | 1 |
| Khabibova, AO | 1 |
| Alves, ND | 1 |
| de Castro-Costa, CM | 1 |
| de Carvalho, AM | 1 |
| Santos, FJ | 1 |
| Silveira, DG | 1 |
| Wassef, AA | 1 |
| Dott, SG | 1 |
| Harris, A | 1 |
| Brown, A | 1 |
| O'Boyle, M | 1 |
| Meyer, WJ | 1 |
| Rose, RM | 1 |
| Packard, RC | 1 |
| Cooper, MA | 1 |
| Groll, A | 1 |
| Rothrock, JF | 1 |
| Robbins, L | 1 |
| Taira, N | 1 |
| Nishi, H | 1 |
| Mano, M | 1 |
| Waki, N | 1 |
| Tsugita, Y | 1 |
| Takashima, S | 1 |
| Fukuda, K | 1 |
| Komatsubara, S | 1 |
| Nugent, AL | 1 |
| Kramer, GL | 1 |
| Teten, A | 1 |
| Schmitt, A | 1 |
| Stone, RC | 1 |
| Solomon, GD | 1 |
| Nagao, T | 1 |
| Ohshimo, T | 1 |
| Mitsunobu, K | 1 |
| Sato, M | 1 |
| Otsuki, S | 1 |
| Penin, H | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Ronthal, M | 1 |
| Terespolsky, PS | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Nishida, N | 1 |
| Kobayashi, Y | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Karper, LP | 1 |
| Seibyl, JP | 1 |
| Krystal, JH | 1 |
| Pezzilli, R | 1 |
| Billi, P | 1 |
| Melandri, R | 1 |
| Broccoli, PL | 1 |
| Fontana, G | 1 |
| Ali, S | 1 |
| García Rojas, JF | 1 |
| Mangas Rojas, A | 1 |
| Barba Chacón, A | 1 |
| García Osle, M | 1 |
| Zamora Madaria, E | 1 |
| Melegh, B | 1 |
| Kerner, J | 1 |
| Acsádi, G | 1 |
| Lakatos, J | 1 |
| Sándor, A | 1 |
| Nasser, D | 1 |
| Thomas, B | 1 |
| Sovner, R | 1 |
| Monteleone, P | 2 |
| Zontini, G | 1 |
| Steardo, L | 2 |
| Lipsky, MS | 1 |
| Maj, M | 1 |
| Iovino, M | 1 |
| Braun, E | 1 |
| Spannagel, B | 1 |
| Bundschu, HD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Double-dummy, Controlled Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide - a Pilot Study[NCT00400088] | Phase 3 | 2 participants (Actual) | Interventional | 2007-06-30 | Terminated (stopped due to Recruitment difficulties) | ||
| Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression: Double-Blind, Placebo-Controlled Study to Establish Efficacy and Safety[NCT00590265] | 50 participants (Anticipated) | Interventional | 2008-01-31 | Active, not recruiting | |||
| Divalproex Sodium in the Treatment of PTSD: A Placebo-Controlled Study[NCT00108576] | Phase 3 | 101 participants (Actual) | Interventional | 2003-10-31 | Completed | ||
| A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire (Non-Invasive Vagus Nerve Stimulator) for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)[NCT04071743] | 0 participants (Actual) | Interventional | 2020-01-01 | Withdrawn (stopped due to Primary Investigator left UT Southwestern and was not replaced.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for valproic acid and Chronic Disease
| Article | Year |
|---|---|
A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report.
Topics: Brain Diseases; Carbamazepine; China; Chronic Disease; Female; Humans; Intellectual Disability; Magn | 2019 |
Role of antiepileptic drugs as preventive agents for migraine.
Topics: Adult; Anticonvulsants; Child; Chronic Disease; Clinical Trials as Topic; Fructose; Humans; Migraine | 2010 |
Optimal dosing of medications (in bipolar disorder).
Topics: Acute Disease; Affect; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Ch | 2003 |
Rethinking the treatment paradigm for bipolar depression: the importance of long-term management.
Topics: Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Ch | 2004 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Anticonvulsant efficacy of valproate-like carboxylic acids: a potential target for anti-bipolar therapy.
Topics: Anticonvulsants; Bipolar Disorder; Carboxylic Acids; Chronic Disease; Humans; Valproic Acid | 2007 |
Divalproex sodium in headache: literature review and clinical guidelines.
Topics: Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Headache; Humans; Migraine Disorders | 1996 |
Diagnosis, prophylaxis, and treatment of headaches in the athlete.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; | 1997 |
Medication-induced headache: overview and systematic review of therapeutic approaches.
Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Chronic Disease; Ergolines; Headache; Humans; M | 1999 |
Pancreatitis induced by valproic acid: report of a case.
Topics: Adult; Anticonvulsants; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Female; Fi | 2001 |
Chronic tension-type headache: advice for the viselike-headache patient.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; | 2002 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
15 trials available for valproic acid and Chronic Disease
| Article | Year |
|---|---|
Levetiracetam in Compare to Sodium Valproate for Prophylaxis in Chronic Migraine Headache: A Randomized Double-Blind Clinical Trial.
Topics: Adolescent; Adult; Analgesics; Chronic Disease; Disability Evaluation; Double-Blind Method; Female; | 2017 |
Effect of Rivastigmine Augmentation in Treatment of Male Patients With Combat-Related Chronic Posttraumatic Stress Disorder: A Randomized Controlled Trial.
Topics: Adult; Cholinesterase Inhibitors; Chronic Disease; Combat Disorders; Double-Blind Method; Drug Syner | 2017 |
Intravenous valproate sodium in the treatment of daily headache.
Topics: Adolescent; Adult; Analgesics; Cerebellar Ataxia; Chronic Disease; Dose-Response Relationship, Drug; | 2002 |
Conventional and sustained-release valproate in children with newly diagnosed epilepsy: a randomized and crossover study comparing clinical effects, patient preference and pharmacokinetics.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Chronic Disease; Cross-Over Studies; Data Inte | 2006 |
Botulinum toxin type A and divalproex sodium for prophylactic treatment of episodic or chronic migraine.
Topics: Adolescent; Adult; Aged; Botulinum Toxins, Type A; Chronic Disease; Disability Evaluation; Double-Bl | 2008 |
Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population.
Topics: Chronic Disease; Combat Disorders; Delayed-Action Preparations; Double-Blind Method; Female; GABA Ag | 2008 |
The effect of sodium valproate on chronic daily headache and its subgroups.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Double-Blind Method; Female; Headache Dis | 2008 |
Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Humans; M | 1994 |
Valproic acid treatment of chronic daily headache.
Topics: Adult; Aged; Chronic Disease; Female; Headache; Humans; Male; Middle Aged; Prospective Studies; Valp | 1995 |
[Depakine syrup in the treatment of therapy-resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Drug Resistance; Electroencephalography; Epilep | 1996 |
[Depakin 300 and Depakin-chrono in the therapy of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Electroencephalography; Epilepsy; Female; Human | 1999 |
Randomized, placebo-controlled pilot study of divalproex sodium in the treatment of acute exacerbations of chronic schizophrenia.
Topics: Acute Disease; Adult; Antipsychotic Agents; Chronic Disease; Double-Blind Method; Drug Therapy, Comb | 2000 |
Management of chronic daily headache utilizing a uniform treatment pathway.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru | 1999 |
Valproate in the treatment of persistent chronic daily headache. An open label study.
Topics: Chronic Disease; Double-Blind Method; Headache; Humans; Prospective Studies; Valproic Acid | 1991 |
Growth hormone response to sodium valproate in chronic schizophrenia.
Topics: Adult; Brain; Chronic Disease; Double-Blind Method; gamma-Aminobutyric Acid; Growth Hormone; Humans; | 1986 |
56 other studies available for valproic acid and Chronic Disease
| Article | Year |
|---|---|
Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Chronic Disease; Female; GABA Agents; Headache Dis | 2022 |
Fremanezumab in individuals with chronic migraine who had inadequate response to onabotulinumtoxinA and topiramate or valproic acid.
Topics: Antibodies, Monoclonal; Botulinum Toxins, Type A; Chronic Disease; Double-Blind Method; Humans; Migr | 2022 |
Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chronic Disease; Disease Models, Animal; Drug Evaluation, Pr | 2020 |
Acute Pancreatitis Associated with Valproate Treatment.
Topics: Acute Disease; Antimanic Agents; Chronic Disease; Humans; Pancreatitis; Valproic Acid | 2018 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Upregulating serotonin transporter expression and downregulating monoamine oxidase-A and indoleamine 2, 3-dioxygenase expression involved in the antidepressant effect of sodium valproate in a rat model.
Topics: Animals; Antidepressive Agents; Chronic Disease; Depressive Disorder; Disease Models, Animal; Hippoc | 2014 |
Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension.
Topics: Acetylation; Acetyltransferases; Animals; Blotting, Western; Chronic Disease; Disease Models, Animal | 2014 |
1-Triacontanol cerotate; isolated from Marsilea quadrifolia Linn. ameliorates reactive oxidative damage in the frontal cortex and hippocampus of chronic epileptic rats.
Topics: Animals; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy, Generalized; Fatty Alcohols; F | 2015 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Yeast bioassay for identification of inositol depleting compounds.
Topics: Anticonvulsants; Antimanic Agents; Biological Assay; Bipolar Disorder; Brain; Carboxylic Acids; Cell | 2009 |
Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.
Topics: Absorptiometry, Photon; Adult; Anticonvulsants; Biomarkers; Bone and Bones; Bone Density; Bone Disea | 2010 |
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1 | 2010 |
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.
Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy.
Topics: Adult; Aged; Anticonvulsants; Bayes Theorem; Carbamazepine; Chronic Disease; Databases, Factual; Dem | 2011 |
Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis.
Topics: Adult; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Ch | 2011 |
[Chronic migraine: not well known but not rare!].
Topics: Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Chronic Disease; Femal | 2011 |
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai | 2012 |
Combined clozapine and valproic acid treatment-induced agranulocytosis.
Topics: Agranulocytosis; Anticonvulsants; Chronic Disease; Clozapine; Drug Therapy, Combination; Humans; Mal | 2002 |
Cortical functional abnormality assessed by auditory-evoked magnetic fields and therapeutic approach in patients with chronic dizziness.
Topics: Acoustic Stimulation; Aged; Anticonvulsants; Auditory Cortex; Auditory Diseases, Central; Brain Mapp | 2002 |
Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects.
Topics: Adult; Anticonvulsants; Biopsy; Chronic Disease; Diagnosis, Differential; Epilepsy, Post-Traumatic; | 2005 |
High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.
Topics: Anticonvulsants; Antipsychotic Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Dibenzothiazepines; | 2005 |
Distribution of spatial complexity of EEG in idiopathic generalized epilepsy and its change after chronic valproate therapy.
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Data Interpretation, Statistical; Dose-Response | 2005 |
Effect of valproic acid on withdrawal therapy in patients with overuse of chronic daily headache medications.
Topics: Adult; Aged; Analgesics; Chronic Disease; Female; GABA Agents; Headache Disorders; Humans; Male; Mid | 2007 |
Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antimanic Agents; Antipsychotic Agents; Be | 2007 |
Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Area Under Curve; Aspartate Am | 2007 |
Effects of a GABA-mimetic drug (sodium valproate) on visually evoked potentials in chronic schizophrenics.
Topics: Adult; Brain; Brief Psychiatric Rating Scale; Chronic Disease; Clozapine; Dibenzazepines; Drug Thera | 1984 |
[Sleep in chronic chorea patients after therapy with sodium valproate].
Topics: Adult; Chorea; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; M | 1984 |
[64-year-old patient with a long-term cramp syndrome].
Topics: Chronic Disease; Electromyography; Humans; Male; Middle Aged; Muscle Cramp; Syndrome; Valproic Acid | 1984 |
Effect of sodium valproate and baclofen in tardive dyskinesia: clinical and neuroendocrine studies.
Topics: Adult; Baclofen; Chronic Disease; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Halop | 1980 |
Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Female; Humans | 1981 |
Sodium valproate in the treatment of the intractable childhood epileptic.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Drug Therapy, Combination; Education of | 1982 |
Valproate in intractable headache.
Topics: Brain; Chronic Disease; Headache; Humans; Migraine Disorders; Neurons; Valproic Acid | 1994 |
[The efficacy of depakin in treatment-resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chronic Disease; Drug Evaluation; Drug | 1993 |
High-dose versus low-dose valproic acid as a prophylactic medication.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; GABA Age | 1996 |
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In | 1997 |
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In | 1997 |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Neuralgia; Phenytoin; Rats; Ra | 1999 |
Treatment of chronic daily posttraumatic headache with divalproex sodium.
Topics: Chronic Disease; Craniocerebral Trauma; Follow-Up Studies; GABA Agents; Headache; Humans; Recurrence | 2000 |
A case of chronic pancreatic insufficiency due to valproic acid in a child.
Topics: Adolescent; Anticonvulsants; Chronic Disease; Exocrine Pancreatic Insufficiency; Follow-Up Studies; | 2001 |
We need better preventative medications.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Headache Disorders; Humans; Selective Serotonin R | 2001 |
Valproate therapy for chronic, combat-induced posttraumatic stress disorder.
Topics: Adult; Arousal; Chronic Disease; Combat Disorders; Humans; Male; Middle Aged; Personality Inventory; | 2002 |
Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor.
Topics: Adult; Chronic Disease; Cyclic AMP; Cyclic GMP; Cyproheptadine; Dyskinesia, Drug-Induced; Female; Ho | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
Early experience with sodium valproate.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; | 1976 |
Abnormal metabolism of carnitine and valproate in a case of acute encephalopathy during chronic valproate therapy.
Topics: Brain Diseases; Carnitine; Cerebral Palsy; Child; Chronic Disease; Female; Gas Chromatography-Mass S | 1992 |
Valproate management of psychosis in a patient with carbamazepine-induced hyponatremia.
Topics: Carbamazepine; Chronic Disease; Drinking; Drug Therapy, Combination; Humans; Hyponatremia; Male; Mid | 1992 |
Anticonvulsant-induced chronic pancreatitis. A case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr | 1992 |
[Clinical remission in Cushing's disease through treatment with sodium valproate and bromocriptine].
Topics: Bromocriptine; Chronic Disease; Cushing Syndrome; Cyproheptadine; Drug Therapy, Combination; Female; | 1991 |
L-carnitine replacement therapy in chronic valproate treatment.
Topics: Adolescent; Carnitine; Child; Chronic Disease; Epilepsy; Female; Humans; Ketone Bodies; Lipid Metabo | 1990 |
Anticonvulsant treatment of psychoses.
Topics: Adult; Chronic Disease; Female; Humans; Male; Neurocognitive Disorders; Psychotic Disorders; Schizop | 1990 |
The use of valproate in the treatment of mentally retarded persons with typical and atypical bipolar disorders.
Topics: Adult; Autistic Disorder; Bipolar Disorder; Chronic Disease; Female; Follow-Up Studies; Fragile X Sy | 1989 |
Failure of the GABAergic drug, sodium valproate, to reduce basal plasma prolactin secretion in chronic schizophrenia.
Topics: Adult; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Mid | 1985 |
Chronic hiccups.
Topics: Adult; Anticonvulsants; Central Nervous System Diseases; Chronic Disease; Diabetes Complications; Fe | 1986 |
[Unapparent course of pancreatitis with pseudocyst development and cholestatic jaundice in anticonvulsive therapy with valproate].
Topics: Adolescent; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis, Extrahepatic; Chronic Dise | 1987 |