valproic acid has been researched along with Chromosomal Translocation in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| "Epilepsy with myoclonic atonic seizures (EMAtS) was previously thought to occur in normally developing children." | 1.91 | A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation. ( Fujita, A; Goji, A; Matsumoto, N; Mizuguchi, T; Mori, T; Sakamoto, M; Tayama, T; Toda, Y; Urushihara, M, 2023) |
| "We present a patient affected by Dravet syndrome." | 1.39 | Dravet phenotype in a subject with a der(4)t(4;8)(p16.3;p23.3) without the involvement of the LETM1 gene. ( Bayindir, B; Brustia, F; Ciccone, R; Dehghani, MR; Della Mina, E; Limongelli, I; Piazza, E; Veggiotti, P; Zuffardi, O, 2013) |
| "Valproic acid (VPA) has extensive effects on leukemic blasts through its inhibition of histone deacetylases." | 1.38 | Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically. ( Mejstrikova, E; Smetana, K; Starkova, J; Stary, J; Trka, J; Zapotocky, M, 2012) |
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Mori, T | 1 |
| Sakamoto, M | 1 |
| Tayama, T | 1 |
| Goji, A | 1 |
| Toda, Y | 1 |
| Fujita, A | 1 |
| Mizuguchi, T | 1 |
| Urushihara, M | 1 |
| Matsumoto, N | 1 |
| Bayindir, B | 1 |
| Piazza, E | 1 |
| Della Mina, E | 1 |
| Limongelli, I | 1 |
| Brustia, F | 1 |
| Ciccone, R | 1 |
| Veggiotti, P | 1 |
| Zuffardi, O | 1 |
| Dehghani, MR | 1 |
| Zapotocky, M | 1 |
| Mejstrikova, E | 1 |
| Smetana, K | 1 |
| Stary, J | 1 |
| Trka, J | 1 |
| Starkova, J | 1 |
| Darling, A | 1 |
| Poo, P | 1 |
| Perez-Duenas, B | 1 |
| Campistol, J | 1 |
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Bug, G | 1 |
| Schwarz, K | 1 |
| Schoch, C | 1 |
| Kampfmann, M | 1 |
| Henschler, R | 1 |
| Hoelzer, D | 1 |
| Ottmann, OG | 1 |
| Ruthardt, M | 1 |
| Monti, B | 1 |
| Polazzi, E | 1 |
| Batti, L | 1 |
| Crochemore, C | 1 |
| Virgili, M | 1 |
| Contestabile, A | 1 |
| Ikonen, E | 1 |
| Salo, A | 1 |
| Somer, M | 1 |
| Somer, H | 1 |
| Pääkkönen, L | 1 |
| Peltonen, L | 1 |
1 review available for valproic acid and Chromosomal Translocation
| Article | Year |
|---|---|
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
7 other studies available for valproic acid and Chromosomal Translocation
| Article | Year |
|---|---|
A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation.
Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; GAB | 2023 |
Dravet phenotype in a subject with a der(4)t(4;8)(p16.3;p23.3) without the involvement of the LETM1 gene.
Topics: Anticonvulsants; Calcium-Binding Proteins; Child; Chromosomes, Human, Pair 4; Epilepsies, Myoclonic; | 2013 |
Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.
Topics: Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Chromosomes, Human, Pair 21; Chromoso | 2012 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.
Topics: Adult; Aged; Antigens, CD34; Cell Culture Techniques; Cell Differentiation; Cell Division; Cell Line | 2007 |
Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death.
Topics: alpha-Synuclein; Animals; Apoptosis; Blotting, Western; Cell Death; Cell Nucleus; Cell Survival; Cer | 2007 |
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
Topics: Abnormalities, Multiple; Adolescent; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pa | 1992 |