valproic acid has been researched along with Chromosomal Triplication in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE." | 3.69 | Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996) |
| " VPA dosage was tapered and discontinued, with accompanying resolution of clinical, immunological and hematological signs of SLE 6 weeks after VPA discontinuation." | 1.29 | Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy. ( Diomedi, M; Gigli, GL; Grazia Pomponi, M; Masala, C; Pauri, F; Placidi, F; Scalise, A; Silvestri, G, 1996) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandes, S | 1 |
| Vinnakota, R | 1 |
| Kumar, J | 1 |
| Kale, V | 1 |
| Limaye, L | 1 |
| Gigli, GL | 2 |
| Scalise, A | 2 |
| Pauri, F | 1 |
| Silvestri, G | 2 |
| Diomedi, M | 2 |
| Placidi, F | 2 |
| Grazia Pomponi, M | 1 |
| Masala, C | 2 |
| Pomponi, MG | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
4 other studies available for valproic acid and Chromosomal Triplication
| Article | Year |
|---|---|
Improved neural differentiation of normal and abnormal induced pluripotent stem cell lines in the presence of valproic acid.
Topics: Cell Differentiation; Cell Line; Cell Lineage; Cellular Reprogramming; Chromosome Deletion; Dopamine | 2019 |
Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy.
Topics: Adult; Chromosomes, Human, Pair 9; Comorbidity; Epilepsy; Female; HLA-DR4 Antigen; Humans; Intellect | 1996 |
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1996 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |